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  1. Article ; Online: An accurate interatomic potential for the TiAlNb ternary alloy developed by deep neural network learning method.

    Lu, Jiajun / Wang, Jinkai / Wan, Kaiwei / Chen, Ying / Wang, Hao / Shi, Xinghua

    The Journal of chemical physics

    2023  Volume 158, Issue 20

    Abstract: The complex phase diagram and bonding nature of the TiAl system make it difficult to accurately describe its various properties and phases by traditional atomistic force fields. Here, we develop a machine learning interatomic potential with a deep neural ...

    Abstract The complex phase diagram and bonding nature of the TiAl system make it difficult to accurately describe its various properties and phases by traditional atomistic force fields. Here, we develop a machine learning interatomic potential with a deep neural network method for the TiAlNb ternary alloy based on a dataset built by first-principles calculations. The training set includes bulk elementary metals and intermetallic structures with slab and amorphous configurations. This potential is validated by comparing bulk properties-including lattice constant and elastic constants, surface energies, vacancy formation energies, and stacking fault energies-with their respective density functional theory values. Moreover, our potential could accurately predict the average formation energy and stacking fault energy of γ-TiAl doped with Nb. The tensile properties of γ-TiAl are simulated by our potential and verified by experiments. These results support the applicability of our potential under more practical conditions.
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0147720
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  2. Article: Superhydrophilic surfaces with hierarchical groove structure for efficient fog collection

    Wan, Yanling / Xu, Jinlong / Lian, Zhongxu / Xu, Jinkai

    Colloids and surfaces. 2021 Nov. 05, v. 628

    2021  

    Abstract: Many biological surfaces with hierarchical microstructures exhibit obvious fog collection abilities. However, it is difficult to effectively fabricate a microstructured metal surface with fog collection performance using a simple but flexible method. ... ...

    Abstract Many biological surfaces with hierarchical microstructures exhibit obvious fog collection abilities. However, it is difficult to effectively fabricate a microstructured metal surface with fog collection performance using a simple but flexible method. Inspired by the abilities of microstructures of Sarracenia trichomes to capture fog and transport water, a series of hierarchical groove surfaces with the fog collection property were fabricated by wire electrical discharge machining (WEDM) method, and the fabricated surfaces showed the obvious superhydrophilicity. Moreover, the results show that the fabricated surface with the hierarchical groove structure had better water transport performance and higher fog collection efficiency compared with the smooth surface, and the abilities of water transport and fog collection are related to the number of low ribs on the surface with the hierarchical microgroove. The microstructure metal materials obtained in this study not only open up the potential applications of WEDM in fog collection, but also have wide application prospects in the fields of microfluidic system, biomedicine, and biological excitation system.
    Keywords Sarracenia ; electric discharges ; hydrophilicity ; medicine ; microstructure ; trichomes ; water harvesting
    Language English
    Dates of publication 2021-1105
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500517-3
    ISSN 0927-7757
    ISSN 0927-7757
    DOI 10.1016/j.colsurfa.2021.127241
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Bio-inspired slippery surfaces with a hierarchical groove structure for efficient fog collection at low temperature

    Xu, Jinlong / Wan, Yanling / Lian, Zhongxu / Hou, Yonggang / Xu, Jinkai / Yu, Huadong

    Colloids and surfaces. 2022 June 20, v. 643

    2022  

    Abstract: Many biological surfaces with hierarchical microstructures have been demonstrated to have the ability of fog collection. However, most of the current fog collection is achieved through a single structure, and the fabrication of hierarchical structures is ...

    Abstract Many biological surfaces with hierarchical microstructures have been demonstrated to have the ability of fog collection. However, most of the current fog collection is achieved through a single structure, and the fabrication of hierarchical structures is mostly achieved through stepwise preparation. Besides, it is inevitable for the fog collector to work at low temperature environment. In this contribution, we fabricated a series of hierarchical slippery groove surfaces inspired by the surface structure of Sarracenia trichomes for efficient fog collection at low temperature, and the sample showed slippery properties after fluorination and oil injection treatments. Moreover, we evaluated the fog collection abilities of the surfaces for the condition of low temperature (0 °C). The results showed that the hierarchical groove surface showed better fog collection ability than the flat surface, and the oil film can hinder the heat transfer between droplet and surface, so as to prevent the droplets from freezing on the surface. So the injection of oil was essential for water transport and fog collection capabilities at low temperature. The proposed research is pioneering work in the area of functional surface towards the realization of fog collection at low temperature, one significant step towards fog collector to work under extreme condition.
    Keywords Sarracenia ; droplets ; heat transfer ; oils ; temperature ; trichomes ; water harvesting
    Language English
    Dates of publication 2022-0620
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500517-3
    ISSN 0927-7757
    ISSN 0927-7757
    DOI 10.1016/j.colsurfa.2022.128722
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti-PD-1 Immunotherapy.

    Zheng, Yimin / Wang, Yining / Lu, Zhou / Wan, Jinkai / Jiang, Lulu / Song, Danjun / Wei, Chuanyuan / Gao, Chao / Shi, Guoming / Zhou, Jian / Fan, Jia / Ke, Aiwu / Zhou, Lu / Cai, Jiabin

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 29, Page(s) e2301928

    Abstract: The combination of immunotherapy and molecular targeted therapy exhibits promising therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still unclear. Here, phosphoglycerate mutase 1 (PGAM1) is identified as a novel ... ...

    Abstract The combination of immunotherapy and molecular targeted therapy exhibits promising therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still unclear. Here, phosphoglycerate mutase 1 (PGAM1) is identified as a novel immunometabolic target by using a bioinformatic algorithm based on multiple HCC datasets. PGAM1 is highly expressed in HCC and associated with a poor prognosis and a poor response to immunotherapy. In vitro and in vivo experiments indicate that targeting PGAM1 inhibited HCC cell growth and promoted the infiltration of CD8
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/metabolism ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Phosphoglycerate Mutase/metabolism ; Phosphoglycerate Mutase/pharmacology ; CD8-Positive T-Lymphocytes/metabolism ; Ferroptosis ; Immunotherapy
    Chemical Substances Phosphoglycerate Mutase (EC 5.4.2.11)
    Language English
    Publishing date 2023-09-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202301928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2

    Cheng Li / Xiaolong Tian / Xiaodong Jia / Jinkai Wan / Lu Lu / Shibo Jiang / Fei Lan / Yinying Lu / Yanling Wu / Tianlei Ying

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    2021  Volume 3

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2.

    Li, Cheng / Tian, Xiaolong / Jia, Xiaodong / Wan, Jinkai / Lu, Lu / Jiang, Shibo / Lan, Fei / Lu, Yinying / Wu, Yanling / Ying, Tianlei

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 132

    MeSH term(s) Amino Acid Substitution ; Antibodies, Viral/genetics ; Antibodies, Viral/immunology ; COVID-19/genetics ; COVID-19/immunology ; Humans ; Mutation, Missense ; Protein Domains ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-03-23
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00536-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Management and Predictors of Treatment Failure in Patients with Chemo-Resistant/Relapsed Gestational Trophoblastic Neoplasia with Lung Metastasis.

    Kong, Yujia / Wang, Weidi / Lin, Jinkai / Wan, Xirun / Feng, Fengzhi / Ren, Tong / Zhao, Jun / Yang, Junjun / Xiang, Yang

    Journal of clinical medicine

    2022  Volume 11, Issue 24

    Abstract: The aim of the study was to assess the effectiveness of a combined treatment modality of salvage chemotherapy and pulmonary resection in chemo-resistant/relapsed gestational trophoblastic neoplasia (GTN) with lung metastasis and identify predictors of ... ...

    Abstract The aim of the study was to assess the effectiveness of a combined treatment modality of salvage chemotherapy and pulmonary resection in chemo-resistant/relapsed gestational trophoblastic neoplasia (GTN) with lung metastasis and identify predictors of treatment failure. Data of patients with chemo-resistant/relapsed GTN with lung metastasis who received salvage chemotherapy combined with pulmonary resection were retrospectively analyzed. Among 134 included patients, the number of preoperative chemotherapy regimens ranged from 2−8 (median, 3), and courses ranged from 4−37 (median, 14). Pulmonary lobectomies, segmentectomies, wedge resections, and lobectomies plus wedge resections were performed in 84, 5, 35, and 10 patients, respectively. After completion of treatment, 130 (97.0%) patients achieved complete remission. In the entire cohort, the 5-year overall survival (OS) rate was 87.6%. OS rates were similar between stage III and stage IV disease cohorts (89.4% vs. 75.0%, p = 0.137). Preoperative β-human chorionic gonadotropin (β-hCG) levels > 10 IU/L (p = 0.027) and number of preoperative chemotherapy regimens > 3 (p = 0.018) were predictors of treatment failure. The combined treatment modality of salvage chemotherapy and pulmonary resection is effective in patients with chemo-resistant/relapsed GTN with lung metastasis, improving their prognoses. Patients with preoperative serum β-hCG >10 IU/L and those with >3 chemotherapy regimens preoperatively may not benefit from this multidisciplinary treatment.
    Language English
    Publishing date 2022-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11247270
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  8. Article ; Online: PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti‐PD‐1 Immunotherapy

    Yimin Zheng / Yining Wang / Zhou Lu / Jinkai Wan / Lulu Jiang / Danjun Song / Chuanyuan Wei / Chao Gao / Guoming Shi / Jian Zhou / Jia Fan / Aiwu Ke / Lu Zhou / Jiabin Cai

    Advanced Science, Vol 10, Iss 29, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract The combination of immunotherapy and molecular targeted therapy exhibits promising therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still unclear. Here, phosphoglycerate mutase 1 (PGAM1) is identified as a ... ...

    Abstract Abstract The combination of immunotherapy and molecular targeted therapy exhibits promising therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still unclear. Here, phosphoglycerate mutase 1 (PGAM1) is identified as a novel immunometabolic target by using a bioinformatic algorithm based on multiple HCC datasets. PGAM1 is highly expressed in HCC and associated with a poor prognosis and a poor response to immunotherapy. In vitro and in vivo experiments indicate that targeting PGAM1 inhibited HCC cell growth and promoted the infiltration of CD8+ T‐cells due to decreased enzymatic activity. Mechanistically, inhibition of PGAM1 promotes HCC cell ferroptosis by downregulating Lipocalin (LCN2) by inducing energy stress and ROS‐dependent AKT inhibition, which can also downregulate Programmed death 1‐ligand 1 (PD‐L1). Moreover, an allosteric PGAM1 inhibitor (KH3) exhibits good antitumor effects in patient‐derived xenograft (PDX) models and enhanced the efficacy of anti‐PD‐1 immunotherapy in subcutaneous and orthotopic HCC models. Taken together, the findings demonstrate that PGAM1 inhibition exerts an antitumor effect by promoting ferroptosis and CD8+ T‐cell infiltration and can synergize with anti‐PD‐1 immunotherapy in HCC. Targeting PGAM1 can be a promising new strategy of “killing two birds with one stone” for HCC treatment.
    Keywords carcinogen metabolism ; ferroptosis ; hepatocellular carcinoma ; immunotherapy ; Science ; Q
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: A Novel Quantitative Electrocardiography Strategy Reveals the Electroinhibitory Effect of Tamoxifen on the Mouse Heart.

    Xie, Ming / Zhu, Shuoji / Liu, Gang / Wu, Yijin / Zhou, Wenkai / Yu, Dingdang / Wan, Jinkai / Xing, Shenghui / Wang, Siqing / Gan, Lin / Li, Ge / Chang, Dehua / Lai, Hao / Liu, Nanbo / Zhu, Ping

    Journal of cardiovascular translational research

    2023  Volume 16, Issue 5, Page(s) 1232–1248

    Abstract: Tamoxifen, a selective estrogen receptor modulator, was initially used to treat cancer in women and more recently to induce conditional gene editing in rodent hearts. However, little is known about the baseline biological effects of tamoxifen on the ... ...

    Abstract Tamoxifen, a selective estrogen receptor modulator, was initially used to treat cancer in women and more recently to induce conditional gene editing in rodent hearts. However, little is known about the baseline biological effects of tamoxifen on the myocardium. In order to clarify the short-term effects of tamoxifen on cardiac electrophysiology of myocardium, we applied a single-chest-lead quantitative method and analyzed the short-term electrocardiographic phenotypes induced by tamoxifen in the heart of adult female mice. We found that tamoxifen prolonged the PP interval and caused a decreased heartbeat, and further induced atrioventricular block by gradually prolonging the PR interval. Further correlation analysis suggested that tamoxifen had a synergistic and dose-independent inhibition on the time course of the PP interval and PR interval. This prolongation of the critical time course may represent a tamoxifen-specific ECG excitatory-inhibitory mechanism, leading to a reduction in the number of supraventricular action potentials and thus bradycardia. Segmental reconstructions showed that tamoxifen induced a decrease in the conduction velocity of action potentials throughout the atria and parts of the ventricles, resulting in a flattening of the P wave and R wave. In addition, we detected the previously reported prolongation of the QT interval, which may be due to a prolonged duration of the ventricular repolarizing T wave rather than the depolarizing QRS complex. Our study highlights that tamoxifen can produce patterning alternations in the cardiac conduction system, including the formation of inhibitory electrical signals with reduced conduction velocity, implying its involvement in the regulation of myocardial ion transport and the mediation of arrhythmias. A Novel Quantitative Electrocardiography Strategy Reveals the Electroinhibitory Effect of Tamoxifen on the Mouse Heart（Figure 9）. A working model of tamoxifen producing acute electrical disturbances in the myocardium. SN, sinus node; AVN, atrioventricular node; RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle.
    MeSH term(s) Humans ; Adult ; Female ; Animals ; Mice ; Tamoxifen/toxicity ; Electrocardiography ; Arrhythmias, Cardiac ; Heart Conduction System ; Heart Ventricles ; Atrioventricular Node
    Chemical Substances Tamoxifen (094ZI81Y45)
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2422411-X
    ISSN 1937-5395 ; 1937-5387
    ISSN (online) 1937-5395
    ISSN 1937-5387
    DOI 10.1007/s12265-023-10395-5
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  10. Article ; Online: Ribosome 18S m

    Rong, Bowen / Zhang, Qian / Wan, Jinkai / Xing, Shenghui / Dai, Ruofei / Li, Yuan / Cai, Jiabin / Xie, Jiaying / Song, Yang / Chen, Jiawei / Zhang, Lei / Yan, Guoquan / Zhang, Wen / Gao, Hai / Han, Jing-Dong J / Qu, Qianhui / Ma, Honghui / Tian, Ye / Lan, Fei

    Cell reports

    2020  Volume 33, Issue 12, Page(s) 108544

    Abstract: N6 methylation at adenosine 1832 ( ... ...

    Abstract N6 methylation at adenosine 1832 (m
    MeSH term(s) Adenosine/metabolism ; Animals ; Breast Neoplasms/enzymology ; Breast Neoplasms/pathology ; Caenorhabditis elegans ; Cell Growth Processes/physiology ; Cell Line, Tumor ; Female ; HEK293 Cells ; HeLa Cells ; Humans ; MCF-7 Cells ; Methylation ; Methyltransferases/metabolism ; RNA, Ribosomal, 18S/metabolism
    Chemical Substances RNA, Ribosomal, 18S ; METTL5 protein, human (EC 2.1.1.-) ; Methyltransferases (EC 2.1.1.-) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2020-12-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2020.108544
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