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  1. Book ; Online ; E-Book: New frontiers

    Mathivanan, Suresh / Fonseka, Pamali / Nedeva, Christina / Atukorala, Ishara

    extracellular vesicles

    (Subcellular biochemistry ; 97)

    2021  

    Author's details Suresh Mathivanan, Pamali Fonseka, Christina Nedeva, Ishara Atukorala editors
    Series title Subcellular biochemistry ; 97
    Collection
    Keywords Cell membranes  ; Cell biology ; Biochemistry
    Subject code 571.64
    Language English
    Size 1 Online-Ressource (xii, 538 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020916232
    ISBN 978-3-030-67171-6 ; 9783030671709 ; 3-030-67171-2 ; 3030671704
    DOI 10.1007/978-3-030-67171-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Proteome bioinformatics

    Keerthikumar, Shivakumar / Mathivanan, Suresh

    (Methods in molecular biology ; 1549 ; Springer protocols)

    2017  

    Author's details edited by Shivakumar Keerthikumar and Suresh Mathivanan
    Series title Methods in molecular biology ; 1549
    Springer protocols
    Collection
    Keywords Computational approaches ; Databases ; MS-based proteomics ; Mass spectrometry instrumentation ; Phylogenetic analysis ; Statistical evaluation ; Tandem MS techniques
    Language English
    Size xi, 233 Seiten, Illustrationen, Diagramme, 25.4 cm x 17.8 cm, 0 g
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019199217
    ISBN 978-1-4939-6738-4 ; 1-4939-6738-X ; 9781493967407 ; 1493967401
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1549- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Extracellular Vesicles Biogenesis, Cargo Sorting and Implications in Disease Conditions.

    Fonseka, Pamali / Mathivanan, Suresh

    Cells

    2023  Volume 12, Issue 2

    Abstract: Extracellular vesicles (EVs) are small packages that contain proteins, lipids and nucleic acids and are released by various cell types [ ... ]. ...

    Abstract Extracellular vesicles (EVs) are small packages that contain proteins, lipids and nucleic acids and are released by various cell types [...].
    MeSH term(s) Extracellular Vesicles/metabolism ; Cell Communication ; Protein Transport ; Nucleic Acids/metabolism ; Proteins/metabolism
    Chemical Substances Nucleic Acids ; Proteins
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12020280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Extracellular Matrix and the Extracellular Environment.

    Mathivanan, Suresh

    Proteomics

    2017  Volume 17, Issue 23-24

    MeSH term(s) Animals ; Extracellular Matrix/physiology ; Extracellular Space ; Humans ; Mechanotransduction, Cellular ; Signal Transduction
    Language English
    Publishing date 2017-12-19
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.2017700185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5386: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.A 1868: Show issues Location:
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  5. Article: Engineering Extracellular Vesicles for Cancer Therapy.

    Nedeva, Christina / Mathivanan, Suresh

    Sub-cellular biochemistry

    2021  Volume 97, Page(s) 375–392

    Abstract: Extracellular vesicles (EVs) are lipid bilayer containing nanovesicles that have a predominant role in intercellular communication and cargo delivery. EVs have recently been used as a means for drug delivery and have been depicted to elicit no or minimal ...

    Abstract Extracellular vesicles (EVs) are lipid bilayer containing nanovesicles that have a predominant role in intercellular communication and cargo delivery. EVs have recently been used as a means for drug delivery and have been depicted to elicit no or minimal immune response in vivo. The stability, biocompatibility and manipulatable tumour homing capabilities of these biological vessels make them an attractive target for the packaging and delivery of drugs and molecules to treat various diseases including cancer. The following chapter will summarise current EV engineering techniques for the purpose of delivering putative drugs and therapeutic molecules for the treatment of cancer. The relevance of EV source will be discussed, as well as the specific modifications required to manufacture them into suitable vehicles for molecular drug delivery. Furthermore, methods of EV cargo encapsulation will be evaluated with emphasis on intercellular coordination to allow for the effective emptying of therapeutic contents into target cells. While EVs possess properties making them naturally suitable nanocarriers for drugs and molecules, many challenges with clinical translation of EV-based platforms remain. These issues need to be addressed in order to harness the true potential of the EV-based therapeutic avenue.
    MeSH term(s) Drug Delivery Systems ; Extracellular Vesicles ; Humans ; Neoplasms/drug therapy
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 0306-0225 ; 0096-8757
    ISSN 0306-0225 ; 0096-8757
    DOI 10.1007/978-3-030-67171-6_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Role of Post-Translational Modifications in Targeting Protein Cargo to Extracellular Vesicles.

    Atukorala, Ishara / Mathivanan, Suresh

    Sub-cellular biochemistry

    2021  Volume 97, Page(s) 45–60

    Abstract: Extracellular vesicles (EVs) are naturally occurring nanoparticles that contain proteins and nucleic acids. It is speculated that cells release EVs loaded with a selective cargo of proteins through highly regulated processes. Several proteomic and ... ...

    Abstract Extracellular vesicles (EVs) are naturally occurring nanoparticles that contain proteins and nucleic acids. It is speculated that cells release EVs loaded with a selective cargo of proteins through highly regulated processes. Several proteomic and biochemical studies have highlighted phosphorylated, glycosylated, ubiquitinated, SUMOylated, oxidated and palmitoylated proteins within the EVs. Emerging evidences suggest that post-translational modifications (PTMs) can regulate the sorting of specific proteins into EVs and such proteins with specific PTMs have also been identified in clinical samples. Hence, it has been proposed that EV proteins with PTMs could be used as potential biomarkers of disease conditions. Among the other cellular mechanisms, the endosomal sorting complex required for transport (ESCRT) is also implicated in cargo sorting into EVs. In this chapter, various PTMs that are shown to regulate protein cargo sorting into EVs will be discussed.
    MeSH term(s) Extracellular Vesicles/metabolism ; Protein Processing, Post-Translational ; Protein Transport ; Proteins/metabolism ; Proteomics
    Chemical Substances Proteins
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 0306-0225 ; 0096-8757
    ISSN 0306-0225 ; 0096-8757
    DOI 10.1007/978-3-030-67171-6_3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Proteomics analysis of C2C12 myotubes treated with atrophy inducing cancer cell-derived factors.

    Marzan, Akbar L / Chitti, Sai V / Gummadi, Sriram / Kang, Taeyoung / Ang, Ching-Seng / Mathivanan, Suresh

    Proteomics

    2023  , Page(s) e2300020

    Abstract: Cancer-associated cachexia is a wasting syndrome that results in dramatic loss of whole-body weight, predominantly due to loss of skeletal muscle mass. It has been established that cachexia inducing cancer cells secrete proteins and extracellular ... ...

    Abstract Cancer-associated cachexia is a wasting syndrome that results in dramatic loss of whole-body weight, predominantly due to loss of skeletal muscle mass. It has been established that cachexia inducing cancer cells secrete proteins and extracellular vesicles (EVs) that can induce muscle atrophy. Though several studies examined these cancer-cell derived factors, targeting some of these components have shown little or no clinical benefit. To develop new therapies, understanding of the dysregulated proteins and signaling pathways that regulate catabolic gene expression during muscle wasting is essential. Here, we sought to examine the effect of conditioned media (CM) that contain secreted factors and EVs from cachexia inducing C26 colon cancer cells on C2C12 myotubes using mass spectrometry-based label-free quantitative proteomics. We identified significant changes in the protein profile of C2C12 cells upon exposure to C26-derived CM. Functional enrichment analysis revealed enrichment of proteins associated with inflammation, mitochondrial dysfunction, muscle catabolism, ROS production, and ER stress in CM treated myotubes. Furthermore, strong downregulation in muscle structural integrity and development and/or regenerative pathways were observed. Together, these enriched proteins in atrophied muscle could be utilized as potential muscle wasting markers and the dysregulated biological processes could be employed for therapeutic benefit in cancer-induced muscle wasting.
    Language English
    Publishing date 2023-10-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.202300020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5386: Show issues Location:
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  8. Article ; Online: Bovine milk-derived extracellular vesicles enhance doxorubicin sensitivity in triple negative breast cancer cells by targeting metabolism and STAT signalling.

    Sanwlani, Rahul / Kang, Taeyoung / Gummadi, Sriram / Nedeva, Christina / Ang, Ching-Seng / Mathivanan, Suresh

    Proteomics

    2023  Volume 23, Issue 18, Page(s) e2200482

    Abstract: Metastatic triple-negative breast cancer (TNBC) has a low 5-year survival rate of below 30% with systemic chemotherapy being the most widely used treatment. Bovine milk-derived extracellular vesicles (MEVs) have been previously demonstrated to have anti- ... ...

    Abstract Metastatic triple-negative breast cancer (TNBC) has a low 5-year survival rate of below 30% with systemic chemotherapy being the most widely used treatment. Bovine milk-derived extracellular vesicles (MEVs) have been previously demonstrated to have anti-cancer attributes. In this study, we isolated bovine MEVs from commercial milk and characterised them according to MISEV guidelines. Bovine MEVs sensitised TNBC cells to doxorubicin, resulting in reduced metabolic potential and cell-viability. Label-free quantitative proteomics of cells treated with MEVs and/or doxorubicin suggested that combinatorial treatment depleted various pro-tumorigenic interferon-inducible gene products and proteins with metabolic function, previously identified as therapeutic targets in TNBC. Combinatorial treatment also led to reduced abundance of various STAT proteins and their downstream oncogenic targets with roles in cell-cycle and apoptosis. Taken together, this study highlights the ability of bovine MEVs to sensitise TNBC cells to standard-of-care therapeutic drug doxorubicin, paving the way for novel treatment regimens.
    MeSH term(s) Humans ; Animals ; Triple Negative Breast Neoplasms/pathology ; Milk/metabolism ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Extracellular Vesicles/metabolism
    Chemical Substances Doxorubicin (80168379AG)
    Language English
    Publishing date 2023-06-27
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.202200482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5386: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: Extracellular Vesicles Regulate Cancer Metastasis.

    Shahi, Sanjay / Cianciarulo, Cassandra / Nedeva, Christina / Mathivanan, Suresh

    Sub-cellular biochemistry

    2021  Volume 97, Page(s) 275–296

    Abstract: Metastatic cancer is a complex disease associated with poor prognosis and accounts for the majority of cancer related deaths. To date, many of the molecular mechanisms driving metastatic disease remain elusive and require further investigation for the ... ...

    Abstract Metastatic cancer is a complex disease associated with poor prognosis and accounts for the majority of cancer related deaths. To date, many of the molecular mechanisms driving metastatic disease remain elusive and require further investigation for the development of effective treatment strategies. Recent studies have shown that extracellular vesicles (EVs) can be exploited by tumors to assist in cancer cell growth, proliferation, migration, invasion and metastasis. Cancer cells have proven efficient in educating fibroblasts, within their microenvironment, to secrete EVs as communicative vessels for mediating phenotypic changes in recipient cells. Using this vesicular delivery system, cancer cells can establish a new metastatic niche within distant sites, away from the primary tumor, thus favoring cancer progression. These findings demonstrate the availability of a new route for therapeutic intervention in the inhibition of cancer dissemination. Although, several approaches to target cancer cell secretion of EVs are detailed in the literature, there is still no defined way to currently apply them in clinical settings. Hence, further studies are required to unravel the molecular mechanisms of metastasis - governed by the establishment and release of cancer associated EVs.
    MeSH term(s) Extracellular Vesicles/pathology ; Humans ; Neoplasm Metastasis/pathology ; Neoplasms/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 0306-0225 ; 0096-8757
    ISSN 0306-0225 ; 0096-8757
    DOI 10.1007/978-3-030-67171-6_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Are Dietary Extracellular Vesicles Bioavailable and Functional in Consuming Organisms?

    Sanwlani, Rahul / Fonseka, Pamali / Mathivanan, Suresh

    Sub-cellular biochemistry

    2021  Volume 97, Page(s) 509–521

    Abstract: It has been well established that diet influences the health status of the consuming organism. Recently, extracellular vesicles (EVs) present in dietary sources are proposed to be involved in cross-species and kingdom communication. As EVs contain a ... ...

    Abstract It has been well established that diet influences the health status of the consuming organism. Recently, extracellular vesicles (EVs) present in dietary sources are proposed to be involved in cross-species and kingdom communication. As EVs contain a lipid bilayer and carry bioactive cargo of proteins and nucleic acids, they are proposed to survive harsh degrading conditions of the gut and enter systemic circulation. Following the bioavailability, several studies have supported the functional role of dietary EVs in various tissues of the consuming organism. Simultaneously, multiple studies have refuted the possibility that dietary EVs mediate cross-species communication and hence the topic is controversial. The feasibility of the concept remains under scrutiny primarily owing to the lack of significant in vivo evidence to complement the in vitro speculations. Concerns surrounding EV stability in the harsh degrading gut environment, lack of mechanism explaining intestinal uptake and bioavailability in systemic circulation have impeded the acceptance of their functional role. This chapter discusses the current evidences that support dietary EV-based cross species communication and enlists several issues that need to be addressed in this field.
    MeSH term(s) Biological Transport ; Diet ; Extracellular Vesicles/metabolism ; Proteins/metabolism
    Chemical Substances Proteins
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 0306-0225 ; 0096-8757
    ISSN 0306-0225 ; 0096-8757
    DOI 10.1007/978-3-030-67171-6_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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