LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 944

Search options

  1. Book: Epistasis

    Wong, Ka-Chun

    methods and protocols

    (Methods in molecular biology ; 2212 ; Springer protocols)

    2021  

    Author's details edited by Ka-Chun Wong
    Series title Methods in molecular biology ; 2212
    Springer protocols
    Collection
    Language English
    Size x, 402 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020884646
    ISBN 978-1-0716-0946-0 ; 9781071609477 ; 1-0716-0946-7 ; 1071609475
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2212- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Editorial: Cardiac rhythmology case reports: Abnormal ECG and beyond.

    Wong, Chun-Ka / Tse, Hung-Fat

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 919117

    Language English
    Publishing date 2022-08-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.919117
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Different layers of disease substrates for ventricular tachyarrhythmias in arrhythmogenic right ventricular cardiomyopathy?

    Wong, Chun-Ka / Tse, Hung-Fat

    Heart rhythm

    2022  Volume 19, Issue 4, Page(s) 546–547

    MeSH term(s) Arrhythmogenic Right Ventricular Dysplasia/complications ; Arrhythmogenic Right Ventricular Dysplasia/diagnosis ; Death, Sudden, Cardiac ; Humans ; Tachycardia, Ventricular/diagnosis ; Tachycardia, Ventricular/etiology
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2021.12.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6278: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Letter by Wong and Siu Regarding Article, "Microthrombi as a Major Cause of Cardiac Injury in COVID-19: A Pathologic Study".

    Wong, Chun-Ka / Siu, Chung-Wah

    Circulation

    2021  Volume 144, Issue 7, Page(s) e156–e157

    MeSH term(s) COVID-19 ; Heart Injuries/etiology ; Humans ; SARS-CoV-2 ; Thrombosis
    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.121.054509
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: New methodological approaches to atrial fibrillation drug discovery.

    Wong, Chun-Ka / Tse, Hung-Fat

    Expert opinion on drug discovery

    2020  Volume 16, Issue 3, Page(s) 319–329

    Abstract: Introduction: Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice and rhythm control using pharmacological agents is required in selected patients. Nonetheless, current medication is only modestly efficacious and ... ...

    Abstract Introduction: Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice and rhythm control using pharmacological agents is required in selected patients. Nonetheless, current medication is only modestly efficacious and associated with significant cardiovascular and systemic side effects. More efficacious and safe drugs are required to restore and maintain sinus rhythm in patients with AF.
    Areas covered: In this review, several potential drug targets are discussed including trans-membrane ion channels, intracellular calcium signaling, gap junction signaling, atrial inflammation and fibrosis, and the autonomic nervous system. New tools and methodologies for AF drug development are also reviewed including gene therapy, genome-guided therapy, stem cell technologies, tissue engineering, and optogenetics.
    Expert opinion: In recent decades, there has been an increased understanding of the underlying pathogenesis of AF. As a result, there is a gradual paradigm shift from focusing only on trans-membrane ion channel inhibition to developing therapeutic agents that target other underlying arrhythmogenic mechanisms. Gene therapy and genome-guided therapy are emerging as novel treatments for AF with some success in proof-of-concept studies. Recent advances in stem cell technology, tissue engineering, and optogenetics may allow more effective
    MeSH term(s) Animals ; Anti-Arrhythmia Agents/adverse effects ; Anti-Arrhythmia Agents/pharmacology ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/physiopathology ; Drug Development/methods ; Drug Discovery/methods ; Genetic Therapy/methods ; Humans ; Molecular Targeted Therapy ; Stem Cells/cytology ; Tissue Engineering/methods
    Chemical Substances Anti-Arrhythmia Agents
    Language English
    Publishing date 2020-10-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1080/17460441.2021.1826432
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6388: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Letter to the Editor on "Atrial fibrillation prevalence and risk profile from novel community-based screening in Thailand: A prospective multi-centre study".

    Zuo, Ming-Liang / Wong, Chun-Ka / Yin, Lixue / Siu, Chung-Wah

    International journal of cardiology. Heart & vasculature

    2021  Volume 33, Page(s) 100733

    Language English
    Publishing date 2021-02-22
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2818464-6
    ISSN 2352-9067
    ISSN 2352-9067
    DOI 10.1016/j.ijcha.2021.100733
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Immunopathogenesis of Immune Checkpoint Inhibitor Induced Myocarditis

    Chun-Ka Wong / Tsun-Ho Lam / Song-Yan Liao / Yee-Man Lau / Hung-Fat Tse / Benjamin Y. F. So

    Biomedicines, Vol 11, Iss 107, p

    Insights from Experimental Models and Treatment Implications

    2023  Volume 107

    Abstract: Despite the extraordinary success of immune checkpoint inhibitors (ICIs) in cancer treatment, their use is associated with a high incidence of immune-related adverse events (IRAEs), resulting from therapy-related autoimmunity against various target ... ...

    Abstract Despite the extraordinary success of immune checkpoint inhibitors (ICIs) in cancer treatment, their use is associated with a high incidence of immune-related adverse events (IRAEs), resulting from therapy-related autoimmunity against various target organs. ICI-induced myocarditis is one of the most severe forms of IRAE, which is associated with risk of hemodynamic compromise and mortality. Despite increasing recognition and prompt treatment by clinicians, there remain significant gaps in knowledge regarding the pathophysiology, diagnosis and treatment of ICI-induced myocarditis. As the newly emerged disease entity is relatively rare, it is challenging for researchers to perform studies involving patients at scale. Alternatively, mouse models have been developed to facilitate research understanding of the pathogenesis of ICI-induced myocarditis and drug discovery. Transgenic mice with immune checkpoint genes knocked out allow induction of myocarditis in a highly reproducible manner. On the other hand, it has not been possible to induce ICI-induced myocarditis in wild type mice by injecting ICIs monotherapy alone. Additional interventions such as combinational ICI, tumor inoculation, cardiac sarcomere immunization, or cardiac irradiation are necessary to mimic the underlying pathophysiology in human cancer patients and to induce ICI-induced myocarditis successfully. This review focuses on the immunopathogenesis of ICI-induced myocarditis, drawing insights from human studies and animal models, and discusses the potential implications for treatment.
    Keywords autoimmunity ; cancer ; immune checkpoint inhibitor ; immunotherapy ; leukocyte ; myocarditis ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Temporary Atrioventricular Sequential Conduction System Pacing in Patients With Acute Conduction Abnormalities and Cardiogenic Shock.

    Ngan, Ho-Ting / Chan, Kwong-Yue / Wong, Chun-Ka / Un, Ka-Chun / Sze, Shu-Yue / Shea, Puigi / Lam, Cheung-Chi / Lam, Yui-Ming / Tam, Chor-Cheung / Lau, Chu-Pak / Tse, Hung-Fat

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 9, Page(s) 1998–2000

    MeSH term(s) Humans ; Shock, Cardiogenic/therapy ; Heart Conduction System ; Cardiac Conduction System Disease
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Letter
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Immunopathogenesis of Immune Checkpoint Inhibitor Induced Myocarditis: Insights from Experimental Models and Treatment Implications.

    Wong, Chun-Ka / Lam, Tsun-Ho / Liao, Song-Yan / Lau, Yee-Man / Tse, Hung-Fat / So, Benjamin Y F

    Biomedicines

    2023  Volume 11, Issue 1

    Abstract: Despite the extraordinary success of immune checkpoint inhibitors (ICIs) in cancer treatment, their use is associated with a high incidence of immune-related adverse events (IRAEs), resulting from therapy-related autoimmunity against various target ... ...

    Abstract Despite the extraordinary success of immune checkpoint inhibitors (ICIs) in cancer treatment, their use is associated with a high incidence of immune-related adverse events (IRAEs), resulting from therapy-related autoimmunity against various target organs. ICI-induced myocarditis is one of the most severe forms of IRAE, which is associated with risk of hemodynamic compromise and mortality. Despite increasing recognition and prompt treatment by clinicians, there remain significant gaps in knowledge regarding the pathophysiology, diagnosis and treatment of ICI-induced myocarditis. As the newly emerged disease entity is relatively rare, it is challenging for researchers to perform studies involving patients at scale. Alternatively, mouse models have been developed to facilitate research understanding of the pathogenesis of ICI-induced myocarditis and drug discovery. Transgenic mice with immune checkpoint genes knocked out allow induction of myocarditis in a highly reproducible manner. On the other hand, it has not been possible to induce ICI-induced myocarditis in wild type mice by injecting ICIs monotherapy alone. Additional interventions such as combinational ICI, tumor inoculation, cardiac sarcomere immunization, or cardiac irradiation are necessary to mimic the underlying pathophysiology in human cancer patients and to induce ICI-induced myocarditis successfully. This review focuses on the immunopathogenesis of ICI-induced myocarditis, drawing insights from human studies and animal models, and discusses the potential implications for treatment.
    Language English
    Publishing date 2023-01-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11010107
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Ventricular rate control with ivabradine in patients with permanent atrial fibrillation.

    Chan, Yap-Hang / Hai, Jo-Jo / Wong, Chun-Ka / Lau, Chu-Pak / Cheung, Bernard Man-Yung / Tse, Hung-Fat

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

    2022  Volume 65, Issue 3, Page(s) 597–599

    MeSH term(s) Humans ; Ivabradine ; Atrial Fibrillation/drug therapy ; Heart Ventricles
    Chemical Substances Ivabradine (3H48L0LPZQ)
    Language English
    Publishing date 2022-08-31
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1329179-8
    ISSN 1572-8595 ; 1383-875X
    ISSN (online) 1572-8595
    ISSN 1383-875X
    DOI 10.1007/s10840-022-01344-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5214: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top