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  1. Book ; Online ; E-Book: Stem cell biology and regenerative medicine

    Durand, Charles / Charbord, Pierre

    (River Publishers series in research and business chronicles ; 3)

    2015  

    Author's details editors Charles Durand, Pierre Charbord
    Series title River Publishers series in research and business chronicles ; 3
    Collection
    Keywords Stem cells ; Regenerative medicine
    Language English
    Size 1 Online-Ressource (xxxiii, 727 Seiten), Illustrationen
    Publisher River Publishers
    Publishing place Aalborg
    Publishing country Denmark
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019158625
    ISBN 978-87-93237-08-7 ; 9788793237070 ; 87-93237-08-1 ; 8793237073
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche.

    Miladinovic, Olivera / Canto, Pierre-Yves / Pouget, Claire / Piau, Olivier / Radic, Nevenka / Freschu, Priscilla / Megherbi, Alexandre / Brujas Prats, Carla / Jacques, Sebastien / Hirsinger, Estelle / Geeverding, Audrey / Dufour, Sylvie / Petit, Laurence / Souyri, Michele / North, Trista / Isambert, Hervé / Traver, David / Jaffredo, Thierry / Charbord, Pierre /
    Durand, Charles

    Development (Cambridge, England)

    2024  Volume 151, Issue 7

    Abstract: The first hematopoietic stem and progenitor cells (HSPCs) emerge in the Aorta-Gonad-Mesonephros (AGM) region of the mid-gestation mouse embryo. However, the precise nature of their supportive mesenchymal microenvironment remains largely unexplored. Here, ...

    Abstract The first hematopoietic stem and progenitor cells (HSPCs) emerge in the Aorta-Gonad-Mesonephros (AGM) region of the mid-gestation mouse embryo. However, the precise nature of their supportive mesenchymal microenvironment remains largely unexplored. Here, we profiled transcriptomes of laser micro-dissected aortic tissues at three developmental stages and individual AGM cells. Computational analyses allowed the identification of several cell subpopulations within the E11.5 AGM mesenchyme, with the presence of a yet unidentified subpopulation characterized by the dual expression of genes implicated in adhesive or neuronal functions. We confirmed the identity of this cell subset as a neuro-mesenchymal population, through morphological and lineage tracing assays. Loss of function in the zebrafish confirmed that Decorin, a characteristic extracellular matrix component of the neuro-mesenchyme, is essential for HSPC development. We further demonstrated that this cell population is not merely derived from the neural crest, and hence, is a bona fide novel subpopulation of the AGM mesenchyme.
    MeSH term(s) Mice ; Animals ; Zebrafish/genetics ; Hematopoietic Stem Cells/metabolism ; Mesenchymal Stem Cells ; Hematopoiesis ; Embryo, Mammalian ; Mesonephros ; Gonads
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.202614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bone marrow mesenchymal stem cells: historical overview and concepts.

    Charbord, Pierre

    Human gene therapy

    2010  Volume 21, Issue 9, Page(s) 1045–1056

    Abstract: This review describes the historical emergence of the concept of bone marrow mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic inductive microenvironment; Dexter's hematopoiesis-supportive stromal cells; Friedenstein's ... ...

    Abstract This review describes the historical emergence of the concept of bone marrow mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic inductive microenvironment; Dexter's hematopoiesis-supportive stromal cells; Friedenstein's osteogenic cells; and Pittenger's trilineal osteoblastic, chondrocytic, and adipocytic precursors; to finally introduce the specific bone marrow mesenchymal stem cells with differentiation potential to four lineages (mesenchymal and vascular smooth muscle lineages), and stromal and immunomodulatory capacities. Two points are the object of detailed discussion. The first point envisions the stem cell attributes (multipotentiality, self-renewal, tissue regeneration, population heterogeneity, plasticity, and lineage priming) compared with that of the paradigmatic hematopoietic stem cell. In the second point, we discuss the possible existence of bone marrow cells with greater differentiation potential, eventually pluripotential cells. The latter point raises the issues of cell fusion, reprogramming, or selection under nonstandardized conditions of rare populations of neuroectodermal origin, or of cells that had undergone mesenchymal-to-epithelial transition. In the last section, we review data on MSC senescence and possible malignant transformation secondary to extensive culture, gene transfer of telomerase, or mutations such as leading to Ewing's sarcoma. The set of data leads to the conclusion that bone marrow MSCs constitute a specific adult tissue stem cell population. The multiple characteristics of this stem cell type account for the versatility of the mechanisms of injured tissue repair. Although MSC administration may be extremely useful in a number of clinical applications, their transplantation is not without risks that must not be overlooked when developing cell therapy protocols.
    MeSH term(s) Bone Marrow Cells/cytology ; Cellular Senescence ; Hematopoiesis ; History, 20th Century ; Humans ; Immunomodulation ; Mesenchymal Stem Cells/cytology ; Multipotent Stem Cells/cytology
    Language English
    Publishing date 2010-06-18
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1028152-6
    ISSN 1557-7422 ; 1043-0342
    ISSN (online) 1557-7422
    ISSN 1043-0342
    DOI 10.1089/hum.2010.115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2988: Show issues Location:
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  4. Article ; Online: The crosstalk between hematopoietic stem cells and their niches.

    Durand, Charles / Charbord, Pierre / Jaffredo, Thierry

    Current opinion in hematology

    2018  Volume 25, Issue 4, Page(s) 285–289

    Abstract: Purpose of review: Hematopoietic stem cells (HSCs) reside in specific microenvironments also called niches that regulate HSC functions. Understanding the molecular and cellular mechanisms involved in the crosstalk between HSCs and niche cells is a major ...

    Abstract Purpose of review: Hematopoietic stem cells (HSCs) reside in specific microenvironments also called niches that regulate HSC functions. Understanding the molecular and cellular mechanisms involved in the crosstalk between HSCs and niche cells is a major issue in stem cell biology and regenerative medicine. The purpose of this review is to discuss recent advances in this field with particular emphasis on the transcriptional landscape of HSC niche cells and the roles of extracellular vesicles (EVs) in the dialog between HSCs and their microenvironments.
    Recent findings: The development of high-throughput technologies combined with computational methods has considerably improved our knowledge on the molecular identity of HSC niche cells. Accumulating evidence strongly suggest that the dialog between HSCs and their niches is bidirectional and that EVs play an important role in this process.
    Summary: These advances bring a unique conceptual and methodological framework for understanding the molecular complexity of the HSC niche and identifying novel HSC regulators. They are also promising for exploring the reciprocal influence of HSCs on niche cells and delivering specific molecules to HSCs in regenerative medicine.
    MeSH term(s) Animals ; Cell Communication/physiology ; Extracellular Vesicles/metabolism ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Regenerative Medicine ; Stem Cell Niche/physiology ; Transcription, Genetic/physiology
    Language English
    Publishing date 2018-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1153887-9
    ISSN 1531-7048 ; 1065-6251
    ISSN (online) 1531-7048
    ISSN 1065-6251
    DOI 10.1097/MOH.0000000000000438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mesenchymal lineage potentials of AGM stromal clones.

    Charbord, Pierre

    Haematologica

    2006  Volume 91, Issue 9, Page(s) 1153B

    MeSH term(s) Animals ; Aorta/cytology ; Cell Lineage ; Gonads/cytology ; Hematopoietic Stem Cells/cytology ; Mesenchymal Stromal Cells/cytology ; Mesonephros/cytology ; Mice ; Stromal Cells/cytology
    Language English
    Publishing date 2006-09
    Publishing country Italy
    Document type Comment ; Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
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  6. Article ; Online: Vésicules extracellulaires stromales et régulation des cellules souches et progéniteurs hématopoïétiques.

    Stik, Grégoire / Petit, Laurence / Charbord, Pierre / Jaffredo, Thierry / Durand, Charles

    Medecine sciences : M/S

    2018  Volume 34, Issue 2, Page(s) 114–116

    Title translation Regulation of hematopoietic stem and progenitor cells by stroma-derived extracellular vesicles.
    MeSH term(s) Adult ; Animals ; Cell Differentiation/genetics ; Cellular Microenvironment/genetics ; Extracellular Vesicles/physiology ; Hematopoietic Stem Cells/physiology ; Humans ; Stem Cell Niche/genetics ; Stem Cell Niche/physiology ; Stromal Cells/physiology ; Stromal Cells/ultrastructure
    Language French
    Publishing date 2018-02-16
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/20183402004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2872: Show issues Location:
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  7. Article ; Online: In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR.

    Charbord, Jérémie / Ren, Lipeng / Sharma, Rohit B / Johansson, Anna / Ågren, Rasmus / Chu, Lianhe / Tworus, Dominika / Schulz, Nadja / Charbord, Pierre / Stewart, Andrew F / Wang, Peng / Alonso, Laura C / Andersson, Olov

    Nature metabolism

    2021  Volume 3, Issue 5, Page(s) 682–700

    Abstract: It is known that β cell proliferation expands the β cell mass during development and under certain hyperglycemic conditions in the adult, a process that may be used for β cell regeneration in diabetes. Here, through a new high-throughput screen using a ... ...

    Abstract It is known that β cell proliferation expands the β cell mass during development and under certain hyperglycemic conditions in the adult, a process that may be used for β cell regeneration in diabetes. Here, through a new high-throughput screen using a luminescence ubiquitination-based cell cycle indicator (LUCCI) in zebrafish, we identify HG-9-91-01 as a driver of proliferation and confirm this effect in mouse and human β cells. HG-9-91-01 is an inhibitor of salt-inducible kinases (SIKs), and overexpression of Sik1 specifically in β cells blocks the effect of HG-9-91-01 on β cell proliferation. Single-cell transcriptomic analyses of mouse β cells demonstrate that HG-9-91-01 induces a wave of activating transcription factor (ATF)6-dependent unfolded protein response (UPR) before cell cycle entry. Importantly, the UPR wave is not associated with an increase in insulin expression. Additional mechanistic studies indicate that HG-9-91-01 induces multiple signalling effectors downstream of SIK inhibition, including CRTC1, CRTC2, ATF6, IRE1 and mTOR, which integrate to collectively drive β cell proliferation.
    MeSH term(s) Activating Transcription Factor 6/metabolism ; Animals ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Drug Evaluation, Preclinical/methods ; Endoribonucleases/metabolism ; Gene Expression Profiling ; High-Throughput Nucleotide Sequencing ; Humans ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Protein Kinase Inhibitors/pharmacology ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction ; Single-Cell Analysis ; Unfolded Protein Response/drug effects ; Zebrafish
    Chemical Substances ATF6 protein, human ; Activating Transcription Factor 6 ; Protein Kinase Inhibitors ; ERN1 protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; SIK1 protein, human (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-)
    Language English
    Publishing date 2021-05-20
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-021-00391-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The EHA Research Roadmap: Hematopoietic Stem Cells and Allotransplantation.

    Fibbe, Willem / Bernardi, Rosa / Charbord, Pierre / Krause, Daniela / Lo Celso, Cristina / Méndez-Ferrer, Simón / Mummery, Christine / Oostendorp, Robert / Raaijmakers, Marc / Socié, Gerard / Staal, Frank / Bacigalupo, Andrea

    HemaSphere

    2022  Volume 6, Issue 5, Page(s) e0714

    Language English
    Publishing date 2022-04-29
    Publishing country United States
    Document type Editorial
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Le cœur moléculaire de la fonction de la niche des cellules souches hématopoïétiques.

    Charbord, Pierre / Jaffredo, Thierry / Durand, Charles

    Medecine sciences : M/S

    2015  Volume 31, Issue 1, Page(s) 12–14

    Title translation Extracting the molecular core of the hematopoietic stem cell niche.
    MeSH term(s) Animals ; Cells, Cultured ; Gene Expression Profiling ; Genomics/methods ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Mesenchymal Stromal Cells/physiology ; Stem Cell Niche/genetics
    Language French
    Publishing date 2015-01
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/20153101003
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  10. Article: La biologie des cellules souchesmésenchymateuses d'origine humaine.

    Charbord, Pierre / Casteilla, Louis

    Medecine sciences : M/S

    2011  Volume 27, Issue 3, Page(s) 261–267

    Abstract: This brief overview summarises the main characteristics of bone marrow mesenchymal stem cells and of adipose-derived stem cells: methods of obtention, phenotype, differentiation potential, hematopoiesis-supportive (stromal) capacity, and ... ...

    Title translation Human mesenchymal stem cell biology.
    Abstract This brief overview summarises the main characteristics of bone marrow mesenchymal stem cells and of adipose-derived stem cells: methods of obtention, phenotype, differentiation potential, hematopoiesis-supportive (stromal) capacity, and immunosuppressive properties. Two points are discussed in detail: 1) criteria for stemness: multipotency, self-renewal, plasticity, and 2) the repair mechanisms implicated in the different indications of cell therapy using these cells: reconstitution of the tissue functional compartment by repopulation consequent to proliferation and differentiation or reprogrammation, stromal effects by secretion of angiogenic, anti-apoptotic, anti-fibrogenic factors, molecules involved in the regulation of inflammation, etc.
    MeSH term(s) Bone Marrow Cells ; Humans ; Mesenchymal Stromal Cells/physiology ; Multipotent Stem Cells ; Regeneration
    Language French
    Publishing date 2011-03
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2011273261
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