Article ; Online: Monocarboxylate transporter-1 (MCT-1) inhibitors screened from autodisplayed F
International journal of biological macromolecules
2024 Volume 265, Issue Pt 1, Page(s) 130854
Abstract: Monocarboxylate transporter-1 (MCT-1) inhibitors were screened from the Fv-antibody library, which contained complementary determining region 3 with randomized amino acid sequences (11 residues) through site-directed mutagenesis. Fv-antibodies against ... ...
Abstract | Monocarboxylate transporter-1 (MCT-1) inhibitors were screened from the Fv-antibody library, which contained complementary determining region 3 with randomized amino acid sequences (11 residues) through site-directed mutagenesis. Fv-antibodies against MCT-1 were screened from the autodisplayed Fv-antibody library. Two clones were screened, and the binding affinity (K |
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MeSH term(s) | Humans ; Molecular Docking Simulation ; HEK293 Cells ; Amino Acid Sequence ; Gene Library ; Carrier Proteins ; Antibodies |
Chemical Substances | Carrier Proteins ; Antibodies |
Language | English |
Publishing date | 2024-03-12 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 282732-3 |
ISSN | 1879-0003 ; 0141-8130 |
ISSN (online) | 1879-0003 |
ISSN | 0141-8130 |
DOI | 10.1016/j.ijbiomac.2024.130854 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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