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  1. Article ; Online: Pulmonary strongyloidiasis and hyperinfection in a Patient with idiopathic inflammatory myopathy：A case report

    Wei Fan / Qiong Fu / Yuetian Yu

    Heliyon, Vol 10, Iss 1, Pp e23484- (2024)

    1481  

    Abstract: Pulmonary strongyloidiasis is a rare infection in patients with autoimmune diseases, and immunosuppression can lead to the development of hyperinfection syndrome with a high mortality rate. We present a case of a 78-year-old male with previous idiopathic ...

    Abstract Pulmonary strongyloidiasis is a rare infection in patients with autoimmune diseases, and immunosuppression can lead to the development of hyperinfection syndrome with a high mortality rate. We present a case of a 78-year-old male with previous idiopathic inflammatory myopathy (IIM) with interstitial lung disease. He developed hyperinfection syndrome and respiratory failure, and diagnostic metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) confirmed the presence of Strongyloides stercoralis. After treatment with ivermectin, the patient's symptoms improved. Therefore, adequate screening and prophylactic treatment are needed for people at risk of immunosuppression, which can reduce the occurrence of the devastating S. stercoralis hyperinfection syndrome. It also highlights mNGS as a highly accurate test for the detection of difficult to atypical pathogens.
    Keywords Strongyloides stercoralis ; Idiopathic inflammatory myopathy ; Hyperinfection syndrome ; Metagenomic next-generation sequencing ; Case report ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Pulmonary strongyloidiasis and hyperinfection in a Patient with idiopathic inflammatory myopathy：A case report.

    Fan, Wei / Fu, Qiong / Yu, Yuetian

    Heliyon

    2023  Volume 10, Issue 1, Page(s) e23484

    Abstract: Pulmonary strongyloidiasis is a rare infection in patients with autoimmune diseases, and immunosuppression can lead to the development of hyperinfection syndrome with a high mortality rate. We present a case of a 78-year-old male with previous idiopathic ...

    Abstract Pulmonary strongyloidiasis is a rare infection in patients with autoimmune diseases, and immunosuppression can lead to the development of hyperinfection syndrome with a high mortality rate. We present a case of a 78-year-old male with previous idiopathic inflammatory myopathy (IIM) with interstitial lung disease. He developed hyperinfection syndrome and respiratory failure, and diagnostic metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) confirmed the presence of
    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e23484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Molecular Insights into the Inhibition and Disaggregation Effects of EGCG on Aβ40 and Aβ42 Cofibrillation.

    Li, Xuhua / Zhang, Yu / Wang, Yuetian / Zhang, Shengli / Zhang, Lei

    The journal of physical chemistry. B

    2024  Volume 128, Issue 8, Page(s) 1843–1853

    Abstract: The misfolding and aggregation of amyloid-β (Aβ) peptides play a pivotal role in the pathogenesis of Alzheimer's disease (AD). Aβ40 and Aβ42, the two primary isoforms of Aβ, can not only self-aggregate into homogeneous aggregates but also coaggregate to ... ...

    Abstract The misfolding and aggregation of amyloid-β (Aβ) peptides play a pivotal role in the pathogenesis of Alzheimer's disease (AD). Aβ40 and Aβ42, the two primary isoforms of Aβ, can not only self-aggregate into homogeneous aggregates but also coaggregate to form mixed fibrils. Epigallocatechin-3-gallate (EGCG), a prominent tea polyphenol, has shown the capability to prevent the self-aggregation of Aβ40 and Aβ42 peptides and disaggregate their homogeneous fibrils. However, its effects on the cofibrillation of Aβ40 and Aβ42 have not yet been explored. Here, we employed molecular dynamic simulations to investigate the effects of EGCG on the coaggregation of Aβ40 and Aβ42, as well as on their mixed fibril. Our findings indicated that EGCG effectively inhibits the codimerization of Aβ40 and Aβ42 primarily by impeding the interchain interaction between the two isoforms. The key binding sites for EGCG on Aβ40 and Aβ42 are the polar residues and aromatic residues, engaging in hydrogen-bond , π-π, and cation-π interactions with EGCG. Additionally, EGCG disaggregates the Aβ40-Aβ42 mixed fibril by reducing its long-range interaction through similar binding sites and interactions as those between EGCG and Aβ40-Aβ42 heterodimers. Our research reveals the comprehensive inhibition and disaggregation effects of EGCG on the cofibrillation of Aβ isoforms, which provides further support for the development of EGCG as an effective antiaggregation agent for AD.
    MeSH term(s) Humans ; Peptide Fragments/chemistry ; Amyloid beta-Peptides/chemistry ; Alzheimer Disease/metabolism ; Protein Isoforms ; Catechin/analogs & derivatives
    Chemical Substances epigallocatechin gallate (BQM438CTEL) ; Peptide Fragments ; Amyloid beta-Peptides ; Protein Isoforms ; Catechin (8R1V1STN48)
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.3c07232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Study on the Effect of Threshold Pressure Gradient on Remaining Oil Distribution in Heavy Oil Reservoirs

    Wenli Ke / Yuetian Liu / Xu Zhao / Gaoming Yu / Jie Wang

    ACS Omega, Vol 7, Iss 5, Pp 3949-

    2022  Volume 3962

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
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  5. Article: Acute Hypoxemic Respiratory Failure in Immunocompromised Patients: Taking Aggressive Measures to Identify Etiology.

    Xu, Jing / Yu, Yuetian / Liu, Jialin

    Frontiers in medicine

    2020  Volume 7, Page(s) 433

    Language English
    Publishing date 2020-09-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00433
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  6. Article ; Online: Cardiovascular health, sleeping duration, and risk of mortality in current and former smokers.

    Yu, Bowei / Sun, Ying / Yu, Yuefeng / Yu, Yuetian / Wang, Yuying / Wang, Bin / Tan, Xiao / Wang, Yu / Lu, Yingli / Wang, Ningjian

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2024  Volume 34, Issue 5, Page(s) 1257–1266

    Abstract: Background and aims: To investigate the associations of ideal cardiovascular health metrics (ICVHMs) with all-cause mortality among former and current smokers compared with never smokers.: Methods and results: A total of 378,147 participants [mean ... ...

    Abstract Background and aims: To investigate the associations of ideal cardiovascular health metrics (ICVHMs) with all-cause mortality among former and current smokers compared with never smokers.
    Methods and results: A total of 378,147 participants [mean age (SD) years: 56.3 (8.1); 47.2 % men] were included from the UK Biobank cohort. The ICVHMs were combined Life's simple 7 from the American Heart Association and sleep duration time. The association was explored using COX regression models. During a median follow-up of 13.3 years, we documented 24,594 deaths. Compared with never smokers, among former smokers, the multivariable-adjusted hazard ratio (HR) for all-cause mortality was 1.82 (95%CI 1.71-1.92) for participants who had ≤2 ICVHMs and 1.03 (0.97-1.10) for participants who had ≥6 ICVHMs; among current smokers, the HRs for mortality were 2.74 (2.60-2.89) and 2.18 (1.78-2.67). The phenomenon was more pronounced among participants younger than 60 years [HR (95%CI), 1.82 (1.71-1.95) for ≤2 ICVHMs vs 1.04 (0.96-1.12) for ≥6 ICVHMs with age ≥60 years and 1.83 (1.62-2.06) vs 0.98 (0.88-1.11) with age <60 years among former smokers; 2.66 (2.49-2.85) vs 2.44 (1.84-3.24) with age ≥60 years and 2.85 (2.62-3.10) vs 1.96 (1.47-2.61) with age <60 years among current smokers]. In addition, the HR for mortality of each 1-number increment in ICVHMs was 0.87 (0.86-0.89) among former smokers and 0.91 (0.89-0.94) among current smokers.
    Conclusion: Our findings indicated the importance of adherence to have more ICVHMs in the mortality risk among former smokers, and priority of smoking cessation in current smokers.
    Implications: Studies have found that former smokers still have higher risks of lung cancer and all-cause mortality than never-smokers. The next question is whether the effects of previous or current smoking could be ameliorated by eight ideal cardiovascular health metrics (ICVHMs). We aim to explore whether ICVHMs may counteract the risk of all-cause mortality among former and current smokers. The results showed that only former smokers with ≥6 ICVHMs exhibited a comparable risk of all-cause mortality with never smokers. Furthermore, current smokers even having ≥6 ICVHMs still exhibited a higher risk of all-cause mortality compared with never smokers.
    MeSH term(s) Male ; Humans ; Middle Aged ; Female ; Risk Factors ; Smokers ; Prospective Studies ; Smoking/adverse effects ; Smoking Cessation
    Language English
    Publishing date 2024-01-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2024.01.005
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  7. Article ; Online: Acute Hypoxemic Respiratory Failure in Immunocompromised Patients

    Jing Xu / Yuetian Yu / Jialin Liu

    Frontiers in Medicine, Vol

    Taking Aggressive Measures to Identify Etiology

    2020  Volume 7

    Keywords non-invasive mechanical ventilation (NIV) ; hypoxeamia ; highflow ; respiratory failure ; immunocompromised host ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  8. Article: Nonalcoholic fatty liver disease and type 2 diabetes: an observational and Mendelian randomization study.

    Yu, Yuetian / Yu, Yuefeng / Wang, Yuying / Chen, Yi / Wang, Ningjian / Wang, Bin / Lu, Yingli

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1156381

    Abstract: Introduction: Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are both chronic multisystem diseases that cause tremendous health burdens worldwide. Previous epidemiological studies have found a bidirectional relationship ... ...

    Abstract Introduction: Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are both chronic multisystem diseases that cause tremendous health burdens worldwide. Previous epidemiological studies have found a bidirectional relationship between these two diseases; however, their causality remains largely unknown. We aim to examine the causal relationship between NAFLD and T2DM.
    Methods: The observational analysis included 2,099 participants from the SPECT-China study and 502,414 participants from the UK Biobank. Logistic regression and Cox regression models were used to examine the bidirectional association between NAFLD and T2DM. Two-sample Mendelian randomization (MR) analyses were conducted to investigate the causal effects of the two diseases using summary statistics of genome-wide association studies from the UK Biobank for T2DM and the FinnGen study for NAFLD.
    Results: During the follow-up, 129 T2DM cases and 263 NAFLD cases were observed in the SPECT-China study, and 30,274 T2DM cases and 4,896 NAFLD cases occurred in the UK Biobank cohort. Baseline NAFLD was associated with an increased risk of incident T2DM in both studies (SPECT-China: OR: 1.74 (95% confidence interval (CI): 1.12-2.70); UK Biobank: HR: 2.16 (95% CI: 1.82-2.56)), while baseline T2DM was associated with incident NAFLD in the UK Biobank study only (HR: 1.58). Bidirectional MR analysis showed that genetically determined NAFLD was significantly associated with an increased risk of T2DM (OR: 1.003 (95% CI: 1.002-1.004,
    Conclusions: Our study suggested the causal effect of NAFLD on T2DM development. The lack of a causal association between T2DM and NAFLD warrants further verification.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/genetics ; China/epidemiology
    Language English
    Publishing date 2023-05-08
    Publishing country Switzerland
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1156381
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  9. Article ; Online: Cryptococcal pneumonia in a patient with rheumatoid arthritis treated with baricitinib.

    Li, Jia / Yu, Yuetian / Xie, Jingjing / Jiang, Yan / Lu, Liangjing

    Rheumatology (Oxford, England)

    2021  Volume 61, Issue 1, Page(s) e6–e7

    MeSH term(s) Aged ; Arthritis, Rheumatoid/complications ; Azetidines/adverse effects ; Cryptococcosis/chemically induced ; Cryptococcus neoformans/isolation & purification ; Humans ; Male ; Pneumonia/chemically induced ; Pneumonia/microbiology ; Purines/adverse effects ; Pyrazoles/adverse effects ; Sulfonamides/adverse effects
    Chemical Substances Azetidines ; Purines ; Pyrazoles ; Sulfonamides ; baricitinib (ISP4442I3Y)
    Language English
    Publishing date 2021-08-23
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keab658
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    Zs.B 240: Show issues Location:
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    Zs.MO 497: Show issues

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  10. Article: The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects.

    Kang, Yuening / Yu, Yuetian / Lu, Liangjing

    Mycobiology

    2020  Volume 48, Issue 1, Page(s) 1–8

    Abstract: Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells. PTX3 is known to play an important protective effect ... ...

    Abstract Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells. PTX3 is known to play an important protective effect against
    Language English
    Publishing date 2020-02-08
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2631580-4
    ISSN 2092-9323 ; 1229-8093
    ISSN (online) 2092-9323
    ISSN 1229-8093
    DOI 10.1080/12298093.2020.1722576
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