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  1. Article ; Online: Human immune responses in cryptosporidiosis.

    Borad, Anoli / Ward, Honorine

    Future microbiology

    2010  Volume 5, Issue 3, Page(s) 507–519

    Abstract: Immune responses play a critical role in protection from, and resolution of, cryptosporidiosis. However, the nature of these responses, particularly in humans, is not completely understood. Both innate and adaptive immune responses are important. Innate ... ...

    Abstract Immune responses play a critical role in protection from, and resolution of, cryptosporidiosis. However, the nature of these responses, particularly in humans, is not completely understood. Both innate and adaptive immune responses are important. Innate immune responses may be mediated by Toll-like receptor pathways, antimicrobial peptides, prostaglandins, mannose-binding lectin, cytokines and chemokines. Cell-mediated responses, particularly those involving CD4(+) T cells and IFN-gamma play a dominant role. Mucosal antibody responses may also be involved. Proteins mediating attachment and invasion may serve as putative protective antigens. Further knowledge of human immune responses in cryptosporidiosis is essential in order to develop targeted prophylactic and therapeutic interventions. This review focuses on recent advances and future prospects in the understanding of human immune responses to Cryptosporidium infection.
    MeSH term(s) Adaptive Immunity ; Animals ; Cryptosporidiosis/immunology ; Cryptosporidiosis/prevention & control ; Cryptosporidiosis/therapy ; Cryptosporidium/immunology ; Humans ; Immunity, Cellular ; Immunity, Innate ; Immunity, Mucosal ; Protozoan Vaccines/immunology
    Chemical Substances Protozoan Vaccines
    Language English
    Publishing date 2010-02-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb.09.128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Antibody responses to the immunodominant Cryptosporidium gp15 antigen and gp15 polymorphisms in a case-control study of cryptosporidiosis in children in Bangladesh.

    Allison, Genève M / Rogers, Kathleen A / Borad, Anoli / Ahmed, Sabeena / Karim, Mohammad Mahbubul / Kane, Anne V / Hibberd, Patricia L / Naumova, Elena N / Calderwood, Stephen B / Ryan, Edward T / Khan, Wasif A / Ward, Honorine D

    The American journal of tropical medicine and hygiene

    2011  Volume 85, Issue 1, Page(s) 97–104

    Abstract: Although Cryptospridium hominis is the dominant Cryptosporidium species infecting humans, immune responses to cognate antigens in C. hominis-infected persons have not been reported. We investigated antibody responses to the immunodominant gp15 antigen ... ...

    Abstract Although Cryptospridium hominis is the dominant Cryptosporidium species infecting humans, immune responses to cognate antigens in C. hominis-infected persons have not been reported. We investigated antibody responses to the immunodominant gp15 antigen from C. hominis and C. parvum, in C. hominis-infected Bangladeshi children less than five years of age with diarrhea (cases) and uninfected children with diarrhea (controls). We also investigated polymorphisms in the C. hominis gp15 sequence from cases. Serum IgG responses to gp15 from both species were significantly greater in cases than controls. In spite of polymorphisms in the gp15 sequence, there was a significant correlation between antibody levels to gp15 from both species, indicating cross-reactivity to conserved epitopes. Cases with acute diarrhea had a significantly greater serum IgA response to gp15 compared with those with persistent diarrhea, suggesting that this response may be associated with protection from prolonged disease. These findings support further investigation of gp15 as a vaccine candidate.
    MeSH term(s) Animals ; Antibodies, Protozoan/biosynthesis ; Antigens, Protozoan/genetics ; Antigens, Protozoan/immunology ; Bangladesh ; Case-Control Studies ; Child, Preschool ; Cryptosporidiosis/immunology ; Cryptosporidium/immunology ; Diarrhea/immunology ; Diarrhea/parasitology ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin G/biosynthesis ; Infant ; Infant, Newborn ; Polymorphism, Genetic
    Chemical Substances Antibodies, Protozoan ; Antigens, Protozoan ; Immunoglobulin G
    Language English
    Publishing date 2011-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.2011.11-0043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Systemic antibody responses to the immunodominant p23 antigen and p23 polymorphisms in children with cryptosporidiosis in Bangladesh.

    Borad, Anoli J / Allison, Geneve M / Wang, David / Ahmed, Sabeena / Karim, Mohammad M / Kane, Anne V / Moy, Joy / Hibberd, Patricia L / Ajjampur, Sitara Swarna Rao / Kang, Gagandeep / Calderwood, Stephen B / Ryan, Edward T / Naumova, Elena / Khan, Wasif A / Ward, Honorine D

    The American journal of tropical medicine and hygiene

    2012  Volume 86, Issue 2, Page(s) 214–222

    Abstract: Cryptosporidium is a major cause of diarrhea in children in developing countries. However, there is no vaccine available and little is known about immune responses to protective antigens. We investigated antibody responses to p23, a putative vaccine ... ...

    Abstract Cryptosporidium is a major cause of diarrhea in children in developing countries. However, there is no vaccine available and little is known about immune responses to protective antigens. We investigated antibody responses to p23, a putative vaccine candidate, in children in Bangladesh with cryptosporidiosis and diarrhea (cases) and uninfected children with diarrhea (controls), and p23 gene polymorphisms in infecting species. Serum IgM, IgG, and IgA responses to p23 were significantly greater in cases than controls after three weeks of follow-up. Cases with acute diarrhea had significantly greater serum IgA and IgM responses than those with persistent diarrhea, which suggested an association with protection from prolonged disease. The p23 sequences were relatively conserved among infecting species and subtype families. Although most children were infected with Cryptosporidium hominis, there was a cross-reactive antibody response to C. parvum antigen. These results support further development of p23 as a vaccine candidate.
    MeSH term(s) Acute Disease ; Adolescent ; Amino Acid Sequence ; Antibodies, Protozoan/blood ; Antibody Formation ; Antigens, Protozoan/genetics ; Antigens, Protozoan/immunology ; Bangladesh/epidemiology ; Case-Control Studies ; Child ; Cryptosporidiosis/epidemiology ; Cryptosporidiosis/immunology ; Cryptosporidium/pathogenicity ; Cryptosporidium parvum/pathogenicity ; Diarrhea/complications ; Diarrhea/immunology ; Diarrhea/parasitology ; Female ; Follow-Up Studies ; Humans ; Immunodominant Epitopes/immunology ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Male ; Molecular Sequence Data ; Polymorphism, Single Nucleotide ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Sequence Alignment/methods ; Sequence Analysis, DNA
    Chemical Substances Antibodies, Protozoan ; Antigens, Protozoan ; Immunodominant Epitopes ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Recombinant Proteins
    Language English
    Publishing date 2012-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.2012.11-0273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.61: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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