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  1. AU=Filingeri Davide
  2. AU=Ahmed Ali AU=Ahmed Ali
  3. AU="Krimmel, Bernd"
  4. AU="Kampner, Doris"
  5. AU="Nafati, Cyril"
  6. AU="Meo, Luciana Agnese"
  7. AU=Uzun Oguz
  8. AU=Cheng Baoli
  9. AU="van der Heijden, Onno"
  10. AU="Freitas, Teresa R"
  11. AU="Tomi Kovacevic"
  12. AU="Claire Hivroz"
  13. AU=Huang L E
  14. AU="More, Jessica"
  15. AU="Eliot, George"
  16. AU="Choi, Kati"
  17. AU="Wiese, Lothar"
  18. AU=Rackova Sylva AU=Rackova Sylva
  19. AU="Akala, Isiaka Olusola"
  20. AU="Nicolás Gonzalo Núñez"
  21. AU="Hernández Solis, Alejandro"
  22. AU="Jadad, Alejandro R"
  23. AU="Lastres, Palma Rico" AU="Lastres, Palma Rico"
  24. AU="Manes, K"
  25. AU="Baugh, Matthew"
  26. AU="Qu, C"
  27. AU="Flett, Heather"
  28. AU="Shueh Lin Lim"
  29. AU="Schröder, Johann"
  30. AU=Butler Taylor
  31. AU="Yang, Fan"
  32. AU="Giacomo Frati"
  33. AU=Kokhaei P
  34. AU="Charikleia Triantopoulou"
  35. AU="Salil Bhargava"
  36. AU="Jong-Eun Lee"
  37. AU="Vargas C, Laura"

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  1. Artikel ; Online: Thermal physiology is a (wo)man's world!

    Filingeri, Davide / Blount, Hannah / Ward, Jade

    The Journal of physiology

    2024  Band 602, Heft 5, Seite(n) 769–770

    Mesh-Begriff(e) Humans ; Male ; Body Temperature Regulation ; Sweating
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP286333
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  2. Artikel ; Online: Female thermal sensitivity and behaviour across the lifespan: A unique journey.

    Filingeri, Davide / Blount, Hannah / Valenza, Alessandro

    Experimental physiology

    2024  

    Abstract: Women are a group of individuals that undergo unique anatomical, physiological and hormonal changes across the lifespan. For example, consider the impact of the menstrual cycle, pregnancy and menopause, all of which are accompanied by both short- and ... ...

    Abstract Women are a group of individuals that undergo unique anatomical, physiological and hormonal changes across the lifespan. For example, consider the impact of the menstrual cycle, pregnancy and menopause, all of which are accompanied by both short- and long-term effects on female body morphology (e.g., changes in breast size) and temperature regulation, heat tolerance, thermal sensitivity and comfort. However, empirical evidence on how skin thermal and wetness sensitivity might change across the lifespan of women, and the implications that this has for female-specific thermal behaviours, continues to be lacking. This paper is based on a symposium presentation given at Physiology 2023 in Harrogate, UK. It aims to review new evidence on anatomical and physiological mechanisms underpinning differences in skin thermal and wetness sensitivity amongst women varying in breast size and age, in addition to their role in driving female thermal behaviours. It is hoped that this brief overview will stimulate the development of testable hypotheses to increase our understanding of the behavioural thermal physiology of women across the lifespan and at a time of climate change.
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP091454
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  3. Artikel ; Online: An evaluation of the effects of localised skin cooling on microvascular, inflammatory, structural, and perceptual responses to sustained mechanical loading of the sacrum: A study protocol.

    Gordon, Ralph J F H / Worsley, Peter R / Filingeri, Davide

    PloS one

    2024  Band 19, Heft 5, Seite(n) e0303342

    Abstract: This study protocol aims to investigate how localised cooling influences the skin's microvascular, inflammatory, structural, and perceptual tolerance to sustained mechanical loading at the sacrum, evaluating factors such as morphology, physiology, and ... ...

    Abstract This study protocol aims to investigate how localised cooling influences the skin's microvascular, inflammatory, structural, and perceptual tolerance to sustained mechanical loading at the sacrum, evaluating factors such as morphology, physiology, and perceptual responses. The protocol will be tested on individuals of different age, sex, skin tone and clinical status, using a repeated-measure design with three participants cohorts: i) young healthy (n = 35); ii) older healthy (n = 35); iii) spinal cord injured (SCI, n = 35). Participants will complete three testing sessions during which their sacrum will be mechanically loaded (60 mmHg; 45 min) and unloaded (20 min) with a custom-built thermal probe, causing pressure-induced ischemia and post-occlusive reactive hyperaemia. Testing sessions will differ by the probe's temperature, which will be set to either 38°C (no cooling), 24°C (mild cooling), or 16°C (strong cooling). We will measure skin blood flow (via Laser Doppler Flowmetry; 40 Hz); pro- and anti-inflammatory biomarkers in skin sebum (Sebutape); structural skin properties (Optical Coherence Tomography); and ratings of thermal sensation, comfort, and acceptance (Likert Scales); throughout the loading and unloading phases. Changes in post-occlusive reactive hyperaemia will be considered as the primary outcome and data will be analysed for the independent and interactive effects of stimuli's temperature and of participant group on within- and between-subject mean differences (and 95% Confidence Intervals) in peak hyperaemia, by means of a 2-way mixed model ANOVA (or Friedman). Regression models will also be developed to assess the relationship between absolute cooling temperatures and peak hyperaemia. Secondary outcomes will be within- and between-subject mean changes in biomarkers' expression, skin structural and perceptual responses. This analysis will help identifying physiological and perceptual thresholds for the protective effects of cooling from mechanically induced damage underlying the development of pressure ulcers in individuals varying in age and clinical status.
    Mesh-Begriff(e) Humans ; Skin/blood supply ; Adult ; Male ; Female ; Sacrum ; Middle Aged ; Young Adult ; Inflammation ; Spinal Cord Injuries/physiopathology ; Cold Temperature ; Aged ; Microvessels/physiopathology ; Weight-Bearing ; Skin Temperature
    Sprache Englisch
    Erscheinungsdatum 2024-05-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0303342
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  4. Artikel ; Online: The visual perception of wetness: Multisensory integration of visual and tactile stimuli.

    Merrick, Charlotte / Rosati, Rodrigo / Filingeri, Davide

    Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

    2023  Band 237, Heft 9, Seite(n) 1072–1081

    Abstract: A multitude of sensory modalities are involved in humans' experience of wetness, yet we know little of the integratory role of vision. Therefore, the aim was to quantify the effect of physical stain volume, chroma and size on wetness perception, and to ... ...

    Abstract A multitude of sensory modalities are involved in humans' experience of wetness, yet we know little of the integratory role of vision. Therefore, the aim was to quantify the effect of physical stain volume, chroma and size on wetness perception, and to compare wetness perception under different sensory conditions, including visuotactile and visual only interactions. Eighteen participants visually observed and/or used their index fingerpad to dynamically interact with stimuli varying in physical wetness (0, 2.16 × 10
    Mesh-Begriff(e) Humans ; Visual Perception
    Sprache Englisch
    Erscheinungsdatum 2023-08-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1065942-0
    ISSN 2041-3033 ; 0046-2039 ; 0954-4119
    ISSN (online) 2041-3033
    ISSN 0046-2039 ; 0954-4119
    DOI 10.1177/09544119231189105
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  5. Artikel ; Online: Body temperatures, thermal comfort, and neuropsychological responses to air temperatures ranging between 12°C and 39°C in people with Multiple Sclerosis.

    Christogianni, Aikaterini / Bibb, Richard / Filingeri, Davide

    Physiology & behavior

    2023  Band 266, Seite(n) 114179

    Abstract: The negative effects of thermal stress on Multiple Sclerosis (MS)' symptoms have long been known. However, the underlying mechanisms of MS heat and cold intolerance remain unclear. The aim of this study was to evaluate body temperatures, thermal comfort, ...

    Abstract The negative effects of thermal stress on Multiple Sclerosis (MS)' symptoms have long been known. However, the underlying mechanisms of MS heat and cold intolerance remain unclear. The aim of this study was to evaluate body temperatures, thermal comfort, and neuropsychological responses to air temperatures between 12 and 39 °C in people with MS compared to healthy controls (CTR). Twelve MS (5 males/7 females; age: 48.3 ± 10.8 years; EDSS range: 1-7) and 11 CTR participants (4 males /7 females; age: 47.5 ± 11.3 years) underwent two 50-min trials in a climatic chamber. Air temperature was ramped from 24 °C to either 39 °C (HEAT) or 12 °C (COLD) and we continuously monitored participants' mean skin (T
    Mesh-Begriff(e) Male ; Female ; Humans ; Adult ; Middle Aged ; Temperature ; Body Temperature ; Multiple Sclerosis/complications ; Cold Temperature ; Hot Temperature ; Fatigue ; Skin Temperature ; Body Temperature Regulation/physiology
    Sprache Englisch
    Erscheinungsdatum 2023-04-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3907-x
    ISSN 1873-507X ; 0031-9384
    ISSN (online) 1873-507X
    ISSN 0031-9384
    DOI 10.1016/j.physbeh.2023.114179
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  6. Artikel ; Online: Optimization of Spatial and Temporal Configuration of a Pressure Sensing Array to Predict Posture and Mobility in Lying.

    Caggiari, Silvia / Jiang, Liudi / Filingeri, Davide / Worsley, Peter

    Sensors (Basel, Switzerland)

    2023  Band 23, Heft 15

    Abstract: Commercial pressure monitoring systems have been developed to assess conditions at the interface between mattress/cushions of individuals at risk of developing pressure ulcers. Recently, they have been used as a surrogate for prolonged posture and ... ...

    Abstract Commercial pressure monitoring systems have been developed to assess conditions at the interface between mattress/cushions of individuals at risk of developing pressure ulcers. Recently, they have been used as a surrogate for prolonged posture and mobility monitoring. However, these systems typically consist of high-resolution sensing arrays, sampling data at more than 1 Hz. This inevitably results in large volumes of data, much of which may be redundant. Our study aimed at evaluating the optimal number of sensors and acquisition frequency that accurately predict posture and mobility during lying. A continuous pressure monitor (ForeSitePT, Xsensor, Calgary, Canada), with 5664 sensors sampling at 1 Hz, was used to assess the interface pressures of healthy volunteers who performed lying postures on two different mattresses (foam and air designs). These data were down sampled in the spatial and temporal domains. For each configuration, pressure parameters were estimated and the area under the Receiver Operating Characteristic curve (AUC) was used to determine their ability in discriminating postural change events. Convolutional Neural Network (CNN) was employed to predict static postures. There was a non-linear decline in AUC values for both spatial and temporal down sampling. Results showed a reduction of the AUC for acquisition frequencies lower than 0.3 Hz. For some parameters, e.g., pressure gradient, the lower the sensors number the higher the AUC. Posture prediction showed a similar accuracy of 63-71% and 84-87% when compared to the commercial configuration, on the foam and air mattress, respectively. This study revealed that accurate detection of posture and mobility events can be achieved with a relatively low number of sensors and sampling frequency.
    Mesh-Begriff(e) Humans ; Posture ; Neural Networks, Computer ; Beds ; Pressure Ulcer ; Healthy Volunteers
    Sprache Englisch
    Erscheinungsdatum 2023-08-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23156872
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  7. Artikel ; Online: Neurophysiology of Skin Thermal Sensations.

    Filingeri, Davide

    Comprehensive Physiology

    2016  Band 6, Heft 3, Seite(n) 1429

    Abstract: Undoubtedly, adjusting our thermoregulatory behavior represents the most effective mechanism to maintain thermal homeostasis and ensure survival in the diverse thermal environments that we face on this planet. Remarkably, our thermal behavior is entirely ...

    Abstract Undoubtedly, adjusting our thermoregulatory behavior represents the most effective mechanism to maintain thermal homeostasis and ensure survival in the diverse thermal environments that we face on this planet. Remarkably, our thermal behavior is entirely dependent on the ability to detect variations in our internal (i.e., body) and external environment, via sensing changes in skin temperature and wetness. In the past 30 years, we have seen a significant expansion of our understanding of the molecular, neuroanatomical, and neurophysiological mechanisms that allow humans to sense temperature and humidity. The discovery of temperature-activated ion channels which gate the generation of action potentials in thermosensitive neurons, along with the characterization of the spino-thalamo-cortical thermosensory pathway, and the development of neural models for the perception of skin wetness, are only some of the recent advances which have provided incredible insights on how biophysical changes in skin temperature and wetness are transduced into those neural signals which constitute the physiological substrate of skin thermal and wetness sensations. Understanding how afferent thermal inputs are integrated and how these contribute to behavioral and autonomic thermoregulatory responses under normal brain function is critical to determine how these mechanisms are disrupted in those neurological conditions, which see the concurrent presence of afferent thermosensory abnormalities and efferent thermoregulatory dysfunctions. Furthermore, advancing the knowledge on skin thermal and wetness sensations is crucial to support the development of neuroprosthetics. In light of the aforementioned text, this review will focus on the peripheral and central neurophysiological mechanisms underpinning skin thermal and wetness sensations in humans. © 2016 American Physiological Society. Compr Physiol 6:1279-1294, 2016.2016.
    Mesh-Begriff(e) Animals ; Body Temperature Regulation/physiology ; Humans ; Psychophysics ; Skin/innervation ; Skin Temperature/physiology ; Spinal Cord/physiology ; Thermoreceptors/physiology ; Thermosensing/physiology
    Sprache Englisch
    Erscheinungsdatum 2016-06-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2040-4603
    ISSN (online) 2040-4603
    DOI 10.1002/cphy.c150040
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  8. Artikel ; Online: The characterization of thermal perception in recreational surfers wearing wetsuits.

    Warner, Mackenzie / Nessler, Jeff A / Filingeri, Davide / Newcomer, Sean C

    Applied ergonomics

    2023  Band 113, Seite(n) 104108

    Abstract: The purpose of this study was to characterize the perception of heat loss, comfort, and wetness in recreational surfers wearing wetsuits, to compare these data with changes in skin temperature reported in prior studies, and to examine the impact of ... ...

    Abstract The purpose of this study was to characterize the perception of heat loss, comfort, and wetness in recreational surfers wearing wetsuits, to compare these data with changes in skin temperature reported in prior studies, and to examine the impact of wetsuit thickness, zipper location, and accessory use on thermal sensation and comfort. Following their surf session, nine-hundred and three male (n = 735) and female (n = 168) recreational surfers responded to a series of questions regarding thermal comfort/sensation, wetsuit characteristics, and surfing history. Average whole body thermal sensation rating was 0.8 ± 3.6 on a scale of -10 to +10 and average whole body thermal comfort rating was 1.5 ± 1.2, midway between "just comfortable" and "comfortable." Overall, surfers felt coldest in their feet, hands, and head. Under their wetsuits, surfers felt the coldest, wettest, and least comfortable in their chest, lower legs, lower arms, and upper back. Wetsuit accessory use had the greatest impact on regions identified as coldest, least comfortable, and wettest. These data suggest that wetsuit design should focus on optimizing water access points and improving accessories for the feet, hands, and head.
    Mesh-Begriff(e) Humans ; Male ; Female ; Sports ; Skin Temperature ; Cold Temperature ; Body Temperature Regulation ; Perception
    Sprache Englisch
    Erscheinungsdatum 2023-08-10
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2003513-5
    ISSN 1872-9126 ; 0003-6870
    ISSN (online) 1872-9126
    ISSN 0003-6870
    DOI 10.1016/j.apergo.2023.104108
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  9. Artikel ; Online: Regional skin wetness perception and its modulation by warm and cold whole body skin temperatures in people with multiple sclerosis.

    Christogianni, Aikaterini / Bibb, Richard / Filtness, Ashleigh / Filingeri, Davide

    American journal of physiology. Regulatory, integrative and comparative physiology

    2022  Band 323, Heft 5, Seite(n) R648–R660

    Abstract: Skin wetness sensing is important for thermal stress resilience. Individuals with multiple sclerosis (MS) present greater vulnerability to thermal stress; yet, it is unclear whether they present wetness-sensing abnormalities. We investigated the effects ... ...

    Abstract Skin wetness sensing is important for thermal stress resilience. Individuals with multiple sclerosis (MS) present greater vulnerability to thermal stress; yet, it is unclear whether they present wetness-sensing abnormalities. We investigated the effects of MS on wetness sensing and their modulation with changes in mean skin temperature (T
    Mesh-Begriff(e) Male ; Female ; Humans ; Skin Temperature ; Multiple Sclerosis ; Thermosensing/physiology ; Cold Temperature ; Skin ; Perception ; Water
    Chemische Substanzen Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2022-08-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00149.2022
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  10. Artikel ; Online: The role of friction on skin wetness perception during dynamic interactions between the human index finger pad and materials of varying moisture content.

    Merrick, Charlotte / Rosati, Rodrigo / Filingeri, Davide

    Journal of neurophysiology

    2022  Band 127, Heft 3, Seite(n) 725–736

    Abstract: Mechanosensory inputs arising from dynamic interactions between the skin and moisture, such as when sliding a finger over a wet substrate, contribute to the perception of skin wetness. Yet, the exact relationship between the mechanical properties of a ... ...

    Abstract Mechanosensory inputs arising from dynamic interactions between the skin and moisture, such as when sliding a finger over a wet substrate, contribute to the perception of skin wetness. Yet, the exact relationship between the mechanical properties of a wet substrate, such as friction, and the resulting wetness perception remains to be established under naturalistic haptic interactions. We modeled the relationship between mechanical and thermal properties of substrates varying in moisture levels (0.49 × 10
    Mesh-Begriff(e) Female ; Friction ; Humans ; Male ; Skin ; Skin Temperature ; Thermosensing ; Touch Perception
    Sprache Englisch
    Erscheinungsdatum 2022-01-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00382.2021
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