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  1. Article: In den Tiefen des Bewusstseins. Was denkt und fühlt ein Patient im Wachkoma? Die Psychologen Boris Kotchoubey und Simone Lang haben eine Reihe von Tests entwickelt, um anhand von Hirnscans verschiedene Komponenten des menschlichen Bewusstseins zu prüfen

    Kotchoubey, Boris / Lang, Simone

    Gehirn & Geist

    2011  Volume -, Issue 9, Page(s) 28

    Language German
    Document type Article
    ZDB-ID 2072879-7
    ISSN 1618-8519
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5667: Show issues Location:
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  2. Article ; Online: Meta-criteria to formulate criteria of consciousness.

    Kotchoubey, Boris

    The Behavioral and brain sciences

    2022  Volume 45, Page(s) e53

    Abstract: Any neurobiological model claiming explanation of a complex human phenomenon should start with an explicit definition of the explanandum. If a classical intensional definition is impossible, we can use a descriptive definition by listing necessary ... ...

    Abstract Any neurobiological model claiming explanation of a complex human phenomenon should start with an explicit definition of the explanandum. If a classical intensional definition is impossible, we can use a descriptive definition by listing necessary criteria (e.g., of consciousness). This commentary suggests four meta-criteria that different proposed criteria of consciousness should fulfill: phenomenological consensus, empirical evidence, domain specificity, and non-circularity.
    MeSH term(s) Consciousness ; Humans
    Language English
    Publishing date 2022-03-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 423721-3
    ISSN 1469-1825 ; 0140-525X
    ISSN (online) 1469-1825
    ISSN 0140-525X
    DOI 10.1017/S0140525X21001898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interrelationships of factors of social development are more complex than Life History Theory predicts.

    Kotchoubey, Boris

    The Behavioral and brain sciences

    2019  Volume 42, Page(s) e204

    Abstract: Life History Theory (LHT) predicts a monotonous relationship between affluence and the rate of innovations and strong correlations within a cluster of behavioral features. Although both predictions can be true in specific cases, they are incorrect in ... ...

    Abstract Life History Theory (LHT) predicts a monotonous relationship between affluence and the rate of innovations and strong correlations within a cluster of behavioral features. Although both predictions can be true in specific cases, they are incorrect in general. Therefore, the author's explanations may be right, but they do not prove LHT and cannot be generalized to other apparently similar processes.
    Language English
    Publishing date 2019-11-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 423721-3
    ISSN 1469-1825 ; 0140-525X
    ISSN (online) 1469-1825
    ISSN 0140-525X
    DOI 10.1017/S0140525X19000177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Predicting outcome in disorders of consciousness: A mega-analysis.

    Pavlov, Yuri G / Spiegelsberger, Franziska / Kotchoubey, Boris

    Annals of clinical and translational neurology

    2024  

    Abstract: Objective: Assessing recovery potential in patients with disorders of consciousness (DoC) is pivotal for guiding clinical and ethical decisions. We conducted a mega-analysis of individual patient data to understand (1) if a time threshold exists, beyond ...

    Abstract Objective: Assessing recovery potential in patients with disorders of consciousness (DoC) is pivotal for guiding clinical and ethical decisions. We conducted a mega-analysis of individual patient data to understand (1) if a time threshold exists, beyond which regaining consciousness is almost impossible, and (2) how recovery varies based on factors such as diagnosis, etiology, age, sex, and neuropsychological status.
    Methods: A systematic literature search revealed a total of 3290 patients. In this sample, we performed a Cox proportional hazards analysis for interval censored data.
    Results: We observed a late saturation of probability to regain consciousness in Kaplan-Meier curves, and the annual rate of recovery was remarkably stable, in that approximately 35% of patients regained consciousness per year. Patients in minimally conscious state (MCS) recovered more frequently than patients in unresponsive wakefulness syndrome (UWS). No significant difference was observed between the recovery dynamics of MCS subgroups: MCS+ and MCS-. Patients with hypoxic brain lesions showed worse recovery rate than patients with traumatic brain injury and patients with vascular brain lesions, while the latter two categories did not differ from each other. Male patients had moderately better chance to regain consciousness. While younger UWS patients recovered more frequently than older patients, it was not the case in MCS.
    Interpretation: Our findings highlight the necessity for neurologists to exercise caution when making negative predictions in individual cases, challenge traditional beliefs regarding recovery timelines, and underscore the importance of conducting detailed and prolonged assessments to better understand recovery prospects in DoC.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2740696-9
    ISSN 2328-9503 ; 2328-9503
    ISSN (online) 2328-9503
    ISSN 2328-9503
    DOI 10.1002/acn3.52061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Human Consciousness: Where Is It From and What Is It for.

    Kotchoubey, Boris

    Frontiers in psychology

    2018  Volume 9, Page(s) 567

    Abstract: Consciousness is not a process in the brain but a kind of behavior that, of course, is controlled by the brain like any other behavior. Human consciousness emerges on the interface between three components of animal behavior: communication, play, and the ...

    Abstract Consciousness is not a process in the brain but a kind of behavior that, of course, is controlled by the brain like any other behavior. Human consciousness emerges on the interface between three components of animal behavior: communication, play, and the use of tools. These three components interact on the basis of anticipatory behavioral control, which is common for all complex forms of animal life. All three do not exclusively distinguish our close relatives, i.e., primates, but are broadly presented among various species of mammals, birds, and even cephalopods; however, their particular combination in humans is unique. The interaction between communication and play yields symbolic games, most importantly language; the interaction between symbols and tools results in human praxis. Taken together, this gives rise to a mechanism that allows a creature, instead of performing controlling actions overtly, to play forward the corresponding behavioral options in a "second reality" of objectively (by means of tools) grounded symbolic systems. The theory possesses the following properties: (1) It is anti-reductionist and anti-eliminativist, and yet, human consciousness is considered as a purely natural (biological) phenomenon. (2) It avoids epiphenomenalism and indicates in which conditions human consciousness has evolutionary advantages, and in which it may even be disadvantageous. (3) It allows to easily explain the most typical features of consciousness, such as objectivity, seriality and limited resources, the relationship between consciousness and explicit memory, the feeling of conscious agency, etc.
    Language English
    Publishing date 2018-04-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2018.00567
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  6. Article: Neurofeedback bei schweren Hirnschädigungen

    Kotchoubey, Boris

    (In: Strehl, Ute (Ed.), Neurofeedback. Theoretische Grundlagen - Praktisches Vorgehen - Wissenschaftliche Evidenz (S. 220-245). Stuttgart: Kohlhammer)

    2020  

    Abstract: Es wird informiert über den Einsatz von Neurofeedback zur Behandlung von schweren Hirnschädigungen. Dabei werden zunächst zwei Behandlungsansätze unterschieden: klassischer Ansatz und BCI-(Brain-Computer-Interface-)Ansatz. Während beim klassischen Ansatz ...

    Title translation Neurofeedback in cases of severe brain damage
    Series title In: Strehl, Ute (Ed.), Neurofeedback. Theoretische Grundlagen - Praktisches Vorgehen - Wissenschaftliche Evidenz (S. 220-245). Stuttgart: Kohlhammer
    Abstract Es wird informiert über den Einsatz von Neurofeedback zur Behandlung von schweren Hirnschädigungen. Dabei werden zunächst zwei Behandlungsansätze unterschieden: klassischer Ansatz und BCI-(Brain-Computer-Interface-)Ansatz. Während beim klassischen Ansatz der möglichst direkte Bezug der gewählten Feedback-Parameter auf die pathophysiologischen Krankheitsmechanismen notwendige Voraussetzung für den Therapieerfolg ist und die Qualität des Signals und die Stabilität der Steuerungsfähigkeit eher etwas im Hintergrund stehen, geht es im BCI-Ansatz in erster Linie um den Patienten mit besonders schweren Hirnverletzungen, der nur schlecht oder gar nicht verbal und nonverbal kommunizieren kann. Das Neurofeedback hat in diesem Fall das Ziel, statt der fehlenden Verhaltenssignale ein direktes Signal vom Gehirn zu bekommen. Das bedeutet, dass im Gegensatz zum klassischen Ansatz die gemessenen neurophysiologischen Merkmale keinerlei Verbindung mit der zugrunde liegenden Pathophysiologie der Hirnerkrankung aufweisen müssen. Die beiden Ansätze werden besprochen, und Möglichkeiten eines kombinierten Einsatzes werden skizziert. Abschließend wird darauf hingewiesen, dass das Gebiet der Neurofeedback-Anwendungen bei schweren Hirnschädigungen immer noch nur ein niedriges Evidenzniveau aufweist.
    Keywords Biofeedback ; Brain Damage ; Electrical Activity ; Electroencephalography ; Electrophysiology ; Elektrische Aktivität ; Elektroenzephalographie ; Elektrophysiologie ; Hirnschädigung ; Human Computer Interaction ; Mensch-Computer-Interaktion ; Neurotherapie ; Neurotherapy
    Language German
    Document type Article
    Database PSYNDEX

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  7. Article ; Online: Evoked and event-related potentials in disorders of consciousness: A quantitative review.

    Kotchoubey, Boris

    Consciousness and cognition

    2017  Volume 54, Page(s) 155–167

    Abstract: Sixty-one publications about evoked and event-related potentials (EP and ERP, respectively) in patients with severe Disorders of Consciousness (DoC) were found and analyzed from a quantitative point of view. Most studies are strongly underpowered, ... ...

    Abstract Sixty-one publications about evoked and event-related potentials (EP and ERP, respectively) in patients with severe Disorders of Consciousness (DoC) were found and analyzed from a quantitative point of view. Most studies are strongly underpowered, resulting in very broad confidence intervals (CI). Results of such studies cannot be correctly interpreted, because, for example, CI>1 (in terms of Cohen's d) indicate that the real effect may be very strong, very weak, or even opposite to the reported effect. Furthermore, strong negative correlations were obtained between sample size and effect size, indicating a possible publication bias. These correlations characterized not only the total data set, but also each thematically selected subset. The minimal criteria of a strong study to EP/ERP in DoC are proposed: at least 25 patients in each patient group; as reliable diagnosis as possible; the complete report of all methodological details and all details of results (including negative results); and the use of appropriate methods of data analysis. Only three of the detected 60 studies (5%) satisfy these criteria. The limitations of the current approach are also discussed.
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1106647-7
    ISSN 1090-2376 ; 1053-8100
    ISSN (online) 1090-2376
    ISSN 1053-8100
    DOI 10.1016/j.concog.2017.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Temporally distinct oscillatory codes of retention and manipulation of verbal working memory.

    Pavlov, Yuri G / Kotchoubey, Boris

    The European journal of neuroscience

    2021  Volume 54, Issue 7, Page(s) 6497–6511

    Abstract: Most psychophysiological studies of working memory (WM) target only the short-term memory construct, whereas short-term memory is only a part of the WM responsible for the storage of sensory information. Here, we aimed to further investigate oscillatory ... ...

    Abstract Most psychophysiological studies of working memory (WM) target only the short-term memory construct, whereas short-term memory is only a part of the WM responsible for the storage of sensory information. Here, we aimed to further investigate oscillatory brain mechanisms supporting the executive components of WM-the part responsible for the manipulation of information. We conducted an exploratory reanalysis of a previously published EEG dataset where 156 participants (82 females) performed tasks requiring either simple retention or retention and manipulation of verbal information in WM. A relatively long delay period (>6 s) was employed to investigate the temporal trajectory of the oscillatory brain activity. Compared with baseline, theta activity was significantly enhanced during encoding and the delay period. Alpha-band power decreased during encoding and switched to an increase in the first part of the delay before returning to the baseline in the second part; beta-band power remained below baseline during encoding and the delay. The difference between the manipulation and retention tasks in spectral power had diverse temporal trajectories in different frequency bands. The difference maintained over encoding and the first part of the delay in theta, during the first part of the delay in beta, and during the whole delay period in alpha. Our results suggest that task-related modulations in theta power co-vary with the demands on the executive control network; beta suppression during mental manipulation can be related to the activation of motor networks; and alpha is likely to reflect the activation of language areas simultaneously with sensory input blockade.
    MeSH term(s) Brain ; Electroencephalography ; Executive Function ; Female ; Humans ; Memory, Short-Term
    Language English
    Publishing date 2021-09-28
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.15457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Life satisfaction in families with a child in an Unresponsive Wakefulness Syndrome.

    Chadasch, Christiane / Kotchoubey, Boris

    BMC pediatrics

    2021  Volume 21, Issue 1, Page(s) 116

    Abstract: Background: The article examines life conditions in families living together with a child in an Unresponsive Wakefulness Syndrome (UWS). Such families experience severe stress at financial, logistical, and existential level.: Methods: We investigated ...

    Abstract Background: The article examines life conditions in families living together with a child in an Unresponsive Wakefulness Syndrome (UWS). Such families experience severe stress at financial, logistical, and existential level.
    Methods: We investigated a large sample of families living with a UWS child (comprising 13% of the total population) and compared these families with families without a chronically ill child. A set of four questionnaires aimed to evaluate life conditions entails a total of 204 items. One of the questionnaires was developed by the corresponding author specifically for this study. The questionnaires were positively accepted by the persons concerned and permitted us to test six specific hypotheses.
    Results: Life satisfaction (LS) in families with a UWS child was significantly lower than in control families. LS was significantly affected by external situational factors (everyday support, home visits, support by a doctor, nursing service, health insurance, etc.). Self-management skills were on average lower in families with a UWS child than in controls. These skills strongly and directly correlated with LS. Further, LS was not significantly related to the acceptance of feelings and negatively correlated with the floods of emotions. The relationship with the own child was equally satisfactory in families with and without a UWS child indicating that the families regard their UWS child as a full family member.
    Conclusions: The data show that happy life is possible in families living together with a UWS child. They further specify conditions for satisfactory life under multiple highly severe challenges. Personal self-management skills, coping strategies, and resilience, as well as outside social support, appear to be critical factors.
    MeSH term(s) Child ; Family ; Humans ; Personal Satisfaction ; Social Support ; Syndrome ; Wakefulness
    Language English
    Publishing date 2021-03-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-021-02549-8
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  10. Article: Objectivity of human consciousness is a product of tool usage.

    Kotchoubey, Boris

    Frontiers in psychology

    2014  Volume 5, Page(s) 1152

    Language English
    Publishing date 2014-10-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2014.01152
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