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  1. Article ; Online: Characterization of

    Yadav, Monika / Kumar, Tarun / Maurya, Ranjeet / Pandey, Rajesh / Chauhan, Nar Singh

    Frontiers in cellular and infection microbiology

    2023  Volume 12, Page(s) 1082674

    Abstract: ... ...

    Abstract Cellulomonas
    MeSH term(s) Humans ; Cellulomonas/genetics ; Cellulomonas/chemistry ; Sequence Analysis, DNA ; Caco-2 Cells ; Ecosystem ; Probiotics ; Glutens ; RNA, Ribosomal, 16S/genetics
    Chemical Substances Glutens (8002-80-0) ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.1082674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Protocol for Treatment of Oral Verrucous Carcinoma - A Systematic Review and Meta-Analysis.

    Pal, Uma Shanker / Maurya, Harshita / Yadav, Shailendra Kumar / Kumar, Vijay / Sowmya, Meleti Venkata / Singh, Ranjeet

    Annals of maxillofacial surgery

    2023  Volume 13, Issue 1, Page(s) 88–94

    Abstract: Background: The objective of this study is to provide a structured protocol for the treatment of verrucous carcinoma (VC) based on size, bone invasion, recurrence and whether neck dissection is necessary or not. In addition, the study evaluates the ... ...

    Abstract Background: The objective of this study is to provide a structured protocol for the treatment of verrucous carcinoma (VC) based on size, bone invasion, recurrence and whether neck dissection is necessary or not. In addition, the study evaluates the probability of a wrong histopathological diagnosis.
    Data sources: A search was conducted in the Cochrane Library, PubMed and Google from January 1962 to October 2022 by using MeSH terms and keywords. Studies reporting treatment modalities for VC and different histopathological diagnoses after excision of the lesion were selected except case reports and review articles.
    Study eligibility criteria: Thirteen articles were selected. Six hundred and thirty cases of VC were treated by surgery, surgery + neck dissection, radiotherapy, chemotherapy and combination therapy. Statistical analysis revealed surgical treatment as a preferred option. Despite being enlarged, the lymph node was negative for metastasis. So, in OVC cases neck dissection adds only unnecessary morbidity to patients.
    Participants and interventions: Radiotherapy or chemotherapy can be used to downstage the disease. 23.3% of cases reported wrong histopathology diagnosis.
    Study appraisal and synthesis methods: Patients treated for squamous cell carcinoma (SCC) will only experience unnecessary morbidity unless the correct diagnosis is made between VC and hybrid VC. Irrespective of size VC does not metastasise until there are no foci of SCC.
    Conclusions: Surgical excision of T1- and T2-sized lesions can be performed under local anaesthetic as a biopsy procedure. T3 or T4 lesion can be resected with a safe margin. If it comes as hybrid VC or VC with close margin (0.5 cm, <0.5 cm), neck dissection and further margin should be excised as a second procedure respectively.
    Language English
    Publishing date 2023-07-31
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2696991-9
    ISSN 2249-3816 ; 2231-0746
    ISSN (online) 2249-3816
    ISSN 2231-0746
    DOI 10.4103/ams.ams_65_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Isolation and Characterization of Human Intestinal Bacteria

    Yadav, Monika / Kumar, Tarun / Kanakan, Akshay / Maurya, Ranjeet / Pandey, Rajesh / Chauhan, Nar Singh

    Frontiers in microbiology

    2022  Volume 13, Page(s) 932795

    Abstract: Systemic characterization of the human gut microbiota highlighted its vast therapeutic potential. Despite having enormous potential, the non-availability of their culture representatives created a bottleneck to understand the concept of microbiome-based ... ...

    Abstract Systemic characterization of the human gut microbiota highlighted its vast therapeutic potential. Despite having enormous potential, the non-availability of their culture representatives created a bottleneck to understand the concept of microbiome-based therapeutics. The present study is aimed to isolate and evaluate the probiotic potential of a human gut isolate. Physiochemical, morphological, and phylogenetic characterization of a human gut isolate identifies it as a rod-shaped gram-negative microbe taxonomically affiliated with the
    Language English
    Publishing date 2022-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.932795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Centenary of Soil and Air Borne Wheat Karnal Bunt Disease Research: A Review.

    Iquebal, Mir Asif / Mishra, Pallavi / Maurya, Ranjeet / Jaiswal, Sarika / Rai, Anil / Kumar, Dinesh

    Biology

    2021  Volume 10, Issue 11

    Abstract: Karnal bunt (KB) of wheat ( ...

    Abstract Karnal bunt (KB) of wheat (
    Language English
    Publishing date 2021-11-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10111152
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  5. Article ; Online: Intertwined Dysregulation of Ribosomal Proteins and Immune Response Delineates SARS-CoV-2 Vaccination Breakthroughs.

    Maurya, Ranjeet / Shamim, Uzma / Mishra, Pallavi / Swaminathan, Aparna / Raina, Aakarshan / Tarai, Bansidhar / Budhiraja, Sandeep / Pandey, Rajesh

    Microbiology spectrum

    2023  Volume 11, Issue 3, Page(s) e0429222

    Abstract: Globally, COVID-19 vaccines have emerged as a boon, especially during the severe pandemic phases to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, saving millions of lives. However, mixed responses to ... ...

    Abstract Globally, COVID-19 vaccines have emerged as a boon, especially during the severe pandemic phases to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, saving millions of lives. However, mixed responses to vaccination with breakthrough challenges provided a rationale to explore the immune responses generated postvaccination, which plausibly alter the subsequent course of infection. In this regard, we comprehensively profiled the nasopharyngeal transcriptomic signature of double-dose-vaccinated individuals with breakthrough infections in comparison to unvaccinated infected persons. The vaccinated individuals demonstrated a gross downregulation of ribosomal proteins along with immune response genes and transcription/translational machinery that methodically modulated the entire innate immune landscape toward immune tolerance, a feature of innate immune memory. This coordinated response was orchestrated through 17 transcription factors captured as differentially expressed in the vaccination breakthroughs, including epigenetic modulators of
    MeSH term(s) Humans ; COVID-19 Vaccines ; SARS-CoV-2/genetics ; COVID-19/prevention & control ; Vaccination ; Immunity, Innate ; Breakthrough Infections
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.04292-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Co-evolution of SARS-CoV-2 variants and host immune response trajectories underlie COVID-19 pandemic to epidemic transition.

    Maurya, Ranjeet / Swaminathan, Aparna / Shamim, Uzma / Arora, Smriti / Mishra, Pallavi / Raina, Aakarshan / Ravi, Varsha / Tarai, Bansidhar / Budhiraja, Sandeep / Pandey, Rajesh

    iScience

    2023  Volume 26, Issue 12, Page(s) 108336

    Abstract: COVID-19 pandemic saw emergence of multiple SAR-CoV-2 variants. Exacerbated risk of severe outcome and hospital admissions led us to comprehend differential host-immune kinetics associated with SARS-CoV-2 variants. Longitudinal investigation was ... ...

    Abstract COVID-19 pandemic saw emergence of multiple SAR-CoV-2 variants. Exacerbated risk of severe outcome and hospital admissions led us to comprehend differential host-immune kinetics associated with SARS-CoV-2 variants. Longitudinal investigation was conducted through different time periods of Pre-VOC and VOCs (Delta & Omicron) mapping host transcriptome features. Robust antiviral type-1 interferon response marked Omicron infection, which was largely missing during Pre-VOC and Delta waves. SARS-CoV-2-host protein-protein interactions and docking complexes highlighted N protein to interact with HNRNPA1 in Pre-VOC, demonstrating its functional role for enhanced viral replication. Omicron revealed enhanced binding efficiency of LARP1 to N protein, probably potentiating antiviral effects of LARP1. Differential expression of zinc finger protein genes, especially in Omicron, mechanistically support induction of strong IFN (Interferon) response, thereby strengthening early viral clearance. Study highlights eventual adaptation of host to immune activation patterns that interrupt virus evolution with enhanced immune-evasion mutations and counteraction mechanisms, delimiting the next phase of COVID-19 pandemic.
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Co-evolution of SARS-CoV-2 variants and host immune response trajectories underlie COVID-19 pandemic to epidemic transition

    Ranjeet Maurya / Aparna Swaminathan / Uzma Shamim / Smriti Arora / Pallavi Mishra / Aakarshan Raina / Varsha Ravi / Bansidhar Tarai / Sandeep Budhiraja / Rajesh Pandey

    iScience, Vol 26, Iss 12, Pp 108336- (2023)

    2023  

    Abstract: Summary: COVID-19 pandemic saw emergence of multiple SAR-CoV-2 variants. Exacerbated risk of severe outcome and hospital admissions led us to comprehend differential host-immune kinetics associated with SARS-CoV-2 variants. Longitudinal investigation was ...

    Abstract Summary: COVID-19 pandemic saw emergence of multiple SAR-CoV-2 variants. Exacerbated risk of severe outcome and hospital admissions led us to comprehend differential host-immune kinetics associated with SARS-CoV-2 variants. Longitudinal investigation was conducted through different time periods of Pre-VOC and VOCs (Delta & Omicron) mapping host transcriptome features. Robust antiviral type-1 interferon response marked Omicron infection, which was largely missing during Pre-VOC and Delta waves. SARS-CoV-2-host protein-protein interactions and docking complexes highlighted N protein to interact with HNRNPA1 in Pre-VOC, demonstrating its functional role for enhanced viral replication. Omicron revealed enhanced binding efficiency of LARP1 to N protein, probably potentiating antiviral effects of LARP1. Differential expression of zinc finger protein genes, especially in Omicron, mechanistically support induction of strong IFN (Interferon) response, thereby strengthening early viral clearance. Study highlights eventual adaptation of host to immune activation patterns that interrupt virus evolution with enhanced immune-evasion mutations and counteraction mechanisms, delimiting the next phase of COVID-19 pandemic.
    Keywords Health sciences ; Medicine ; Virology ; Science ; Q
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Draft genome sequence and functional analysis of Lysinibacillus

    Phazna, T A / Ngashangva, N G / Yentrembam, Randhir-Babu Singh / Maurya, Ranjeet / Mukherjee, Pulok / Sharma, Chandradev / Verma, Praveen K / Sarangthem, Indira

    Journal of biosciences

    2022  Volume 47

    Abstract: Capsicum chinense is the chilli species containing the highest amount of capsaicin, and is an important traditional spice crop of Northeast India. Capsaicinoids derived ... ...

    Abstract Capsicum chinense is the chilli species containing the highest amount of capsaicin, and is an important traditional spice crop of Northeast India. Capsaicinoids derived from
    MeSH term(s) Agrochemicals/metabolism ; Bacillaceae ; Bacteria/genetics ; Bacteriocins/metabolism ; Capsaicin/metabolism ; Capsicum/metabolism ; Humans ; Pesticides ; Plant Diseases/microbiology ; Plant Diseases/prevention & control ; Polyketides/metabolism ; Rhizosphere ; Siderophores ; Soil ; Soil Microbiology ; Terpenes/metabolism
    Chemical Substances Agrochemicals ; Bacteriocins ; Pesticides ; Polyketides ; Siderophores ; Soil ; Terpenes ; Capsaicin (S07O44R1ZM)
    Language English
    Publishing date 2022-10-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 756157-x
    ISSN 0973-7138 ; 0250-5991
    ISSN (online) 0973-7138
    ISSN 0250-5991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1907: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Infection outcome needs two to tango: human host and the pathogen.

    Maurya, Ranjeet / Kanakan, Akshay / Vasudevan, Janani Srinivasa / Chattopadhyay, Partha / Pandey, Rajesh

    Briefings in functional genomics

    2021  Volume 21, Issue 2, Page(s) 90–102

    Abstract: Infectious diseases are potential drivers for human evolution, through a complex, continuous and dynamic interaction between the host and the pathogen/s. It is this dynamic interaction that contributes toward the clinical outcome of a pathogenic disease. ...

    Abstract Infectious diseases are potential drivers for human evolution, through a complex, continuous and dynamic interaction between the host and the pathogen/s. It is this dynamic interaction that contributes toward the clinical outcome of a pathogenic disease. These are modulated by contributions from the human genetic variants, transcriptional response (including noncoding RNA) and the pathogen's genome architecture. Modern genomic tools and techniques have been crucial for the detection and genomic characterization of pathogens with respect to the emerging infectious diseases. Aided by next-generation sequencing (NGS), risk stratification of host population/s allows for the identification of susceptible subgroups and better disease management. Nevertheless, many challenges to a general understanding of host-pathogen interactions remain. In this review, we elucidate how a better understanding of the human host-pathogen interplay can substantially enhance, and in turn benefit from, current and future applications of multi-omics based approaches in infectious and rare diseases. This includes the RNA-level response, which modulates the disease severity and outcome. The need to understand the role of human genetic variants in disease severity and clinical outcome has been further highlighted during the Coronavirus disease 2019 (COVID-19) pandemic. This would enhance and contribute toward our future pandemic preparedness.
    MeSH term(s) COVID-19/genetics ; Genomics/methods ; High-Throughput Nucleotide Sequencing ; Host-Pathogen Interactions/genetics ; Humans ; Pandemics
    Language English
    Publishing date 2021-07-07
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2540916-5
    ISSN 2041-2657 ; 2041-2649 ; 2041-2647
    ISSN (online) 2041-2657
    ISSN 2041-2649 ; 2041-2647
    DOI 10.1093/bfgp/elab037
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6076: Show issues Location:
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  10. Article ; Online: Early transcriptomic host response signatures in the serum of dengue patients provides insights into clinical pathogenesis and disease severity.

    Yadav, Aanchal / Shamim, Uzma / Ravi, Varsha / Devi, Priti / Kumari, Pallawi / Maurya, Ranjeet / Das, Poonam / Somani, Madhuri / Budhiraja, Sandeep / Tarai, Bansidhar / Pandey, Rajesh

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 14170

    Abstract: Dengue virus (DENV), known to cause viral infection, belongs to the family Flaviviridae, having four serotypes (DENV1-4) that spreads by the bite of the Aedes aegypti mosquito. India has been suffering from dengue outbreaks annually with widespread ... ...

    Abstract Dengue virus (DENV), known to cause viral infection, belongs to the family Flaviviridae, having four serotypes (DENV1-4) that spreads by the bite of the Aedes aegypti mosquito. India has been suffering from dengue outbreaks annually with widespread epidemics by prevalence of all the four DENV serotypes. The diverse spectrum of clinical manifestations in dengue infection, mild to severe forms, makes the need of timely diagnosis and prompt treatment an essence. The identification of a dengue host response signature in serum can increase the understanding of dengue pathogenesis since most dengue NS1 Ag tests have been developed and evaluated in serum samples. Here, to understand the same, we undertook a dual RNA-sequencing (RNA-Seq) based approach from the serum samples of dengue-infected patients. The results thus yield the early transcriptional signatures that discriminated the high viral reads patients from patients who had low dengue viral reads. We identified a significant upregulation of two sets of genes, key antiviral (IFIT3, RSAD2, SAT1) and vascular dysfunction (TNFS10, CXCL8) related genes in the high viral reads group. Deeper delving of this gene profile revealed a unique two-way response, where the antiviral genes can mediate the disease course to mild, contrarily the increased expression of the other gene set might act as pointers of severe disease course. Further, we explored the hematologic parameters from the complete blood count (CBC), which suggests that lymphocytes (low) and neutrophils (high) might serve as an early predictor of prognosis in dengue infection. Collectively, our findings give insights into the foundation for further investigation of the early host response using the RNA isolated from dengue patients' serum samples and opens the door for careful monitoring of the early clinical and transcriptome profiles for management of the dengue patients.
    MeSH term(s) Animals ; Humans ; Transcriptome ; Patient Acuity ; Aedes/genetics ; Antiviral Agents ; Dengue/genetics
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-41205-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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