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Article ; Online: Trained immunity and macrophage reprogramming in allergic disorders.

Chen, Pei-Chi / Hsieh, Miao-Hsi / Kuo, Wen-Shuo / Wu, Lawrence Shih-Hsin / Wang, Jiu-Yao

2023 Volume 20, Issue 9, Page(s) 1084–1086

MeSH term(s)	Trained Immunity ; Macrophages ; Immunity, Innate
Language	English
Publishing date	2023-04-04
Publishing country	China
Document type	Letter
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-023-01005-0
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Article ; Online: Xin-Yi-Qing-Fei-Tang and its critical components reduce asthma symptoms by suppressing GM-CSF and COX-2 expression in RBL-2H3 cells.

Wang, Shulhn-Der / Chen, Po-Ting / Hsieh, Miao-Hsi / Wang, Jiu-Yao / Chiang, Chung-Jen / Lin, Li-Jen

Journal of ethnopharmacology

2024 Volume 330, Page(s) 118105

Abstract: Ethnopharmacological relevance: The traditional Chinese medicine (TCM) XYQFT is composed of 10 herbs. According to the NHIRD, XYQFT is one of the top ten most commonly used TCM prescriptions for asthma treatment.: Aim of the study: The aim of this ... ...

Abstract	Ethnopharmacological relevance: The traditional Chinese medicine (TCM) XYQFT is composed of 10 herbs. According to the NHIRD, XYQFT is one of the top ten most commonly used TCM prescriptions for asthma treatment. Aim of the study: The aim of this study was to explore whether XYQFT reduces asthma symptoms in a mouse model of chronic asthma and determine the immunomodulatory mechanism of mast cells. Materials and methods: BALB/c mice were intratracheally (it) stimulated with 40 μL (2.5 μg/μL) of Dermatophagoides pteronyssinus (Der p) once a week for 6 consecutive weeks and orally administered XYQFT at 1 g/kg 30 min before Der p stimulation. Airway hypersensitivity, inflammatory cells in the BALF and total IgE in the blood were assessed in mice. In addition, RBL-2H3 cells (mast cells) were stimulated with DNP-IgE, after which different concentrations of XYQFT were added for 30 min to evaluate the effect of XYQFT on the gene expression and degranulation of DNP-stimulated RBL-2H3 cells. After the compounds in XYQFT were identified using LC‒MS/MS, the PBD method was used to identify the chemical components that inhibited the expression of the GM-CSF and COX-2 genes in mast cells. Results: The airway hypersensitivity assay demonstrated that XYQFT significantly alleviated Der p-induced airway hypersensitivity. Moreover, cell counting and typing of bronchoalveolar lavage fluid revealed a significant reduction in Der p-induced inflammatory cell infiltration with XYQFT treatment. ELISA examination further indicated a significant decrease in Der p-induced total IgE levels in serum following XYQFT administration. In addition, XYQFT inhibited the degranulation and expression of genes (IL-3, IL-4, ALOX-5, IL-13, GM-CSF, COX-2, TNF-α, and MCP-1) in RBL-2H3 cells after DNP stimulation. The compounds timosaponin AIII and genkwanin in XYQFT were found to be key factors in the inhibition of COX-2 and GM-CSF gene expression in mast cells. Conclusion: By regulating mast cells, XYQFT inhibited inflammatory cell infiltration, airway hypersensitivity and specific immunity in a mouse model of asthma. In addition, XYQFT synergistically inhibited the expression of the GM-CSF and COX-2 genes in mast cells through timosaponin AIII and genkwanin.
Language	English
Publishing date	2024-04-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118105
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Article ; Online: Genetic Diversity in Bronchial Asthma Susceptibility: Exploring the Role of Vitamin D Receptor Gene Polymorphisms in Varied Geographic Contexts.

Paramonova, Natalia / Trapina, Ilva / Gradauskiene Sitkauskiene, Brigita / Plavina, Samanta / Tamasauskiene, Laura / Bastyte, Daina / Rumba-Rozenfelde, Ingrida / Tapina, Sandra / Stakaitiene, Ieva / Ugenskiene, Rasa / Shih-Hsin Wu, Lawrence / Wang, Jiu-Yao / Hsieh, Miao-Hsi / Chen, Pei-Chi / Sjakste, Nikolajs

International journal of molecular sciences

2024 Volume 25, Issue 3

Abstract: Bronchial asthma (BA) exhibits varying prevalence across global populations, prompting a comprehensive investigation into genetic and environmental determinants. Vitamin D is a potent immunomodulator capable of suppressing inflammatory signals in several ...

Abstract	Bronchial asthma (BA) exhibits varying prevalence across global populations, prompting a comprehensive investigation into genetic and environmental determinants. Vitamin D is a potent immunomodulator capable of suppressing inflammatory signals in several cell types involved in the asthmatic response; it exerts effects on the immune system by binding to the nuclear vitamin D receptor (VDR). VDR gene genetic variations are affecting serum vitamin D levels with a possible role in the BA risk. The current study aimed to examine the complex interaction of various factors (genetic background, serum vitamin D levels, and geographic location) to identify differences in the influence of these factors on the susceptibility to asthma between populations at different latitudes. Focusing on Eastern European cohorts from Latvia and Lithuania and comparing them with published data on East Asian populations, we explore the impact of VDR gene polymorphisms on BA susceptibility. Genotyping four key
MeSH term(s)	Humans ; Receptors, Calcitriol/genetics ; Genetic Predisposition to Disease ; Genotype ; Vitamin D/genetics ; Polymorphism, Single Nucleotide ; Asthma/genetics ; Case-Control Studies
Chemical Substances	Receptors, Calcitriol ; Vitamin D (1406-16-2)
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25031943
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Article ; Online: Two-Photon-Near Infrared-II Antimicrobial Graphene-Nanoagent for Ultraviolet-Near Infrared Imaging and Photoinactivation.

Kuo, Wen-Shuo / Lin, Yen-Sung / Wu, Ping-Ching / Chang, Chia-Yuan / Wang, Jiu-Yao / Chen, Pei-Chi / Hsieh, Miao-Hsi / Kao, Hui-Fang / Lin, Sheng-Han / Chang, Chan-Chi

International journal of molecular sciences

2022 Volume 23, Issue 6

Abstract: Nitrogen doping and amino group functionalization through chemical modification lead to strong electron donation. Applying these processes to a ... ...

Abstract	Nitrogen doping and amino group functionalization through chemical modification lead to strong electron donation. Applying these processes to a large
MeSH term(s)	Anti-Bacterial Agents ; Anti-Infective Agents ; Graphite/pharmacology ; Nitrogen ; Photons ; Quantum Dots
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Graphite (7782-42-5) ; Nitrogen (N762921K75)
Language	English
Publishing date	2022-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23063230
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Article ; Online: Two-Photon–Near Infrared-II Antimicrobial Graphene-Nanoagent for Ultraviolet–Near Infrared Imaging and Photoinactivation

Wen-Shuo Kuo / Yen-Sung Lin / Ping-Ching Wu / Chia-Yuan Chang / Jiu-Yao Wang / Pei-Chi Chen / Miao-Hsi Hsieh / Hui-Fang Kao / Sheng-Han Lin / Chan-Chi Chang

International Journal of Molecular Sciences, Vol 23, Iss 3230, p

2022 Volume 3230

Abstract: Nitrogen doping and amino group functionalization through chemical modification lead to strong electron donation. Applying these processes to a large π -conjugated system of graphene quantum dot (GQD)-based materials as electron donors increases the ... ...

Abstract	Nitrogen doping and amino group functionalization through chemical modification lead to strong electron donation. Applying these processes to a large π -conjugated system of graphene quantum dot (GQD)-based materials as electron donors increases the charge transfer efficiency of nitrogen-doped amino acid-functionalized GQDs (amino-N-GQDs), resulting in enhanced two-photon absorption, post-two-photon excitation (TPE) stability, TPE cross-sections, and two-photon luminescence through the radiative pathway when the lifetime decreases and the quantum yield increases. Additionally, it leads to the generation of reactive oxygen species through two-photon photodynamic therapy (PDT). The sorted amino-N-GQDs prepared in this study exhibited excitation-wavelength-independent two-photon luminescence in the near-infrared region through TPE in the near-infrared-II region. The increase in size resulted in size-dependent photochemical and electrochemical efficacy, increased photoluminescence quantum yield, and efficient two-photon PDT. Therefore, the sorted amino-N-GQDs can be applicable as two-photon contrast probes to track and localize analytes in in-depth two-photon imaging executed in a biological environment along with two-photon PDT to eliminate infectious or multidrug-resistant microbes.
Keywords	sorted-graphene quantum dot ; excitation-wavelength-independent photoluminescence ; two-photon photoinactivation ; near-infrared-II two-photon bioimaging ; multi-drug resistant microbe ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	535
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Nasal Microbiome Change During and After Exacerbation in Asthmatic Children.

Liu, Tsunglin / Lin, Cheng-Han / Chen, Yi-Lin / Jeng, Shuen-Lin / Tsai, Hui-Ju / Ho, Chung-Liang / Kuo, Wen-Shuo / Hsieh, Miao-Hsi / Chen, Pei-Chi / Wu, Lawrence Shih-Hsin / Wang, Jiu-Yao

Frontiers in microbiology

2022 Volume 12, Page(s) 833726

Abstract: Airway and gut microbiota are important in asthma pathogenesis. Although several studies have revealed distinct microbiota in asthmatic airways at baseline compared to healthy controls, limited studies compared microbiota during acute exacerbation (AE) ... ...

Abstract	Airway and gut microbiota are important in asthma pathogenesis. Although several studies have revealed distinct microbiota in asthmatic airways at baseline compared to healthy controls, limited studies compared microbiota during acute exacerbation (AE) and in the recovery phase (RP) in the same asthmatic children. We aim to investigate association between microbiota and asthma status in children and explore their relationship with clinical features of asthma. We recruited 56 asthmatic children and investigated their nasal, throat, and stool microbiota during AE and in the RP. Totally, 320 samples were subjected to 16S rRNA sequencing. Although the microbial communities were clearly separated by body site, within each site the overall communities during AE and in the RP could not be distinguished. Most nasal microbiota were dominated by only one or two of six bacterial genera. The domination was associated with mite allergy and patient age only during AE but not in the RP. When moving into RP, the relative abundance of
Language	English
Publishing date	2022-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.833726
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Article ; Online: Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages.

Chen, Pei-Chi / Hsieh, Miao-Hsi / Kuo, Wen-Shuo / Wu, Lawrence Shih-Hsin / Kao, Hui-Fang / Liu, Li-Fan / Liu, Zhi-Gang / Jeng, Wen-Yih / Wang, Jiu-Yao

Journal of biomedical science

2022 Volume 29, Issue 1, Page(s) 75

Abstract: Background: The extra-intestinal effects of probiotics for preventing allergic diseases are well known. However, the probiotic components that interact with host target molecules and have a beneficial effect on allergic asthma remain unknown. ... ...

Abstract	Background: The extra-intestinal effects of probiotics for preventing allergic diseases are well known. However, the probiotic components that interact with host target molecules and have a beneficial effect on allergic asthma remain unknown. Lactobacillus gasseri attenuates allergic airway inflammation through the activation of peroxisome proliferator- activated receptor γ (PPARγ) in dendritic cells. Therefore, we aimed to isolate and investigate the immunomodulatory effect of the PPARγ activation component from L. gasseri. Methods: Culture supernatants of L. gasseri were fractionated and screened for the active component for allergic asthma. The isolated component was subjected to in vitro functional assays and then cloned. The crystal structure of this component protein was determined using X-ray crystallography. Intrarectal inoculation of the active component-overexpressing Clear coli (lipopolysaccharide-free Escherichia coli) and intraperitoneal injection of recombinant component protein were used in a house dust mite (HDM)-induced allergic asthma mouse model to investigate the protective effect. Recombinant mutant component proteins were assayed, and their structures were superimposed to identify the detailed mechanism of alleviating allergic inflammation. Results: A moonlighting protein, glycolytic glyceraldehyde 3-phosphate dehydrogenase (GAPDH), LGp40, that has multifunctional effects was purified from cultured L. gasseri, and the crystal structure was determined. Both intrarectal inoculation of LGp40-overexpressing Clear coli and intraperitoneal administration of recombinant LGp40 protein attenuated allergic inflammation in a mouse model of allergic asthma. However, CDp40, GAPDH isolated from Clostridium difficile did not possess this anti-asthma effect. LGp40 redirected allergic M2 macrophages toward the M1 phenotype and impeded M2-prompted Th2 cell activation through glycolytic activity that induced immunometabolic changes. Recombinant mutant LGp40, without enzyme activity, showed no protective effect against HDM-induced airway inflammation. Conclusions: We found a novel mechanism of moonlighting LGp40 in the reversal of M2-prompted Th2 cell activation through glycolytic activity, which has an important immunoregulatory role in preventing allergic asthma. Our results provide a new strategy for probiotics application in alleviating allergic asthma.
MeSH term(s)	Animals ; Asthma/therapy ; Disease Models, Animal ; Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism ; Glyceraldehyde-3-Phosphate Dehydrogenases/pharmacology ; Inflammation ; Lactobacillus gasseri ; Lung ; Macrophages/metabolism ; Mice ; PPAR gamma/metabolism ; Peroxisome Proliferators/metabolism ; Peroxisome Proliferators/pharmacology ; Pyroglyphidae
Chemical Substances	PPAR gamma ; Peroxisome Proliferators ; Glyceraldehyde-3-Phosphate Dehydrogenases (EC 1.2.1.-)
Language	English
Publishing date	2022-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1193378-1
ISSN	1423-0127 ; 1021-7770
ISSN (online)	1423-0127
ISSN	1021-7770
DOI	10.1186/s12929-022-00861-8
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Zs.A 4037: Show issues

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Article: Graphene near infrared-I/II probe in two-photon excitation-wavelength-independent photoluminescence and photoinactivation

Kuo, Wen-Shuo / Wu, Ping-Ching / Chang, Chia-Yuan / Wang, Jiu-Yao / Chen, Pei-Chi / Hsieh, Miao-Hsi / Lin, Sheng-Han / Cheng, Jen-Suo / Chou, Yu-Tsung

Carbon. 2022 June 30, v. 193

2022

Abstract: Nitrogen doping and amino-group functionalization through chemical modification can engender enhance electron donation. Using a homemade femtosecond titanium:sapphire laser optical system operated at a low energy and short photoexcitation time [power: ... ...

Abstract	Nitrogen doping and amino-group functionalization through chemical modification can engender enhance electron donation. Using a homemade femtosecond titanium:sapphire laser optical system operated at a low energy and short photoexcitation time [power: 200.0 nJ pixel⁻¹; scanning frequency: 150 scans (∼0.80–1.33 s); excitation wavelength: 870, 910, or 970 nm], this study conducted these processes on the large π-conjugated system of graphene quantum dot (GQD)-based materials functioning as electron donors; this improved the efficiency of charge transfer to the prepared amino-N-GQDs, resulting in enhanced two-photon absorption, excitation-wavelength-independent photoluminescence (EWI-PL), radiative efficiency, excitation absolute cross section, and excitation from the near-infrared (NIR)-I to the NIR-II region. The lifetime decreased and quantum yield (QY) increased. The sorted amino-N-GQDs exhibited two-photon EWI-PL emissions between the ultraviolet and NIR-I regions, leading to the generation of reactive oxygen species (ROS), which functioned as two-photon photosensitizers for photodynamic therapy (PDT). Increasing the mean lateral size of the particles increased the N-functionality-dependent photochemical and electrochemical activities, which improved the PL QY and thus enhanced the efficiency of two-photon PDT. Additionally, a polystyrene sulfonate (PSS) coating was applied (forming sorted amino-N-GQD-PSS); the sulfur atoms introduced by the PSS induced the radiative recombination of localized electron–hole pairs and then improved the sorted amino-N-GQD surfaces by strengthening the quantum confinement of their emissive energy. Thus, compared with the sorted amino-N-GQDs that were not coated, the PSS-coated materials had superior two-photon properties. No ROS were detected. Accordingly, these materials are suitable for use as two-photon contrast probes for analyte tracking and localization.
Keywords	absorption ; electrochemistry ; energy ; graphene ; nitrogen ; photochemical reactions ; photochemotherapy ; photoluminescence ; polystyrenes ; quantum dots ; reactive oxygen species ; sulfonates ; sulfur ; wavelengths
Language	English
Dates of publication	2022-0630
Size	p. 205-215.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0008-6223
DOI	10.1016/j.carbon.2022.03.019
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Nitrogen Functionalities of Amino-Functionalized Nitrogen-Doped Graphene Quantum Dots for Highly Efficient Enhancement of Antimicrobial Therapy to Eliminate Methicillin-Resistant Staphylococcus aureus and Utilization as a Contrast Agent

Wen-Shuo Kuo / Ping-Ching Wu / Chi-Yao Hung / Chia-Yuan Chang / Jiu-Yao Wang / Pei-Chi Chen / Miao-Hsi Hsieh / Sheng-Han Lin / Chan-Chi Chang / Yen-Sung Lin

International Journal of Molecular Sciences, Vol 22, Iss 9695, p

2021 Volume 9695

Abstract: There is an urgent need for materials that can efficiently generate reactive oxygen species (ROS) and be used in photodynamic therapy (PDT) as two-photon imaging contrast probes. In this study, graphene quantum dots (GQDs) were subjected to amino group ... ...

Abstract	There is an urgent need for materials that can efficiently generate reactive oxygen species (ROS) and be used in photodynamic therapy (PDT) as two-photon imaging contrast probes. In this study, graphene quantum dots (GQDs) were subjected to amino group functionalization and nitrogen doping (amino-N-GQDs) via annealing and hydrothermal ammonia autoclave treatments. The synthesized dots could serve as a photosensitizer in PDT and generate more ROS than conventional GQDs under 60-s low-energy (fixed output power: 0.07 W·cm −2 ) excitation exerted by a 670-nm continuous-wave laser. The generated ROS were used to completely eliminate a multidrug-resistant strain of methicillin-resistant Staphylococcus aureus (MRSA), a Gram-positive bacterium. Compared with conventional GQDs, the amino-N-GQDs had superior optical properties, including stronger absorption, higher quantum yield (0.34), stronger luminescence, and high stability under exposure. The high photostability and intrinsic luminescence of amino-N-GQDs contribute to their suitability as contrast probes for use in biomedical imaging, in addition to their bacteria tracking and localization abilities. Herein, the dual-modality amino-N-GQDs in PDT easily eliminated multidrug-resistant bacteria, ultimately revealing their potential for use in future clinical applications.
Keywords	graphene quantum dot with nitrogen doping and amino group functionalization ; photodynamic therapy ; multidrug-resistant methicillin-resistant Staphylococcus aureus ; reactive oxygen species ; contrast probe ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease.

Hsieh, Miao-Hsi / Chen, Pei-Chi / Hsu, Han-Yin / Liu, Jui-Chang / Ho, Yu-Sheng / Lin, Yuh Jyh / Kuo, Chin-Wei / Kuo, Wen-Shuo / Kao, Hui-Fang / Wang, Shulhn-Der / Liu, Zhi-Gang / Wu, Lawrence Shih-Hsin / Wang, Jiu-Yao

Cellular & molecular immunology

2022 Volume 20, Issue 1, Page(s) 38–50

Abstract: Increased levels of surfactant protein D (SP-D) and lipid-laden foamy macrophages (FMs) are frequently found under oxidative stress conditions and/or in patients with chronic obstructive pulmonary disease (COPD) who are also chronically exposed to ... ...

Abstract	Increased levels of surfactant protein D (SP-D) and lipid-laden foamy macrophages (FMs) are frequently found under oxidative stress conditions and/or in patients with chronic obstructive pulmonary disease (COPD) who are also chronically exposed to cigarette smoke (CS). However, the roles and molecular mechanisms of SP-D and FMs in COPD have not yet been determined. In this study, increased levels of SP-D were found in the bronchoalveolar lavage fluid (BALF) and sera of ozone- and CS-exposed mice. Furthermore, SP-D-knockout mice showed increased lipid-laden FMs and airway inflammation caused by ozone and CS exposure, similar to that exhibited by our study cohort of chronic smokers and COPD patients. We also showed that an exogenous recombinant fragment of human SP-D (rfhSP-D) prevented the formation of oxidized low-density lipoprotein (oxLDL)-induced FMs in vitro and reversed the airway inflammation and emphysematous changes caused by oxidative stress and CS exposure in vivo. SP-D upregulated bone marrow-derived macrophage (BMDM) expression of genes involved in countering the oxidative stress and lipid metabolism perturbations induced by CS and oxLDL. Our study demonstrates the crucial roles of SP-D in the lipid homeostasis of dysfunctional alveolar macrophages caused by ozone and CS exposure in experimental mouse emphysema, which may provide a novel opportunity for the clinical application of SP-D in patients with COPD.
MeSH term(s)	Humans ; Mice ; Animals ; Lung/metabolism ; Pulmonary Surfactant-Associated Protein D/genetics ; Pulmonary Surfactant-Associated Protein D/metabolism ; Pulmonary Disease, Chronic Obstructive ; Pneumonia ; Macrophages/metabolism ; Bronchoalveolar Lavage Fluid ; Inflammation/metabolism ; Ozone/pharmacology ; Ozone/metabolism ; Lipids ; Mice, Inbred C57BL
Chemical Substances	Pulmonary Surfactant-Associated Protein D ; Ozone (66H7ZZK23N) ; Lipids
Language	English
Publishing date	2022-11-14
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-022-00946-2
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