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  1. Article ; Conference proceedings: Das Chamäleon erkennen, seltene Diabetes Fälle in der diabetologischen Praxis

    Berndt-Zipfel, Christine / Maxeiner, Stephan

    Diabetologie und Stoffwechsel

    (Diabetes Kongress 2024 – 58. Jahrestagung der DDG)

    2024  Volume 19, Issue S 01

    Event/congress Diabetes. Umwelt. Leben. Perspektiven aus allen Blickwinkeln, CityCube Berlin, 2024-05-08
    Series title Diabetes Kongress 2024 – 58. Jahrestagung der DDG
    Language German
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2222993-0
    ISSN 1861-9010 ; 1861-9002
    ISSN (online) 1861-9010
    ISSN 1861-9002
    DOI 10.1055/s-0044-1785297
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  2. Article ; Online: Prostate volume and its influence on clinical parameters in prostate cancer detection.

    Stephan, Carsten / Peters, Robert / Jung, Klaus / Maxeiner, Andreas

    Journal of clinical laboratory analysis

    2023  Volume 37, Issue 2, Page(s) e24832

    MeSH term(s) Male ; Humans ; Prostate ; Prostatic Neoplasms/diagnosis ; Prostate-Specific Antigen
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.24832
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  3. Article ; Conference proceedings: Ein Vergleich aktueller AID Hybrid closed loop Insulinpumpen in der real world (diabetologische Schwerpunktpraxis Rheinland-Pfalz)

    Berndt-Zipfel, Christine / Maxeiner, Stephan / Behr, Andreas

    Diabetologie und Stoffwechsel

    (Diabetes Kongress 2024 – 58. Jahrestagung der DDG)

    2024  Volume 19, Issue S 01

    Event/congress Diabetes. Umwelt. Leben. Perspektiven aus allen Blickwinkeln, CityCube Berlin, 2024-05-08
    Series title Diabetes Kongress 2024 – 58. Jahrestagung der DDG
    Language German
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2222993-0
    ISSN 1861-9010 ; 1861-9002
    ISSN (online) 1861-9010
    ISSN 1861-9002
    DOI 10.1055/s-0044-1785326
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  4. Article ; Online: Pitfalls of using sequence databases for heterologous expression studies - a technical review.

    Maxeiner, Stephan / Krasteva-Christ, Gabriela / Althaus, Mike

    The Journal of physiology

    2023  Volume 601, Issue 9, Page(s) 1611–1623

    Abstract: Synthesis of DNA fragments based on gene sequences that are available in public resources has become an efficient and affordable method that has gradually replaced traditional cloning efforts such as PCR cloning from cDNA. However, database entries based ...

    Abstract Synthesis of DNA fragments based on gene sequences that are available in public resources has become an efficient and affordable method that has gradually replaced traditional cloning efforts such as PCR cloning from cDNA. However, database entries based on genome sequencing results are prone to errors which can lead to false sequence information and, ultimately, errors in functional characterisation of proteins such as ion channels and transporters in heterologous expression systems. We have identified five common problems that repeatedly appear in public resources: (1) Not every gene has yet been annotated; (2) not all gene annotations are necessarily correct; (3) transcripts may contain automated corrections; (4) there are mismatches between gene, mRNA and protein sequences; and (5) splicing patterns often lack experimental validation. This technical review highlights and provides a strategy to bypass these issues in order to avoid critical mistakes that could impact future studies of any gene/protein of interest in heterologous expression systems.
    MeSH term(s) Base Sequence ; Amino Acid Sequence ; DNA, Complementary/genetics ; DNA, Complementary/metabolism ; Proteins/genetics
    Chemical Substances DNA, Complementary ; Proteins
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial.

    Maxeiner, Stephan / Tschernig, Thomas / Brenner, Erich

    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

    2022  Volume 243, Page(s) 151947

    Language English
    Publishing date 2022-04-22
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1106738-x
    ISSN 1618-0402 ; 0940-9602
    ISSN (online) 1618-0402
    ISSN 0940-9602
    DOI 10.1016/j.aanat.2022.151947
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  6. Article ; Conference proceedings: Fallbericht: Closed-Loop Insulinpumpentherapie bei Mitochondrialem Diabetes

    Berndt-Zipfel, Christine / Maxeiner, Stephan

    Diabetologie und Stoffwechsel

    2022  Volume 17, Issue S 01

    Event/congress Diabetes Kongress 2022 - 56. Jahrestagung der DDG, CityCube Berlin, 2022-05-25
    Language German
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2222993-0
    ISSN 1861-9010 ; 1861-9002
    ISSN (online) 1861-9010
    ISSN 1861-9002
    DOI 10.1055/s-0042-1746328
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  7. Article: Of Humans and Gerbils- Independent Diversification of Neuroligin-4 Into X- and Y-Specific Genes in Primates and Rodents.

    Maxeiner, Stephan / Benseler, Fritz / Brose, Nils / Krasteva-Christ, Gabriela

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 838262

    Abstract: The neural cell adhesion protein neuroligin-4 has puzzled neuroscientists and geneticist alike for almost two decades. Its clinical association with autism spectrum disorders (ASD) is well established, however, its diversification into sex chromosome- ... ...

    Abstract The neural cell adhesion protein neuroligin-4 has puzzled neuroscientists and geneticist alike for almost two decades. Its clinical association with autism spectrum disorders (ASD) is well established, however, its diversification into sex chromosome-specific copies,
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.838262
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  8. Article ; Online: Correction: Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters.

    Trotter, Justin H / Hao, Junjie / Maxeiner, Stephan / Tsetsenis, Theodoros / Liu, Zhihui / Zhuang, Xiaowei / Südhof, Thomas C

    The Journal of cell biology

    2023  Volume 222, Issue 10

    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.20181207608242023c
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  9. Article ; Online: Synaptic ribbons foster active zone stability and illumination-dependent active zone enrichment of RIM2 and Cav1.4 in photoreceptor synapses.

    Dembla, Ekta / Dembla, Mayur / Maxeiner, Stephan / Schmitz, Frank

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 5957

    Abstract: Rod photoreceptor synapses use large, ribbon-type active zones for continuous synaptic transmission during light and dark. Since ribbons are physically connected to the active zones, we asked whether illumination-dependent changes of ribbons influence ... ...

    Abstract Rod photoreceptor synapses use large, ribbon-type active zones for continuous synaptic transmission during light and dark. Since ribbons are physically connected to the active zones, we asked whether illumination-dependent changes of ribbons influence Cav1.4/RIM2 protein clusters at the active zone and whether these illumination-dependent effects at the active zone require the presence of the synaptic ribbon. We found that synaptic ribbon length and the length of presynaptic Cav1.4/RIM2 clusters are tightly correlated. Dark-adaptation did not change the number of ribbons and active zone puncta. However, mean ribbon length and length of presynaptic Cav1.4/RIM2 clusters increased significantly during dark-adaptation when tonic exocytosis is highest. In the present study, we identified by the analyses of synaptic ribbon-deficient RIBEYE knockout mice that synaptic ribbons are (1) needed to stabilize Cav1.4/RIM2 at rod photoreceptor active zones and (2) are required for the darkness-induced active zone enrichment of Cav1.4/RIM2. These data propose a role of the ribbon in active zone stabilization and suggest a homeostatic function of the ribbon in illumination-dependent active zone remodeling.
    MeSH term(s) Animals ; Calcium Channels, L-Type/genetics ; Calcium Channels, L-Type/metabolism ; Dark Adaptation/physiology ; Female ; Homeostasis/physiology ; Male ; Mice ; Mice, Knockout ; Retinal Rod Photoreceptor Cells/metabolism ; Synapses/metabolism ; Synaptic Transmission/physiology ; rab3 GTP-Binding Proteins/genetics ; rab3 GTP-Binding Proteins/metabolism
    Chemical Substances Cacna1f protein, mouse ; Calcium Channels, L-Type ; Rim2 protein, mouse (EC 3.6.1.-) ; rab3 GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2020-04-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-62734-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Human airway tuft cells influence the mucociliary clearance through cholinergic signalling.

    Hollenhorst, Monika I / Husnik, Thomas / Zylka, Malin / Duda, Nele / Flockerzi, Veit / Tschernig, Thomas / Maxeiner, Stephan / Krasteva-Christ, Gabriela

    Respiratory research

    2023  Volume 24, Issue 1, Page(s) 267

    Abstract: Background: Airway tuft cells, formerly called brush cells have long been described only morphologically in human airways. More recent RNAseq studies described a chemosensory cell population, which includes tuft cells, by a distinct gene transcription ... ...

    Abstract Background: Airway tuft cells, formerly called brush cells have long been described only morphologically in human airways. More recent RNAseq studies described a chemosensory cell population, which includes tuft cells, by a distinct gene transcription signature. Yet, until which level in the tracheobronchial tree in native human airway epithelium tuft cells occur and if they function as regulators of innate immunity, e.g., by regulating mucociliary clearance, remained largely elusive.
    Methods: We performed immunohistochemistry, RT-PCR and immunoblotting analyses for various tuft cell markers to confirm the presence of this cell type in human tracheal samples. Immunohistochemistry was conducted to study the distribution of tuft cells along the intrapulmonary airways in humans. We assessed the influence of bitter substances and the taste transduction pathway on mucociliary clearance in mouse and human tracheal samples by measuring particle transport speed.
    Results: Tuft cells identified by the expression of their well-established marker POU class 2 homeobox 3 (POU2F3) were present from the trachea to the bronchioles. We identified choline acetyltransferase in POU2F3 expressing cells as well as the transient receptor potential melastatin 5 (TRPM5) channel in a small population of tracheal epithelial cells with morphological appearance of tuft cells. Application of bitter substances, such as denatonium, led to an increase in mucociliary clearance in human tracheal preparations. This was dependent on activation of the TRPM5 channel and involved cholinergic and nitric oxide signalling, indicating a functional role for human tuft cells in the regulation of mucociliary clearance.
    Conclusions: We were able to detect tuft cells in the tracheobronchial tree down to the level of the bronchioles. Moreover, taste transduction and cholinergic signalling occur in the same cells and regulate mucociliary clearance. Thus, tuft cells are potentially involved in the regulation of innate immunity in human airways.
    MeSH term(s) Humans ; Mice ; Animals ; Mucociliary Clearance ; Trachea/physiology ; Signal Transduction ; Taste ; Cholinergic Agents/metabolism
    Chemical Substances Cholinergic Agents
    Language English
    Publishing date 2023-11-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-023-02570-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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