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Article ; Online: Novel BRICHOS-Related Antimicrobial Peptides from the Marine Worm

Panteleev, Pavel V / Safronova, Victoria N / Duan, Shuting / Komlev, Alexey S / Bolosov, Ilia A / Kruglikov, Roman N / Kombarova, Tatiana I / Korobova, Olga V / Pereskokova, Eugenia S / Borzilov, Alexander I / Dyachenko, Igor A / Shamova, Olga V / Huang, Yu / Shi, Qiong / Ovchinnikova, Tatiana V

Marine drugs

2023 Volume 21, Issue 12

Abstract: Marine polychaetes represent an extremely rich and underexplored source of novel families of antimicrobial peptides (AMPs). The rapid development of next generation sequencing technologies and modern bioinformatics approaches allows us to apply them for ... ...

Abstract	Marine polychaetes represent an extremely rich and underexplored source of novel families of antimicrobial peptides (AMPs). The rapid development of next generation sequencing technologies and modern bioinformatics approaches allows us to apply them for characterization of AMP-derived genes and the identification of encoded immune-related peptides with the aid of genome and transcriptome mining. Here, we describe a universal bioinformatic approach based on the conserved BRICHOS domain as a search query for the identification of novel structurally unique AMP families in annelids. In this paper, we report the discovery of 13 novel BRICHOS-related peptides, ranging from 18 to 91 amino acid residues in length, in the cosmopolitan marine worm
MeSH term(s)	Animals ; Mice ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Peptides ; Escherichia coli/genetics ; Transcriptome ; Amino Acids/genetics ; Anti-Bacterial Agents/pharmacology ; Mammals/metabolism
Chemical Substances	Antimicrobial Cationic Peptides ; Antimicrobial Peptides ; Amino Acids ; Anti-Bacterial Agents
Language	English
Publishing date	2023-12-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md21120639
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy.

Burmistrov, Vladimir V / Morisseau, Christophe / Danilov, Dmitry V / Gladkikh, Boris P / D'yachenko, Vladimir S / Zefirov, Nikolay A / Zefirova, Olga N / Butov, Gennady M / Hammock, Bruce D

Journal of enzyme inhibition and medicinal chemistry

2023 Volume 38, Issue 1, Page(s) 2274797

Abstract: Series of 1,3-disubstituted ureas and diadamantyl disubstituted diureas with fluorinated and chlorinated adamantane residues were shown to inhibit human soluble epoxide hydrolase (sEH) with inhibition potency ranging from 40 pM to 9.2 nM. The measured ... ...

Abstract	Series of 1,3-disubstituted ureas and diadamantyl disubstituted diureas with fluorinated and chlorinated adamantane residues were shown to inhibit human soluble epoxide hydrolase (sEH) with inhibition potency ranging from 40 pM to 9.2 nM. The measured IC
MeSH term(s)	Humans ; Fluorine ; Chlorine ; Epoxide Hydrolases ; Urea/pharmacology ; Urea/chemistry ; Molecular Dynamics Simulation
Chemical Substances	Fluorine (284SYP0193) ; Chlorine (4R7X1O2820) ; Epoxide Hydrolases (EC 3.3.2.-) ; Urea (8W8T17847W)
Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2082578-X
ISSN	1475-6374 ; 1475-6366
ISSN (online)	1475-6374
ISSN	1475-6366
DOI	10.1080/14756366.2023.2274797
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Combined use of the GRACE ACS risk score and comorbidity indices to increase the effectiveness of hospital mortality risk assessment in patients with acute coronary syndrome

Mikhail V. Zykov / Nikita V. Dyachenko / Rufana M. Velieva / Vasily V. Kashtalap / Olga L. Barbarash

Терапевтический архив, Vol 94, Iss 7, Pp 816-

2022 Volume 821

Abstract: Aim. To assess the possibilities of using comorbidity indices together with the GRACE (Global Registry of Acute Coronary Events) scale to assess the risk of hospital mortality in acute coronary syndrome (ACS). Materials and methods. The registry study ... ...

Abstract	Aim. To assess the possibilities of using comorbidity indices together with the GRACE (Global Registry of Acute Coronary Events) scale to assess the risk of hospital mortality in acute coronary syndrome (ACS). Materials and methods. The registry study included 2,305 patients with ACS. The frequency of coronary angiography was 54.0%, percutaneous coronary intervention (PCI) 26.9%. Hospital mortality with ACS was 4.8%, with myocardial infarction 9.4%. All patients underwent a comorbidity assessment according to the CIRS system (Cumulative Illness Rating Scale), according to the CCI (Charlson Comorbidity Index) and the CDS (Chronic Disease Score) scale, according to their own scale, which is based on the summation of 9 diseases (diabetes mellitus, atrial fibrillation, stroke, arterial hypertension, obesity, peripheral atherosclerosis, thrombocytopenia, anemia, chronic kidney disease). All patients underwent a mortality risk assessment using the GRACE ACS Risk scale. Results. It was found that the CDS and CIRS indices are not associated with the risk of hospital mortality. With CCI3, the frequency of death outcomes increased from 4.1 to 6.1% (2=4.12, p=0.042). With an increase in the severity of comorbidity from minimal (no more than 1 disease) to severe (4 or more diseases) according to its own scale, hospital mortality increased from 1.2 to 7.4% (2=23.8, p0.0001). In contrast to other scales of comorbidity, our own model more efficiently estimates the hospital prognosis both in the conservative treatment group (2=8.0, p=0.018) and in the PCI group (2=28.5, p=0.00001). It was in the PCI subgroup that the comorbidity factors included in their own model made it possible to increase the area under the ROC curve of the GRACE scale from 0.80 (0.740.87) to 0.90 (0.850.95). Conclusion. CCI and its own comorbidity model, but not CDS and CIRS, are associated with the risk of hospital mortality. The model for assessing comorbidity on a 9-point scale, but not CCI, CDS and CIRS, can significantly improve the predictive value ...
Keywords	acute coronary syndrome ; comorbidity ; grace acs risk score ; hospital prognosis ; Medicine ; R
Subject code	610
Language	Russian
Publishing date	2022-08-01T00:00:00Z
Publisher	"Consilium Medicum" Publishing house
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Novel BRICHOS-Related Antimicrobial Peptides from the Marine Worm Heteromastus filiformis

Pavel V. Panteleev / Victoria N. Safronova / Shuting Duan / Alexey S. Komlev / Ilia A. Bolosov / Roman N. Kruglikov / Tatiana I. Kombarova / Olga V. Korobova / Eugenia S. Pereskokova / Alexander I. Borzilov / Igor A. Dyachenko / Olga V. Shamova / Yu Huang / Qiong Shi / Tatiana V. Ovchinnikova

Marine Drugs, Vol 21, Iss 12, p

Transcriptome Mining, Synthesis, Biological Activities, and Therapeutic Potential

2023 Volume 639

Abstract	Marine polychaetes represent an extremely rich and underexplored source of novel families of antimicrobial peptides (AMPs). The rapid development of next generation sequencing technologies and modern bioinformatics approaches allows us to apply them for characterization of AMP-derived genes and the identification of encoded immune-related peptides with the aid of genome and transcriptome mining. Here, we describe a universal bioinformatic approach based on the conserved BRICHOS domain as a search query for the identification of novel structurally unique AMP families in annelids. In this paper, we report the discovery of 13 novel BRICHOS-related peptides, ranging from 18 to 91 amino acid residues in length, in the cosmopolitan marine worm Heteromastus filiformis with the assistance of transcriptome mining. Two characteristic peptides with a low homology in relation to known AMPs—the α-helical amphiphilic linear peptide, consisting of 28 amino acid residues and designated as HfBRI-28, and the 25-mer β-hairpin peptide, specified as HfBRI-25 and having a unique structure stabilized by two disulfide bonds—were obtained and analyzed as potential antimicrobials. Interestingly, both peptides showed the ability to kill bacteria via membrane damage, but mechanisms of their action and spectra of their activity differed significantly. Being non-cytotoxic towards mammalian cells and stable to proteolysis in the blood serum, HfBRI-25 was selected for further in vivo studies in a lethal murine model of the Escherichia coli infection, where the peptide contributed to the 100% survival rate in animals. A high activity against uropathogenic strains of E. coli (UPEC) as well as a strong ability to kill bacteria within biofilms allow us to consider the novel peptide HfBRI-25 as a promising candidate for the clinical therapy of urinary tract infections (UTI) associated with UPEC.
Keywords	antimicrobial peptide ; Annelida ; Polychaeta ; Heteromastus filiformis ; transcriptome mining ; BRICHOS domain ; Biology (General) ; QH301-705.5
Subject code	540
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Brassica napus L. plants expressing antimicrobial peptide cecropin P1 are safe for colonization by beneficial associative microorganisms

Natalia S. Zakharchenko / Olga V. Furs / Elena B. Rukavtsova / Sergey V. Tarlachkov / Anatolii A. Kosobryukhov / Vladimir D. Kreslavski / Olga V. Dyachenko / Yaroslav I. Buryanov / Taras V. Shevchuk

Journal of Plant Interactions, Vol 16, Iss 1, Pp 432-

2021 Volume 442

Abstract: This work was aimed to study the opportunity of transgenic oilseed rape (Brassica napus L.), expressing the gene of antimicrobial peptide cecropin P1 (cecP1) to be inhabited with associative microorganisms Methylobacterium mesophilicum and Pseudomonas ... ...

Abstract	This work was aimed to study the opportunity of transgenic oilseed rape (Brassica napus L.), expressing the gene of antimicrobial peptide cecropin P1 (cecP1) to be inhabited with associative microorganisms Methylobacterium mesophilicum and Pseudomonas aureofaciens. Previously, resistance was demonstrated to the microbial pathogens:Erwinia carotovora B15, Pseudomonas syringae, Fusarium oxysporum, and Botrytis cinerea. Analysis of the fatty acid composition of transgenic plant seeds showed an increase in the proportion of unsaturated fatty acids. Plants studied showed increased photosynthetic activity in oxidative stress induced by paraquat instead of in oxidative stress and UV radiation compared to control ones. A study of the interaction of transgenic plants with the associative microorganisms showed that bacteria were located in all initially colonized plants, as well as in plants obtained after several passages of microproliferation. Accordingly, transgenic plants, containing the cecP1 gene were actively colonized by associative bacteria, indicating their safety for associative bacteria, indicating their safety for beneficial microorganisms.
Keywords	cecropin p1 ; associative microorganisms ; brassica napus l ; disease resistance ; methylobacterium mesophilicum ; pseudomonas aureofaciens ; Plant culture ; SB1-1110 ; Plant ecology ; QK900-989
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis of fused heterocyclic systems via the Mallory photoreaction of arylthienylethenes.

Dyachenko, Natalia V / Khoroshutin, Andrey V / Sotnikova, Yulia A / Karnoukhova, Valentina A / Tokarev, Sergey D / Anisimov, Alexander V / Fedorov, Yurii V / Fedorova, Olga A

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

2019 Volume 18, Issue 12, Page(s) 2901–2911

Abstract: Photochemical oxidative cyclization of 2- and 3-thienylstilbenes (heterostilbenes) containing mono-, di- and trimethoxy groups in the benzene ring or heterocyclic fragment results in the formation of isomeric thieno-annelated polycyclic aromatic ... ...

Abstract	Photochemical oxidative cyclization of 2- and 3-thienylstilbenes (heterostilbenes) containing mono-, di- and trimethoxy groups in the benzene ring or heterocyclic fragment results in the formation of isomeric thieno-annelated polycyclic aromatic compounds demonstrating optical properties that differ from those of initial stilbene derivatives. The structures of cyclic products were evaluated via
Language	English
Publishing date	2019-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2072584-X
ISSN	1474-9092 ; 1474-905X
ISSN (online)	1474-9092
ISSN	1474-905X
DOI	10.1039/c9pp00289h
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Article ; Online: Clinical characteristics of COVID-19 in patients with tuberculosis and factors associated with the disease severity.

Parolina, Liubov / Pshenichnaya, Natalia / Vasilyeva, Irina / Lizinfed, Irina / Urushadze, Natalia / Guseva, Valeriya / Otpushchennikova, Olga / Dyachenko, Olga / Kharitonov, Pavel

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2022 Volume 124 Suppl 1, Page(s) S82–S89

Abstract: Background: Data on patients with COVID-19 who have pulmonary tuberculosis (TB) are limited. In this study, we compared the clinical characteristics of patients with COVID-19/TB and patients with COVID-19 only. In addition, we analyzed the links between ...

Abstract	Background: Data on patients with COVID-19 who have pulmonary tuberculosis (TB) are limited. In this study, we compared the clinical characteristics of patients with COVID-19/TB and patients with COVID-19 only. In addition, we analyzed the links between the severity of COVID-19 disease and the clinical characteristics of patients with COVID-19/TB. Methods: We conducted a retrospective, anonymized, cross-sectional study of 111 patients who met inclusion criteria for analysis (75 patients with COVID-19/TB and 36 patients with COVID-19). Results: Patients in both groups (COVID-19/TB vs COVID-19) mainly suffered from fever (72.0% vs 100%, p < 0.001), fatigue (76.0% vs 94.4%, p = 0.018), chest pain (72.0% vs 36.1%, p < 0.001), followed by cough (60.0% vs 97.2%, p < 0.001) and dyspnea (44.0% vs 63.9%, p = 0.05). In group COVID-19/TB the most frequently reported co-morbidities were chronic liver disease (17 [22.7%]), cardiovascular diseases (25 [33.3%]), and diseases of the nervous system (13 [17.3%]). Female gender, fever, dyspnea, pulmonary bilateral TB lesion, and three or more co-morbidities have a statistically significant positive effect on the severity of the disease among patients with COVID-19/TB. Conclusion: It is important to perform rapid molecular testing and computed tomography to correctly distinguish COVID-19 and TB because of the similar clinical characteristics of both diseases. Bilateral pulmonary TB lesion and co-morbidity should be considered risk factors for severe COVID-19.
MeSH term(s)	Humans ; Female ; COVID-19/diagnosis ; COVID-19/complications ; Retrospective Studies ; Cross-Sectional Studies ; Tuberculosis/complications ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology ; Tuberculosis, Pulmonary/complications ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/epidemiology ; Patient Acuity ; Fever/complications
Language	English
Publishing date	2022-04-26
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2022.04.041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synthesis and study of

Stogniy, Marina Yu / Kazheva, Olga N / Chudak, Denis M / Shilov, Gennady V / Filippov, Oleg A / Sivaev, Igor B / Kravchenko, Andrey V / Starodub, Vladimir A / Buravov, Lev I / Bregadze, Vladimir I / Dyachenko, Oleg A

RSC advances

2020 Volume 10, Issue 5, Page(s) 2887–2896

Abstract: ... ...

Abstract	The
Language	English
Publishing date	2020-01-16
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra08551c
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Brassica napus L. plants expressing antimicrobial peptide cecropin P1 are safe for colonization by beneficial associative microorganisms

Zakharchenko, Natalia S. / Furs, Olga V. / Rukavtsova, Elena B. / Tarlachkov, Sergey V. / Kosobryukhov, Anatolii A. / Kreslavski, Vladimir D. / Dyachenko, Olga V. / Buryanov, Yaroslav I. / Shevchuk, Taras V.

Journal of plant interactions. 2021 Jan. 01, v. 16, no. 1

2021

Abstract	This work was aimed to study the opportunity of transgenic oilseed rape (Brassica napus L.), expressing the gene of antimicrobial peptide cecropin P1 (cecP1) to be inhabited with associative microorganisms Methylobacterium mesophilicum and Pseudomonas aureofaciens. Previously, resistance was demonstrated to the microbial pathogens:Erwinia carotovora B15, Pseudomonas syringae, Fusarium oxysporum, and Botrytis cinerea. Analysis of the fatty acid composition of transgenic plant seeds showed an increase in the proportion of unsaturated fatty acids. Plants studied showed increased photosynthetic activity in oxidative stress induced by paraquat instead of in oxidative stress and UV radiation compared to control ones. A study of the interaction of transgenic plants with the associative microorganisms showed that bacteria were located in all initially colonized plants, as well as in plants obtained after several passages of microproliferation. Accordingly, transgenic plants, containing the cecP1 gene were actively colonized by associative bacteria, indicating their safety for associative bacteria, indicating their safety for beneficial microorganisms.
Keywords	Botrytis cinerea ; Brassica napus ; Fusarium oxysporum ; Methylobacterium mesophilicum ; Pseudomonas chlororaphis ; Pseudomonas syringae ; cecropins ; fatty acid composition ; genes ; oxidative stress ; paraquat ; photosynthesis ; transgenic plants ; ultraviolet radiation
Language	English
Dates of publication	2021-0101
Size	p. 432-442.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2234941-8
ISSN	1742-9153 ; 1742-9145
ISSN (online)	1742-9153
ISSN	1742-9145
DOI	10.1080/17429145.2021.1950228
Database	NAL-Catalogue (AGRICOLA)

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Article: TRPV1 Blocker HCRG21 Suppresses TNF-α Production and Prevents the Development of Edema and Hypersensitivity in Carrageenan-Induced Acute Local Inflammation.

Sintsova, Oksana / Gladkikh, Irina / Klimovich, Anna / Palikova, Yulia / Palikov, Viktor / Styshova, Olga / Monastyrnaya, Margarita / Dyachenko, Igor / Kozlov, Sergey / Leychenko, Elena

Biomedicines

2021 Volume 9, Issue 7

Abstract: Currently the TRPV1 (transient receptor potential vanilloid type 1) channel is considered to be one of the main targets for pro-inflammatory mediators including TNF-α. Similarly, the inhibition of TRPV1 activity in the peripheral nervous system affects ... ...

Abstract	Currently the TRPV1 (transient receptor potential vanilloid type 1) channel is considered to be one of the main targets for pro-inflammatory mediators including TNF-α. Similarly, the inhibition of TRPV1 activity in the peripheral nervous system affects pro-inflammatory mediator production and enhances analgesia in total. In this study, the analgesic and anti-inflammatory effects of HCRG21, the first peptide blocker of TRPV1, were demonstrated in a mice model of carrageenan-induced paw edema. HCRG21 in doses of 0.1 and 1 mg/kg inhibited edema formation compared to the control, demonstrated complete edema disappearance in 24 h in a dose of 1 mg/kg, and effectively reduced the productionof TNF-α in both doses examined. ELISA analysis of blood taken 24 h after carrageenan administration showed a dramatic cytokine value decrease to 25 pg/mL by HCRG21 versus 100 pg/mL in the negative control group, which was less than the TNF-α level in the intact group (40 pg/mL). The HCRG21 demonstrated potent analgesic effects on the models of mechanical and thermal hyperalgesia in carrageenan-induced paw edema. The HCRG21 relief effect was comparable to that of indomethacin taken orally in a dose of 5 mg/kg, but was superior to this nonsteroidal anti-inflammatory drug (NSAID) in duration (which lasted 24 h) in the mechanical sensitivity experiment. The results confirm the existence of a close relationship between TRPV1 activity and TNF-α production once again, and prove the superior pharmacological potential of TRPV1 blockers and the HCRG21 peptide in particular.
Language	English
Publishing date	2021-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9070716
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