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Article: Combination of Antistaphylococcal β-Lactam With Standard Therapy Compared to Standard Therapy Alone for the Treatment of Methicillin-Resistant

Petersiel, Neta / Davis, Joshua S / Meagher, Niamh / Price, David J / Tong, Steven Y C

2024 Volume 11, Issue 5, Page(s) ofae181

Abstract: Background: Desirability of outcome ranking (DOOR) is an emerging approach to clinical trial outcome measurement using an ordinal scale to incorporate efficacy and safety endpoints.: Methods: We applied a previously validated DOOR endpoint to a ... ...

Abstract	Background: Desirability of outcome ranking (DOOR) is an emerging approach to clinical trial outcome measurement using an ordinal scale to incorporate efficacy and safety endpoints. Methods: We applied a previously validated DOOR endpoint to a cohort of CAMERA2 trial participants with methicillin-resistant Results: Participants assigned combination therapy had a 54.5% (95% confidence interval [CI], 48.9%-60.1%; Conclusions: When considering both efficacy and safety, treatment of MRSAB with a combination of standard therapy and a β-lactam likely results in a worse clinical outcome than standard therapy. However, a small benefit of combination therapy cannot be excluded. Most likely the toxicity of combination therapy outweighed any benefit from faster clearance of bacteremia.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofae181
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Article ; Online: Mandatory COVID-19 vaccination for healthcare workers: The experience of chaplains evaluating religious accommodation requests from coworkers.

Wirpsa, M J / Galchutt, P / Price, C S / Schaefer, B / Szilagyi, C / Palmer, P K

Social science & medicine (1982)

2023 Volume 332, Page(s) 116103

Abstract: ... conducted from 6/1/2022 to 7/15/2022 with U.S. healthcare chaplains (n = 76) who were involved ...

Abstract	Mandatory COVID-19 vaccination requirements for healthcare workers in the United States, instituted at the height of the pandemic to protect vulnerable patients and preserve the infrastructure of healthcare, nonetheless met with resistance by some members of the work force. As unprecedented numbers of employees sought religious accommodations, chaplain leaders were recruited by institutional leadership to adjudicate these requests, either alone or as part of a committee. This study reports results of a survey conducted from 6/1/2022 to 7/15/2022 with U.S. healthcare chaplains (n = 76) who were involved in the evaluation of coworker requests for religious exemption to the COVID-19 vaccine anytime during the pandemic until they accessed the survey. Chaplains were recruited online through national chaplaincy and ethics organizations. A mixed methods design facilitates integration of statistically significant associations with chaplains' in-depth reflections on their experience. Surveying the religious experts on the review committee affords a rare look into how the tension between the free exercise of religion in the workplace and the obligation to protect the public played out during the pandemic. The study further addresses a gap in research literature on the experience of chaplains during the pandemic and identifies unique features of moral injury experienced by a subset of healthcare providers. Chaplains largely perceived their involvement as promoting an ethical, informed process of review. Although all chaplains found this role stressful, high levels of meaning were protective against distress. Sources of distress identified included: ethical concern that granting exemptions would lead to the spread of the virus; inconsistencies in the review process; and, repeated exposure to coworkers' misunderstanding and political use of religious teachings. Featuring prominently in comments from chaplains was the difficulty navigating requests in the context of anti-science, anti-vaccine, and politically charged public discourse.
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2023.116103
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Article ; Online: Cortical layering disrupts multi-electrode current steering.

Meikle, Sabrina J / Hagan, Maureen A / Price, Nicholas S C / Wong, Yan T

Journal of neural engineering

2023 Volume 20, Issue 3

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Rats ; Animals ; Electrodes, Implanted ; Electric Stimulation/methods ; Rats, Sprague-Dawley ; Visual Prosthesis ; Evoked Potentials, Visual
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2170901-4
ISSN	1741-2552 ; 1741-2560
ISSN (online)	1741-2552
ISSN	1741-2560
DOI	10.1088/1741-2552/acdaf7
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Article ; Online: The outcomes of acute periprosthetic joint infection following unicompartmental knee replacement managed with early debridement, Antibiotics, and implant retention.

Asadollahi, S / Hamilton, T W / Sabah, S A / Scarborough, M / Price, A J / Gibbons, C L M H / Murray, D W / Alvand, A

The Knee

2024 Volume 47, Page(s) 13–20

Abstract: Background: Periprosthetic joint infection (PJI) following unicompartmental knee replacement (UKR) is an uncommon, yet serious, complication. There is a paucity of evidence regarding the effectiveness of Debridement-Antibiotics-and-Implant-Retention ( ... ...

Abstract	Background: Periprosthetic joint infection (PJI) following unicompartmental knee replacement (UKR) is an uncommon, yet serious, complication. There is a paucity of evidence regarding the effectiveness of Debridement-Antibiotics-and-Implant-Retention (DAIR) in this setting. The aim of this study is to investigate the effectiveness of DAIR for acute UKR PJI. Method: Between 2006 and 2019, 5195 UKR were performed at our institution. Over this period, sixteen patients underwent DAIR for early, acute PJI. All patients met MSIS PJI diagnostic criteria. The median age at DAIR was 67 years (range 40-73) and 12 patients were male (75.0%). The median time to DAIR was 24 days (range 6-60). Patients were followed up for a median of 6.5 years (range1.4-10.5) following DAIR. Results: 0.3% (16/5195) of UKR in our institution had a DAIR within 3 months. 15 of 16 patients (93.8%) were culture positive, with the most common organism MSSA (n = 8, 50.0%). Patients were treated with an organism-specific intravenous antibiotic regime for a median of 6 weeks, followed by oral antibiotics for a median duration of 6 months. The Kaplan-Meier survivor estimate for revision for PJI was 57% (95%CI: 28-78%) at five years, and survivor estimate for all cause revision 52% (95%CI: 25-74%).The median Oxford Knee Score for patients with a viable implant at final follow-up was 45 points (range 39-46). Conclusion: Early, acute PJI after UKR is rare. DAIR had a moderate success rate, with infection-free survivorship of 57% at 5 years. Those successfully treated with DAIR had excellent functional outcome and implant survival.
MeSH term(s)	Humans ; Prosthesis-Related Infections/etiology ; Prosthesis-Related Infections/drug therapy ; Prosthesis-Related Infections/therapy ; Male ; Arthroplasty, Replacement, Knee/adverse effects ; Debridement ; Female ; Middle Aged ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/administration & dosage ; Aged ; Adult ; Knee Prosthesis/adverse effects ; Retrospective Studies ; Prosthesis Retention ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-01-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200476-5
ISSN	1873-5800 ; 0968-0160
ISSN (online)	1873-5800
ISSN	0968-0160
DOI	10.1016/j.knee.2023.12.001
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Zs.A 4043: Show issues

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Article ; Online: Thermography and conversion of fast-cure composite photocured with quad-wave and laser curing lights compared to a conventional curing light.

Thanoon, Halah / Price, Richard B / Watts, David C

Dental materials : official publication of the Academy of Dental Materials

2024 Volume 40, Issue 3, Page(s) 546–556

Abstract: ... Fill (EVO). Three LCUs were used: (i) Monet laser for 1 s and 3 s (MONET-1 s, MONET-3 s); (ii) PinkWave ... quad-wave used for 3 s in Boost mode (PW-3 s) and for 20 s in standard mode (PW-20 s); (iii) Elipar S10 ... for 5 s (S10-5 s) and for 20 s in standard mode (S10-20 s). 2-dimensional temperature maps were obtained ...

Abstract	Objectives: This study investigated effects of the different emittance-mode protocols from three light curing units (LCUs): (i) a Laser (Monet); (ii) a quad-wave (PinkWave); (iii) a conventional LED (Elipar S10) on the temperature rise (ΔT) and degree of conversion (DC) when photo-curing fast or conventional bulk-fill resin-based composites (RBC). The aim was to correlate ΔT and DC, and the radiant exposure delivered to RBC specimens. Methods: A 3D-printed resin mold of 4 mm depth was filled with two bulk-fill RBCs: Tetric PowerFill® (fast photo-polymerised composite) (TPF) or Tetric EvoCeram® Bulk-Fill (EVO). Three LCUs were used: (i) Monet laser for 1 s and 3 s (MONET-1 s, MONET-3 s); (ii) PinkWave quad-wave used for 3 s in Boost mode (PW-3 s) and for 20 s in standard mode (PW-20 s); (iii) Elipar S10 for 5 s (S10-5 s) and for 20 s in standard mode (S10-20 s). 2-dimensional temperature maps were obtained before, during and for 60 s after the LCU had turned off using a thermal imaging camera. Thermal changes were analysed at five depths: (0, 1, 2, 3, and 4 mm from the top surface of the RBC). The maximum temperature rise (T Results: Radiant exposures delivered by the various irradiation protocols were between 4.5-30.3 J/cm
MeSH term(s)	Thermography ; Curing Lights, Dental ; Materials Testing ; Composite Resins/chemistry ; Dental Materials ; Light-Curing of Dental Adhesives/methods ; Polymerization
Chemical Substances	Composite Resins ; Dental Materials
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	605995-8
ISSN	1879-0097 ; 0109-5641
ISSN (online)	1879-0097
ISSN	0109-5641
DOI	10.1016/j.dental.2024.01.003
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Article: Molecular signatures of cortical expansion in the human fetal brain.

Ball, G / Oldham, S / Kyriakopoulou, V / Williams, L Z J / Karolis, V / Price, A / Hutter, J / Seal, M L / Alexander-Bloch, A / Hajnal, J V / Edwards, A D / Robinson, E C / Seidlitz, J

bioRxiv : the preprint server for biology

2024

Abstract: The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. A growing catalogue of cells in the prenatal brain has revealed remarkable molecular diversity across cortical areas. ...

Abstract	The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. A growing catalogue of cells in the prenatal brain has revealed remarkable molecular diversity across cortical areas.
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.13.580198
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Article ; Online: Effect of Radiant Exposure on the Physical and Mechanical Properties of 10 Flowable and High-viscosity Bulk-fill Resin Composites.

de Deus, R A / Oliveira, Lrs / Braga, Ssl / Ribeiro, Mth / Price, R B / Núñez, A / Loguercio, A D / Soares, C J

Operative dentistry

2024 Volume 49, Issue 2, Page(s) 136–156

Abstract: ... cm2 for 40 s (16 J/cm2), and 800 mW/cm2 for 20 seconds (16 J/cm2) or 1200 mW/cm2 for 10 seconds (12 J ... 8, 12, 16, 24, 32, or 48 J/cm2. Post-gel shrinkage (Shr) was calculated using strain-gauge test ... that resulted in radiant exposure between 24 J/cm2 to 48 J/cm2 produced better results than delivering 400 mW ...

Abstract	Objectives: To evaluate the effect of the different radiant exposures from a multipeak light curing unit on the physical and mechanical properties of flowable and high-viscosity bulk-fill resin-based composites (RBC). Methods: Five flowable bulk-fill RBCs (Tetric N-Flow Bulk-fill, Ivoclar Vivadent; Filtek Bulk Fill Flow, 3M Oral Care; Opus Bulk Fill Flow APS, FGM; Admira Fusion x-base, Voco and; and SDR Plus Bulk Fill Flowable, Dentsply Sirona) and five high-viscosity bulk-fill RBCs (Tetric N-Ceram Bulk-fill, Ivoclar Vivadent; Filtek One Bulk Fill, 3M Oral Care; Opus Bulk Fill APS, FGM; Admira Fusion x-tra, Voco; and SonicFill 2, Kerr) were photo-cured using a VALO Cordless light (Ultradent) for 10, 20, and 40 seconds at an irradiance of 1200, 800, or 400 mW/cm2, resulting in the delivery of 4, 8, 12, 16, 24, 32, or 48 J/cm2. Post-gel shrinkage (Shr) was calculated using strain-gauge test. The degree of conversion (DC, %) was calculated using FTIR. Knoop hardness (KH, N/mm2) and elastic modulus (E, MPa) were measured at the top and bottom surfaces. Logarithmic regressions between the radiant exposures and mechanical properties were calculated. Radiodensity was calculated using digital radiographs. Data of Shr and radiodensity were analyzed using two-way analysis of variance (ANOVA), and the DC, KH, and E data were analyzed with two-way ANOVA using split-plot repeated measurement tests followed by the Tukey test (a = 0.05). Results: Delivering higher radiant exposures produced higher Shr values (p<0.001) and higher DC values (R2=0.808-0.922; R2=0.648-0.914, p<0.001), KH (R2=0.707-0.952; R2=0.738-0.919; p<0.001), and E (R2=0.501-0.925; R2=0.823-0.919; p<0.001) values for the flowable and high-viscosity RBCs respectively. Lower KH, E and Shr were observed for the flowable bulk-fill RBCs. All bulk-fill RBCs had a radiopacity level greater than the 4-mm thick aluminum step wedge. The radiant exposure did not affect the radiopacity. Conclusion: The Shr, DC, KH, and E values were highly correlated to the radiant exposure delivered to the RBCs. The combination of the higher irradiance for longer exposure time that resulted in radiant exposure between 24 J/cm2 to 48 J/cm2 produced better results than delivering 400 mW/cm2 for 40 s (16 J/cm2), and 800 mW/cm2 for 20 seconds (16 J/cm2) or 1200 mW/cm2 for 10 seconds (12 J/cm2). All the bulk-fill RBCs were sufficiently radiopaque compared to 4 mm of aluminum.
MeSH term(s)	Viscosity ; Aluminum ; Materials Testing ; Polymerization ; Composite Resins ; Dental Materials ; Surface Properties ; Acrylic Resins ; Methacrylates ; Polyurethanes ; Siloxanes
Chemical Substances	Vivadent ; admira ; Aluminum (CPD4NFA903) ; Composite Resins ; Dental Materials ; Acrylic Resins ; Methacrylates ; Polyurethanes ; Siloxanes
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	752995-8
ISSN	1559-2863 ; 0361-7734
ISSN (online)	1559-2863
ISSN	0361-7734
DOI	10.2341/23-025-L
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Article ; Online: Adapting a measure of gross motor skills for individuals with CDKL5 deficiency disorder: A psychometric study.

Saldaris, J M / Jacoby, P / Marsh, E D / Suter, B / Leonard, H / Olson, H E / Rajaraman, R / Pestana-Knight, E / Weisenberg, J / Price, D / Drummond, C / Benke, T A / Demarest, S / Downs, J

Epilepsy research

2024 Volume 200, Page(s) 107287

Abstract: Purpose: Validated measures capable of demonstrating meaningful interventional change in the CDKL5 deficiency disorder (CDD) are lacking. The study objective was to modify the Rett Syndrome Gross Motor Scale (RSGMS) and evaluate its psychometric ... ...

Abstract	Purpose: Validated measures capable of demonstrating meaningful interventional change in the CDKL5 deficiency disorder (CDD) are lacking. The study objective was to modify the Rett Syndrome Gross Motor Scale (RSGMS) and evaluate its psychometric properties for individuals with CDD. Methods: Item and scoring categories of the RSGMS were modified. Caregivers registered with the International CDKL5 Clinical Research Network uploaded motor videos filmed at home to a protected server and completed a feedback questionnaire (n = 70). Rasch (n = 137), known groups (n = 109), and intra- and inter-rater reliability analyses (n = 50) were conducted. Results: The age of individuals with CDD ranged from 1.5 to 34.1 years. The modified scale, Gross Motor-Complex Disability (GM-CD), comprised 17 items. There were no floor or ceiling effects and inter- and intra-rater reliability were good. Rasch analysis demonstrated that the items encompassed a large range of performance difficulty, although there was some item redundancy and some disordered categories. One item, Prone Head Position, was a poor fit. Caregiver-reported acceptability was positive. Scores differed by age and functional abilities. Summary: GM-CD appears to be a suitable remotely administered measure and psychometrically sound for individuals with CDD. This study provides the foundation to propose the use of GM-CD in CDD clinical trials. Longitudinal evaluation is planned.
MeSH term(s)	Humans ; Infant ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Psychometrics ; Motor Skills ; Reproducibility of Results ; Spasms, Infantile ; Rett Syndrome/diagnosis ; Rett Syndrome/genetics ; Protein Serine-Threonine Kinases/genetics ; Epileptic Syndromes
Chemical Substances	CDKL5 protein, human (EC 2.7.11.22) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2024-01-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632939-1
ISSN	1872-6844 ; 0920-1211
ISSN (online)	1872-6844
ISSN	0920-1211
DOI	10.1016/j.eplepsyres.2024.107287
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Zs.A 2193: Show issues

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Article ; Online: Relationship Between the Cost of 12 Light-curing Units and Their Radiant Power, Emission Spectrum, Radiant Exitance, and Beam Profile.

Soares, C J / Braga, Ssl / Price, R B

Operative dentistry

2021 Volume 46, Issue 3, Page(s) 283–292

Abstract: ... Bluephase G4,VALO Grand, VALO Cordless, Radii Xpert, Elipar DeepCure-S, and Radii plus) and six low-cost ... LCUs costing less than US$500 (Radii Cal, Optilight Max, High Power LED 3M, Emitter D, Emitter C, and ... between the cost of the LCUs and the radiant power and tip diameter. The VALO Grand, Elipar DeepCure-S ...

Abstract	Objectives: To correlate the radiant power (mW), radiant exitance (or tip irradiance in mW/cm2), emission spectrum (mW/cm2/nm), and beam irradiance profile of 12 light-curing units (LCUs) available in the Brazilian market with their market cost. Methods and materials: Six LCUs that cost more than US$900 (Bluephase G4,VALO Grand, VALO Cordless, Radii Xpert, Elipar DeepCure-S, and Radii plus) and six low-cost LCUs costing less than US$500 (Radii Cal, Optilight Max, High Power LED 3M, Emitter D, Emitter C, and LED B) were examined. Radiant power (mW) and emission spectrum (mW/nm) were measured using an integrating sphere connected to a fiber-optic spectroradiometer. The internal tip diameter (mm) of each LCU was measured using a digital caliper and was used to calculate the average radiant exitance (mW/cm2). Irradiance profiles at the light tip were measured using a commercial laser beam profiler. The cost of each LCU in Brazil was correlated with internal tip diameter, radiant power, and tip irradiance. Results: None of the low-cost LCUs were broad spectrum multiple peak LCUs. There was no correlation between the cost of the LCUs and their averaged tip irradiance; however, there was a high positive correlation between the cost of the LCUs and the radiant power and tip diameter. The VALO Grand, Elipar DeepCure-S, VALO Cordless, and Bluephase G4 all emitted a higher radiant power. They also had a significantly greater tip diameter than other LCUs. For the LCUs with a nonuniform output, some areas of the light tip delivered less than 400 mW/cm2, while other areas delivered more than 2500 mW/cm2. Conclusions: In general, LCUs that had a higher cost (US$971-US$1800) delivered more power (mW) and had a greater tip diameter (mm), which covered more of a tooth. In general, the low-cost LCUs (US$224-US$470) emitted a lower radiant power and had a smaller tip diameter.
MeSH term(s)	Brazil ; Composite Resins ; Curing Lights, Dental ; Light-Curing of Dental Adhesives ; Materials Testing ; Tooth
Chemical Substances	Composite Resins
Language	English
Publishing date	2021-08-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	752995-8
ISSN	1559-2863 ; 0361-7734
ISSN (online)	1559-2863
ISSN	0361-7734
DOI	10.2341/19-274-L
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Article ; Online: Single-cell mapping of focused ultrasound-transfected brain.

Mathew, A S / Gorick, C M / Price, R J

Gene therapy

2021 Volume 30, Issue 3-4, Page(s) 255–263

Abstract: Gene delivery via focused ultrasound (FUS) mediated blood-brain barrier (BBB) opening is a disruptive therapeutic modality. Unlocking its full potential will require an understanding of how FUS parameters (e.g., peak-negative pressure (PNP)) affect ... ...

Abstract	Gene delivery via focused ultrasound (FUS) mediated blood-brain barrier (BBB) opening is a disruptive therapeutic modality. Unlocking its full potential will require an understanding of how FUS parameters (e.g., peak-negative pressure (PNP)) affect transfected cell populations. Following plasmid (mRuby) delivery across the BBB with 1 MHz FUS, we used single-cell RNA-sequencing to ascertain that distributions of transfected cell types were highly dependent on PNP. Cells of the BBB (i.e., endothelial cells, pericytes, and astrocytes) were enriched at 0.2 MPa PNP, while transfection of cells distal to the BBB (i.e., neurons, oligodendrocytes, and microglia) was augmented at 0.4 MPa PNP. PNP-dependent differential gene expression was observed for multiple cell types. Cell stress genes were upregulated proportional to PNP, independent of cell type. Our results underscore how FUS may be tuned to bias transfection toward specific brain cell types in vivo and predict how those cells will respond to transfection.
MeSH term(s)	Endothelial Cells ; Microbubbles ; Brain/diagnostic imaging ; Brain/physiology ; Blood-Brain Barrier/metabolism ; Astrocytes ; Drug Delivery Systems/methods ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2021-02-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1191036-7
ISSN	1476-5462 ; 0969-7128
ISSN (online)	1476-5462
ISSN	0969-7128
DOI	10.1038/s41434-021-00226-0
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