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Article ; Online: Using occipital ⍺-bursts to modulate behavior in real-time.

Vigué-Guix, Irene / Soto-Faraco, Salvador

Cerebral cortex (New York, N.Y. : 1991)

2023 Volume 33, Issue 16, Page(s) 9465–9477

Abstract: Pre-stimulus endogenous neural activity can influence the processing of upcoming sensory input and subsequent behavioral reactions. Despite it is known that spontaneous oscillatory activity mostly appears in stochastic bursts, typical approaches based on ...

Abstract	Pre-stimulus endogenous neural activity can influence the processing of upcoming sensory input and subsequent behavioral reactions. Despite it is known that spontaneous oscillatory activity mostly appears in stochastic bursts, typical approaches based on trial averaging fail to capture this. We aimed at relating spontaneous oscillatory bursts in the alpha band (8-13 Hz) to visual detection behavior, via an electroencephalography-based brain-computer interface (BCI) that allowed for burst-triggered stimulus presentation in real-time. According to alpha theories, we hypothesized that visual targets presented during alpha-bursts should lead to slower responses and higher miss rates, whereas targets presented in the absence of bursts (low alpha activity) should lead to faster responses and higher false alarm rates. Our findings support the role of bursts of alpha oscillations in visual perception and exemplify how real-time BCI systems can be used as a test bench for brain-behavioral theories.
MeSH term(s)	Brain/physiology ; Electroencephalography ; Photic Stimulation ; Visual Perception/physiology ; Humans
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhad217
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Article ; Online: Impact of the implementation of a telemedicine program on patients diagnosed with asthma.

Cabrerizo-Carreño, Héctor / Muñoz-Esquerre, Mariana / Santos Pérez, Salud / Romero-Ortiz, Ana Maria / Fabrellas, Núria / Guix-Comellas, Eva Maria

BMC pulmonary medicine

2024 Volume 24, Issue 1, Page(s) 32

Abstract: Background: Asthma is one of the most common respiratory ailments worldwide. Despite broad understanding of the illness and of the available therapeutic options for it, patients with serious asthma suffer poor monitoring of their illness in 50% of cases. ...

Abstract	Background: Asthma is one of the most common respiratory ailments worldwide. Despite broad understanding of the illness and of the available therapeutic options for it, patients with serious asthma suffer poor monitoring of their illness in 50% of cases. Aim: To assess the impact of the implementation of a mobile application (ESTOI) to control asthma in patients diagnosed with the illness, their adherence to treatment, and their perceived quality of life. Methodology: Randomized clinical trial with 52 weeks' follow-up of patients with asthma seen in a specialized hospital for their treatment in Spain. Some 108 included patients will be divided into two groups. The intervention group will undergo more exhaustive follow-up than normal, including access to the ESTOI application, which will have various categories of attention: control of symptoms, health recommendations, current treatment and personalized action plan, PEF record, nutritional plan, and chat access with a medical team. The asthma control questionnaire ACT is the main assessment variable. Other variables to be studied include an adherence test for the use of inhalers (TAI), the number of exacerbations, maximum exhalation flow, exhaled nitric oxide test, hospital anxiety and depression scale, asthma quality-of-life questionnaire, forced spirometry parameters (FVC, FEV1, and PBD), and analytic parameters (eosinophilia and IGE). The data will be collected during outpatient visits. Trial registration: This trial has registered at ClinicalTrials.gov (Identifier: NCT06116292).
MeSH term(s)	Humans ; Quality of Life ; Asthma/diagnosis ; Asthma/drug therapy ; Nebulizers and Vaporizers ; Spirometry ; Telemedicine
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-024-02843-y
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Article ; Online: Improvement of quality of care provided to outpatients with hepatic cirrhosis after an educational intervention.

Amador, Alberto / Salord, Silvia / Xiol, Xavier / Garcia-Guix, Marta / Cachero, Alba / Rota, Rosa / Hernandez Aretxabaleta, Nerea / Baliellas, Carme / Castellote, Jose

European journal of gastroenterology & hepatology

2024

Abstract: Objective: A set of indicators has been reported to measure the quality of care for cirrhotic patients, and previously published studies report variable adherence rates to these indicators. This study aimed to assess the quality of care provided to ... ...

Abstract	Objective: A set of indicators has been reported to measure the quality of care for cirrhotic patients, and previously published studies report variable adherence rates to these indicators. This study aimed to assess the quality of care provided to cirrhotic outpatients before and after an educational intervention by determining its impact on adherence to quality indicators. Methods: We conducted a quasi-experimental, cross-sectional study including 324 cirrhotic patients seen in 2017 and 2019 at a tertiary teaching hospital in Spain. Quality indicators were assessed in five domains: documentation of cirrhosis etiology, disease severity assessment, hepatocellular carcinoma (HCC) screening, variceal bleeding prophylaxis, and vaccination. After identifying areas for improvement, an educational intervention was implemented. A second evaluation was performed after the intervention to assess changes in adherence rates. Results: Before the intervention, adherence rates were excellent (>90%) for indicators related to variceal bleeding prophylaxis and documentation of cirrhosis etiology, acceptable (60-80%) for HCC screening and disease severity assessment, and poor (<50%) for vaccinations. After the educational intervention, there was a statistically significant improvement in adherence rates for eight indicators related to HCC screening (70-90%), disease severity assessment (90%), variceal bleeding prophylaxis (>90%), and vaccinations (60-90%). Conclusion: Our study demonstrates a significant improvement in the quality of care provided to cirrhotic outpatients after an educational intervention. The findings highlight the importance of targeted educational interventions to enhance adherence to quality indicators in the management of cirrhosis.
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002778
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Article ; Online: Long-Range α-Synchronization as Control Signal for BCI: A Feasibility Study.

Esparza-Iaizzo, Martín / Vigué-Guix, Irene / Ruzzoli, Manuela / Torralba-Cuello, Mireia / Soto-Faraco, Salvador

eNeuro

2023 Volume 10, Issue 3

Abstract: Shifts in spatial attention are associated with variations in α band (α, 8-14 Hz) activity, specifically in interhemispheric imbalance. The underlying mechanism is attributed to local α-synchronization, which regulates local inhibition of neural ... ...

Abstract	Shifts in spatial attention are associated with variations in α band (α, 8-14 Hz) activity, specifically in interhemispheric imbalance. The underlying mechanism is attributed to local α-synchronization, which regulates local inhibition of neural excitability, and frontoparietal synchronization reflecting long-range communication. The direction-specific nature of this neural correlate brings forward its potential as a control signal in brain-computer interfaces (BCIs). In the present study, we explored whether long-range α-synchronization presents lateralized patterns dependent on voluntary attention orienting and whether these neural patterns can be picked up at a single-trial level to provide a control signal for active BCI. We collected electroencephalography (EEG) data from a cohort of healthy adults (
MeSH term(s)	Adult ; Humans ; Brain-Computer Interfaces ; Feasibility Studies ; Electroencephalography ; Attention/physiology
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2800598-3
ISSN	2373-2822 ; 2373-2822
ISSN (online)	2373-2822
ISSN	2373-2822
DOI	10.1523/ENEURO.0203-22.2023
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Article ; Online: Analysis of SARS-CoV-2 in wastewater for prevalence estimation and investigating clinical diagnostic test biases.

Mattei, Mattia / Pintó, Rosa M / Guix, Susana / Bosch, Albert / Arenas, Alex

Water research

2023 Volume 242, Page(s) 120223

Abstract: Here we analyze SARS-CoV-2 genome copies in Catalonia's wastewater during the Omicron peak and develop a mathematical model to estimate the number of infections and the temporal relationship between reported and unreported cases. 1-liter samples from 16 ... ...

Abstract	Here we analyze SARS-CoV-2 genome copies in Catalonia's wastewater during the Omicron peak and develop a mathematical model to estimate the number of infections and the temporal relationship between reported and unreported cases. 1-liter samples from 16 wastewater treatment plants were collected and used in a compartmental epidemiological model. The average correlation between genome copies and reported cases was 0.85, with an average delay of 8.8 days. The model estimated that 53% of the population was infected, compared to the 19% reported cases. The under-reporting was highest in November and December 2021. The maximum genome copies shed in feces by an infected individual was estimated to range from 1.4×10
MeSH term(s)	Humans ; COVID-19/epidemiology ; Prevalence ; SARS-CoV-2 ; Wastewater ; Bias ; Diagnostic Tests, Routine ; RNA, Viral ; COVID-19 Testing
Chemical Substances	Wastewater ; RNA, Viral
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2023.120223
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Article ; Online: Micromotor-in-Sponge Platform for Multicycle Large-Volume Degradation of Organic Pollutants.

Vilela, Diana / Guix, Maria / Parmar, Jemish / Blanco-Blanes, Àngel / Sánchez, Samuel

Small (Weinheim an der Bergstrasse, Germany)

2022 Volume 18, Issue 23, Page(s) e2107619

Abstract: The presence of organic pollutants in the environment is a global threat to human health and ecosystems due to their bioaccumulation and long-term persistence. Hereby a micromotor-in-sponge concept is presented that aims not only at pollutant removal, ... ...

Abstract	The presence of organic pollutants in the environment is a global threat to human health and ecosystems due to their bioaccumulation and long-term persistence. Hereby a micromotor-in-sponge concept is presented that aims not only at pollutant removal, but towards an efficient in situ degradation by exploiting the synergy between the sponge hydrophobic nature and the rapid pollutant degradation promoted by the cobalt-ferrite (CFO) micromotors embedded at the sponge's core. Such a platform allows the use of extremely low fuel concentration (0.13% H
MeSH term(s)	Catalysis ; Ecosystem ; Environmental Pollutants ; Humans
Chemical Substances	Environmental Pollutants
Language	English
Publishing date	2022-05-01
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202107619
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Article: Dynamic and Seasonal Distribution of Enteric Viruses in Surface and Well Water in Riyadh (Saudi Arabia).

Abid, Islem / Blanco, Albert / Al-Otaibi, Nawal / Guix, Susana / Costafreda, Maria I / Pintó, Rosa M / Bosch, Albert

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 12

Abstract: Enteric viruses are the major cause of gastroenteritis and enteric hepatitis worldwide, but in some areas like Saudi Arabia, little is known about their presence in water sources. The available information from clinical samples is not enough to figure ... ...

Abstract	Enteric viruses are the major cause of gastroenteritis and enteric hepatitis worldwide, but in some areas like Saudi Arabia, little is known about their presence in water sources. The available information from clinical samples is not enough to figure out their actual prevalence. The aim of this study was to gather information for the first time in Saudi Arabia on the presence of the Norovirus (NoV) genogroup GI and GII, hepatitis A virus (HAV), and hepatitis E virus (HEV) in water. For this purpose, thirteen monthly samples were collected from Lake Wadi Hanifa and surrounding wells from December 2014 to November 2015. Viruses were detected and quantified using real-time RT-qPCR. Despite HEV findings being anecdotic, our results highlight interesting behaviors of the other viruses. There was a higher prevalence of noroviruses in Wadi Hanifa samples than in well water samples (46.43% vs. 12.5% of NoV GI; 66.67% vs. 8.33% of NoV GII). On the contrary, similar levels of HAV positivity were observed (40.48% in surface water vs. 43.06% in well water). Also, a strong influence of flooding events on HAV and NoV GI occurrence was observed in both surface and well water samples, with NoV GII apparently not affected.
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12121405
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Article ; Online: Guided accumulation of active particles by topological design of a second-order skin effect.

Palacios, Lucas S / Tchoumakov, Serguei / Guix, Maria / Pagonabarraga, Ignacio / Sánchez, Samuel / G Grushin, Adolfo

Nature communications

2021 Volume 12, Issue 1, Page(s) 4691

Abstract: Collective guidance of out-of-equilibrium systems without using external fields is a challenge of paramount importance in active matter, ranging from bacterial colonies to swarms of self-propelled particles. Designing strategies to guide active matter ... ...

Abstract	Collective guidance of out-of-equilibrium systems without using external fields is a challenge of paramount importance in active matter, ranging from bacterial colonies to swarms of self-propelled particles. Designing strategies to guide active matter and exploiting enhanced diffusion associated to its motion will provide insights for application from sensing, drug delivery to water remediation. However, achieving directed motion without breaking detailed balance, for example by asymmetric topographical patterning, is challenging. Here we engineer a two-dimensional periodic topographical design with detailed balance in its unit cell where we observe spontaneous particle edge guidance and corner accumulation of self-propelled particles. This emergent behaviour is guaranteed by a second-order non-Hermitian skin effect, a topologically robust non-equilibrium phenomenon, that we use to dynamically break detailed balance. Our stochastic circuit model predicts, without fitting parameters, how guidance and accumulation can be controlled and enhanced by design: a device guides particles more efficiently if the topological invariant characterizing it is non-zero. Our work establishes a fruitful bridge between active and topological matter, and our design principles offer a blueprint to design devices that display spontaneous, robust and predictable guided motion and accumulation, guaranteed by out-of-equilibrium topology.
MeSH term(s)	Equipment Design ; Lab-On-A-Chip Devices ; Models, Theoretical ; Motion ; Multifunctional Nanoparticles/chemistry ; Phase Transition ; Stochastic Processes
Language	English
Publishing date	2021-08-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-24948-2
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Article ; Online: Final Consumer Options to Control and Prevent Foodborne Norovirus Infections.

Guix, Susana / Pintó, Rosa M / Bosch, Albert

Viruses

2019 Volume 11, Issue 4

Abstract: Norovirus (NoV) causes about one-fifth of all cases of foodborne diseases and is a foremost cause of domestically acquired foodborne acute gastroenteritis and outbreaks. NoV infections are often associated with the consumption of contaminated fresh and ... ...

Abstract	Norovirus (NoV) causes about one-fifth of all cases of foodborne diseases and is a foremost cause of domestically acquired foodborne acute gastroenteritis and outbreaks. NoV infections are often associated with the consumption of contaminated fresh and ready-to-eat produce, fresh and frozen berries, raw/undercooked bivalve mollusks and products which become contaminated during handling. Despite many industrial efforts to control and prevent NoV contamination of foods, the prevalence of NoV in high-risk foodstuffs at retail is still significant. Although certain consumer behaviors may even increase the risk of virus transmission, interventions aiming at changing/implementing consumer habits may be considered as opportunities for risk mitigation. This review aims at providing an update on the progress made in characterizing the effect that consumer habits, which are most critical to prevent NoV transmission (food choice and hygiene, disinfection and cooking during food preparation), may have on reducing the risk of NoV infection. A better understanding of the options for NoV control and prevention may be translated into innovative educational, social or even technological tools targeting consumers with the objective of mitigating the risk of NoV transmission.
MeSH term(s)	Behavior Therapy/methods ; Caliciviridae Infections/prevention & control ; Caliciviridae Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Feeding Behavior ; Foodborne Diseases/prevention & control ; Humans ; Infection Control/methods
Language	English
Publishing date	2019-04-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v11040333
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Article ; Online: Loss of the epithelial marker CDX1 predicts poor prognosis in early-stage CRC patients.

Solé, Laura / Lobo-Jarne, Teresa / Cabré-Romans, Júlia-Jié / González, Antón / Fernández, Lierni / Marruecos, Laura / Guix, Marta / Cuatrecasas, Miriam / López, Sandra / Bellosillo, Beatriz / Torres, Ferran / Iglesias, Mar / Bigas, Anna / Espinosa, Lluís

Biochimica et biophysica acta. Molecular cell research

2024 Volume 1871, Issue 3, Page(s) 119658

Abstract: Background: We have previously shown that non-curative chemotherapy imposes fetal conversion and high metastatic capacity to cancer cells. From the set of genes differentially expressed in Chemotherapy Resistant Cells, we obtained a characteristic fetal ...

Abstract	Background: We have previously shown that non-curative chemotherapy imposes fetal conversion and high metastatic capacity to cancer cells. From the set of genes differentially expressed in Chemotherapy Resistant Cells, we obtained a characteristic fetal intestinal cell signature that is present in a group of untreated tumors and is sufficient to predict patient prognosis. A feature of this fetal signature is the loss of CDX1. Methods: We have analyzed transcriptomic data in public datasets and performed immunohistochemistry analysis of paraffin embedded tumor samples from two cohorts of colorectal cancer patients. Results: We demonstrated that low levels of CDX1 are sufficient to identify patients with poorest outcome at the early tumor stages II and III. Presence tumor areas that are negative for CDX1 staining in stage I cancers is associated with tumor relapse. Conclusions: Our results reveal the actual possibility of incorporating CDX1 immunostaining as a valuable biomarker for CRC patients.
MeSH term(s)	Humans ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/drug therapy ; Gene Expression Profiling ; Transcriptome ; Immunohistochemistry ; Homeodomain Proteins/genetics
Chemical Substances	CDX1 protein, human ; Homeodomain Proteins
Language	English
Publishing date	2024-01-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamcr.2024.119658
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