LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 111

Search options

  1. Article ; Online: Modulating airway glucose to reduce respiratory infections.

    Tregoning, John S / Mallia, Patrick

    Expert review of respiratory medicine

    2019  Volume 13, Issue 2, Page(s) 121–124

    Language English
    Publishing date 2019-01-07
    Publishing country England
    Document type Editorial
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2019.1563487
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Lesson of the month 2: A case of nitrous oxide-induced pancytopenia.

    Norris, Felicity / Mallia, Patrick

    Clinical medicine (London, England)

    2019  Volume 19, Issue 2, Page(s) 129–130

    Abstract: An 18-year-old female patient presented to the emergency department with non-specific neurological and gastrointestinal symptoms and was found to be pancytopenic. Her vitamin ... ...

    Abstract An 18-year-old female patient presented to the emergency department with non-specific neurological and gastrointestinal symptoms and was found to be pancytopenic. Her vitamin B
    MeSH term(s) Adolescent ; Female ; Humans ; Hydroxocobalamin/administration & dosage ; Hydroxocobalamin/therapeutic use ; Nitrous Oxide/adverse effects ; Pancytopenia/etiology ; Vitamin B 12 Deficiency/chemically induced ; Vitamin B 12 Deficiency/complications ; Vitamin B 12 Deficiency/drug therapy
    Chemical Substances Nitrous Oxide (K50XQU1029) ; Hydroxocobalamin (Q40X8H422O)
    Language English
    Publishing date 2019-03-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmedicine.19-2-129
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Experimental Antiviral Therapeutic Studies for Human Rhinovirus Infections.

    Coultas, James A / Cafferkey, John / Mallia, Patrick / Johnston, Sebastian L

    Journal of experimental pharmacology

    2021  Volume 13, Page(s) 645–659

    Abstract: Rhinovirus infection is common and usually causes mild, self-limiting upper respiratory tract symptoms. Rhinoviruses can cause exacerbation of chronic respiratory diseases, such as asthma or chronic obstructive pulmonary disease, leading to a significant ...

    Abstract Rhinovirus infection is common and usually causes mild, self-limiting upper respiratory tract symptoms. Rhinoviruses can cause exacerbation of chronic respiratory diseases, such as asthma or chronic obstructive pulmonary disease, leading to a significant burden of morbidity and mortality. There has been a great deal of progress in efforts to understand the immunological basis of rhinovirus infection. However, despite a number of in vitro and in vivo attempts, there have been no effective treatments developed. This review article summarises the up to date virological and immunological understanding of these infections. We discuss the challenges researchers face, and key solutions, in their work to investigate potential therapies including in vivo rhinovirus challenge studies. Finally, we explore past and present experimental therapeutic strategies employed in the treatment of rhinovirus infections and highlight promising areas of future work.
    Language English
    Publishing date 2021-07-09
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2587465-2
    ISSN 1179-1454
    ISSN 1179-1454
    DOI 10.2147/JEP.S255211
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Human rhinovirus infection and COPD: role in exacerbations and potential for therapeutic targets.

    Cafferkey, John / Coultas, James Andrew / Mallia, Patrick

    Expert review of respiratory medicine

    2020  Volume 14, Issue 8, Page(s) 777–789

    Abstract: Introduction: Respiratory virus infections (predominantly rhinoviruses) are the commonly identified in COPD exacerbations but debate about their role as a trigger of exacerbations continues. Experimental infection studies have provided significant new ... ...

    Abstract Introduction: Respiratory virus infections (predominantly rhinoviruses) are the commonly identified in COPD exacerbations but debate about their role as a trigger of exacerbations continues. Experimental infection studies have provided significant new evidence establishing a causal relationship between virus infection and COPD exacerbations and contributed to a better understanding of the mechanisms of virus-induced exacerbations. However as yet no anti-viral treatments have undergone clinical trials in COPD patients.
    Areas covered: This review discusses the evidence for and against respiratory viruses being the main trigger of COPD exacerbations from both epidemiological studies and experimental infection studies. The host immune response to rhinovirus infection and how abnormalities in host immunity may underlie increased susceptibility to virus infection in COPD are discussed and the role of dual viral-bacterial infection in COPD exacerbations. Finally the current state of anti-viral therapy is discussed and how these may be used in the future treatment of COPD exacerbations.
    Expert opinion: Respiratory virus infections are the trigger of a substantial proportion of COPD exacerbations and rhinoviruses are the most common virus type. Clinical trials of anti-viral agents are needed in COPD patients to determine whether they are effective in virus-induced COPD exacerbations.
    MeSH term(s) Antiviral Agents ; Disease Progression ; Humans ; Picornaviridae Infections/complications ; Picornaviridae Infections/drug therapy ; Picornaviridae Infections/immunology ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/immunology ; Pulmonary Disease, Chronic Obstructive/pathology ; Rhinovirus
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2020-06-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2020.1764354
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Asthma and viruses: A focus on rhinoviruses and SARS-CoV-2.

    Padayachee, Yorissa / Faiez, Tasnim Shahridan / Singanayagam, Aran / Mallia, Patrick / Johnston, Sebastian Lennox

    The Journal of allergy and clinical immunology

    2021  Volume 147, Issue 5, Page(s) 1648–1651

    MeSH term(s) Asthma/complications ; Asthma/immunology ; COVID-19/etiology ; COVID-19/immunology ; Humans ; Picornaviridae Infections/etiology ; Picornaviridae Infections/immunology ; Rhinovirus/immunology ; SARS-CoV-2/immunology
    Language English
    Publishing date 2021-03-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.92: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: REQUENT EXACERBATORS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

    Richard Hewitt / Patrick Mallia

    European Medical Journal Respiratory, Vol 3, Iss 1, Pp 29-

    FROM RESEARCH TO CLINICAL PRACTICE

    2015  Volume 66

    Abstract: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of morbidity and mortality and contribute to disease progression. The frequency with which COPD patients experience exacerbations can differ markedly between patients, ... ...

    Abstract Acute exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of morbidity and mortality and contribute to disease progression. The frequency with which COPD patients experience exacerbations can differ markedly between patients, even those with a similar severity of airflow obstruction. This has led to the concept of ‘frequent exacerbators’ that represent a unique phenotype of COPD patients who experience frequent exacerbations and have poorer outcomes compared with patients with infrequent exacerbations. However, the mechanisms whereby some COPD patients experience frequent exacerbations remain undetermined. Understanding the mechanisms of frequent exacerbations will lead to the development of new therapies that can be targeted to these high-risk patients, thereby reducing exacerbations and improving outcomes.
    Keywords chronic obstructive pulmonary disease (copd) ; exacerbations ; frequent exacerbators ; biomarkers ; Medicine ; R ; Diseases of the respiratory system ; RC705-779
    Subject code 610
    Language English
    Publishing date 2015-05-01T00:00:00Z
    Publisher European Medical Journal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Factors associated with reattendance to emergency services following COVID-19 hospitalization.

    Daunt, Anna / Perez-Guzman, Pablo N / Cafferkey, John / Manalan, Kavina / Cooke, Graham / White, Peter J / Hauck, Katharina / Mallia, Patrick / Nayagam, Shevanthi

    Journal of medical virology

    2020  Volume 93, Issue 3, Page(s) 1250–1252

    MeSH term(s) COVID-19 ; China ; Hospitalization ; Humans ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26594
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Chest CT features and functional correlates of COVID-19 at 3 months and 12 months follow-up.

    Kumar, Kartik / Ratnakumar, Ratnaprashanthika / Collin, Simon M / Berrocal-Almanza, Luis C / Ricci, Piera / Al-Zubaidy, Mustafa / Coker, Robina K / Coleman, Meg / Elkin, Sarah L / Mallia, Patrick / Meghji, Jamilah / Ross, Clare / Russell, Georgina K / Ward, Katie / Wickremasinghe, Melissa / Sheard, Sarah / Copley, Susan J / Kon, Onn Min

    Clinical medicine (London, England)

    2023  Volume 23, Issue 5, Page(s) 467–477

    Abstract: Long-term pulmonary sequelae of Coronavirus 2019 (COVID-19) remain unclear. Thus, we aimed to establish post-COVID-19 temporal changes in chest computed tomography (CT) features of pulmonary fibrosis and to investigate associations with respiratory ... ...

    Abstract Long-term pulmonary sequelae of Coronavirus 2019 (COVID-19) remain unclear. Thus, we aimed to establish post-COVID-19 temporal changes in chest computed tomography (CT) features of pulmonary fibrosis and to investigate associations with respiratory symptoms and physiological parameters at 3 and 12 months' follow-up. Adult patients who attended our initial COVID-19 follow-up service and developed chest CT features of interstitial lung disease, in addition to cases identified using British Society of Thoracic Imaging codes, were evaluated retrospectively. Clinical data were gathered on respiratory symptoms and physiological parameters at baseline, 3 months, and 12 months. Corresponding chest CT scans were reviewed by two thoracic radiologists. Associations between CT features and functional correlates were estimated using random effects logistic or linear regression adjusted for age, sex and body mass index. In total, 58 patients were assessed. No changes in reticular pattern, honeycombing, traction bronchiectasis/bronchiolectasis index or pulmonary distortion were observed. Subpleural curvilinear lines were associated with lower odds of breathlessness over time. Parenchymal bands were not associated with breathlessness or impaired lung function overall. Based on our results, we conclude that post-COVID-19 chest CT features of irreversible pulmonary fibrosis remain static over time; other features either resolve or remain unchanged. Subpleural curvilinear lines do not correlate with breathlessness. Parenchymal bands are not functionally significant. An awareness of the different potential functional implications of post-COVID-19 chest CT changes is important in the assessment of patients who present with multi-systemic sequelae of COVID-19 infection.
    MeSH term(s) Adult ; Humans ; Pulmonary Fibrosis/diagnostic imaging ; COVID-19/diagnostic imaging ; Retrospective Studies ; Follow-Up Studies ; Lung/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Bronchiectasis ; Disease Progression ; Dyspnea
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2023-0059
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Validity of the diagnosis of pneumonia in hospitalised patients with COPD.

    Finney, Lydia J / Padmanaban, Vijay / Todd, Samuel / Ahmed, Nadia / Elkin, Sarah L / Mallia, Patrick

    ERJ open research

    2019  Volume 5, Issue 2

    Abstract: Rationale: Exacerbations of chronic obstructive pulmonary disease (COPD) and pneumonia are two of the most common reasons for acute hospital admissions. Acute exacerbations and pneumonia present with similar symptoms in COPD patients, representing a ... ...

    Abstract Rationale: Exacerbations of chronic obstructive pulmonary disease (COPD) and pneumonia are two of the most common reasons for acute hospital admissions. Acute exacerbations and pneumonia present with similar symptoms in COPD patients, representing a diagnostic challenge with a significant impact on patient outcomes. The objectives of this study were to compare the prevalence of radiographic consolidation with the discharge diagnoses of hospitalised COPD patients.
    Methods: COPD patients admitted to three UK hospitals over a 3-year period were identified. Participants were included if they were admitted with an acute respiratory illness, COPD was confirmed by spirometry and a chest radiograph was performed within 24 h of admission. Pneumonia was defined as consolidation on chest radiograph reviewed by two independent observers.
    Results: There were 941 admissions in 621 patients included in the final analysis. In 235 admissions, consolidation was present on chest radiography and there were 706 admissions without consolidation. Of the 235 admissions with consolidation, only 42.9% had a discharge diagnosis of pneumonia; 90.7% of patients without consolidation had a discharge diagnosis of COPD exacerbation. The presence of consolidation was associated with increased rate of high-dependency care admission, increased mortality and prolonged length of stay. Inhaled corticosteroid use was associated with recurrent pneumonia.
    Conclusions: Pneumonia is underdiagnosed in patients with COPD. Radiographic consolidation is associated with worse outcomes and prolonged length of stay. Incorrect diagnosis could result in inappropriate use of inhaled corticosteroids. Future guidelines should specifically address the diagnosis and management of pneumonia in COPD.
    Language English
    Publishing date 2019-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00031-2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Chapter 8 In vivo experimental models of infection and disease

    Girkin, Jason / Maltby, Steven / Singanayagam, Aran / Bartlett, Nathan / Mallia, Patrick

    Rhinovirus Infections

    Abstract: Abstract Human and animal models continue to play a crucial role in research to understand host immunity to rhinovirus (RV) and identify disease mechanisms. Human models have provided direct evidence that RV infection is capable of exacerbating chronic ... ...

    Abstract Abstract Human and animal models continue to play a crucial role in research to understand host immunity to rhinovirus (RV) and identify disease mechanisms. Human models have provided direct evidence that RV infection is capable of exacerbating chronic respiratory diseases and identified immunological processes that correlate with clinical disease outcomes. Mice are the most commonly used nonhuman experimental RV infection model. Although semipermissive, under defined experimental conditions sufficient replication occurs to induce host immune responses that recapitulate immunity and disease during human infection. The capacity to use genetically modified mouse strains and drug interventions has shown the mouse model to be an invaluable research tool defining causal relationships between host immunity and disease and supporting development of new treatments. Used in combination the insights achieved from human and animal experimental infection models provide complementary insights into RV biology and yield novel therapeutic options to reduce the burden of RV-induced disease.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/b978-0-12-816417-4.00008-1
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top