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  1. Article ; Online: Is peripartum anhedonia a missing target?

    Mazza, Marianna / Marano, Giuseppe

    Bipolar disorders

    2024  

    Abstract: The perinatal period is an extremely delicate phase that can involve a high risk for onset of depressive disorders. The Edinburgh Postnatal Depression Scale (EPDS) is a widely validated instrument for assessing perinatal depressive symptoms, including ... ...

    Abstract The perinatal period is an extremely delicate phase that can involve a high risk for onset of depressive disorders. The Edinburgh Postnatal Depression Scale (EPDS) is a widely validated instrument for assessing perinatal depressive symptoms, including the dimension of anhedonia. There are studies suggesting that the neural mechanism underlying the occurrence of anhedonia in patients with major depressive disorder (MDD) and bipolar depression (BD) might be distinct. Anhedonia seems to represent a more stable and frequent symptom in women with postpartum bipolar relative to unipolar depressive disorder and is associated with significantly higher depressive symptom severity. Perinatal medicine is an important component of women's health. Treatment of anhedonia can be challenging, and the most effective treatment can be a combination of psychotherapy and medication, but the screening of anhedonia in peripartum women can prevent the development of other psychiatric disorders and maladaptive behaviors.
    Language English
    Publishing date 2024-02-01
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5604: Show issues Location:
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  2. Article: Keep in mind sex differences when prescribing psychotropic drugs.

    Mazza, Marianna / De Berardis, Domenico / Marano, Giuseppe

    World journal of psychiatry

    2024  Volume 14, Issue 2, Page(s) 194–198

    Abstract: Women represent the majority of patients with psychiatric diagnoses and also the largest users of psychotropic drugs. There are inevitable differences in efficacy, side effects and long-term treatment response between men and women. Psychopharmacological ...

    Abstract Women represent the majority of patients with psychiatric diagnoses and also the largest users of psychotropic drugs. There are inevitable differences in efficacy, side effects and long-term treatment response between men and women. Psychopharmacological research needs to develop adequately powered animal and human trials aimed to consider pharmacokinetics and pharmacodynamics of central nervous system drugs in both male and female subjects. Healthcare professionals have the responsibility to prescribe sex-specific psychopharmacotherapies with a priority to differentiate between men and women in order to minimize adverse drugs reactions, to maximize therapeutic effectiveness and to provide personalized management of care.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Editorial
    ISSN 2220-3206
    ISSN 2220-3206
    DOI 10.5498/wjp.v14.i2.194
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  3. Article ; Online: Propranolol Promotes Monocyte-to-Macrophage Differentiation and Enhances Macrophage Anti-Inflammatory and Antioxidant Activities by NRF2 Activation.

    Maccari, Sonia / Profumo, Elisabetta / Saso, Luciano / Marano, Giuseppe / Buttari, Brigitta

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Adrenergic pathways represent the main channel of communication between the nervous system and the immune system. During inflammation, blood monocytes migrate within tissue and differentiate into macrophages, which polarize to M1 or M2 macrophages with ... ...

    Abstract Adrenergic pathways represent the main channel of communication between the nervous system and the immune system. During inflammation, blood monocytes migrate within tissue and differentiate into macrophages, which polarize to M1 or M2 macrophages with tissue-damaging or -reparative properties, respectively. This study investigates whether the β-adrenergic receptor (β-AR)-blocking drug propranolol modulates the monocyte-to-macrophage differentiation process and further influences macrophages in their polarization toward M1- and M2-like phenotypes. Six-day-human monocytes were cultured with M-CSF in the presence or absence of propranolol and then activated toward an M1 pro-inflammatory state or an M2 anti-inflammatory state. The chronic exposure of monocytes to propranolol during their differentiation into macrophages promoted the increase in the M1 marker CD16 and in the M2 markers CD206 and CD163 and peroxisome proliferator-activated receptor ɣ expression. It also increased endocytosis and the release of IL-10, whereas it reduced physiological reactive oxygen species. Exposure to the pro-inflammatory conditions of propranolol-differentiated macrophages resulted in an anti-inflammatory promoting effect. At the molecular level, propranolol upregulated the expression of the oxidative stress regulators NRF2, heme oxygenase-1 and NQO1. By contributing to regulating macrophage activities, propranolol may represent a novel anti-inflammatory and immunomodulating compound with relevant therapeutic potential in several inflammatory diseases.
    MeSH term(s) Humans ; Monocytes ; Propranolol/pharmacology ; Antioxidants/pharmacology ; NF-E2-Related Factor 2 ; Macrophages ; Anti-Inflammatory Agents/pharmacology
    Chemical Substances Propranolol (9Y8NXQ24VQ) ; Antioxidants ; NF-E2-Related Factor 2 ; Anti-Inflammatory Agents
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073683
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  4. Article ; Online: Gut microbiota in women: The secret of psychological and physical well-being.

    Marano, Giuseppe / Traversi, Gianandrea / Gaetani, Eleonora / Gasbarrini, Antonio / Mazza, Marianna

    World journal of gastroenterology

    2023  Volume 29, Issue 45, Page(s) 5945–5952

    Abstract: The gut microbiota works in unison with the host, promoting its health. In particular, it has been shown to exert protective, metabolic and structural functions. Recent evidence has revealed the influence of the gut microbiota on other organs such as the ...

    Abstract The gut microbiota works in unison with the host, promoting its health. In particular, it has been shown to exert protective, metabolic and structural functions. Recent evidence has revealed the influence of the gut microbiota on other organs such as the central nervous system, cardiovascular and the endocrine-metabolic systems and the digestive system. The study of the gut microbiota is outlining new and broader frontiers every day and holds enormous innovation potential for the medical and pharmaceutical fields. Prevention and treatment of specific women's diseases involves the need to deepen the function of the gut as a junction organ where certain positive bacteria can be very beneficial to health. The gut microbiota is unique and dynamic at the same time, subject to external factors that can change it, and is capable of modulating itself at different stages of a woman's life, playing an important role that arises from the intertwining of biological mechanisms between the microbiota and the female genital system. The gut microbiota could play a key role in personalized medicine.
    MeSH term(s) Female ; Humans ; Gastrointestinal Microbiome/physiology ; Microbiota ; Brain ; Central Nervous System
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i45.5945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
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  5. Article: An Unusual Case of Pemphigus Vulgaris.

    Marano, Laura / Fabbrocini, Gabriella / Monfrecola, Giuseppe / Martora, Fabrizio

    Skin appendage disorders

    2022  Volume 8, Issue 2, Page(s) 158–160

    Abstract: Introduction: Pemphigus is a potential life-threatening skin disorder belonging to the group of the autoimmune bullous diseases affecting the skin and mucosa. The most common subtypes are pemphigus foliaceus (PF) and pemphigus vulgaris.: Case ... ...

    Abstract Introduction: Pemphigus is a potential life-threatening skin disorder belonging to the group of the autoimmune bullous diseases affecting the skin and mucosa. The most common subtypes are pemphigus foliaceus (PF) and pemphigus vulgaris.
    Case presentation: We present the case of a young woman with scalp manifestations diagnosed as seborrhiasis who came to our office where a more careful history and clinical examination directed us toward another diagnostic suspicion. The histological examination confirmed our suspicion of pemphigus and therefore we believe it is important to report our experience to avoid misdiagnosis.
    Discussion/conclusion: Our case may be useful in the literature to identify cases of PF with atypical manifestations that may mimic other diseases.
    Language English
    Publishing date 2022-01-11
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2806972-9
    ISSN 2296-9160 ; 2296-9195
    ISSN (online) 2296-9160
    ISSN 2296-9195
    DOI 10.1159/000521333
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  6. Article ; Online: Acoustic Emission and Artificial Intelligence Procedure for Crack Source Localization.

    Melchiorre, Jonathan / Manuello Bertetto, Amedeo / Rosso, Marco Martino / Marano, Giuseppe Carlo

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 2

    Abstract: The acoustic emission (AE) technique is one of the most widely used in the field of structural monitoring. Its popularity mainly stems from the fact that it belongs to the category of non-destructive techniques (NDT) and allows the passive monitoring of ... ...

    Abstract The acoustic emission (AE) technique is one of the most widely used in the field of structural monitoring. Its popularity mainly stems from the fact that it belongs to the category of non-destructive techniques (NDT) and allows the passive monitoring of structures. The technique employs piezoelectric sensors to measure the elastic ultrasonic wave that propagates in the material as a result of the crack formation's abrupt release of energy. The recorded signal can be investigated to obtain information about the source crack, its position, and its typology (Mode I, Mode II). Over the years, many techniques have been developed for the localization, characterization, and quantification of damage from the study of acoustic emission. The onset time of the signal is an essential information item to be derived from waveform analysis. This information combined with the use of the triangulation technique allows for the identification of the crack location. In the literature, it is possible to find many methods to identify, with increasing accuracy, the onset time of the P-wave. Indeed, the precision of the onset time detection affects the accuracy of identifying the location of the crack. In this paper, two techniques for the definition of the onset time of acoustic emission signals are presented. The first method is based on the Akaike Information Criterion (AIC) while the second one relies on the use of artificial intelligence (AI). A recurrent convolutional neural network (R-CNN) designed for sound event detection (SED) is trained on three different datasets composed of seismic signals and acoustic emission signals to be tested on a real-world acoustic emission dataset. The new method allows taking advantage of the similarities between acoustic emissions, seismic signals, and sound signals, enhancing the accuracy in determining the onset time.
    MeSH term(s) Artificial Intelligence ; Acoustics ; Sound ; Neural Networks, Computer ; Ultrasonics
    Language English
    Publishing date 2023-01-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23020693
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  7. Article ; Online: Visible light antibacterial potential of cement mortar incorporating Cu-ZnO/g-C

    Liu, Xiaomin / Yang, Zhengxian / Li, Kang / Briseghella, Bruno / Marano, Giuseppe Carlo / Xu, Jiankun

    RSC advances

    2023  Volume 13, Issue 14, Page(s) 9448–9456

    Abstract: In this work, a hybrid Cu-ZnO/g- ... ...

    Abstract In this work, a hybrid Cu-ZnO/g-C
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra08281k
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  8. Article ; Online: Web-mediated Counseling Relationship in Support of the New Sexuality and Affectivity During the COVID-19 Epidemic: A Continuum Between Desire and Fear.

    Marano, Giuseppe / Traversi, Gianandrea / Mazza, Marianna

    Archives of sexual behavior

    2021  Volume 50, Issue 3, Page(s) 753–755

    MeSH term(s) COVID-19/psychology ; Counseling ; Epidemics ; Fear ; Female ; Humans ; Internet ; Male ; SARS-CoV-2 ; Sexual Behavior/psychology ; Sexuality
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Letter
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-020-01908-3
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    Zs.A 1106: Show issues Location:
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  9. Article ; Online: NO

    Yang, Zhengxian / Xiong, Xiaoli / Yan, Xueyuan / Luo, Shengyang / Zhang, Yong / Briseghella, Bruno / Marano, Giuseppe Carlo

    RSC advances

    2023  Volume 13, Issue 31, Page(s) 21510–21520

    Abstract: In this study a new photocatalytic nanocomposite, S-g- ... ...

    Abstract In this study a new photocatalytic nanocomposite, S-g-C
    Language English
    Publishing date 2023-07-18
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra04243j
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  10. Article ; Online: Emotional atypical arousal ratings for unpleasant stimuli in patients with Parkinson's disease.

    Migliore, Simone / Toro, Stefano / Proietti, Francesca / Magliozzi, Alessandro / Anzini, Gaia / Pistoia, Francesca / Di Lazzaro, Vincenzo / Curcio, Giuseppe / Marano, Massimo

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2024  

    Abstract: Introduction: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including alteration in emotional processing and recognition of emotions. We explored the effects of PD on the emotional behavioral ... ...

    Abstract Introduction: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including alteration in emotional processing and recognition of emotions. We explored the effects of PD on the emotional behavioral ratings using a battery of affective visual stimuli selected from the International Affective Picture System (IAPS).
    Methods: Twenty-two patients diagnosed with idiopathic PD and 22 healthy controls (HC), matched by age, gender, and education, were enrolled in the study. Following a clinical assessment, each participant was asked to evaluate the arousal and valence of affective visual stimuli, and response time was recorded. Disease-specific measures including the MDS Unified Parkinson's Disease Rating Scale (MDS UPDRS) and the Non-Motor Symptom Scale (NMSS) were also collected.
    Results: PD patients exhibited higher arousal responses compared to HC for negative/unpleasant pictures (scoring 7.32 ± 0.88 vs 5.43 ± 2.06, p < 0.001). The arousal response to negative/unpleasant pictures was correlated with measures of non-motor burden in PD (MDS UPDRS I and NMSS, rho = 0.480 and p = 0.023, rho = 0.533 and p = 0.010, respectively).
    Conclusion: Impaired emotional processing characterizes PD patients with mild disease and is related to the non-motor symptom burden. Given the importance of emotional processing for the development and maintenance of close interpersonal relationship and for coping with specific medical situations, it is crucial to direct PD patients towards therapeutic interventions focused on the recognition and processing of emotions.
    Language English
    Publishing date 2024-03-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-024-07434-7
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    Zs.A 1877: Show issues Location:
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