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  1. Article: [Human herpesvirus-6B encephalitis following allogeneic hematopoietic stem cell transplantation: how should it be managed?]

    Ogata, Masao

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2020  Volume 61, Issue 8, Page(s) 945–952

    Abstract: Human herpesvirus (HHV)-6B encephalitis has been increasingly recognized as an important central nervous system (CNS) complication after allogeneic hematopoietic stem cell transplantation. In this review, the best way to diagnose and treat this ... ...

    Abstract Human herpesvirus (HHV)-6B encephalitis has been increasingly recognized as an important central nervous system (CNS) complication after allogeneic hematopoietic stem cell transplantation. In this review, the best way to diagnose and treat this devastating complication is described. Diagnostic pitfalls: HHV-6B encephalitis should be diagnosed based on the presence of CNS symptoms, positive results for HHV-6 DNA in the cerebrospinal fluid (CSF), and exclusion of other causes of CNS symptoms. There are potential pitfalls when diagnosing HHV-6B encephalitis. Moreover, false-positive detection of HHV-6 DNA in the CSF can occur. Pleocytosis is observed in few patients, and CSF protein levels are often normal. Limbic encephalitis findings are not commonly detected through a brain MRI at the time of development. Prevention: Neither routine monitoring nor routine prophylactic antiviral therapy is recommended to prevent the development of HHV-6B encephalitis. Treatment: Empiric therapy should be started immediately after HHV-6B encephalitis is suspected. The Guideline Committee of the JSHCT recommends full-dose foscarnet (180 mg/kg/day) for the treatment of HHV-6B encephalitis. Therapeutic effect of anti-HHV6 therapy is assessed based on CNS symptoms and HHV-6 DNA in the CSF, which should be evaluated 1-2 weeks after initiating treatment. Even in patients exhibiting good therapeutic effects, antiviral treatment should be continued for at least 3 weeks.
    MeSH term(s) Encephalitis, Viral ; Foscarnet ; Hematopoietic Stem Cell Transplantation ; Herpesvirus 6, Human ; Humans ; Roseolovirus Infections ; Transplantation, Homologous
    Chemical Substances Foscarnet (364P9RVW4X)
    Language Japanese
    Publishing date 2020-09-09
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.61.945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Thermoelectric transport of type-I, II, and III massless Dirac fermions in two-dimensional lattice model

    Mizoguchi, Tomonari / Matsuura, Hiroyasu / Ogata, Masao

    2021  

    Abstract: We study longitudinal electric and thermoelectric transport coefficients of Dirac fermions on a simple lattice model where tuning of a single parameter enables us to change the type of Dirac cones from type-I to type-II. We pay particular attention to ... ...

    Abstract We study longitudinal electric and thermoelectric transport coefficients of Dirac fermions on a simple lattice model where tuning of a single parameter enables us to change the type of Dirac cones from type-I to type-II. We pay particular attention to the behavior of the critical situation, i.e., the type-III Dirac cone. We find that the transport coefficients of the type-III Dirac fermions behave as the limiting case of neither the type-I nor type-II. On the one hand, the qualitative behaviors of the type-III case are similar to those of the type-I case. On the other hand, the transport coefficients do not change monotonically upon increasing the tilting; namely, the largest thermoelectric response is obtained not for the type-III case but for the optimally tilted type-I case. For the optimal case, the sizable transport coefficients are obtained; for example, the dimensionless figure of merit is 0.18.

    Comment: 12 pages, 11 figures
    Keywords Condensed Matter - Materials Science ; Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Strongly Correlated Electrons
    Publishing date 2021-06-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Thrombophlebitis Migrans As the Prodrome of Adult T-Cell Leukemia-Lymphoma.

    Matsuda-Hirose, Haruna / Nashimoto, Yuko / Tanabe, Aki / Ogata, Masao / Iwao, Masao / Mizukami, Kazuhiro / Nishida, Haruto / Hatano, Yutaka

    Annals of dermatology

    2022  Volume 34, Issue 4, Page(s) 312–314

    Language English
    Publishing date 2022-08-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 1012662-4
    ISSN 2005-3894 ; 1013-9087
    ISSN (online) 2005-3894
    ISSN 1013-9087
    DOI 10.5021/ad.20.184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Seebeck Coefficient of Two-dimensional Dirac Electrons in Organic Conductor under Pressure

    Suzumura, Yoshikazu / Ogata, Masao

    2022  

    Abstract: The Seebeck coefficient, which is proportional to a ratio of the thermoelectric conductivity to electrical conductivity has been examined for Dirac electrons in the organic conductor $\alpha$-(BEDT-TTF)$_2$I$_3$ [BEDT-TTF denotes a molecule given by bis( ... ...

    Abstract The Seebeck coefficient, which is proportional to a ratio of the thermoelectric conductivity to electrical conductivity has been examined for Dirac electrons in the organic conductor $\alpha$-(BEDT-TTF)$_2$I$_3$ [BEDT-TTF denotes a molecule given by bis(ethylenedithio)tetrathiafulvalene] under a uniaxial pressure using a two-dimensional tight-binding model with both impurity and electron--phonon (e--p) scatterings. We calculate an anomalous temperature ($T$) dependence of the Seebeck coefficient $S_{\nu}$ with $\nu = x$ (perpendicular to the molecular stacking axis) and $y$, which shows $S_\nu > 0$ with a maximum at high temperatures and $S_{\nu} < 0$ with a minimum at low temperatures.The microscopic mechanism of such a sign change of $S_\nu$ is clarified in terms of the spectral conductivity. The result is compared with experiments on $\alpha$-(BEDT-TTF)$_2$I$_3$.

    Comment: 6 pages,4 figures
    Keywords Condensed Matter - Materials Science
    Publishing date 2022-11-02
    Publishing country us
    Document type Book ; Online
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  5. Article: [Human herpesvirus-6-associated diseases in hematopoietic stem cell transplantation: an update].

    Ogata, Masao

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2016  Volume 57, Issue 3, Page(s) 298–306

    Abstract: Human herpesvirus (HHV)-6 belongs to the Betaherpesvirinae subfamily of human herpesviruses. Primary HHV-6 infection commonly causes exanthem subitum. Like other herpesviruses, HHV-6 is capable of persisting in the host after the primary infection. Under ...

    Abstract Human herpesvirus (HHV)-6 belongs to the Betaherpesvirinae subfamily of human herpesviruses. Primary HHV-6 infection commonly causes exanthem subitum. Like other herpesviruses, HHV-6 is capable of persisting in the host after the primary infection. Under conditions of immunosuppression, latent HHV-6 can be reactivated. Between 30% and 70% of patients who undergo allogeneic hematopoietic cell transplantation (allo-HCT) experience HHV-6 reactivation at 2-4 weeks after transplantation. Accumulating evidence indicates that HHV-6 is an actual cause of encephalitis after allo-HCT. Risk factors for HHV-6 encephalitis include cord blood transplantation and an inflammatory milieu, which occurs in the early period after allo-HCT. Although HHV-6 encephalitis is associated with a poor prognosis, no validated treatments or preventative measures have as yet been established. HHV-6 reactivation may also cause myelitis, bone marrow suppression, lung disease, hepatitis, delirium, and graft-versus-host disease. However, such associations have not been consistently demonstrated and causality remains uncertain. This review updates the latest information regarding the clinical syndrome accompanying HHV-6 reactivation, with a particular focus on HHV-6 encephalitis, in the form of a series of questions and answers.
    MeSH term(s) Hematopoietic Stem Cell Transplantation/adverse effects ; Herpesvirus 6, Human/physiology ; Humans ; Risk Factors ; Roseolovirus Infections/etiology ; Transplantation, Homologous/adverse effects ; Virus Activation
    Language Japanese
    Publishing date 2016-03
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.57.298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Human herpesvirus-6 associated with hematopoietic stem cell transplantation].

    Ogata, Masao

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2015  Volume 56, Issue 10, Page(s) 2160–2169

    Abstract: Reactivation of human herpesvirus (HHV)-6B is a relatively common occurrence after allogeneic stem cell transplantation (SCT), and it is associated with the development of various post-transplant complications. HHV-6 encephalitis appears to be a ... ...

    Abstract Reactivation of human herpesvirus (HHV)-6B is a relatively common occurrence after allogeneic stem cell transplantation (SCT), and it is associated with the development of various post-transplant complications. HHV-6 encephalitis appears to be a significant, life-threatening complication caused by HHV-6B reactivation. HHV-6 encephalitis typically develops 2-6 weeks after SCT, and the symptoms are characterized by memory loss, seizures, and consciousness loss. Magnetic resonance imaging typically shows limbic encephalitis. Recent large-scale studies and a prospective study showed a similar incidence of HHV-6 encephalitis development, with 7.9-9.9% in cord blood transplant recipients and 0.5-1.2% in bone marrow or peripheral blood stem cell transplant recipients. Epidemiological studies suggest that post-transplant immune reactions such as GVHD, pre-engraftment immune reaction, or engraftment syndrome play important roles in the development of HHV-6 encephalitis. The mortality rate remains high, and even among survivors, many patients are left with serious neurological impairments, such as memory disturbance and seizures. Elucidation of the pathophysiology and establishment of appropriate prophylactic measures are necessary to overcome this serious complication. Besides encephalitis, associations between HHV-6 and various post-transplant complications have been reported, including pneumonitis, gastroenterocolitis, hepatitis, bone marrow suppression, and GVHD. Further investigations are needed to determine the role of HHV-6 in these complications.
    MeSH term(s) Encephalitis, Viral/virology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Herpesvirus 6, Human/physiology ; Humans ; Risk Factors ; Roseolovirus Infections/virology ; Virus Activation
    Language Japanese
    Publishing date 2015-10
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.56.2160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Human Herpesvirus-6 Encephalitis in Allogeneic Hematopoietic Stem Cell Transplantation].

    Ogata, Masao

    Brain and nerve = Shinkei kenkyu no shinpo

    2015  Volume 67, Issue 7, Page(s) 919–930

    Abstract: The reactivation of human herpesvirus-6B (HHV-6B) is common after allogeneic hematopoietic cell transplantation (allo-HCT), and it is sporadically associated with the development of HHV-6 encephalitis. HHV-6 encephalitis typically develops around 2-6 ... ...

    Abstract The reactivation of human herpesvirus-6B (HHV-6B) is common after allogeneic hematopoietic cell transplantation (allo-HCT), and it is sporadically associated with the development of HHV-6 encephalitis. HHV-6 encephalitis typically develops around 2-6 weeks after allo-HCT, and it is characterized by short-term memory loss. Magnetic resonance imaging typically shows bilateral signal abnormalities in the limbic system. The incidence of HHV-6 encephalitis is reportedly 0-11.6% after bone marrow or peripheral blood stem cell transplantation and 4.9-21.4% after cord blood transplantation. The mortality of HHV-6 encephalitis is high, and survivors are often left with serious sequelae. Antiviral therapy using foscarnet or ganciclovir is recommended for the treatment of HHV-6 encephalitis, but the efficacy of the currently available treatment is insufficient once HHV-6 encephalitis has developed. The elucidation of the pathogenesis of HHV-6 encephalitis and the establishment of preventative therapy are needed to overcome this disease.
    MeSH term(s) Encephalitis, Viral/drug therapy ; Encephalitis, Viral/prevention & control ; Encephalitis, Viral/virology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Herpesvirus 6, Human/physiology ; Humans ; Prognosis ; Risk Factors ; Roseolovirus Infections/drug therapy ; Roseolovirus Infections/prevention & control ; Roseolovirus Infections/virology ; Virus Activation
    Language Japanese
    Publishing date 2015-07
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416200231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Conference proceedings ; Online: International Workshop on Dirac Electrons in Solids 2015

    Ogata, Masao

    14 - 15 January 2015, Tokyo, Japan

    (Journal of physics : Conference series ; 603)

    2015  

    Event/congress International Workshop on Dirac Electrons in Solids (2015.01.14-15, Tokyo)
    Author's details organizing committee and editors Masao Ogata
    Series title Journal of physics : Conference series ; 603
    Language English
    Size Online-Ressource, Ill., graph. Darst.
    Publisher IOP Publ
    Publishing place Bristol
    Document type Book ; Conference proceedings ; Online
    Note Literaturangaben
    ISBN 9781510802636 ; 1510802630
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book ; Conference proceedings: International Workshop on Dirac Electrons in Solids 2015

    Ogata, Masao

    Tokyo, Japan, 14 - 15 January 2015

    (Journal of physics : Conference series ; 603)

    2015  

    Event/congress International Workshop on Dirac Electrons in Solids (2015.01.14-15, Tokyo)
    Author's details ed.: M. Ogata
    Series title Journal of physics : Conference series ; 603
    Language English
    Size 196 S., Ill., graph. Darst.
    Publisher Curran
    Publishing place Red Hook, NY
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 9781510802636 ; 1510802630
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article ; Online: An Alternative Approach to Determining Metabolic Syndrome Component Cutoffs in Children and Adolescents Using Segmental Regression Analysis.

    Miyazaki, Ayumi / Yoshinaga, Masao / Ogata, Hiromitsu / Ito, Yoshiya / Aoki, Machiko / Kubo, Toshihide / Shinomiya, Masaki / Horigome, Hitoshi / Tokuda, Masakuni / Lin, Lisheng / Takahashi, Hideto / Nagashima, Masami

    Circulation reports

    2024  Volume 6, Issue 4, Page(s) 118–126

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-09
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-24-0007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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