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  1. Book ; Online ; E-Book: Applications of nanobiotechnology for neglected tropical diseases

    Formiga, Fabio Rocha / Inamuddin / Severino, Patrícia

    2021  

    Author's details edited by Fabio Rocha, Inamuddin, Patrícia Severino
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxix, 577 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020866114
    ISBN 978-0-12-821101-4 ; 9780128211007 ; 0-12-821101-6 ; 0128211008
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Physiologically based pharmacokinetic modelling to inform combination dosing regimens of ceftaroline and daptomycin in special populations.

    Martins, Frederico Severino / Martins, José Eduardo Severino / Severino, Patricia / Annaert, Pieter / Sy, Sherwin K B

    British journal of clinical pharmacology

    2023  Volume 89, Issue 9, Page(s) 2726–2738

    Abstract: Aims: The combination of daptomycin and ceftaroline used as salvage therapy is associated with higher survival and decreased clinical failure in complicated methicillin-resistant Staphylococcus aureus (MRSA) infections that are resistant to standard ... ...

    Abstract Aims: The combination of daptomycin and ceftaroline used as salvage therapy is associated with higher survival and decreased clinical failure in complicated methicillin-resistant Staphylococcus aureus (MRSA) infections that are resistant to standard MRSA treatment. This study aimed to evaluate dosing regimens for coadministration of daptomycin and ceftaroline in special populations including paediatrics, renally impaired (RI), obese and geriatrics that generate sufficient coverage against daptomycin-resistant MRSA.
    Methods: Physiologically based pharmacokinetic models were developed from pharmacokinetic studies of healthy adults, geriatric, paediatric, obese and RI patients. The predicted profiles were used to evaluate joint probability of target attainment (PTA), as well as tissue-to-plasma ratios.
    Results: The adult dosing regimens of 6 mg/kg every (q)24h or q48h daptomycin and 300-600 mg q12h ceftaroline fosamil by RI categories achieved ≥90% joint PTA when the minimum inhibitory concentrations in the combination are at or below 1 and 4 μg/mL against MRSA. In paediatrics, wherein there is no recommended daptomycin dosing regimen for S. aureus bacteraemia, ≥90% joint PTA is achieved when the minimum inhibitory concentrations in the combination are up to 0.5 and 2 μg/mL for standard paediatric dosing regimens of 7 mg/kg q24h daptomycin and 12 mg/kg q8h ceftaroline fosamil. Model predicted tissue-to-plasma ratios of 0.3 and 0.7 in the skin and lung, respectively, for ceftaroline and 0.8 in the skin for daptomycin.
    Conclusion: Our work illustrates how physiologically based pharmacokinetic modelling can inform appropriate dosing of adult and paediatric patients and thereby enable prediction of target attainment in the patients during multitherapies.
    MeSH term(s) Adult ; Humans ; Child ; Aged ; Daptomycin/pharmacokinetics ; Anti-Bacterial Agents ; Methicillin-Resistant Staphylococcus aureus ; Bacteremia/drug therapy ; Staphylococcus aureus ; Staphylococcal Infections/drug therapy ; Cephalosporins/pharmacokinetics ; Cephalosporins/therapeutic use ; Microbial Sensitivity Tests ; Ceftaroline
    Chemical Substances Daptomycin (NWQ5N31VKK) ; Anti-Bacterial Agents ; Cephalosporins
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15731
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1118: Show issues Location:
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  3. Article: A Comprehensive Genomic Analysis of the Emergent

    de Sales, Romário Oliveira / Leaden, Laura / Migliorini, Letícia Busato / Severino, Patricia

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 12

    Abstract: Klebsiella ... ...

    Abstract Klebsiella pneumoniae
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11121394
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  4. Article ; Online: Corrigendum to "Aloe vera and copaiba oleoresin-loaded chitosan films for wound dressings: Microbial permeation, cytotoxicity, and in vivo proof of concept" [Int. J. Pharm. 634 (2023) 122648].

    Genesi, Bianca P / de Melo Barbosa, Raquel / Severino, Patricia / Rodas, Andrea C D / Yoshida, Cristiana M P / Mathor, Mônica B / Lopes, Patrícia S / Viseras, César / Souto, Eliana B / da Silva, Classius Ferreira

    International journal of pharmaceutics

    2024  Volume 652, Page(s) 123823

    Language English
    Publishing date 2024-01-26
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2024.123823
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    Zs.A 1409: Show issues Location:
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  5. Article: Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies.

    Portugal, Isabella / Jain, Sona / Severino, Patrícia / Priefer, Ronny

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 8

    Abstract: Photodynamic therapy is one of the more unique cancer treatment options available in today's arsenal against this devastating disease. It has historically been explored in cutaneous lesions due to the possibility of focal/specific effects and ... ...

    Abstract Photodynamic therapy is one of the more unique cancer treatment options available in today's arsenal against this devastating disease. It has historically been explored in cutaneous lesions due to the possibility of focal/specific effects and minimization of adverse events. Advances in drug delivery have mostly been based on biomaterials, such as liposomal and hybrid lipoidal vesicles, nanoemulsions, microneedling, and laser-assisted photosensitizer delivery systems. This review summarizes the most promising approaches to enhancing the photosensitizers' transdermal delivery efficacy for the photodynamic treatment for cutaneous pre-cancerous lesions and skin cancers. Additionally, discussions on strategies and advantages in these approaches, as well as summarized challenges, perspectives, and translational potential for future applications, will be discussed.
    Language English
    Publishing date 2021-08-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14080772
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  6. Article ; Online: Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies

    Isabella Portugal / Sona Jain / Patrícia Severino / Ronny Priefer

    Pharmaceuticals, Vol 14, Iss 772, p

    2021  Volume 772

    Abstract: Photodynamic therapy is one of the more unique cancer treatment options available in today’s arsenal against this devastating disease. It has historically been explored in cutaneous lesions due to the possibility of focal/specific effects and ... ...

    Abstract Photodynamic therapy is one of the more unique cancer treatment options available in today’s arsenal against this devastating disease. It has historically been explored in cutaneous lesions due to the possibility of focal/specific effects and minimization of adverse events. Advances in drug delivery have mostly been based on biomaterials, such as liposomal and hybrid lipoidal vesicles, nanoemulsions, microneedling, and laser-assisted photosensitizer delivery systems. This review summarizes the most promising approaches to enhancing the photosensitizers’ transdermal delivery efficacy for the photodynamic treatment for cutaneous pre-cancerous lesions and skin cancers. Additionally, discussions on strategies and advantages in these approaches, as well as summarized challenges, perspectives, and translational potential for future applications, will be discussed.
    Keywords photodynamic therapy ; drug delivery ; transdermal ; cutaneous ; cancer ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 610
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Biosensor-Integrated Drug Delivery Systems as New Materials for Biomedical Applications.

    Cicha, Iwona / Priefer, Ronny / Severino, Patrícia / Souto, Eliana B / Jain, Sona

    Biomolecules

    2022  Volume 12, Issue 9

    Abstract: Biosensor-integrated drug delivery systems are innovative devices in the health area, enabling continuous monitoring and drug administration. The use of smart polymer, bioMEMS, and electrochemical sensors have been extensively studied for these systems, ... ...

    Abstract Biosensor-integrated drug delivery systems are innovative devices in the health area, enabling continuous monitoring and drug administration. The use of smart polymer, bioMEMS, and electrochemical sensors have been extensively studied for these systems, especially for chronic diseases such as diabetes mellitus, cancer and cardiovascular diseases as well as advances in regenerative medicine. Basically, the technology involves sensors designed for the continuous analysis of biological molecules followed by drug release in response to specific signals. The advantages include high sensitivity and fast drug release. In this work, the main advances of biosensor-integrated drug delivery systems as new biomedical materials to improve the patients' quality of life with chronic diseases are discussed.
    MeSH term(s) Biosensing Techniques ; Chronic Disease ; Drug Delivery Systems ; Humans ; Pharmaceutical Preparations ; Quality of Life ; Stimuli Responsive Polymers
    Chemical Substances Pharmaceutical Preparations ; Stimuli Responsive Polymers
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12091198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Inquietações, provocações, reflexões, acolhida e encontro promovido pela educação popular e o serviço social

    Fabricio Gobetti Leonardi / Raiane Patrícia Severino Assumpção

    Revista de Educação Popular, Pp 242-

    um diálogo com Oscar Jara

    2020  Volume 258

    Abstract: As inquietações das reflexões que constituíram a entrevista advieram dos desafios interpostos na relação entre educação popular e serviço social, levando em conta que esta é uma das profissões da área da saúde e que a primeira tem sido relegada após o ... ...

    Abstract As inquietações das reflexões que constituíram a entrevista advieram dos desafios interpostos na relação entre educação popular e serviço social, levando em conta que esta é uma das profissões da área da saúde e que a primeira tem sido relegada após o movimento de reconceituação, no anos de 1980, que marca a aproximação e, logo em seguida, um afastamento entre ambos. Nesse sentido, a partir do contato com Oscar Jara buscou-se problematizar algumas questões que são centrais para esse debate.
    Keywords educação popular ; serviço social ; transformação social ; conscientização ; Social Sciences ; H ; Labor in politics. Political activity of the working class ; HD8031
    Language Portuguese
    Publishing date 2020-07-01T00:00:00Z
    Publisher Editora da Universidade Federal de Uberlândia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Aloe vera and copaiba oleoresin-loaded chitosan films for wound dressings: microbial permeation, cytotoxicity, and in vivo proof of concept.

    Genesi, Bianca P / de Melo Barbosa, Raquel / Severino, Patricia / Rodas, Andrea C D / Yoshida, Cristiana M P / Mathor, Mônica B / Lopes, Patrícia S / Viseras, César / Souto, Eliana B / Ferreira da Silva, Classius

    International journal of pharmaceutics

    2023  Volume 634, Page(s) 122648

    Abstract: Chitosan films are commonly used for wound dressing, provided that this polymer has healing, mucoadhesiveness and antimicrobial properties. These properties can be further reinforced by the combination of chitosan with polysaccharides and glycoproteins ... ...

    Abstract Chitosan films are commonly used for wound dressing, provided that this polymer has healing, mucoadhesiveness and antimicrobial properties. These properties can be further reinforced by the combination of chitosan with polysaccharides and glycoproteins present in aloe vera, together with copaiba oleoresin's pharmacological activity attributed to sesquiterpenes. In this work, we developed chitosan films containing either aloe vera, copaiba oil or both, by casting technique, and evaluated their microbial permeation, antimicrobial activity, cytotoxicity, and in vivo healing potential in female adult rats. None of the developed chitosan films promoted microbial permeation, while the cytotoxicity in Balb/c 3 T3 clone A31 cell line revealed no toxicity of films produced with 2 % of chitosan and up to 1 % of aloe vera and copaiba oleoresin. Films obtained with either 0.5 % chitosan or 0.5 % copaiba oleoresin induced cell proliferation which anticipate their potential for closure of wound and for the healing process. The in vivo results confirmed that tested films (0.5 % copaiba-loaded chitosan film and 0.5 % aloe vera-loaded chitosan film) were superior to a commercial dressing film. For all tested groups, a fully formed epithelium was seen, while neoformation of vessels seemed to be greater in formulations-treated groups than those treated with the control. Our work confirms the added value of combining chitosan with aloe vera and copaiba oil in the healing process of wounds.
    MeSH term(s) Female ; Rats ; Animals ; Chitosan ; Aloe ; Anti-Infective Agents/pharmacology ; Bandages
    Chemical Substances Chitosan (9012-76-4) ; copaiba oleoresin ; Anti-Infective Agents
    Language English
    Publishing date 2023-01-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2023.122648
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    Zs.A 1409: Show issues Location:
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  10. Article ; Online: Causes of knee pain evaluated by arthroscopy after knee arthroplasty: a case series.

    Severino, Fabricio Roberto / de Oliveira, Victor Marques / de Paula Leite Cury, Ricardo / Severino, Nilson Roberto / de Moraes Barros Fucs, Patricia Maria

    International orthopaedics

    2022  Volume 46, Issue 4, Page(s) 697–703

    Abstract: Background: The origin of persistent pain and joint limitation after knee arthroplasty are controversial and difficult to diagnose. Knee arthroscopy is indicated when the results of routine evaluation tests are not clear. The purpose of this study was ... ...

    Abstract Background: The origin of persistent pain and joint limitation after knee arthroplasty are controversial and difficult to diagnose. Knee arthroscopy is indicated when the results of routine evaluation tests are not clear. The purpose of this study was to determine through arthroscopy the cause of post-knee-arthroplasty pain symptoms in patients without a prior diagnosis of cause of pain.
    Methods: This prospective case series study described the outcomes of 34 patients (35 knees) with pain and limited function in the arthroplastic joint, who underwent diagnostic and therapeutic arthroscopy. Patients were clinically evaluated using range-of-motion tests and the Lysholm, Hospital for Special Surgery (HSS) and Knee Society Score (KSS) scales.
    Results: The procedure found cyclops in 17 knees, synovitis in 9 knees, arthrofibrosis in 6 knees, polyethylene wear with debris in two knees, and polyethylene bouncing in one knee with unicompartmental arthroplasty with a mobile polyethylene platform. It was effective for the relief of pain symptoms, with excellent or good outcomes in 80% of cases; there was a poor outcome in 11.43%, which maintained the presentation of pain and underwent revision arthroplasty, and, in 8.57%, did not undergo another surgery despite symptom persistence.
    Conclusions: Post-arthroplasty knee arthroscopy seems beneficial in patients with pain and without a pre-established diagnosis and who had already undergone conservative treatment unsuccessfully.
    MeSH term(s) Arthroplasty, Replacement, Knee/adverse effects ; Arthroplasty, Replacement, Knee/methods ; Arthroscopy/adverse effects ; Humans ; Knee Joint/surgery ; Knee Prosthesis ; Osteoarthritis, Knee/etiology ; Osteoarthritis, Knee/surgery ; Pain/etiology ; Polyethylene ; Reoperation ; Treatment Outcome
    Chemical Substances Polyethylene (9002-88-4)
    Language English
    Publishing date 2022-01-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-021-05048-8
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