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  1. Article: My experience on taeniasis and neurocysticercosis.

    Prasad, Kashi Nath

    Tropical parasitology

    2021  Volume 11, Issue 2, Page(s) 71–77

    Abstract: Taeniasis and neurocysticercosis (NCC) are major public health problems in developing countries. NCC is the leading cause of community-acquired active epilepsy. NCC may present as a medical emergency, especially when there is cysticercotic encephalitis ... ...

    Abstract Taeniasis and neurocysticercosis (NCC) are major public health problems in developing countries. NCC is the leading cause of community-acquired active epilepsy. NCC may present as a medical emergency, especially when there is cysticercotic encephalitis or raised intracranial hypertension. Systematic community-based studies on taeniasis and NCC are lacking. We studied taeniasis and NCC-related active epilepsy disease burden in the pig farming community of Lucknow district, Uttar Pradesh, India. Based on the 30 cluster sampling approach as recommended by the World Health Organization, we estimated the prevalence of taeniasis, NCC-related active epilepsy, and silent NCC in the community. We also estimated the prevalence of swine cysticercosis. Taeniasis was detected in 18.6% of populations. Expulsions of tapeworm segments in stool, consumption of undercooked pork, age above 15 years, and handwash with clay or plain water after defecation were associated with taeniasis. On molecular analyses of positive stool samples,
    Language English
    Publishing date 2021-10-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 2628177-6
    ISSN 2229-7758 ; 2229-5070
    ISSN (online) 2229-7758
    ISSN 2229-5070
    DOI 10.4103/tp.tp_6_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Characterisation of OXA-48-like carbapenemases in

    Singh, Sanjay / Pathak, Ashutosh / Fatima, Nida / Sahu, Chinmoy / Prasad, Kashi Nath

    3 Biotech

    2023  Volume 13, Issue 5, Page(s) 134

    Abstract: The oxacillinase-48 (OXA-48)-like carbapenemases are class D β-lactamases and increasingly reported in Enterobacterial species. The detection of these carbapenemases is challenging and little information is available on the epidemiology and plasmid ... ...

    Abstract The oxacillinase-48 (OXA-48)-like carbapenemases are class D β-lactamases and increasingly reported in Enterobacterial species. The detection of these carbapenemases is challenging and little information is available on the epidemiology and plasmid characteristics of OXA-48-like carbapenemase producers. We detected the presence of OXA-48-like carbapenemases in 500 clinical isolates of
    Language English
    Publishing date 2023-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-023-03537-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Neurocysticercosis Burden in Pig Farming Community of North India

    Kashi Nath Prasad

    Annals of the National Academy of Medical Sciences (India), Vol 52, Iss 04, Pp 211-

    2016  Volume 221

    Abstract: Neurocysticercosis (NCC) is the most common cause of acquired active epilepsy (AE). NCC is under reported in India due to lack of systematic systematic studies. We investigated NCC burden in pig farming community of Lucknow district. Total 294 families ... ...

    Abstract Neurocysticercosis (NCC) is the most common cause of acquired active epilepsy (AE). NCC is under reported in India due to lack of systematic systematic studies. We investigated NCC burden in pig farming community of Lucknow district. Total 294 families with 1640 subjects from 30 villages were surveyed for AE; 595 asymptomatic individuals underwent magnetic resonance imaging of brain. TLR4, MMP9, ICAM1 and GST genes polymorphisms were studied for their role in symptomatic disease. Slaughtered pigs were screened for cysticercosis. Total 95 (5.8%) subjects with AE were identified; 48.3% of them had NCC. Ninety (15%) asymptomatic individuals had NCC. Thirteen (26%) of 50 pigs slaughtered had cysticercosis. The results showed high NCC burden in pig farming community and NCC as major cause of AE. Individuals with polymorphic TLR4, MMP9, ICAM1 and GST genotypes were susceptible for symptomatic disease. High swine cysticercosis prevalence suggests the transmission dynamic between human and swine in the community.
    Keywords active epilepsy ; host genetic factors ; neurocysticercosis ; seizure ; swine cysticercosis ; General works ; R5-130.5 ; Science ; Q
    Language English
    Publishing date 2016-10-01T00:00:00Z
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Neurocysticercosis Burden in Pig Farming Community of North India

    Prasad, Kashi Nath

    Annals of the National Academy of Medical Sciences (India)

    2016  Volume 52, Issue 04, Page(s) 211–221

    Abstract: Neurocysticercosis (NCC) is the most common cause of acquired active epilepsy (AE). NCC is under reported in India due to lack of systematic systematic studies. We investigated NCC burden in pig farming community of Lucknow district. Total 294 families ... ...

    Abstract Neurocysticercosis (NCC) is the most common cause of acquired active epilepsy (AE). NCC is under reported in India due to lack of systematic systematic studies. We investigated NCC burden in pig farming community of Lucknow district. Total 294 families with 1640 subjects from 30 villages were surveyed for AE; 595 asymptomatic individuals underwent magnetic resonance imaging of brain. TLR4, MMP9, ICAM1 and GST genes polymorphisms were studied for their role in symptomatic disease. Slaughtered pigs were screened for cysticercosis. Total 95 (5.8%) subjects with AE were identified; 48.3% of them had NCC. Ninety (15%) asymptomatic individuals had NCC. Thirteen (26%) of 50 pigs slaughtered had cysticercosis. The results showed high NCC burden in pig farming community and NCC as major cause of AE. Individuals with polymorphic TLR4, MMP9, ICAM1 and GST genotypes were susceptible for symptomatic disease. High swine cysticercosis prevalence suggests the transmission dynamic between human and swine in the community.
    Keywords Active epilepsy ; host genetic factors ; neurocysticercosis ; seizure ; swine cysticercosis
    Language English
    Publishing date 2016-10-01
    Publisher Thieme Medical and Scientific Publishers Private Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 632986-x
    ISSN 2454-5635 ; 0379-038X
    ISSN (online) 2454-5635
    ISSN 0379-038X
    DOI 10.1055/s-0040-1712737
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Localized outbreaks of

    Pulusu, Chanakya Pachi / Manivannan, Bhavani / Raman, Sai Suguna / Singh, Sanjay / Khamari, Balaram / Lama, Manmath / Peketi, Arun Sai Kumar / Datta, Chandreyee / Prasad, Kashi Nath / Nagaraja, Valakunja / Pradeep, Bulagonda Eswarappa

    Journal of medical microbiology

    2022  Volume 71, Issue 3

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Clone Cells ; Disease Outbreaks ; Hospitals ; Humans ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa
    Language English
    Publishing date 2022-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001500
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Complete genome sequence of an extensively drug-resistant Pseudomonas aeruginosa ST773 clinical isolate from North India.

    Singh, Sanjay / Pulusu, Chanakya Pachi / Pathak, Ashutosh / Pradeep, Bulagonda Eswarappa / Prasad, Kashi Nath

    Journal of global antimicrobial resistance

    2021  Volume 27, Page(s) 244–246

    Abstract: Objectives: Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen causing a wide range of community- and hospital-acquired infections. Here we report the complete genome sequence of an extensively drug-resistant (XDR) P. aeruginosa strain ( ... ...

    Abstract Objectives: Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen causing a wide range of community- and hospital-acquired infections. Here we report the complete genome sequence of an extensively drug-resistant (XDR) P. aeruginosa strain (PA790) in order to understand the antibiotic resistance genes (ARGs) harboured by such a strain.
    Methods: Whole-genome sequencing (WGS) was performed using Illumina HiSeq and Nanopore MinION platforms. Genome assembly was performed using Unicycler v.0.4.8. The genome was annotated using the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). In silico predictions were fulfilled using curated bioinformatics tools.
    Results: Pseudomonas aeruginosa PA790 was classified as XDR and belongs to sequence type 773 (ST773). The complete genome size is 6 932 250 bp with a G+C content of 66.02% and a BUSCO (Benchmarking Universal Single-Copy Orthologs) score of 100. Strain PA790 harboured 12 different ARGs conferring resistance to eight different classes of antibiotics. It was identified as the nineteenth ST773 strain among 5785 whole-genome sequences of P. aeruginosa available in the NCBI database.
    Conclusion: Pseudomonas aeruginosa PA790 belongs to ST773 and was identified as the nineteenth such isolate to be submitted to NCBI and the first complete ST773 genome from India. The WGS data with multiple ARGs of P. aeruginosa PA790 (ST773) will aid in understanding the evolution and phylogeny of such high-risk clones and provide a solid basis for further research on XDR strains.
    MeSH term(s) Drug Resistance, Multiple, Bacterial ; Genome, Bacterial ; Pharmaceutical Preparations ; Pseudomonas aeruginosa/genetics ; Sequence Analysis, DNA
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2021-10-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2021.10.010
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  7. Article ; Online: Antimicrobial susceptibility to azithromycin among Salmonella enterica Typhi and Paratyphi A isolates from India.

    Misra, Richa / Prasad, Kashi Nath

    Journal of medical microbiology

    2016  Volume 65, Issue 12, Page(s) 1536–1539

    Abstract: Decreased ciprofloxacin susceptibility (DCS) and multidrug resistance in typhoidal Salmonella isolates in areas of endemicity are significant therapeutic problems. Guidelines for azithromycin disc diffusion and MIC interpretive criteria for Salmonella ... ...

    Abstract Decreased ciprofloxacin susceptibility (DCS) and multidrug resistance in typhoidal Salmonella isolates in areas of endemicity are significant therapeutic problems. Guidelines for azithromycin disc diffusion and MIC interpretive criteria for Salmonella enterica serovar Typhi were published recently by the Clinical and Laboratory Standards Institute in 2015. We investigated the antimicrobial susceptibility pattern of azithromycin in 100 isolates of Salmonella Typhi (n=80), Paratyphi A (n=18) and B (n=2) recovered from bloodstream infections from January 2013 to December 2015. Zone sizes were extrapolated against MIC values, and a scatter plot was constructed. The azithromycin MICs by Etest ranged from 2 to 16 µg ml-1, while the disc diffusion diameters were from 13 to 22 mm. We observed that the margin of the zone of inhibition around the azithromycin disc may not be very clear and therefore difficult to interpret and that there was wide variation in the zone sizes for the same MIC value in both serovars. DCS was observed in 85 % of Salmonella Typhi recovered (68/80) and in 15/18 (83.3 %) Paratyphi A isolates. Judicious use of azithromycin is advocated as an alternative oral agent in endemic areas where DCS is common.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Azithromycin/pharmacology ; Bacteremia/microbiology ; Ciprofloxacin/pharmacology ; Drug Resistance, Bacterial/drug effects ; Humans ; India/epidemiology ; Microbial Sensitivity Tests ; Salmonella paratyphi A/drug effects ; Salmonella paratyphi A/isolation & purification ; Salmonella paratyphi B/drug effects ; Salmonella paratyphi B/isolation & purification ; Salmonella typhi/drug effects ; Salmonella typhi/isolation & purification ; Serogroup ; Typhoid Fever/epidemiology ; Typhoid Fever/microbiology
    Chemical Substances Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U) ; Azithromycin (83905-01-5)
    Language English
    Publishing date 2016-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.000390
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    Zs.A 634: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Genetic Characterisation of Colistin Resistant

    Singh, Sanjay / Pathak, Ashutosh / Rahman, Mohibur / Singh, Avinash / Nag, Soumyabrata / Sahu, Chinmoy / Prasad, Kashi Nath

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 666030

    Abstract: Background: Increasing use of colistin has led to the world-wide emergence of mobile colistin resistant gene (: Methods: Twenty-two colistin resistant : Results: Nineteen colistin resistant : Conclusions: Colistin resistance ... ...

    Abstract Background: Increasing use of colistin has led to the world-wide emergence of mobile colistin resistant gene (
    Methods: Twenty-two colistin resistant
    Results: Nineteen colistin resistant
    Conclusions: Colistin resistance in
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/pharmacology ; Colistin/pharmacology ; Drug Resistance, Bacterial/genetics ; Humans ; India ; Klebsiella Infections ; Klebsiella pneumoniae/genetics ; Microbial Sensitivity Tests ; Multilocus Sequence Typing ; Plasmids ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; Colistin (Z67X93HJG1)
    Language English
    Publishing date 2021-06-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.666030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Simultaneous isolation of

    Jain, Vidhi / Hussain, Nayani Amrin Fatema Afzal / Siddiqui, Tasneem / Sahu, Chinmoy / Ghar, Malay / Prasad, Kashi Nath

    JMM case reports

    2017  Volume 4, Issue 10, Page(s) e005122

    Abstract: Introduction. ...

    Abstract Introduction.
    Language English
    Publishing date 2017-10-16
    Publishing country England
    Document type Case Reports
    ZDB-ID 2755673-6
    ISSN 2053-3721
    ISSN 2053-3721
    DOI 10.1099/jmmcr.0.005122
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  10. Article ; Online: First report of peritonitis caused by the vancomycin-resistant coccus

    Gupta, Shefali / Sahu, Chinmoy / Nag, Soumyabrata / Saha, Uma Shankar / Prasad, Narayan / Prasad, Kashi Nath

    Access microbiology

    2019  Volume 1, Issue 5, Page(s) e000007

    Abstract: Introduction: Worldwide, about one-tenth of end-stage renal disease (ESRD) patients are on peritoneal dialysis (PD). Peritonitis is a major cause of PD failure and change of therapy to haemodialysis. An update on peritoneal dialysis-related infections ... ...

    Abstract Introduction: Worldwide, about one-tenth of end-stage renal disease (ESRD) patients are on peritoneal dialysis (PD). Peritonitis is a major cause of PD failure and change of therapy to haemodialysis. An update on peritoneal dialysis-related infections has recommended the use of a first generation cephalosporin or vancomycin as an empirical therapy for Gram-positive organisms.
    Case presentation: An elderly female patient of ESRD on continuous ambulatory peritoneal dialysis (CAPD) was admitted with complaints of high fever and cloudy PD effluent for 2 days. She was started with vancomycin and imipenem empirically but did not improve even after 4 days. Pus cells were seen when PD fluid was examined microscopically. BACTEC culture of PD fluid isolated growth of Gram-positive cocci, which was confirmed as
    Conclusion: This is the first case report of
    Language English
    Publishing date 2019-04-23
    Publishing country England
    Document type Case Reports
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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