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Article ; Online: Resolving Multielement Semiconductor Nanocrystals at the Atomic Level: Complete Deciphering of Domains and Order in Complex Cu

Ren, Huan / Sun, Yuanwei / Hoffmann, Frank / Vandichel, Matthias / Adegoke, Temilade E / Liu, Ning / McCarthy, Conor / Gao, Peng / Ryan, Kevin M

Nano letters

2024 Volume 24, Issue 7, Page(s) 2125–2130

Abstract: Semiconductor nanocrystals (NCs) with high elemental and structural complexity can be engineered to tailor for electronic, photovoltaic, thermoelectric, and battery applications etc. However, this greater complexity causes ambiguity in the atomic ... ...

Abstract	Semiconductor nanocrystals (NCs) with high elemental and structural complexity can be engineered to tailor for electronic, photovoltaic, thermoelectric, and battery applications etc. However, this greater complexity causes ambiguity in the atomic structure understanding. This in turn hinders the mechanistic studies of nucleation and growth, the theoretical calculations of functional properties, and the capability to extend functional design across complementary semiconductor nanocrystals. Herein, we successfully deciphered the atomic arrangements of 4 different nanocrystal domains in Cu
Language	English
Publishing date	2024-02-11
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.3c02810
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Article ; Online: Influenza A Virus Uses PSMA2 for Downregulation of the NRF2-Mediated Oxidative Stress Response.

Rashid, Mahamud-Ur / Gao, Ang / Coombs, Kevin M

Journal of virology

2022 Volume 96, Issue 5, Page(s) e0199021

Abstract: Influenza A virus (IAV), an obligatory intracellular parasite, uses host cellular molecules to complete its replication cycle and suppress immune responses. Proteasome subunit alpha type 2 (PSMA2) is a cellular protein highly expressed in IAV-infected ... ...

Abstract	Influenza A virus (IAV), an obligatory intracellular parasite, uses host cellular molecules to complete its replication cycle and suppress immune responses. Proteasome subunit alpha type 2 (PSMA2) is a cellular protein highly expressed in IAV-infected human lung epithelial A549 cells. PSMA2 is part of the 20S proteasome complex that degrades or recycles defective proteins and involves proteolytic modification of many cellular regulatory proteins. However, the role of PSMA2 in IAV replication is not well understood. In this study, PSMA2 knockdown (KD) in A549 cells caused a significant reduction in extracellular progeny IAV, but intracellular viral protein translation and viral RNA transcription were not affected. This indicates that PSMA2 is a critical host factor for IAV maturation. To better understand the interplay between PSMA2 KD and IAV infection at the proteomic level, we used the SomaScan 1.3K version, which measures 1,307 proteins to analyze alterations induced by these treatments. We found seven cellular signaling pathways, including phospholipase C signaling, Pak signaling, and nuclear factor erythroid 2p45-related factor 2 (NRF2)-mediated oxidative stress response signaling, that were inhibited by IAV infection but significantly activated by PSMA2 KD. Further analysis of NRF2-mediated oxidative stress response signaling indicated IAV inhibits accumulation of reactive oxygen species (ROS), but ROS levels significantly increased during IAV infection in PSMA2 KD cells. However, IAV infection caused significantly higher NFR2 nuclear translocation that was inhibited in PSMA2 KD cells. This indicates that PSMA2 is required for NRF2-mediated ROS neutralization and that IAV uses PSMA2 to escape viral clearance via the NRF2-mediated cellular oxidative response.
MeSH term(s)	Down-Regulation ; Host-Pathogen Interactions/genetics ; Humans ; Immune Evasion/genetics ; Influenza A virus/genetics ; Influenza A virus/immunology ; Influenza, Human/immunology ; Influenza, Human/virology ; NF-E2-Related Factor 2/genetics ; Oxidative Stress ; Proteasome Endopeptidase Complex/genetics ; Proteasome Endopeptidase Complex/metabolism ; Proteomics ; Reactive Oxygen Species/metabolism ; Virus Replication/genetics
Chemical Substances	NF-E2-Related Factor 2 ; Reactive Oxygen Species ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2022-01-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01990-21
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Article ; Online: Efficient Cu

Xia, Meng / Pan, Linfeng / Liu, Yongpeng / Gao, Jing / Li, Jun / Mensi, Mounir / Sivula, Kevin / Zakeeruddin, Shaik M / Ren, Dan / Grätzel, Michael

Journal of the American Chemical Society

2023 Volume 145, Issue 51, Page(s) 27939–27949

Abstract: Photoelectrochemical carbon dioxide reduction (PEC- ... ...

Abstract	Photoelectrochemical carbon dioxide reduction (PEC-CO
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c06146
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Article ; Online: The N-terminal intrinsically disordered region of Ncb5or docks with the cytochrome b

Benson, David R / Deng, Bin / Kashipathy, Maithri M / Lovell, Scott / Battaile, Kevin P / Cooper, Anne / Gao, Philip / Fenton, Aron W / Zhu, Hao

Proteins

2023 Volume 92, Issue 4, Page(s) 554–566

Abstract: NADH cytochrome ... ...

Abstract	NADH cytochrome b
MeSH term(s)	Animals ; Humans ; Cytochromes b ; NAD ; Cytochrome-B(5) Reductase/chemistry ; Oxidoreductases ; Heme/chemistry
Chemical Substances	Cytochromes b (9035-37-4) ; NAD (0U46U6E8UK) ; Cytochrome-B(5) Reductase (EC 1.6.2.2) ; Oxidoreductases (EC 1.-) ; Heme (42VZT0U6YR)
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	806683-8
ISSN	1097-0134 ; 0887-3585
ISSN (online)	1097-0134
ISSN	0887-3585
DOI	10.1002/prot.26647
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Article ; Online: Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration.

Gao, Kevin MingJie / Chiang, Kristy / Jiang, Zhaozhao / Korkmaz, Filiz T / Janardhan, Harish P / Trivedi, Chinmay M / Quinton, Lee J / Gingras, Sebastien / Fitzgerald, Katherine A / Marshak-Rothstein, Ann

Cell reports

2024 Volume 43, Issue 4, Page(s) 114114

Abstract: Patients afflicted with Stimulator of interferon gene (STING) gain-of-function mutations frequently present with debilitating interstitial lung disease (ILD) that is recapitulated in mice expressing the ... ...

Abstract	Patients afflicted with Stimulator of interferon gene (STING) gain-of-function mutations frequently present with debilitating interstitial lung disease (ILD) that is recapitulated in mice expressing the STING
MeSH term(s)	Animals ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Gain of Function Mutation ; Mice ; Lung/pathology ; Lung/metabolism ; Lymphocytes/metabolism ; Lung Diseases, Interstitial/pathology ; Lung Diseases, Interstitial/genetics ; Lung Diseases, Interstitial/metabolism ; Mice, Inbred C57BL ; Humans
Chemical Substances	Membrane Proteins ; Sting1 protein, mouse
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.114114
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Article ; Online: Highly Efficient Inverted Light-Emitting Diodes Based on Vertically Aligned CdSe/CdS Nanorod Layers Fabricated by Electrophoretic Deposition.

Zhang, Yongliang / Pham, Xuan-Manh / Keating, Thomas / Jia, Na / Mullen, Anthony / Laishram, Devika / Gao, Mei-Yan / Corbett, Brian / Liu, Pai / Sun, Xiao Wei / Soulimane, Tewfik / Silien, Christophe / Ryan, Kevin M / Ma, Zhenhui / Liu, Ning

ACS applied materials & interfaces

2024 Volume 16, Issue 8, Page(s) 10459–10467

Abstract: ... fabricated yields an external quantum efficiency (EQE) of 6.3% and a maximum luminance of 4320 cd/m ...

Abstract	Inverted colloidal-nanocrystal-based LEDs (NC-LEDs) are highly interesting and invaluable for large-scale display technology and flexible electronics. Semiconductor nanorods (NRs), in addition to the tunable wavelengths of the emitted light (achieved, for example, by the variation of the NR diameter or the diameter of core in a core-shell configuration), also exhibit linearly polarized emission, a larger Stokes shift, faster radiative decay, and slower bleaching kinetics than quantum dots (QDs). Despite these advantages, it is difficult to achieve void-free active NR layers using simple spin-coating techniques. Herein, we employ electrophoretic deposition (EPD) to make closely packed, vertically aligned CdSe/CdS core/shell nanorods (NRs) as the emissive layer. Following an inverted architecture, the device fabricated yields an external quantum efficiency (EQE) of 6.3% and a maximum luminance of 4320 cd/m
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c15542
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Article ; Online: RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge-like alcohol consumption in mice.

DeBaker, Margot C / Mitten, Eric H / Rose, Timothy R / Marron Fernandez de Velasco, Ezequiel / Gao, Runbo / Lee, Anna M / Wickman, Kevin

British journal of pharmacology

2023 Volume 180, Issue 16, Page(s) 2140–2155

Abstract: Background and purpose: Drugs of abuse, including alcohol, increase dopamine in the mesocorticolimbic system via actions on dopamine neurons in the ventral tegmental area (VTA). Increased dopamine transmission can activate inhibitory G protein ... ...

Abstract	Background and purpose: Drugs of abuse, including alcohol, increase dopamine in the mesocorticolimbic system via actions on dopamine neurons in the ventral tegmental area (VTA). Increased dopamine transmission can activate inhibitory G protein signalling pathways in VTA dopamine neurons, including those controlled by GABA Experimental approach: We used molecular, electrophysiological and genetic approaches to probe the impact of RGS6 on inhibitory G protein signalling in VTA dopamine neurons and on binge-like alcohol consumption in mice. Key results: RGS6 is expressed in adult mouse VTA dopamine neurons and it modulates inhibitory G protein signalling in a receptor-dependent manner, tempering D Conclusions and implications: RGS6 negatively regulates GABA
MeSH term(s)	Animals ; Female ; Mice ; Alcohol Drinking ; Dopamine/metabolism ; Dopaminergic Neurons/metabolism ; gamma-Aminobutyric Acid/metabolism ; Signal Transduction ; Ventral Tegmental Area/metabolism ; Male
Chemical Substances	Dopamine (VTD58H1Z2X) ; gamma-Aminobutyric Acid (56-12-2) ; Rgs6 protein, mouse
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.16071
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Article ; Online: Preoperative Hemodynamics Impact the Benefit of Fenestration on Fontan Postoperative Length of Stay.

Hill, Garick D / Wu, Danny T Y / Ferguson, M Eric / Flores, Saul / Ginde, Salil / Hill, Kevin D / Johansen, Michael / Newburger, Jane W / Gao, Zhiqian / Cnota, James F

JACC. Advances

2024 Volume 3, Issue 3

Abstract: Background: Utilization of Fontan fenestration varies considerably by center.: Objectives: Using a multicenter Pediatric Heart Network dataset linking surgical and preoperative hemodynamic variables, the authors evaluated factors associated with use ... ...

Abstract	Background: Utilization of Fontan fenestration varies considerably by center. Objectives: Using a multicenter Pediatric Heart Network dataset linking surgical and preoperative hemodynamic variables, the authors evaluated factors associated with use of Fontan fenestration and the impact of fenestration on post-Fontan length of stay (LOS). Methods: Patients 2 to 6 years old at Fontan surgery from 2010 to 2020 with catheterization<1 year prior were included. Factors associated with fenestration were evaluated using multivariable logistic regression adjusting for key covariates. Restrictive cubic spline analysis was used to evaluate potential cut-points for hemodynamic variables associated with longer postoperative LOS stratified by fenestration with multivariable linear regression to evaluate the magnitude of effect. Results: Fenestration was used in 465 of 702 patients (66.2%). Placement of a fenestration was associated with center (range 27%-93% use, Conclusions: There is wide center variability in use of Fontan fenestration that is not explained by preoperative hemodynamics. Fenestration is independently associated with shorter LOS, and those with mPAP ≥13 mm Hg at pre-Fontan catheterization benefit the most. We propose this threshold as minimal criteria for fenestration.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ISSN	2772-963X
ISSN (online)	2772-963X
DOI	10.1016/j.jacadv.2024.100846
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Article ; Online: Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome.

Sher, Affan Ali / Gao, Ang / Coombs, Kevin M

Cells

2020 Volume 9, Issue 4

Abstract: Autophagy is a key cellular process that involves constituent degradation and recycling during cellular development and homeostasis. Autophagy also plays key roles in antimicrobial host defense and numerous pathogenic organisms have developed strategies ... ...

Abstract	Autophagy is a key cellular process that involves constituent degradation and recycling during cellular development and homeostasis. Autophagy also plays key roles in antimicrobial host defense and numerous pathogenic organisms have developed strategies to take advantage of and/or modulate cellular autophagy. Several pharmacologic compounds, such as BafilomycinA1, an autophagy inducer, and Rapamycin, an autophagy inhibitor, have been used to modulate autophagy, and their effects upon notable autophagy markers, such as LC3 protein lipidation and Sequestosome-1/p62 alterations are well defined. We sought to understand whether such autophagy modulators have a more global effect upon host cells and used a recently developed aptamer-based proteomic platform (SOMAscan
MeSH term(s)	Astrocytes/cytology ; Astrocytes/drug effects ; Astrocytes/metabolism ; Astrocytoma/genetics ; Astrocytoma/pathology ; Autophagy/drug effects ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cytokines/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Macrolides/pharmacology ; Microtubule-Associated Proteins/metabolism ; Proteome/metabolism ; Sequestosome-1 Protein/metabolism ; Sirolimus/pharmacology
Chemical Substances	Biomarkers, Tumor ; Cytokines ; MAP1LC3A protein, human ; Macrolides ; Microtubule-Associated Proteins ; Proteome ; SQSTM1 protein, human ; Sequestosome-1 Protein ; bafilomycin A1 (88899-55-2) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2020-03-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9040805
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Article ; Online: Increased Donnan exclusion in charged polymer networks at high salt concentrations.

Gao, Kevin W / Yu, Xiaopeng / Darling, Robert M / Newman, John / Balsara, Nitash P

Soft matter

2022 Volume 18, Issue 2, Page(s) 282–292

Abstract: The swelling of univalent and multivalent charged polymeric networks in electrolytic solutions is studied using a classical thermodynamic model. Such systems were first modeled by Donnan, who derived an expression for the chemical potential of the ions ... ...

Abstract	The swelling of univalent and multivalent charged polymeric networks in electrolytic solutions is studied using a classical thermodynamic model. Such systems were first modeled by Donnan, who derived an expression for the chemical potential of the ions by introducing an electric potential that is commonly referred to as the Donnan potential. This well-established theory leads to a simple quadratic relationship for the partitioning of ions between the network and the external solution. When the concentration of fixed charges in the swollen gel is large enough, the electrolyte in the external solution is "excluded" from the gel (commonly referred to as Donnan exclusion). In the standard Donnan theory, and in virtually all subsequent theories, the magnitude of Donnan exclusion decreases with increasing electrolyte concentration in the external solution. Our model predicts this is not necessarily true; we show that the magnitude of Donnan exclusion increases with increasing electrolyte concentration over a broad range of parameter space (average chain length between crosslinks, fraction of charged monomers in the network, the nature of the interactions between the ions, solvent molecules and polymer chains, and ion concentration in the external solution). We also present explicit bounds for the validity of Donnan's original theory. Model predictions are compared to simulations and experimental data obtained for a cationic gel immersed in electrolytic solutions of salts containing univalent and bivalent cations.
Language	English
Publishing date	2022-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/d1sm01511g
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