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  1. Article ; Online: A step closer to making the mother of stem cells.

    Pera, Martin F

    Nature

    2023  Volume 617, Issue 7962, Page(s) 683–684

    MeSH term(s) Stem Cells
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-022-01932-4
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  2. Article ; Online: Seven days in the life cycle of Homo sapiens.

    Pera, Martin F

    Cell

    2023  Volume 186, Issue 18, Page(s) 3755–3757

    Abstract: The second week of embryonic development is a critical phase of the human life cycle and one that has been largely inaccessible to scientific investigation. Recent studies of human embryo models built from stem cells promise to yield dramatic insights ... ...

    Abstract The second week of embryonic development is a critical phase of the human life cycle and one that has been largely inaccessible to scientific investigation. Recent studies of human embryo models built from stem cells promise to yield dramatic insights into the key events of cell specification and morphogenesis that occur during this brief window of embryogenesis.
    MeSH term(s) Female ; Pregnancy ; Animals ; Humans ; Embryo, Mammalian ; Embryonic Development ; Life Cycle Stages ; Morphogenesis ; Stem Cells
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.08.007
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  3. Article ; Online: Pluripotent cell states and unexpected fates.

    Pera, Martin F

    Stem cell reports

    2022  Volume 17, Issue 6, Page(s) 1235–1236

    Abstract: Pluripotent stem cells provide a powerful model for the study of human development and its disorders. Recent studies, including two in this issue of Stem Cell Reports, raise important questions concerning the developmental potential of human pluripotent ... ...

    Abstract Pluripotent stem cells provide a powerful model for the study of human development and its disorders. Recent studies, including two in this issue of Stem Cell Reports, raise important questions concerning the developmental potential of human pluripotent stem cells, and how the behavior of these cells in vitro mirrors normal embryogenesis.
    MeSH term(s) Cell Differentiation ; Embryonic Development ; Humans ; Pluripotent Stem Cells
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2022.05.011
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  4. Article ; Online: The exploration of pluripotency space: Charting cell state transitions in peri-implantation development.

    Pera, Martin F / Rossant, Janet

    Cell stem cell

    2021  Volume 28, Issue 11, Page(s) 1896–1906

    Abstract: Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in patterns of gene expression and developmental potential as they progress from pre-implantation through post-implantation stages of development. Recent studies of ... ...

    Abstract Pluripotent cells in the mammalian embryo undergo state transitions marked by changes in patterns of gene expression and developmental potential as they progress from pre-implantation through post-implantation stages of development. Recent studies of cultured mouse and human pluripotent stem cells (hPSCs) have identified cells representative of an intermediate stage (referred to as the formative state) between naive pluripotency (equivalent to pre-implantation epiblast) and primed pluripotency (equivalent to late post-implantation epiblast). We examine these recent findings in light of our knowledge of peri-implantation mouse and human development, and we consider the implications of this work for deriving human embryo models from pluripotent cells.
    MeSH term(s) Animals ; Cell Differentiation ; Embryo Implantation ; Embryo, Mammalian ; Germ Layers ; Humans ; Mice ; Pluripotent Stem Cells
    Language English
    Publishing date 2021-10-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2021.10.001
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  5. Article ; Online: The genetic basis of inter-individual variation in recovery from traumatic brain injury.

    Cortes, Daniel / Pera, Martin F

    NPJ Regenerative medicine

    2021  Volume 6, Issue 1, Page(s) 5

    Abstract: Traumatic brain injury (TBI) is one of the leading causes of death among young people, and is increasingly prevalent in the aging population. Survivors of TBI face a spectrum of outcomes from short-term non-incapacitating injuries to long-lasting serious ...

    Abstract Traumatic brain injury (TBI) is one of the leading causes of death among young people, and is increasingly prevalent in the aging population. Survivors of TBI face a spectrum of outcomes from short-term non-incapacitating injuries to long-lasting serious and deteriorating sequelae. TBI is a highly complex condition to treat; many variables can account for the observed heterogeneity in patient outcome. The limited success of neuroprotection strategies in the clinic has led to a new emphasis on neurorestorative approaches. In TBI, it is well recognized clinically that patients with similar lesions, age, and health status often display differences in recovery of function after injury. Despite this heterogeneity of outcomes in TBI, restorative treatment has remained generic. There is now a new emphasis on developing a personalized medicine approach in TBI, and this will require an improved understanding of how genetics impacts on long-term outcomes. Studies in animal model systems indicate clearly that the genetic background plays a role in determining the extent of recovery following an insult. A candidate gene approach in human studies has led to the identification of factors that can influence recovery. Here we review studies of the genetic basis for individual differences in functional recovery in the CNS in animals and man. The application of in vitro modeling with human cells and organoid cultures, along with whole-organism studies, will help to identify genes and networks that account for individual variation in recovery from brain injury, and will point the way towards the development of new therapeutic approaches.
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2057-3995
    ISSN (online) 2057-3995
    DOI 10.1038/s41536-020-00114-y
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  6. Article ; Online: Human embryo research and the 14-day rule.

    Pera, Martin F

    Development (Cambridge, England)

    2017  Volume 144, Issue 11, Page(s) 1923–1925

    Abstract: In many jurisdictions, restrictions prohibit the culture of human embryos beyond 14 days of development. However, recent reports describing the successful maintenance of ... ...

    Abstract In many jurisdictions, restrictions prohibit the culture of human embryos beyond 14 days of development. However, recent reports describing the successful maintenance of embryos
    MeSH term(s) Embryo Culture Techniques ; Embryo Research ; Embryo, Mammalian ; Embryonic Development ; Feasibility Studies ; Humans ; Models, Biological
    Language English
    Publishing date 2017--01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.151191
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    Ub I Zs.183: Show issues Location:
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  7. Article ; Online: Cancer Stem Cells: Notes for Authors.

    Eaves, Connie J / Pera, Martin F

    Stem cell reports

    2020  Volume 14, Issue 2, Page(s) 167–168

    Abstract: Stem Cell Reports frequently receives manuscripts dealing with the topic of cancer stem cells. Many of the submissions on this topic have major shortcomings in their content or limits to the conclusions that can be drawn from the results presented. The ... ...

    Abstract Stem Cell Reports frequently receives manuscripts dealing with the topic of cancer stem cells. Many of the submissions on this topic have major shortcomings in their content or limits to the conclusions that can be drawn from the results presented. The purpose of this Commentary is to highlight some of the underlying issues so that authors can enhance the strength of their research contributions.
    MeSH term(s) Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Humans ; Neoplastic Stem Cells/pathology ; Publishing
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2020.01.011
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  8. Article ; Online: The genetic basis of inter-individual variation in recovery from traumatic brain injury

    Daniel Cortes / Martin F. Pera

    npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-

    2021  Volume 9

    Abstract: Abstract Traumatic brain injury (TBI) is one of the leading causes of death among young people, and is increasingly prevalent in the aging population. Survivors of TBI face a spectrum of outcomes from short-term non-incapacitating injuries to long- ... ...

    Abstract Abstract Traumatic brain injury (TBI) is one of the leading causes of death among young people, and is increasingly prevalent in the aging population. Survivors of TBI face a spectrum of outcomes from short-term non-incapacitating injuries to long-lasting serious and deteriorating sequelae. TBI is a highly complex condition to treat; many variables can account for the observed heterogeneity in patient outcome. The limited success of neuroprotection strategies in the clinic has led to a new emphasis on neurorestorative approaches. In TBI, it is well recognized clinically that patients with similar lesions, age, and health status often display differences in recovery of function after injury. Despite this heterogeneity of outcomes in TBI, restorative treatment has remained generic. There is now a new emphasis on developing a personalized medicine approach in TBI, and this will require an improved understanding of how genetics impacts on long-term outcomes. Studies in animal model systems indicate clearly that the genetic background plays a role in determining the extent of recovery following an insult. A candidate gene approach in human studies has led to the identification of factors that can influence recovery. Here we review studies of the genetic basis for individual differences in functional recovery in the CNS in animals and man. The application of in vitro modeling with human cells and organoid cultures, along with whole-organism studies, will help to identify genes and networks that account for individual variation in recovery from brain injury, and will point the way towards the development of new therapeutic approaches.
    Keywords Medicine ; R
    Subject code 150
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: An ethical framework for human embryology with embryo models.

    Rivron, Nicolas C / Martinez Arias, Alfonso / Pera, Martin F / Moris, Naomi / M'hamdi, Hafez Ismaili

    Cell

    2023  Volume 186, Issue 17, Page(s) 3548–3557

    Abstract: A human embryo's legal definition and its entitlement to protection vary greatly worldwide. Recently, human pluripotent stem cells have been used to form in vitro models of early embryos that have challenged legal definitions and raised questions ... ...

    Abstract A human embryo's legal definition and its entitlement to protection vary greatly worldwide. Recently, human pluripotent stem cells have been used to form in vitro models of early embryos that have challenged legal definitions and raised questions regarding their usage. In this light, we propose a refined legal definition of an embryo, suggest "tipping points" for when human embryo models could eventually be afforded similar protection to that of embryos, and then revisit basic ethical principles that might help to draft a roadmap for the gradual, justified usage of embryo models in a manner that aims to maximize benefits to society.
    MeSH term(s) Humans ; Embryo, Mammalian ; Pluripotent Stem Cells ; Embryo Research/ethics
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.07.028
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  10. Article ; Online: A case for revisiting Nodal signaling in human pluripotent stem cells.

    Hayes, Kevin / Kim, Yun-Kyo / Pera, Martin F

    Stem cells (Dayton, Ohio)

    2021  Volume 39, Issue 9, Page(s) 1137–1144

    Abstract: Nodal is a transforming growth factor-β (TGF-β) superfamily member that plays a number of critical roles in mammalian embryonic development. Nodal is essential for the support of the peri-implantation epiblast in the mouse embryo and subsequently acts to ...

    Abstract Nodal is a transforming growth factor-β (TGF-β) superfamily member that plays a number of critical roles in mammalian embryonic development. Nodal is essential for the support of the peri-implantation epiblast in the mouse embryo and subsequently acts to specify mesendodermal fate at the time of gastrulation and, later, left-right asymmetry. Maintenance of human pluripotent stem cells (hPSCs) in vitro is dependent on Nodal signaling. Because it has proven difficult to prepare a biologically active form of recombinant Nodal protein, Activin or TGFB1 are widely used as surrogates for NODAL in hPSC culture. Nonetheless, the expression of the components of an endogenous Nodal signaling pathway in hPSC provides a potential autocrine pathway for the regulation of self-renewal in this system. Here we review recent studies that have clarified the role of Nodal signaling in pluripotent stem cell populations, highlighted spatial restrictions on Nodal signaling, and shown that Nodal functions in vivo as a heterodimer with GDF3, another TGF-β superfamily member expressed by hPSC. We discuss the role of this pathway in the maintenance of the epiblast and hPSC in light of these new advances.
    MeSH term(s) Animals ; Cell Differentiation/physiology ; Gene Expression Regulation, Developmental ; Humans ; Nodal Protein/genetics ; Nodal Protein/metabolism ; Pluripotent Stem Cells/metabolism ; Signal Transduction/physiology ; Transforming Growth Factor beta/metabolism
    Chemical Substances Nodal Protein ; Transforming Growth Factor beta
    Language English
    Publishing date 2021-05-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1143556-2
    ISSN 1549-4918 ; 1066-5099
    ISSN (online) 1549-4918
    ISSN 1066-5099
    DOI 10.1002/stem.3383
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