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Article: Cancer Care-Post-Independence Evolution in West Bengal and Eastern India.

Gupta, Arnab

2022 Volume 13, Issue Suppl 1, Page(s) 70–75

Abstract: The Cancer Care in Eastern India, especially West Bengal, started evolving a long time back along with a few other centres in India. Some of them were government institutes and the others were NGOs and private hospitals. The last decade however saw a ... ...

Abstract	The Cancer Care in Eastern India, especially West Bengal, started evolving a long time back along with a few other centres in India. Some of them were government institutes and the others were NGOs and private hospitals. The last decade however saw a huge boom of many cancer centres-either a part of government hospitals/multispecialty private hospitals or some as standalone comprehensive cancer centres. This article briefly covers the evolution, referring to the Official Websites of the Institutes. References were taken from the Official Websites of the cancer hospitals and also Google search for Cancer Care facilities in Eastern and North East India.
Language	English
Publishing date	2022-08-25
Publishing country	India
Document type	Journal Article
ZDB-ID	2568289-1
ISSN	0976-6952 ; 0975-7651
ISSN (online)	0976-6952
ISSN	0975-7651
DOI	10.1007/s13193-022-01603-w
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Article ; Online: Biomechanical modeling of footwear-fluid-floor interaction during slips.

Gupta, Shubham / Chanda, Arnab

Journal of biomechanics

2023 Volume 156, Page(s) 111690

Abstract: Slips and falls are among the major concerns for public safety. Slipping risks can be reduced by ensuring adequate traction at the shoe-floor interface. The outsole design of footwear is a critical factor to maintain sufficient shoe-floor traction in the ...

Abstract	Slips and falls are among the major concerns for public safety. Slipping risks can be reduced by ensuring adequate traction at the shoe-floor interface. The outsole design of footwear is a critical factor to maintain sufficient shoe-floor traction in the presence of slippery contaminants such as water or oil. While the role of floorings and contaminants on footwear traction has been studied widely, limited works have investigated the role of footwear outsole geometry and tread patterns on shoe-floor traction. In this work, eight footwear outsole designs and their traction performance were tested on a common flooring with water contamination, through the development of a novel fluid-structure interaction based computational framework. Induced fluid pressure, mass flow rates, and contact areas were quantified across the outsole patterns, and their effect on footwear friction was investigated. The study results were validated using mechanical slip testing experiments. The results indicated that the outsoles which had horizontal treads or untreaded heel regions can lead to drastic reduction of footwear friction. Also, contact area alone was quantified to be a poor choice in estimating the traction performance of footwear on water contaminated floorings. Such novel study results have not been reported to date, and are anticipated to provide important guidelines to footwear manufacturers to evaluate and optimize footwear tread parameters which would help in reducing the risk of slips.
MeSH term(s)	Friction ; Floors and Floorcoverings ; Shoes ; Accidental Falls/prevention & control ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	218076-5
ISSN	1873-2380 ; 0021-9290
ISSN (online)	1873-2380
ISSN	0021-9290
DOI	10.1016/j.jbiomech.2023.111690
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Article ; Online: Synthesis of Self Permeable Antisense PMO Using C5-Guanidino-Functionalized Pyrimidines at the 5'-End Enables Sox2 Downregulation in Triple Negative Breast Cancer Cells.

Das, Arnab / Gupta, Shalini / Shaw, Pallab / Sinha, Surajit

Molecular pharmaceutics

2024 Volume 21, Issue 3, Page(s) 1256–1271

Abstract: Delivery of macromolecular drugs inside cells has been a huge challenge in the field of oligonucleotide therapeutics for the past few decades. Earliest natural inspirations included the arginine rich stretch of cell permeable HIV-TAT peptide, which led ... ...

Abstract	Delivery of macromolecular drugs inside cells has been a huge challenge in the field of oligonucleotide therapeutics for the past few decades. Earliest natural inspirations included the arginine rich stretch of cell permeable HIV-TAT peptide, which led to the design of several molecular transporters with varying numbers of rigid or flexible guanidinium units with different tethering groups. These transporters have been shown to efficiently deliver phosphorodiamidate morpholino oligonucleotides, which have a neutral backbone and cannot form lipoplexes. In this report, PMO based delivery agents having 3 or 4 guanidinium groups at the C5 position of the nucleobases of cytosine and uracil have been explored, which can be assimilated within the desired stretch of the antisense oligonucleotide. Guanidinium units have been connected by varying the flexibility with either a saturated (propyl) or an unsaturated (propargyl) spacer, which showed different serum dependency along with varied cytoplasmic distribution. The effect of cholesterol conjugation in the delivery agent as well as at the 5'-end of full length PMO in cellular delivery has also been studied. Finally, the efficacy of the delivery has been studied by the PMO mediated downregulation of the stemness marker Sox2 in the triple-negative breast cancer cell line MDA-MB 231. These results have validated the use of this class of delivery agents, which permit
MeSH term(s)	Humans ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/therapy ; Down-Regulation ; Pyrimidines ; Guanidine ; Morpholinos/chemistry ; Oligonucleotides
Chemical Substances	Pyrimidines ; Guanidine (JU58VJ6Y3B) ; Morpholinos ; Oligonucleotides
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.3c00924
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Article ; Online: Synthesis and Biophysical Properties of Triazole-Incorporated PMOs (TzPMOs): A Convergent, Click Ligation Approach.

Banerjee, Arpan / Das, Arnab / Ghosh, Atanu / Gupta, Abhishek / Sinha, Surajit

The Journal of organic chemistry

2024 Volume 89, Issue 5, Page(s) 2895–2903

Abstract: The synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) incorporating single or double triazole rings in the backbone has been achieved via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The synthetic approach implemented is ... ...

Abstract	The synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) incorporating single or double triazole rings in the backbone has been achieved via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The synthetic approach implemented is fundamentally convergent, involving the ligation of a 5'-azide PMO fragment to a 3'-alkyne fragment both in solution and on solid support. To access the 3'-alkyne PMO fragment, we synthesized 3'-
MeSH term(s)	Azides ; Morpholinos ; Alkynes ; Circular Dichroism ; Triazoles
Chemical Substances	Azides ; Morpholinos ; Alkynes ; Triazoles
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c02242
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Article ; Online: Development of an ultra-low-cost planar biaxial tester for soft tissue characterization.

Gupta, Vivek / Gupta, Shubham / Chanda, Arnab

Biomedical physics & engineering express

2023 Volume 9, Issue 2

Abstract: Nowadays, the research in the arena of biomedical engineering or specifically soft tissue characterization is rapidly increasing. Due to the complex properties of soft tissues such as, anisotropy and viscoelasticity, it is difficult to predict the ... ...

Abstract	Nowadays, the research in the arena of biomedical engineering or specifically soft tissue characterization is rapidly increasing. Due to the complex properties of soft tissues such as, anisotropy and viscoelasticity, it is difficult to predict the deformation behaviour. Hence, soft tissue characterization is essential to analyze these metrics. Soft tissue characterization, specifically, can be done by implementing a planar biaxial tester. Currently, available biaxial testers are mostly developed with respect to other mechanical components such as metals, and not for the soft tissues. Also, these devices are very costly, which makes it difficult for the low and middle income countries to perform this characterization. To solve this problem, in this work, an extremely low-cost biaxial tester was designed and developed. The design of the biaxial tester was simple and modular to allow device modifications according to the applications. The device has a force capability of less than 0.4 kN and a variable speed of 18 mm min
MeSH term(s)	Humans ; Stress, Mechanical ; Materials Testing ; Anisotropy
Language	English
Publishing date	2023-02-20
Publishing country	England
Document type	Journal Article
ISSN	2057-1976
ISSN (online)	2057-1976
DOI	10.1088/2057-1976/acb940
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Article ; Online: Development of patient-specific finite element model for study of composite dental implants.

Gupta, Vivek / Garg, Anshika / Tewari, Nitesh / Srivastav, Sukeshana / Chanda, Arnab

Biomedical physics & engineering express

2024 Volume 10, Issue 2

Abstract: Traumatic dental injuries can occur due to various reasons such as accidents, sports injuries, fights, falls, and others. These injuries can affect the teeth, gums, and surrounding tissues, and can range from minor chips and cracks to severe fractures, ... ...

Abstract	Traumatic dental injuries can occur due to various reasons such as accidents, sports injuries, fights, falls, and others. These injuries can affect the teeth, gums, and surrounding tissues, and can range from minor chips and cracks to severe fractures, dislocations, and avulsions (when the tooth is completely knocked out of the socket). The most common way to address this is by replacing affected teeth with dental implants. The purpose of this research is to evaluate the use of composite materials in dental implants and compare them with the traditionally used materials using a patient specific cone beam computed tomography (CBCT) based finite element model (FEM). To conduct this research, two different implant groups i.e., traditional implant and composite implant were designed using Titanium grade 4, zirconium oxide-reinforced lithium silicate (ZLS), and Zirconia (ZrO
MeSH term(s)	Humans ; Dental Implants ; Finite Element Analysis ; Software ; Maxilla ; Crowns ; Zirconium
Chemical Substances	Dental Implants ; zirconium oxide (S38N85C5G0) ; Zirconium (C6V6S92N3C)
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ISSN	2057-1976
ISSN (online)	2057-1976
DOI	10.1088/2057-1976/ad28ce
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Article ; Online: Capturing surface complementarity in proteins using unsupervised learning and robust curvature measure.

Gupta, Abhijit / Mukherjee, Arnab

Proteins

2022 Volume 90, Issue 9, Page(s) 1669–1683

Abstract: The structure of a protein plays a pivotal role in determining its function. Often, the protein surface's shape and curvature dictate its nature of interaction with other proteins and biomolecules. However, marked by corrugations and roughness, a protein' ...

Abstract	The structure of a protein plays a pivotal role in determining its function. Often, the protein surface's shape and curvature dictate its nature of interaction with other proteins and biomolecules. However, marked by corrugations and roughness, a protein's surface representation poses significant challenges for its curvature-based characterization. In the present study, we employ unsupervised machine learning to segment the protein surface into patches. To measure the surface curvature of a patch, we present an algebraic sphere fitting method that is fast, accurate, and robust. Moreover, we use local curvatures to show the existence of "shape complementarity" in protein-protein, antigen-antibody, and protein-ligand interfaces. We believe that the current approach could help understand the relationship between protein structure and its biological function and can be used to find binding partners of a given protein.
MeSH term(s)	Algorithms ; Ligands ; Models, Molecular ; Proteins/chemistry ; Unsupervised Machine Learning
Chemical Substances	Ligands ; Proteins
Language	English
Publishing date	2022-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	806683-8
ISSN	1097-0134 ; 0887-3585
ISSN (online)	1097-0134
ISSN	0887-3585
DOI	10.1002/prot.26345
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Article ; Online: Finite element analysis of a hybrid corrugated hip implant for stability and loading during gait phases.

Gupta, Vivek / Chanda, Arnab

Biomedical physics & engineering express

2022 Volume 8, Issue 3

Abstract: Implants used in total hip replacements (THR) exhibit high failure rates and up to a decade of operational life. These surgical failures could be mainly attributed to the improper positioning, post-surgical stability and loading, of the implants during ... ...

Abstract	Implants used in total hip replacements (THR) exhibit high failure rates and up to a decade of operational life. These surgical failures could be mainly attributed to the improper positioning, post-surgical stability and loading, of the implants during different phases of the gait. Typically, revised surgeries are suggested within a few years of hip implantation, which requires multiple femoral drilling operations to remove an existing implant, and to install a new implant. The pain and trauma associated with such procedures are also challenging with the existing hip implants. In this work, we designed a novel corrugated hip implant with innovative dimensioning as per ASTM standards, and grooves for directed insertion and removal (using a single femoral drilling and positioning operation). Biocompatible titanium alloy (Ti6Al4V) was chosen as the implant material, and the novel implant was placed into a femur model through a virtual surgery to study its stability and loading during a dynamic gait cycle. A detailed mesh convergence study was conducted to select a computationally accurate finite element (FE) mesh. Tight fit and frictional fit attachment conditions were simulated, and the gait induced displacements and stresses on the implant, cortical and cancellous bone sections were characterized. During walking, the implant encountered the maximum von-Mises stress of 254.97 MPa at the femoral head. The analyses indicated low micro-motions (i.e., approximately 7
MeSH term(s)	Arthroplasty, Replacement, Hip ; Finite Element Analysis ; Gait ; Hip Prosthesis ; Stress, Mechanical
Language	English
Publishing date	2022-04-27
Publishing country	England
Document type	Journal Article
ISSN	2057-1976
ISSN (online)	2057-1976
DOI	10.1088/2057-1976/ac669c
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Article: IASO COVID-19 Guidelines (Updated on 9th April 2020).

Desai, Sharad / Gupta, Arnab

Indian journal of surgical oncology

2020 Volume 11, Issue 2, Page(s) 171–174

Keywords	covid19
Language	English
Publishing date	2020-05-06
Publishing country	India
Document type	Case Reports
ZDB-ID	2568289-1
ISSN	0976-6952 ; 0975-7651
ISSN (online)	0976-6952
ISSN	0975-7651
DOI	10.1007/s13193-020-01081-y
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Article ; Online: Development of Soft Composite Based Anisotropic Synthetic Skin for Biomechanical Testing

Vivek Gupta / Rohan Singla / Gurpreet Singh / Arnab Chanda

Fibers, Vol 11, Iss 55, p

2023 Volume 55

Abstract: Human skin exhibits highly varying mechanical properties, thickness, hardness, and anisotropy by virtue of changing fiber distributions and orientations, across different body locations. To date, only a few studies have computationally simulated skin ... ...

Abstract	Human skin exhibits highly varying mechanical properties, thickness, hardness, and anisotropy by virtue of changing fiber distributions and orientations, across different body locations. To date, only a few studies have computationally simulated skin anisotropy and no experimental study on synthetic skin exists which can mimic the accurate biomechanical properties of the skin. In this work, unique anisotropic synthetic skin samples were created using an elastic composite-based structure. Both single and multi-layer synthetic skin were fabricated with consistent fiber density and fiber dimensions and varying fiber angles to generate over 100 compositions. The compositions implied stress versus stretch responses in mechanical biaxial testing were compared to those of the skin of a person. Hyperelastic constitutive models were used to characterize the non-uniform test results. The created anisotropic synthetic skin must be essential for reliable Biomechanical investigation of skin free from ethical concerns, undertaking medical training and researching skin pathophysiology and injuries.
Keywords	synthetic skin ; biaxial testing ; anisotropy ; hyperlasticity ; composite ; Chemicals: Manufacture ; use ; etc ; TP200-248 ; Textile bleaching ; dyeing ; printing ; TP890-933 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999
Subject code	571
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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