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Article: Network pharmacology prediction and molecular docking-based strategy to discover the potential pharmacological mechanism of action of Wang Bu Liu Xing (

Shi, Yongquan / Zhang, Yunshu / Liu, Jifeng / Zhao, Yanping / Liu, Wei

2023 Volume 14, Issue 2, Page(s) 504–515

Abstract: ... Bu Liu Xing [: Methods: The open database and online platform were used in this study, Symptom ...

Abstract	Background: Colorectal cancer (CRC) is the leading cause of cancer-related death worldwide. Wang Bu Liu Xing [ Methods: The open database and online platform were used in this study, Symptom Mapping (SymMap) and Traditional Chinese Medicine Systems Pharmacology (TCMSP) for SV ingredient and targets, Gene Expression Omnibus (GEO) for differentially expressed genes (DEGs) of CRC, Database for Annotation Visualization and Integrated Discovery (DAVID) for Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, STRING-Cytoscape for protein-protein interaction (PPI), AutoDockTools for Molecular docking and others. were conducted to determine how SV affects CRC and what are the most important components, potential targets, and signaling pathways. Results: The findings of the network pharmacology study indicated that swerchirin and Conclusions: In this study, the pharmacological effects of SV were examined, along with its potential therapeutic impact on CRC. These effects of SV appear to be mediated via a variety of substances, targets, and pathways. SV exerts pharmacological effects in CRC, p53 signaling pathway is great value. The main molecular docking is
Language	English
Publishing date	2023-04-24
Publishing country	China
Document type	Journal Article
ZDB-ID	2594644-4
ISSN	2219-679X ; 2078-6891
ISSN (online)	2219-679X
ISSN	2078-6891
DOI	10.21037/jgo-23-83
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Deciphering the Pharmacological Mechanisms of Ma Xing Shi Gan Decoction against COVID-19 through Integrating Network Pharmacology and Experimental Exploration.

Li, Qianqian / Bai, Chen / Yang, Ruocong / Xing, Weiying / Pang, Xiaohan / Wu, Siying / Liu, Shaoyang / Chen, Jianxin / Liu, Tiegang / Gu, Xiaohong

Frontiers in pharmacology

2020 Volume 11, Page(s) 581691

Abstract: ... viral pneumonia. In this study, we revealed the efficacy and pharmacological mechanism of Ma Xing Shi Gan (MXSG ...

Abstract	The outbreak of new infectious pneumonia caused by SARS-CoV-2 has posed a significant threat to public health, but specific medicines and vaccines are still being developed. Traditional Chinese medicine (TCM) has thousands of years of experience in facing the epidemic disease, such as influenza and viral pneumonia. In this study, we revealed the efficacy and pharmacological mechanism of Ma Xing Shi Gan (MXSG) Decoction against COVID-19. First, we used liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) to analyze the chemical components in MXSG and identified a total of 97 components from MXSG. Then, the intervention pathway of MXSG based on these components was analyzed with network pharmacology, and it was found that the pathways related to the virus infection process were enriched in some of MXSG component targets. Simultaneously, through literature research, it was preliminarily determined that MXSG, which is an essential prescription for treating COVID-19, shared the feature of antiviral, improving clinical symptoms, regulating immune inflammation, and inhibiting lung injury. The regulatory mechanisms associated with its treatment of COVID-19 were proposed. That MXSG might directly inhibit the adsorption and replication of SARS-CoV-2 at the viral entry step. Besides, MXSG might play a critical role in inflammation and immune regulatory, that is, to prevent cytokine storm and relieve lung injury through toll-like receptors signaling pathway. Next, in this study, the regulatory effect of MXSG on inflammatory lung injury was validated through transcriptome results. In summary, MXSG is a relatively active and safe treatment for influenza and viral pneumonia, and its therapeutic effect may be attributed to its antiviral and anti-inflammatory effects.
Language	English
Publishing date	2020-11-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.581691
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Article ; Online: Erratum: SILVIA FABRIZI, WAN-GANG LIU, MING BAI, XING-KE YANG amp; DIRK AHRENS (2021) A monograph of the genus Maladera Mulsant amp; Rey, 1871 of China (Coleoptera: Scarabaeidae: Melolonthinae: Sericini). Zootaxa, 4922 (1): 001400.

Fabrizi, Silvia / Liu, Wan-Gang / Bai, Ming / Yang, Xing-Ke / Ahrens, Dirk

Zootaxa

2022 Volume 5169, Issue 6, Page(s) 600

Language	English
Publishing date	2022-08-03
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5169.6.7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluations on the Consequences of Fire Suppression and the Ecological Effects of Fuel Treatment Scenarios in a Boreal Forest of the Great Xing’an Mountains, China

Han He / Yu Chang / Zhihua Liu / Zaiping Xiong / Lujia Zhao

Forests, Vol 14, Iss 85, p

2023 Volume 85

Abstract: ... Xing’an Mountains, China. Four simulation scenarios were designed, focusing on whether to conduct fuel ... for the Great Xing’an Mountains. The results showed that long-term fire suppression increases fuel loads and ... landscapes. We suggest a suitable fuel treatment plan for the Great Xing’an Mountains, with a low treatment ...

Abstract	With global warming, catastrophic forest fires have frequently occurred in recent years, posing a major threat to forest resources and people. How to reduce forest fire risk is a hot topic in forest management. Concerns regarding fire suppression and forest fuel treatments are rising. Few studies have evaluated the ecological effects of fuel treatments. In this study, we used the LANDIS PRO model to simulate the consequences of fire suppression and the ecological effects of fuel treatments in a boreal forest of the Great Xing’an Mountains, China. Four simulation scenarios were designed, focusing on whether to conduct fuel treatments or not under two fire-control policies (current fire suppression policy and no fire suppression policy). Each scenario contains nine fuel treatment plans based on the combinations of different treatment methods (coarse woody debris reduction, prescribed burning, coarse woody debris reduction plus prescribed burning), treatment frequency (low, medium, and high), and treatment area (large, medium, and small). The ecological effects of the fuel treatments were evaluated according to the changes in fire regimes, species succession, and forest landscape patterns to find a forest fuel management plan that is suitable for the Great Xing’an Mountains. The results showed that long-term fire suppression increases fuel loads and the probability of high-intensity forest fires. The nine fuel management plans did not show significant differences in terms of species succession and forest landscape patterns while lowering forest fire intensity, and none of them were able to restore historical vegetation structure and composition. Our results consolidate the foundation for the practical performance of forest fuel treatments in fire-prone forest landscapes. We suggest a suitable fuel treatment plan for the Great Xing’an Mountains, with a low treatment frequency (20 years), large treatment area (10%), and coarse woody debris reduction, plus the prescribed burning measure.
Keywords	forest management ; fuel treatments ; LANDIS PRO ; the Great Xing’an Mountains ; ecological effects ; fire suppression ; Plant ecology ; QK900-989
Subject code	600
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluations on the Consequences of Fire Suppression and the Ecological Effects of Fuel Treatment Scenarios in a Boreal Forest of the Great Xing’an Mountains, China

He, Han / Chang, Yu / Liu, Zhihua / Xiong, Zaiping / Zhao, Lujia

Forests. 2023 Jan. 02, v. 14, no. 1

2023

Abstract	With global warming, catastrophic forest fires have frequently occurred in recent years, posing a major threat to forest resources and people. How to reduce forest fire risk is a hot topic in forest management. Concerns regarding fire suppression and forest fuel treatments are rising. Few studies have evaluated the ecological effects of fuel treatments. In this study, we used the LANDIS PRO model to simulate the consequences of fire suppression and the ecological effects of fuel treatments in a boreal forest of the Great Xing’an Mountains, China. Four simulation scenarios were designed, focusing on whether to conduct fuel treatments or not under two fire-control policies (current fire suppression policy and no fire suppression policy). Each scenario contains nine fuel treatment plans based on the combinations of different treatment methods (coarse woody debris reduction, prescribed burning, coarse woody debris reduction plus prescribed burning), treatment frequency (low, medium, and high), and treatment area (large, medium, and small). The ecological effects of the fuel treatments were evaluated according to the changes in fire regimes, species succession, and forest landscape patterns to find a forest fuel management plan that is suitable for the Great Xing’an Mountains. The results showed that long-term fire suppression increases fuel loads and the probability of high-intensity forest fires. The nine fuel management plans did not show significant differences in terms of species succession and forest landscape patterns while lowering forest fire intensity, and none of them were able to restore historical vegetation structure and composition. Our results consolidate the foundation for the practical performance of forest fuel treatments in fire-prone forest landscapes. We suggest a suitable fuel treatment plan for the Great Xing’an Mountains, with a low treatment frequency (20 years), large treatment area (10%), and coarse woody debris reduction, plus the prescribed burning measure.
Keywords	boreal forests ; coarse woody debris ; fire intensity ; fire suppression ; forest fires ; forest management ; fuels ; fuels (fire ecology) ; issues and policy ; landscapes ; risk ; simulation models ; vegetation structure ; China
Language	English
Dates of publication	2023-0102
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f14010085
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Diagenesis of Xing’anling Oil Reservoir in Sudeerte Area

Yu Haoran / Yu Xuntao / Liu Chengzhi / Yuan Hongqi

E3S Web of Conferences, Vol 218, p

2020 Volume 02031

Abstract: ... identification, it is clear that the Xing’anling oil layer is mainly affected by compaction, cementation ...

Abstract	In order to explore the types of diagenesis in Sudeerte area, through core and thin slice identification, it is clear that the Xing’anling oil layer is mainly affected by compaction, cementation, andrecrystallization. The compaction is mainly early compaction, late pressure dissolution is not obvious; cementation presents two forms of crystalline quartz and amorphous opal; recrystallization is manifested as the conversion process of opal t-ochalcedony quartz.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Characterizing Post-Fire Forest Structure Recovery in the Great Xing’an Mountain Using GEDI and Time Series Landsat Data

Simei Lin / Huiqing Zhang / Shangbo Liu / Ge Gao / Linyuan Li / Huaguo Huang

Remote Sensing, Vol 15, Iss 3107, p

2023 Volume 3107

Abstract: ... structural development has rarely been evaluated in the Great Xing’an Mountain. In this study, we extracted ... forest management strategies in Great Xing’an Mountain. ...

Abstract	Understanding post-fire forest recovery is critical to the study of forest carbon dynamics. Many previous studies have used multispectral imagery to estimate post-fire recovery, yet post-fire forest structural development has rarely been evaluated in the Great Xing’an Mountain. In this study, we extracted the historical fire events from 1987 to 2019 based on a classification of Landsat imagery and assessed post-fire forest structure for these burned patches using Global Ecosystem Dynamics Investigation (GEDI)-derived metrics from 2019 to 2021. Two drivers were assessed for the influence on post-fire structure recovery, these being pre-fire canopy cover (i.e., dense forest and open forest) and burn severity levels (i.e., low, moderate, and high). We used these burnt patches to establish a 25-year chronosequence of forest structural succession by a space-for-time substitution method. Our result showed that the structural indices suggested delayed recovery following the fire, indicating a successional process from the decomposition of residual structures to the regeneration of new tree species in the post-fire forest. Across the past 25-years, the dense forest tends toward greater recovery than open forest, and the recovery rate was faster for low severity, followed by moderate severity and high severity. Specifically, in the recovery trajectory, the recovery indices were 21.7% and 17.4% for dense forest and open forest, and were 27.1%, 25.8%, and 25.4% for low, moderate, and high burn severity, respectively. Additionally, a different response to the fire was found in the canopy structure and height structure since total canopy cover (TCC) and plant area index (PAI) recovered faster than relative height (i.e., RH75 and RH95). Our results provide valuable information on forest structural restoration status, that can be used to support the formulation of post-fire forest management strategies in Great Xing’an Mountain.
Keywords	GEDI metrics ; time-series Landsat data ; post-fire structure recovery ; burn severity ; pre-fire canopy cover ; Science ; Q
Subject code	550
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Correction: Xing, G. et al.'s Diameter- and Length-Controlled Synthesis of Ultrathin ZnS Nanowires and Their Size-Dependent UV Absorption Properties, Photocatalytical Activities and Band-Edge Energy Levels.

Xing, Guanjie / Liu, Xiaoli / Hao, Simeng / Li, Xiaohong / Fan, Louzhen / Li, Yunchao

Nanomaterials (Basel, Switzerland)

2020 Volume 10, Issue 6

Abstract: The authors wish to make the following corrections to this article [1][ ... ]. ...

Abstract	The authors wish to make the following corrections to this article [1][...].
Language	English
Publishing date	2020-05-28
Publishing country	Switzerland
Document type	Journal Article ; Published Erratum
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano10061029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inhibiting virus replication and excessive inflammatory response: Mechanism of combined prescription of Ma-Xing-Shi-Gan decoction and Xiao-Chai-Hu decoction against influenza virus.

Cheng, Miao / Zhang, Yanan / Yan, Jun / Huang, Yuanming / Wang, Mingzhe / Zhai, Zhiguang / Liu, Guoxing / Liu, Chang / Li, Jintong / Zhang, Yue / Xiao, Yuchun / Wang, Chengxiang / Ban, Chengjun / Ren, Zhihong / Song, Liqiong

Journal of ethnopharmacology

2023 Volume 313, Page(s) 116481

Abstract: Ethnopharmacological relevance: The combined prescription of two classical decoctions (Ma-Xing-Shi ...

Abstract	Ethnopharmacological relevance: The combined prescription of two classical decoctions (Ma-Xing-Shi-Gan decoction with Xiao-Chai-Hu decoction), named as San-Yang-He-Zhi (SYHZ) decoction, has been widely used for the treatment of influenza virus (IFV) infections for decades. Aim of the study: This study aimed to evaluate the anti-influenza effect of SYHZ decoction and explore the underlying mechanism. Materials and methods: The ingredients of SYHZ decoction were analyzed by mass spectrometry. An animal model of IFV infection was established by challenging C57BL/6J mice with PR8 virus. Three groups of mice were infected with lethal or non-lethal doses of IFV, then followed by oral administration of phosphate-buffered saline (PBS), or SYHZ, or oseltamir; blank control mice (without IFV infection) were treated with PBS. Survival rate, Lung index, colon length, body weight loss and IFV viral load were measured 7 days post infection; histology and electron-microscopy examinations of lung tissue were performed; cytokine and chemokine levels in lung and serum were measured; and the intestinal metagenome, the cecum metabolome, and the lung transcriptome were analyzed. Results: SYHZ treatment significantly improved survival rate compared with PBS (40% vs 0%); improved lung index, colon length, and body weight loss; and alleviated lung histological damage and viral load. SYHZ-treated mice had significantly lower levels of IL-1β, TNF-α, IL-6, CCL2, CXCL10 in lung and serum, and increased levels of multiple bioactive components in cecum. Pro-inflammatory cytokines, Toll- and NOD-like receptors, pro-apoptosis molecules, and lung-injury-related proteins were downregulated in SYHZ mice, whereas surfactant protein and mucin were upregulated. The NOD-like receptor pathway, Toll-like receptor pathway, and NF-κB pathway were downregulated by SYHZ treatment. Conclusions: SYHZ decoction alleviated IFV infection in a mouse model. Multiple bioactive ingredients of SYHZ may inhibit replication of IFV and suppress excessive immune response.
MeSH term(s)	Mice ; Animals ; Mice, Inbred C57BL ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Lung ; Orthomyxoviridae Infections ; Cytokines/metabolism ; Orthomyxoviridae/metabolism ; Virus Replication ; Weight Loss
Chemical Substances	Drugs, Chinese Herbal ; Cytokines
Language	English
Publishing date	2023-04-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116481
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Yin-xing-tong-mai decoction attenuates atherosclerosis via activating PPARγ-LXRα-ABCA1/ABCG1 pathway.

Zheng, Shasha / Huang, Hong / Li, Yizhuo / Wang, Ye / Zheng, Yawei / Liang, Junya / Zhang, Siqi / Liu, Ming / Fang, Zhuyuan

Pharmacological research

2021 Volume 169, Page(s) 105639

Abstract: ... Many traditional Chinese medicine has been well accepted and applied in atherosclerosis treatment. Yin-xing-tong-mai decoction ...

Abstract	Atherosclerosis is now the major cause of mortality and morbidity worldwide. Formation of macrophage-derived foam cells is a hallmark of atherosclerosis, which is regulated by cholesterol uptake, intracellular metabolism, and efflux. PPARγ-LXRα-ABCA1/ABCG1 pathway plays an important part in regulating cholesterol efflux and this pathway could be a promising target for treating atherosclerosis. However, due to undesirable systemic effects, PPARγ agonist therapy for atherosclerosis remains challenging. Many traditional Chinese medicine has been well accepted and applied in atherosclerosis treatment. Yin-xing-tong-mai decoction (YXTMD) has been applied for treating atherosclerosis for decades. However, the mechanism remains to be explored. Here, we showed that YXTMD effectively attenuated atherosclerosis in ApoE
MeSH term(s)	ATP Binding Cassette Transporter 1/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 1/metabolism ; Animals ; Atherosclerosis/drug therapy ; Cholesterol/metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal/therapeutic use ; Liver X Receptors/metabolism ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; PPAR gamma/metabolism ; Signal Transduction/drug effects
Chemical Substances	ABCA1 protein, mouse ; ABCG1 protein, mouse ; ATP Binding Cassette Transporter 1 ; ATP Binding Cassette Transporter, Subfamily G, Member 1 ; Drugs, Chinese Herbal ; Liver X Receptors ; PPAR gamma ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2021-04-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2021.105639
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