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  1. Book ; Online: Hidden Attractions of Administration : The Peculiar Appeal of Meetings and Documents

    Åkerström, Malin / Jacobsson, Katarina / Andersson Cederholm, Erika / Wästerfors, David

    2021  

    Keywords Sociology ; administration ; administrative work ; attractions ; bureaucratization ; documents ; Eigendynamik ; emotional attrativeness ; emotional sociology ; human service organizations ; meetings ; meeting cultures ; moral conflicts ; New Public Management ; pressure from above ; pressure from below ; Simmel ; sociology of organizations ; sociology of work ; working life ; work dynamics
    Size 1 electronic resource (170 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021051412
    ISBN 9780367622275 ; 0367622270
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Thesis: Transcriptional dysregulation in L-DOPA-induced dyskinesia

    Andersson, Malin

    2003  

    Author's details av Malin Andersson
    Language English ; Swedish
    Size Getr. Zählung : Ill., graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lund, Univ., Diss., 2003
    Note Zsfassung in schwed. Sprache
    HBZ-ID HT013778722
    ISBN 91-628-5722-3 ; 978-91-628-5722-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 E 2657 order for loan Magazin

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  3. Article ; Online: Appearance of hexahydrocannabinols as recreational drugs and implications for cannabis drug testing - focus on HHC, HHC-P, HHC-O and HHC-H.

    Helander, Anders / Johansson, Malin / Villén, Tomas / Andersson, Annika

    Scandinavian journal of clinical and laboratory investigation

    2024  Volume 84, Issue 2, Page(s) 125–132

    Abstract: This study investigated the effects of hexahydrocannabinol (HHC) and other unclassified cannabinoids, which were recently introduced to the recreational drug market, on cannabis drug testing in urine and oral fluid samples. After the appearance of HHC in ...

    Abstract This study investigated the effects of hexahydrocannabinol (HHC) and other unclassified cannabinoids, which were recently introduced to the recreational drug market, on cannabis drug testing in urine and oral fluid samples. After the appearance of HHC in Sweden in 2022, the number of posts about HHC on an online drug discussion forum increased significantly in the spring of 2023, indicating increased interest and use. In parallel, the frequency of false positive screening tests for tetrahydrocannabinol (THC) in oral fluid, and for its carboxy metabolite (THC-COOH) in urine, rose from <2% to >10%. This suggested that HHC cross-reacted with the antibodies in the immunoassay screening, which was confirmed in spiking experiments with HHC, HHC-COOH, HHC acetate (HHC-O), hexahydrocannabihexol (HHC-H), hexahydrocannabiphorol (HHC-P), and THC-P. When HHC and HHC-P were classified as narcotics in Sweden on 11 July 2023, they disappeared from the online and street shops market and were replaced by other unregulated variants (e.g. HHC-O and THC-P). In urine samples submitted for routine cannabis drug testing, HHC-COOH concentrations up to 205 (mean 60, median 27) µg/L were observed. To conclude, cannabis drug testing cannot rely on results from immunoassay screening, as it cannot distinguish between different tetra- and hexahydrocannabinols, some being classified but others unregulated. The current trend for increased use of unregulated cannabinols will likely increase the proportion of positive cannabis screening results that need to be confirmed with mass spectrometric methods. However, the observed cross-reactivity also means a way to pick up use of new cannabinoids that otherwise risk going undetected.
    MeSH term(s) Humans ; Substance Abuse Detection/methods ; Illicit Drugs/urine ; Illicit Drugs/analysis ; Sweden ; Dronabinol/urine ; Dronabinol/analysis ; Dronabinol/analogs & derivatives ; Cannabis/chemistry ; Saliva/chemistry ; Cannabinoids/urine ; Cannabinoids/analysis ; Cannabinol/analysis ; Cannabinol/urine ; Cross Reactions ; Immunoassay/methods
    Chemical Substances Illicit Drugs ; Dronabinol (7J8897W37S) ; Cannabinoids ; Cannabinol (7UYP6MC9GH)
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 3150-1
    ISSN 1502-7686 ; 0036-5513
    ISSN (online) 1502-7686
    ISSN 0036-5513
    DOI 10.1080/00365513.2024.2340039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment.

    Selvin, Tove / Berglund, Malin / Lenhammar, Lena / Lindskog, Magnus / Jarvius, Malin / Larsson, Rolf / Nygren, Peter / Fryknäs, Mårten / Andersson, Claes R

    BMC pharmacology & toxicology

    2024  Volume 25, Issue 1, Page(s) 25

    Abstract: Background: It has become evident in the field of oncology that the outcome of medical treatment is influenced by the combined effect exerted on both cancer- and immune cells. Therefore, we evaluated potential immunological effects of 46 standard ... ...

    Abstract Background: It has become evident in the field of oncology that the outcome of medical treatment is influenced by the combined effect exerted on both cancer- and immune cells. Therefore, we evaluated potential immunological effects of 46 standard anticancer agents and 22 commonly administered concomitant non-cancer drugs.
    Methods: We utilized a miniaturized in vitro model system comprised of fluorescently labeled human colon and lung cancer cell lines grown as monocultures and co-cultured with activated peripheral blood mononuclear cells (PBMCs). The Bliss Independence Model was then applied to detect antagonism and synergy between the drugs and activated immune cells.
    Results: Among the standard anticancer agents, tyrosine kinase inhibitors (TKIs) stood out as the top inducers of both antagonism and synergy. Ruxolitinib and dasatinib emerged as the most notably antagonistic substances, exhibiting the lowest Bliss scores, whereas sorafenib was shown to synergize with activated PBMCs. Most concomitant drugs did not induce neither antagonism nor synergy. However, the statins mevastatin and simvastatin were uniquely shown to synergize with activated PBMC at all tested drug concentrations in the colon cancer model.
    Conclusion: We utilized a miniaturized tumor-immune model to enable time and cost-effective evaluation of a broad panel of drugs in an immuno-oncology setting in vitro. Using this approach, immunomodulatory effects exerted by TKIs and statins were identified.
    MeSH term(s) Humans ; Leukocytes, Mononuclear ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Antineoplastic Agents/pharmacology ; Dasatinib/pharmacology ; Lung Neoplasms
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Antineoplastic Agents ; Dasatinib (RBZ1571X5H)
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2680259-4
    ISSN 2050-6511 ; 2050-6511
    ISSN (online) 2050-6511
    ISSN 2050-6511
    DOI 10.1186/s40360-024-00746-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cardiomyocytes, sphingolipids and cardio myotoxicity.

    Levin, Malin C / Andersson, Linda / Borén, Jan

    Current opinion in lipidology

    2023  Volume 34, Issue 4, Page(s) 180–188

    Abstract: Purpose of review: Sphingolipids are structurally diverse membrane lipids localized in lipid bilayers. Sphingolipids are not only important structural components of cellular membranes, but they are also important regulators of cellular trafficking and ... ...

    Abstract Purpose of review: Sphingolipids are structurally diverse membrane lipids localized in lipid bilayers. Sphingolipids are not only important structural components of cellular membranes, but they are also important regulators of cellular trafficking and signal transduction and are implicated in several diseases. Here, we review the latest insights into sphingolipids and their role in cardiac function and cardiometabolic disease.
    Recent findings: The underlying mechanisms linking sphingolipids to cardiac dysfunction are still not fully clarified. Sphingolipids, and in particular ceramides, have emerged as important players in lipotoxicity, mediating inflammation, impaired insulin signalling and apoptosis. In addition, recent findings highlight the importance of glycosphingolipid homeostasis in cardiomyocyte membranes, where they are required to maintain β-adrenergic signalling and contractile capacity to preserve normal heart function. Thus, glycosphingolipid homeostasis in cardiac membranes characterizes a novel mechanism linking sphingolipids to cardiac disease.
    Summary: Modulation of cardiac sphingolipids may represent a promising therapeutic approach. Sustained investigation of the link between sphingolipids and cardiomyocyte function is therefore needed and we hope that this review may inspire researchers to further elucidate the action of these lipids.
    MeSH term(s) Humans ; Myocytes, Cardiac ; Sphingolipids ; Myotoxicity ; Ceramides ; Membrane Lipids
    Chemical Substances Sphingolipids ; Ceramides ; Membrane Lipids
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1045394-5
    ISSN 1473-6535 ; 0957-9672
    ISSN (online) 1473-6535
    ISSN 0957-9672
    DOI 10.1097/MOL.0000000000000829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3010: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Using the 5-Item Medication Adherence Report Scale (MARS-5) to Screen for Non-adherence to Vitamin and Mineral Supplementation After Bariatric Surgery.

    Spetz, Kristina / Olbers, Torsten / Östbring, Malin / Moon, Zoe / Horne, Rob / Andersson, Ellen

    Obesity surgery

    2024  Volume 34, Issue 2, Page(s) 576–582

    Abstract: Introduction: Poor adherence to recommended vitamin and mineral supplementation after bariatric surgery is common and challenging for healthcare professionals to identify. There are several questionnaires for self-reporting of adherence to chronic ... ...

    Abstract Introduction: Poor adherence to recommended vitamin and mineral supplementation after bariatric surgery is common and challenging for healthcare professionals to identify. There are several questionnaires for self-reporting of adherence to chronic medication, but none has so far been evaluated for assessment of adherence to vitamin and mineral supplementation after bariatric surgery. The aim of this study was to assess the accuracy of the 5-item Medication Adherence Report Scale (MARS-5) in measuring adherence to vitamin and mineral supplementation post bariatric surgery (gastric bypass or sleeve gastrectomy).
    Method: The psychometric properties of MARS-5 for vitamin and mineral supplementation were validated in two cohorts: one at 1 year post bariatric surgery (n = 120) and the other at 2 years post-surgery (n = 211). MARS-5 was compared to pharmacy refill data for vitamin B
    Results: Correlation analyses demonstrated that the MARS-5 had acceptable validity compared to objectively measured adherence rates from pharmacy refill data (calculated as continuous, multiple-interval measures of medication availability/gaps-coefficient ranged from 0.49 to 0.54). Internal reliability (Cronbach's α) was high: 0.81 and 0.95, respectively. There was a clear ceiling effect where one out of three had a maximum score on MARS-5.
    Conclusion: MARS-5 demonstrated acceptable psychometric properties for assessment of adherence to vitamin and mineral supplementation post bariatric surgery.
    MeSH term(s) Humans ; Vitamins/therapeutic use ; Reproducibility of Results ; Obesity, Morbid/surgery ; Bariatric Surgery ; Gastric Bypass ; Dietary Supplements ; Minerals ; Medication Adherence
    Chemical Substances Vitamins ; Minerals
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-023-07027-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3381: Show issues Location:
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  7. Article ; Online: Introducing Mechanically Assisted Cough for Patients with Progressive Neurological Disease: Patient-Physical Therapist Interaction and Physical Therapist Perspective.

    Andersson-Watz, Anna / Nygren-Bonnier, Malin / Bergdahl, Elisabeth / Crommert, Martin Eriksson / Svantesson, Mia

    Physical therapy

    2024  

    Abstract: Objective: The goal of this study was to explore patient-physical therapist interaction and the physical therapist's experience of the introductory session for mechanical insufflation-exsufflation (MI-E) device treatment for patients with progressive ... ...

    Abstract Objective: The goal of this study was to explore patient-physical therapist interaction and the physical therapist's experience of the introductory session for mechanical insufflation-exsufflation (MI-E) device treatment for patients with progressive neurological disease.
    Methods: Qualitative content analysis of participant-observation of interaction between patients and physical therapists during 9 MI-E introduction sessions in different clinical care settings and 10 follow-up interviews with 6 physical therapists.
    Results: The introduction of MI-E emerged as a process of instilling a sense of security in the patient. The process can be described in 4 steps: (1) gain understanding by being responsive to the person's whole life-situation; (2) share knowledge and expectations in a respectful and permissive way; (3) introduce the device in a gentle and reciprocal interactivity; and (4) adapt to home-use in an inclusive dialogue with the patient and their significant others. Physical therapists described a need for assurance to instill a sense of security in the patient, implying a need for confidence, competent peers, guiding yet flexible routines, and emotional support.
    Conclusion: Physical therapists have a need to foster assurance in employing a person-centered approach to make a patient feel secure in the process of introducing MI-E treatment. Multiple modes of professional knowledge were used together with action-based and relational-based ethics to facilitate a person-centered care approach. This seems to be a promising approach for providing good care when introducing MI-E to patients. Further research is needed to explore this from the patient's perspective.
    Impact: This study added to the body of knowledge regarding MI-E treatment in relation to patients. This has direct implication, particularly for inexperienced physical therapists, for informed care for the patient during introduction. Our study also supports that person-centered care should be implemented at all levels of health care to make it possible for physical therapists to practice person-centered care.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 415886-6
    ISSN 1538-6724 ; 0031-9023
    ISSN (online) 1538-6724
    ISSN 0031-9023
    DOI 10.1093/ptj/pzae012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The STAIR OF KNOWLEDGE-a codesigned intervention to prevent pressure ulcers, malnutrition, poor oral health and falls among older persons in nursing homes in Sweden: development of a complex intervention.

    Neziraj, Merita / Axelsson, Malin / Kumlien, Christine / Hellman, Peter / Andersson, Magdalena

    BMJ open

    2023  Volume 13, Issue 8, Page(s) e072453

    Abstract: Objectives: To describe the development of a codesigned complex intervention intended to prevent the risks of pressure ulcers, malnutrition, poor oral health and falls among older persons in nursing homes.: Design: A complex intervention development ... ...

    Abstract Objectives: To describe the development of a codesigned complex intervention intended to prevent the risks of pressure ulcers, malnutrition, poor oral health and falls among older persons in nursing homes.
    Design: A complex intervention development study. The development of the intervention was conducted in three phases. We established contact with stakeholders in the municipality, updated us of current status of the literature in this area and conducted studies in the local context (1). We codesigned the intervention in workshops together with end users (2). We codesigned the final outline of the intervention in an iterative process with stakeholders (3).
    Participants: End users (n=16) in nursing homes (n=4) codesigned the intervention together with the research group in workshops (n=4) in March-April 2022. Additionally, stakeholders (n=17) who were considered to play an important role in developing the intervention participated throughout this process. Data were analysed using reflexive thematic analysis.
    Results: Four workshops were conducted with end users (n=16) and 13 meetings with stakeholders (n=12) were held during the development process. The intervention aims to bridge the evidence-practice gap regarding the preventive care process of the risks of pressure ulcers, malnutrition, poor oral health and falls among older persons in nursing homes. The intervention is aimed at end users, lasts for 3 weeks and is divided into two parts. First, end users obtain knowledge on their own by following written instructions. Second, they meet, interact and discuss the knowledge acquired during part 1.
    Conclusion: The intervention is robustly developed and thoroughly described. The study highlights the extensive process that is necessary for developing tailored complex interventions. The description of the entire development process may enhance the replicability of this intervention. The intervention needs to be tested and evaluated in an upcoming feasibility study.
    Trial registration number: NCT05308862.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Accidental Falls/prevention & control ; Pressure Ulcer/prevention & control ; Sweden ; Oral Health ; Nursing Homes ; Malnutrition/prevention & control
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-072453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Supraglottoplasty for severe laryngomalacia can be effective and safe also in children with high-risk comorbidities - Experience from a tertiary center.

    Medin, Gabriel / Wendt, Malin / Ekborn, Andreas / Andersson, Andreas / Gahm, Caroline

    International journal of pediatric otorhinolaryngology

    2023  Volume 171, Page(s) 111632

    Abstract: Objectives: Supraglottoplasty (SGP) for severe laryngomalacia (LM) in children with medical comorbidities has been associated with high risk of surgical failure and increased need of postoperative pediatric intensive care unit (PICU) intervention, but ... ...

    Abstract Objectives: Supraglottoplasty (SGP) for severe laryngomalacia (LM) in children with medical comorbidities has been associated with high risk of surgical failure and increased need of postoperative pediatric intensive care unit (PICU) intervention, but evidence for this is ambiguous. The objective was to evaluate surgical outcome and risk of need for PICU-intervention following SGP for severe LM in comorbid patients.
    Methods: Retrospective observational study of 116 patients treated with SGP for severe LM between 2000 and 2021 at a tertial referral pediatric airway surgery center Karolinska University Hospital. Medical records were reviewed and patient data regarding surgical timing, type of SGP procedure, PICU-intervention, complications, and outcomes were recorded. Patients were defined as non-comorbid vs high-risk comorbid (HRC) based on a coexisting comorbidity for risk of surgical failure and postoperative PICU-intervention. Surgical failure was defined as need of revision surgery, tracheostomy or assisted ventilation (continuous positive airway pressure and bilevel positive airway pressure). PICU intervention was defined as need of postoperative assisted ventilation or intubation. Statistical comparisons were performed with outcome of SGP on children with LM and no comorbidities.
    Results: 41/116 patients included had a HRC associated with an increased risk of PICU-intervention and surgical failure. 75/116 patients were defined as non-comorbid. The overall surgical success in the study population was 89.7% (104/116), 94.7% in the non HRC group vs 80.5% in the HRC-group. 5/41 HRC patients and 1/75 non-comorbid patients needed SGP revision in which 5/6 was successful. There was no significantly increased need for postoperative PICU intervention in HRC patients.
    Conclusion: SGP for severe LM patients with high-risk comorbidities performed in a tertiary setting had an overall good result and low risk of PICU-intervention. Revision SGP was more common in HRC patients but had a good outcome. Multidisciplinary experience in perioperative care of comorbid patients may be of key importance for outcome and children with high-risk comorbidities should thus not be withheld the possible benefit of SGP without assessment at a tertiary pediatric airway center.
    MeSH term(s) Humans ; Child ; Infant ; Laryngomalacia/surgery ; Glottis/surgery ; Tracheostomy ; Comorbidity ; Reoperation ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2023-06-17
    Publishing country Ireland
    Document type Observational Study ; Journal Article
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2023.111632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Can our experience with surveillance for inherited pancreatic cancer help to identify early pancreatic cancer in the general population?

    Löhr, J-Matthias / Öhlund, Daniel / Söreskog, Emma / Andersson, Emil / Vujasinovic, Miroslav / Zethraeus, Niklas / Sund, Malin

    Familial cancer

    2024  

    Abstract: Screening of the general population for cancer is a matter of primary prevention reducing the burden of disease. Whilst this is successful for several cancers including breast, colon and prostate, the situation to screen and hence prevent pancreatic ... ...

    Abstract Screening of the general population for cancer is a matter of primary prevention reducing the burden of disease. Whilst this is successful for several cancers including breast, colon and prostate, the situation to screen and hence prevent pancreatic cancer is different. The organ is not as accessible to simple physical exam or biological samples (fecal or blood test). Neither exists a blood test such as PSA that is cost-effective. Reviewing the evidence from screening risk groups for pancreatic cancer, one must conclude that there is no rational at present to screen the general population, for a lack of appropriate tests.
    Language English
    Publishing date 2024-03-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1502496-9
    ISSN 1573-7292 ; 1389-9600
    ISSN (online) 1573-7292
    ISSN 1389-9600
    DOI 10.1007/s10689-024-00363-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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