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Article ; Online: Two new species of the genus Austerocardiochiles Dangerfield, Austin amp; Whitfield, 1999 (Hymenoptera: Braconidae: Cardiochilinae) from Vietnam.

Long, Khuat Dang / Oanh, Nguyen Thi / Dzuong, Nguyen VAN / Hoa, Dang Thi

Zootaxa

2019 Volume 4657, Issue 3, Page(s) zootaxa.4657.3.11

Abstract: Two new species of the genus Austerocardiochiles Dangerfield, Austin Whitfield, 1999 from Vietnam ...

Abstract	Two new species of the genus Austerocardiochiles Dangerfield, Austin Whitfield, 1999 from Vietnam, viz. A. mellosus Long, sp. n. and A. simulatus Long, sp. n., are described and illustrated. Additionally, the genus Austerocardiochiles is newly recorded for the braconid fauna of Vietnam. The checklist and distribution of already known species of the genus Austerocardiochiles are given. A comprehensive key to Austerocardiochiles species from Oriental region is also provided.
MeSH term(s)	Animals ; Hymenoptera ; Vietnam
Language	English
Publishing date	2019-08-20
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4657.3.11
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Marked variations in gut microbiota and some innate immune responses of fresh water crayfish, marron (Cherax cainii, Austin 2002) fed dietary supplementation of Clostridium butyricum

Md Javed Foysal / Thi Thu Thuy Nguyen / Md Reaz Chaklader / Muhammad A.B. Siddik / Chin-Yen Tay / Ravi Fotedar / Sanjay Kumar Gupta

PeerJ, Vol 7, p e

2019 Volume 7553

Abstract: This study aimed to investigate the effects of Clostridium butyricum as a dietary probiotic supplement in fishmeal based diet on growth, gut microbiota and immune performance of marron (Cherax cainii). Marron were randomly distributed into two different ... ...

Abstract	This study aimed to investigate the effects of Clostridium butyricum as a dietary probiotic supplement in fishmeal based diet on growth, gut microbiota and immune performance of marron (Cherax cainii). Marron were randomly distributed into two different treatment groups, control and probiotic fed group. After 42 days of feeding trial, the results revealed a significant (P < 0.05) increase in growth due to increase in number of moults in marron fed probiotics. The probiotic diet also significantly enhanced the total haemocyte counts (THC), lysozyme activity in the haemolymph and protein content of the tail muscle in marron. Compared to control, the 16S rRNA sequences data demonstrated an enrichment of bacterial diversity in the probiotic fed marron where significant increase of Clostridium abundance was observed. The abundance for crayfish pathogen Vibrio and Aeromonas were found to be significantly reduced post feeding with probiotic diet. Predicted metabolic pathway revealed an increased activity for the metabolism and absorption of carbohydrate, degradation of amino acid, fatty acid and toxic compounds, and biosynthesis of secondary metabolites. C. butyricum supplementation also significantly modulated the expression level of immune-responsive genes of marron post challenged with Vibrio mimicus. The overall results suggest that C. butyricum could be used as dietary probiotic supplement in marron aquaculture.
Keywords	Marron ; Probiotic bacteria ; Health and immune indices ; High throughput sequencing ; Bioinformatics ; Gene expression profiling ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
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Article ; Online: A Curious Cause of Corkscrew Esophagus.

Dickerson, Austin / Weng, Kayson / Ford, Kenneth / Nguyen, Anh D

The American journal of gastroenterology

2024

Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000002705
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Article ; Online: Workplace Psychosocial Factors and Their Association With Musculoskeletal Disorders: A Systematic Review of Longitudinal Studies.

Bezzina, Aaron / Austin, Emma / Nguyen, Ha / James, Carole

Workplace health & safety

2023 Volume 71, Issue 12, Page(s) 578–588

Abstract: This systematic review examines literature regarding the relationship between workplace psychosocial factors and musculoskeletal disorders (MSDs). Musculoskeletal disorders are the leading cause of work disability, resulting in billions of dollars of ... ...

Abstract	This systematic review examines literature regarding the relationship between workplace psychosocial factors and musculoskeletal disorders (MSDs). Musculoskeletal disorders are the leading cause of work disability, resulting in billions of dollars of financial losses. Evidence suggests that workplace psychosocial factors can lead to the development and progression of MSDs. A data search was conducted in MEDLINE, EMBASE, PsychINFO, Scopus, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) from August 2009 to May 2020 inclusive. Other eligibility criteria included studies published in English, conducted on adults within a workplace setting, conducted in developed economies, and were stability-control longitudinal observational studies. Studies were independently screened for eligibility, using COVIDENCE (software for managing and streamlining systematic reviews) and assessed for quality by multiple authors, using the JBI Evidence synthesis tool. From 6,812 studies, 47 articles were included in the final analysis. The most common MSDs investigated were lower back pain, neck and shoulder pain, and upper extremity symptoms and disorders. Included articles identified that psychosocial workplace factors of support, collaboration, job control, and job demands were statistically significantly associated with risk and progression of MSDs. Review of the articles included in this article supports the theory that MSDs have a multifactorial, complex etiology that includes psychosocial factors. Interventions to enhance psychosocial work environment provide opportunities to reduce the risk of MSDs.
MeSH term(s)	Adult ; Humans ; Occupational Diseases/etiology ; Musculoskeletal Diseases/epidemiology ; Musculoskeletal Diseases/etiology ; Workplace/psychology ; Shoulder Pain ; Longitudinal Studies ; Risk Factors
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2649181-3
ISSN	2165-0969 ; 2165-0799
ISSN (online)	2165-0969
ISSN	2165-0799
DOI	10.1177/21650799231193578
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Article ; Online: Functional regulation of aquaporin dynamics by lipid bilayer composition.

Nguyen, Anh T P / Weigle, Austin T / Shukla, Diwakar

Nature communications

2024 Volume 15, Issue 1, Page(s) 1848

Abstract: With the diversity of lipid-protein interactions, any observed membrane protein dynamics or functions directly depend on the lipid bilayer selection. However, the implications of lipid bilayer choice are seldom considered unless characteristic lipid- ... ...

Abstract	With the diversity of lipid-protein interactions, any observed membrane protein dynamics or functions directly depend on the lipid bilayer selection. However, the implications of lipid bilayer choice are seldom considered unless characteristic lipid-protein interactions have been previously reported. Using molecular dynamics simulation, we characterize the effects of membrane embedding on plant aquaporin SoPIP2;1, which has no reported high-affinity lipid interactions. The regulatory impacts of a realistic lipid bilayer, and nine different homogeneous bilayers, on varying SoPIP2;1 dynamics are examined. We demonstrate that SoPIP2;1's structure, thermodynamics, kinetics, and water transport are altered as a function of each membrane construct's ensemble properties. Notably, the realistic bilayer provides stabilization of non-functional SoPIP2;1 metastable states. Hydrophobic mismatch and lipid order parameter calculations further explain how lipid ensemble properties manipulate SoPIP2;1 behavior. Our results illustrate the importance of careful bilayer selection when studying membrane proteins. To this end, we advise cautionary measures when performing membrane protein molecular dynamics simulations.
MeSH term(s)	Lipid Bilayers/chemistry ; Molecular Dynamics Simulation ; Thermodynamics ; Aquaporins/metabolism ; Membrane Proteins/metabolism
Chemical Substances	Lipid Bilayers ; Aquaporins ; Membrane Proteins
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46027-y
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Article ; Online: Interdisciplinary analysis of drugs: Structural features and clinical data.

Austin, Daniel / Biswas, Kumari / Pollock, Kailee / Nguyen, Linh

Journal of clinical and translational science

2022 Volume 6, Issue 1, Page(s) e43

Abstract: Background: Chemical structure is a vital consideration early in the drug development process. Its role in analysis of safety and efficacy is relatively diminished after drugs are approved for clinical use. This interdisciplinary study explores a ... ...

Abstract	Background: Chemical structure is a vital consideration early in the drug development process. Its role in analysis of safety and efficacy is relatively diminished after drugs are approved for clinical use. This interdisciplinary study explores a strategy by which readily available clinical data may be used along with structural features of drugs to identify associations with potential utility for both clinical decision-making and drug development. Methods: Chemical functional groups and structural groups (SGs) of 261 drugs were manually classified in tiers, and their incidence of gastrointestinal (GI) and central nervous system (CNS) adverse drug reactions (ADRs) were obtained from a clinical database. Drugs with an GI or CNS ADR incidence of at least 10% were analyzed for correlations with their functional and SGs. Results: Eight statistically significant associations were detected by preliminary analysis: piperazine and methylene groups were associated with higher rate of CNS ADRs; while amides, secondary alcohols, and di-substituted phenyl groups were associated with lower rates of GI or CNS ADRs or both. Conclusions: Although further study is necessary to understand these associations and build upon this strategy, this exploratory analysis establishes a methodology by which chemical properties of drugs may be used to aid in clinical decision-making when choosing between otherwise equivalent drug therapy options, as the presence of specific groups on drugs may be associated with increased or decreased risks of specific ADRs.
Language	English
Publishing date	2022-04-29
Publishing country	England
Document type	Journal Article
ISSN	2059-8661
ISSN (online)	2059-8661
DOI	10.1017/cts.2022.375
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Article: Functional Regulation of Aquaporin Dynamics by Lipid Bilayer Composition.

Nguyen, Anh T P / Weigle, Austin T / Shukla, Diwakar

bioRxiv : the preprint server for biology

2023

Abstract	With the diversity of lipid-protein interactions, any observed membrane protein dynamics or functions directly depend on the lipid bilayer selection. However, the implications of lipid bilayer choice are seldom considered unless characteristic lipid-protein interactions have been previously reported. Using molecular dynamics simulation, we characterize the effects of membrane embedding on plant aquaporin SoPIP2;1, which has no reported high-affinity lipid interactions. The regulatory impacts of a realistic lipid bilayer, and nine different homogeneous bilayers, on varying SoPIP2;1 dynamics were examined. We demonstrate that SoPIP2;1s structure, thermodynamics, kinetics, and water transport are altered as a function of each membrane construct's ensemble properties. Notably, the realistic bilayer provides stabilization of non-functional SoPIP2;1 metastable states. Hydrophobic mismatch and lipid order parameter calculations further explain how lipid ensemble properties manipulate SoPIP2;1 behavior. Our results illustrate the importance of careful bilayer selection when studying membrane proteins. To this end, we advise cautionary measures when performing membrane protein molecular dynamics simulations.
Language	English
Publishing date	2023-07-22
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.20.549977
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Article ; Online: Short-term and Long-term Complications of Cervical Disc Arthroplasty.

Nguyen, Austin Q / Credille, Kevin / Saifi, Comron

Clinical spine surgery

2023 Volume 36, Issue 9, Page(s) 404–410

Abstract: Study design: A narrative review.: Objective: This review discusses the short and long-term complications associated with cervical disc arthroplasty (CDA).: Summary of background data: CDA is a safe and effective motion-sparing alternative to ... ...

Abstract	Study design: A narrative review. Objective: This review discusses the short and long-term complications associated with cervical disc arthroplasty (CDA). Summary of background data: CDA is a safe and effective motion-sparing alternative to fusion for the treatment of cervical disc pathology in patients with cervical radiculopathy or myelopathy. Although CDA offers advantages over fusion within a narrower set of indications, it introduces new technical challenges and potential complications. Methods: A systematic search of several large databases, including Cochrane Central, PubMed, ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry, was conducted from January 2005 to August 2023 to identify published studies and clinical trials evaluating cervical disc replacement complications and outcomes. Results: Short-term complications are primarily related to surgical approach and include dysphagia reported as high as ~70%, laryngeal nerve injury ~0%-1.25%, Horner syndrome ~0.06%, hematoma ~0.01%, gross device extrusion ~0.3%, whereas long-term complications include adjacent segment disease reported at ~3.8%, osteolysis ~44%-64%, heterotopic ossification ~7.3%-69.2%, implant failure ~3.3%-3.7%, and implant wear, which varies depending on design. Conclusions: Approaches for mitigating complications broadly include meticulous dissection, intraoperative techniques, and diligent postoperative follow-up. This review emphasizes the need for a comprehensive understanding and management of complications to enhance the safety, reproducibility, and success of CDA. As CDA continues to evolve, there remains a critical need for ongoing research to delve deeper into evaluating risk for complications and long-term patient outcomes.
MeSH term(s)	Humans ; Intervertebral Disc Degeneration/surgery ; Treatment Outcome ; Diskectomy/methods ; Reproducibility of Results ; Cervical Vertebrae/surgery ; Arthroplasty/adverse effects ; Arthroplasty/methods ; Spinal Fusion/methods
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2849646-2
ISSN	2380-0194 ; 2380-0186
ISSN (online)	2380-0194
ISSN	2380-0186
DOI	10.1097/BSD.0000000000001541
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Book ; Online: Scalable, Decentralized Multi-Agent Reinforcement Learning Methods Inspired by Stigmergy and Ant Colonies

Nguyen, Austin Anhkhoi

2021

Abstract: Bolstering multi-agent learning algorithms to tackle complex coordination and control tasks has been a long-standing challenge of on-going research. Numerous methods have been proposed to help reduce the effects of non-stationarity and unscalability. In ... ...

Abstract	Bolstering multi-agent learning algorithms to tackle complex coordination and control tasks has been a long-standing challenge of on-going research. Numerous methods have been proposed to help reduce the effects of non-stationarity and unscalability. In this work, we investigate a novel approach to decentralized multi-agent learning and planning that attempts to address these two challenges. In particular, this method is inspired by the cohesion, coordination, and behavior of ant colonies. As a result, these algorithms are designed to be naturally scalable to systems with numerous agents. While no optimality is guaranteed, the method is intended to work well in practice and scale better in efficacy with the number of agents present than others. The approach combines single-agent RL and an ant-colony-inspired decentralized, stigmergic algorithm for multi-agent path planning and environment modification. Specifically, we apply this algorithm in a setting where agents must navigate to a goal location, learning to push rectangular boxes into holes to yield new traversable pathways. It is shown that while the approach yields promising success in this particular environment, it may not be as easily generalized to others. The algorithm designed is notably scalable to numerous agents but is limited in its performance due to its relatively simplistic, rule-based approach. Furthermore, the composability of RL-trained policies is called into question, where, while policies are successful in their training environments, applying trained policies to a larger-scale, multi-agent framework results in unpredictable behavior. Comment: 50 pages, 40 figures
Keywords	Computer Science - Multiagent Systems ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning ; Computer Science - Robotics
Subject code	006
Publishing date	2021-05-07
Publishing country	us
Document type	Book ; Online
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Article: A Quality Improvement Initiative to Decrease Inappropriate Intravenous Acetaminophen Use at an Academic Medical Center.

Nguyen, Linda P / Nguyen, Lam / Austin, Jared P

Hospital pharmacy

2019 Volume 55, Issue 4, Page(s) 253–260

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2019-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1468893-1
ISSN	0018-5787
ISSN	0018-5787
DOI	10.1177/0018578719841054
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