Article ; Online: Chevalones H–M
Marine Drugs, Vol 20, Iss 71, p
Six New α-Pyrone Meroterpenoids from the Gorgonian Coral-Derived Fungus Aspergillus hiratsukae SCSIO 7S2001
2022 Volume 71
Abstract: Six new α-pyrone meroterpenoid chevalones H–M ( 1 – 6 ), together with six known compounds ( 7 – 12 ...
Abstract | Six new α-pyrone meroterpenoid chevalones H–M ( 1 – 6 ), together with six known compounds ( 7 – 12 ), were isolated from the gorgonian coral-derived fungus Aspergillus hiratsukae SCSIO 7S2001 collected from Mischief Reef in the South China Sea. Their structures, including absolute configurations, were elucidated on the basis of spectroscopic analysis and X-ray diffraction data. Compounds 1 – 5 and 7 showed different degrees of antibacterial activity with MIC values of 6.25–100 μg/mL. Compound 8 exhibited potent cytotoxicity against SF-268, MCF-7, and A549 cell lines with IC 50 values of 12.75, 9.29, and 20.11 μM, respectively. |
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Keywords | coral-derived fungi ; Aspergillus hiratsukae ; meroterpenoids ; antibacterial activity ; cytotoxic activity ; Biology (General) ; QH301-705.5 |
Language | English |
Publishing date | 2022-01-01T00:00:00Z |
Publisher | MDPI AG |
Document type | Article ; Online |
Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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