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  1. Book: The Th1, Th2 paradigm in disease

    Romagnani, Sergio

    (Molecular biology intelligence unit)

    1997  

    Author's details Sergio Romagnani
    Series title Molecular biology intelligence unit
    Keywords T-Lymphocytes, Helper-Inducer ; Immunity, Cellular ; Lymphokines / immunology ; Helferzelle ; Pathophysiologie
    Subject Accessory cell ; Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie
    Language English
    Size 241 S. : Ill., graph. Darst.
    Publisher Springer u.a.
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Literaturverz. S. 167 - 235
    HBZ-ID HT007544118
    ISBN 3-540-61949-6 ; 0570594090 ; 978-3-540-61949-9 ; 9780570594093
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 4554 order for loan Magazin

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  2. Article ; Online: IL4I1: Key immunoregulator at a crossroads of divergent T-cell functions.

    Romagnani, Sergio

    European journal of immunology

    2016  Volume 46, Issue 10, Page(s) 2302–2305

    Abstract: The interleukin (IL)-4-induced gene1 (IL4I1), which encodes the L-amino acid oxidase enzyme, plays an important immunoregulatory role. Indeed, this enzyme which is produced by B cells-including neoplastic B cells-dendritic cells and macrophages has been ... ...

    Abstract The interleukin (IL)-4-induced gene1 (IL4I1), which encodes the L-amino acid oxidase enzyme, plays an important immunoregulatory role. Indeed, this enzyme which is produced by B cells-including neoplastic B cells-dendritic cells and macrophages has been shown to inhibit proliferation, cytotoxicity and IFN-γ production by tumor-infiltrating CD8
    MeSH term(s) Adaptive Immunity ; Animals ; B-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation ; Cell Proliferation ; Cytotoxicity, Immunologic ; Humans ; Immunomodulation ; Interferon-gamma/metabolism ; L-Amino Acid Oxidase/genetics ; L-Amino Acid Oxidase/metabolism ; Th17 Cells/immunology ; Tumor Escape
    Chemical Substances Interferon-gamma (82115-62-6) ; IL4I1 protein, human (EC 1.4.3.2) ; L-Amino Acid Oxidase (EC 1.4.3.2)
    Language English
    Publishing date 2016-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201646617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
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    Zs.MG 85: Show issues

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  3. Book: Th1 and Th2 cells in health and disease

    Romagnani, Sergio

    9 tables

    (Chemical immunology ; 63)

    1996  

    Author's details vol. ed. S. Romagnani
    Series title Chemical immunology ; 63
    Collection
    Keywords Th1 Cells ; Th2 Cells ; Helferzelle ; Pathophysiologie ; Physiologie
    Subject Humanphysiologie ; Mensch ; Körperfunktion ; Accessory cell ; Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie
    Language English
    Size XII, 222 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT007114228
    ISBN 3-8055-6241-1 ; 978-3-8055-6241-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Uh III Zs 129 -63- verfügbar in Königswinter Königswinter

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  4. Book ; Conference proceedings: Cytokines

    Romagnani, Sergio

    basic principles and clinical applications ; [symposium]

    (Challenges of modern medicine ; 8 ; Ares-Serono Symposia publications)

    1994  

    Author's details ed. S. Romagnani
    Series title Challenges of modern medicine ; 8
    Ares-Serono Symposia publications
    Collection
    Keywords Cytokines / congresses ; Immunity, Cellular / congresses
    Language English
    Size XII, 332 S. : Ill., graph. Darst.
    Publisher Ares-Serono Symposia Publ
    Publishing place Rome
    Publishing country Italy
    Document type Book ; Conference proceedings
    HBZ-ID HT006551316
    ISBN 88-85974-25-2 ; 978-88-85974-25-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 1504 order for loan Magazin

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  5. Book: New advances on cytokines

    Romagnani, Sergio

    (Serono Symposia publications from Raven Press ; 92)

    1992  

    Author's details ed. S. Romagnani
    Series title Serono Symposia publications from Raven Press ; 92
    Collection
    Keywords Cytokines / congresses ; Cytokine
    Subject Zytokine
    Size XVI, 386 S. : Ill., graph. Darst.
    Publisher Raven Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT004527877
    ISBN 0-88167-902-X ; 978-0-88167-902-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 A 1636 order for loan Magazin

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  6. Article ; Online: T cell subpopulations.

    Romagnani, Sergio

    Chemical immunology and allergy

    2014  Volume 100, Page(s) 155–164

    Abstract: The role of allergen-specific CD4+ effector type 2 helper (Th2) cells in the pathogenesis of allergic disorders is an established fact. Th2 cells produce interleukin (IL)-4 and IL-13, which induce immunoglobulin E production by B cells, and IL-5 that ... ...

    Abstract The role of allergen-specific CD4+ effector type 2 helper (Th2) cells in the pathogenesis of allergic disorders is an established fact. Th2 cells produce interleukin (IL)-4 and IL-13, which induce immunoglobulin E production by B cells, and IL-5 that allows recruitment of eosinophils. Two main mechanisms control the Th2-mediated allergic inflammation: immune deviation (or Th1 redirection) and immune regulation. Regulatory T (Treg) cells exhibit a CD4+ phenotype and include Foxp3-positive thymic and induced Tregs, as well as Foxp3-negative IL-10-producing cells. Both immune deviation and immune regulation evoked by the maternal and newborn microbial environment probably operate in preventing allergen-specific Th2 responses. However, microbe-related protection from allergy seems to mainly depend on epigenetically controlled acetylation of the IFNG promoter of CD4+ T cells. Even Th17 and Th9 cells, as well as invariant NKT cells, have been implicated in the pathogenesis of allergic disorders, but their role is certainly more limited. Recently, innate lymphoid type 2 cells (ILC2) have been found to be able to produce high amounts of IL-5 and IL-13 in response to stimulation with IL-25 and IL-33 produced by non-immune cells. Together with Th2 cells, ILC2 may contribute to the induction and maintenance of allergic inflammation.
    MeSH term(s) Cytokines/metabolism ; Forkhead Transcription Factors/metabolism ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/pathology ; Immunity, Innate ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Th1 Cells/immunology ; Th1 Cells/metabolism ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Th2 Cells/immunology ; Th2 Cells/metabolism
    Chemical Substances Cytokines ; FOXP3 protein, human ; Forkhead Transcription Factors ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1662-2898 ; 1660-2242
    ISSN (online) 1662-2898
    ISSN 1660-2242
    DOI 10.1159/000358622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Conference proceedings: Cytokines

    Romagnani, Sergio

    basic principles and clinical applications ; [symposium]

    (Serono Symposia publications from Raven Press ; 68)

    1990  

    Author's details ed. S. Romagnani
    Series title Serono Symposia publications from Raven Press ; 68
    Collection
    Keywords Cytokines ; Cytokine ; Physiologie
    Subject Humanphysiologie ; Mensch ; Körperfunktion ; Zytokine
    Size XIX, 370 S. : Ill., graph. Darst.
    Publisher Raven Pr
    Publishing place New York
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003757270
    ISBN 0-88167-647-0 ; 978-0-88167-647-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 1944 order for loan Magazin

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  8. Article: Coming back to a missing immune deviation as the main explanatory mechanism for the hygiene hypothesis.

    Romagnani, Sergio

    The Journal of allergy and clinical immunology

    2007  Volume 119, Issue 6, Page(s) 1511–1513

    MeSH term(s) Allergens/immunology ; Animals ; Humans ; Hygiene ; Hypersensitivity/epidemiology ; Hypersensitivity/immunology ; Hypersensitivity/prevention & control ; Hypersensitivity/therapy ; Prevalence
    Chemical Substances Allergens
    Language English
    Publishing date 2007-06
    Publishing country United States
    Document type Editorial ; Review
    ZDB-ID 121011-7
    ISSN 1085-8725 ; 1097-6825 ; 0091-6749
    ISSN (online) 1085-8725 ; 1097-6825
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2007.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.92: Show issues Location:
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  9. Article ; Online: Human Th17 cells.

    Romagnani, Sergio

    Arthritis research & therapy

    2008  Volume 10, Issue 2, Page(s) 206

    Abstract: The discovery in mice of a new lineage of CD4+ effector T helper (Th) cells that selectively produce IL-17 has provided exciting new insights into immune regulation, host defence, and the pathogenesis of autoimmune and other chronic inflammatory ... ...

    Abstract The discovery in mice of a new lineage of CD4+ effector T helper (Th) cells that selectively produce IL-17 has provided exciting new insights into immune regulation, host defence, and the pathogenesis of autoimmune and other chronic inflammatory disorders. This population of CD4+ Th cells, which has been termed 'Th17', indeed plays an apparently critical role in the pathogenesis of some murine models of autoimmunity. Interestingly, murine Th17 cells share a common origin with Foxp3+ T regulatory cells, because both populations are produced in response to transforming growth factor-beta, but they develop into Th17 cells only when IL-6 is simultaneously produced. Initial studies in humans have confirmed the existence of Th17 cells, but they have shown that the origin of these cells in humans differs from that in mice, with IL-1beta and IL-23 being the major cytokines responsible for their development. Moreover, the presence in the circulation and in various tissues of Th cells that can produce both IL-17 and interferon-gamma, as well as the flexibility of human Th17 clones to produce interferon-gamma in addition to IL-17 in response to IL-12, suggests that there may be a developmental relationship between Th17 and Th1 cells, at least in humans. Resolving this issue has great implications in tems of establishing the respective pathogenic roles of Th1 and Th17 cells in autoimmune disorders. In contrast, it is unlikely that Th17 cells contribute to the pathogenesis of human allergic IgE-mediated disorders, because IL-4 and IL-25 (a powerful inducer of IL-4) are both potent inhibitors of Th17 cell development.
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Humans ; Interleukin-17/immunology ; Mice ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes, Helper-Inducer/cytology ; T-Lymphocytes, Helper-Inducer/immunology
    Chemical Substances Interleukin-17
    Language English
    Publishing date 2008-04-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/ar2392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5490: Show issues Location:
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  10. Article ; Online: The COVID-19 infection: lessons from the Italian experience.

    Romagnani, Paola / Gnone, Guido / Guzzi, Francesco / Negrini, Simone / Guastalla, Andrea / Annunziato, Francesco / Romagnani, Sergio / De Palma, Raffaele

    Journal of public health policy

    2020  Volume 41, Issue 3, Page(s) 238–244

    Abstract: The first case of the new coronavirus, COVID-19, was reported in China on 17 November 2019. By the end of March 2020, the rapid global spread of infection affected over 1 million people. Italy is one of the countries most impacted, with over 100,000 ... ...

    Abstract The first case of the new coronavirus, COVID-19, was reported in China on 17 November 2019. By the end of March 2020, the rapid global spread of infection affected over 1 million people. Italy is one of the countries most impacted, with over 100,000 positive cases identified. The first detected cases were reported on 21 February 2020 in two Italian towns: Vo' Euganeo in the Province of Padua, Veneto region, and Codogno, in the Province of Lodi, Lombardy. In the next weeks the epidemic spread quickly across the country but mainly in the north of Italy. The two regions: Veneto and Lombardy, implemented different strategies to control the viral spread. In Veneto, health personnel tested both symptomatic and asymptomatic subjects, while in Lombardy only symptomatic cases were investigated. We analyzed the evolution of the epidemic in these regions and showed that testing both symptomatic and asymptomatic cases is a more effective strategy to mitigate the epidemic impact. We strongly recommend that decision-makers: ensure early isolation of symptomatic patients and rapid identification of their contacts; maximize testing rapidly, especially among people with multiple daily contacts with infected populations, high exposure to the public in essential services; rapidly increase diagnostic capacity by mobilizing trained personnel capable of performing rRT-PCR on respiratory samples; equip the population with protective masks.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Communicable Disease Control/organization & administration ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Humans ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 603208-4
    ISSN 1745-655X ; 0197-5897
    ISSN (online) 1745-655X
    ISSN 0197-5897
    DOI 10.1057/s41271-020-00229-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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