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Article ; Online: What is required for better progress in clinical and scientific andrology involving sperm assessments?

Björndahl, Lars

2024

Language	English
Publishing date	2024-01-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2075824-8
ISSN	1745-7262 ; 1008-682X
ISSN (online)	1745-7262
ISSN	1008-682X
DOI	10.4103/aja202380
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A paradigmatic shift in the care of male factor infertility: how can the recommendations for basic semen examination in the sixth edition of the WHO manual and the ISO 23162:2021 standard help?

Björndahl, Lars

Reproductive biomedicine online

2022 Volume 45, Issue 4, Page(s) 731–736

Abstract: The WHO laboratory manual for the examination and processing of human semen is a worldwide recognized source of information on reliable techniques for semen examination. Since its initial publication, aimed at providing useful data in the evaluation of ... ...

Abstract	The WHO laboratory manual for the examination and processing of human semen is a worldwide recognized source of information on reliable techniques for semen examination. Since its initial publication, aimed at providing useful data in the evaluation of male contraceptive drugs, the manual has developed to focus mainly on discovering male factors of infertility as a basis for medical assisted reproduction. The principles for basic semen examination remain mainly unchanged in the sixth edition. Some important adjustments have been made to improve efficacy, compliance with basic laboratory science and user-friendly instructions. For human sperm morphology assessment, more rationale and techniques are given for the assessment of defects in all parts of the spermatozoa. More data from men in couples with less than 1 year to initiation of pregnancy have been incorporated into the manual. The general problem, however, has been that these ranges and limits have been misinterpreted as distinct limits between fertility and infertility. This review discusses how the available distribution of data from men in couples achieving pregnancy should be interpreted. Another important aspect is the use of human sperm morphology for better understanding of functions and disorders of the male reproductive organs to increase the focus on men's reproductive health.
MeSH term(s)	Contraceptive Agents, Male ; Female ; Humans ; Infertility, Male/diagnosis ; Infertility, Male/therapy ; Male ; Pregnancy ; Semen ; Semen Analysis ; Sperm Count ; Sperm Motility ; Spermatozoa ; World Health Organization
Chemical Substances	Contraceptive Agents, Male
Language	English
Publishing date	2022-03-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2022.03.011
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Zs.A 5792: Show issues

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Book ; Online ; Conference proceedings ; E-Book: XIIIth international symposium on Spermatology

Bjorndahl, Lars / Flanagan, John / Holmberg, Rebecka

2021

Abstract: These proceedings of the 2018 XIII International Symposium on Spermatology focus on comparative biology, and encourages discussion and the exchange of ideas. The aim of this Symposium was to provide a unique opportunity and bring together scientists from ...

Author's details	edited by Lars Bjorndahl, John Flanagan, Rebecka Holmberg
Abstract	These proceedings of the 2018 XIII International Symposium on Spermatology focus on comparative biology, and encourages discussion and the exchange of ideas. The aim of this Symposium was to provide a unique opportunity and bring together scientists from a wide spectrum of research fields - human, domestic animals and other mammals, vertebrates, insects, and plants. The underlying focus is on the function of the spermatozoon - a common feature for sexual reproduction, but extremely varied. By exploring the variability, a better understanding of male reproductive functions can develop. These proceedings address the mechanisms of physiology and pathophysiology, rather than diagnosis and treatment. The symposium featured keynote lectures by invited speakers, followed by presentations on specific aspects of the general topic of the session. Experimental studies are given priority over clinical studies of patient populations.The proceedings comprise both keynote speakers' texts and selected free communications. Posters were considered for publication in the proceedings, and the volume includes exhibited materials on the work of prominent spermatologists, highlighting their important past achievements in the field.
Keywords	Spermatozoa ; Espermatozoides
Subject code	571.8451
Language	English
Size	1 online resource (352 pages)
Publisher	Springer
Publishing place	Cham, Switzerland
Document type	Book ; Online ; Conference proceedings ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-66292-6 ; 3-030-66291-8 ; 978-3-030-66292-9 ; 978-3-030-66291-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: A practical guide to basic laboratory andrology

Björndahl, Lars

2010

Title variant	Basic laboratory andrology
Author's details	Lars Bjorndahl
Keywords	Semen Analysis ; Infertility, Male / diagnosis ; Spermatozoa
Language	English
Size	XII, 336 S., [4] Bl. : Ill., graph. Darst., 24 cm
Publisher	Cambridge Univ. Press
Publishing place	Cambridge
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT016321302
ISBN	978-0-521-73590-2 ; 0-521-73590-4
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2010 A 1955	order for loan	Magazin

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Book: Clinical andrology

Björndahl, Lars

EAU/ESAU course guidelines

2010

Institution	European Association of Urology European Society of Andrological Urology
Author's details	ed. by Lars Björndahl
Language	English
Size	XIII, 429 S. : Ill., graph. Darst.
Publisher	Informa Healthcare
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT015591829
ISBN	978-1-8418-4680-4 ; 1-8418-4680-5
Database	Catalogue ZB MED Medicine, Health

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2010 A 3436	order for loan	Magazin

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Book: A practical guide to basic laboratory andrology

Mortimer, David / Björndahl, Lars / Barratt, Christopher / Castilla, José Antonio / Menkveld, Roelof

2022

Author's details	David Mortimer, Lars Björndahl, Christopher L.R. Barratt, José Antonio Castilla, Roelof Menkveld, Ulrik Kvist, Juan G. Alvarez, Trine B. Haugen
Keywords	Semen Analysis ; Infertility, Male ; Spermatozoa
Language	English
Size	x,369 Seiten, Illustrationen
Edition	Second edition
Publisher	Cambridge University Press
Publishing place	Cambridge
Publishing country	Great Britain
Document type	Book
Note	Preceded by A practical guide to basic labratory andrology / Lars Björndahl... [et al.]. 2010. - Includes bibliographical references and index
HBZ-ID	HT021375417
ISBN	978-1-00-918163-1 ; 9781009181648 ; 1-00-918163-7 ; 1009181645
Database	Catalogue ZB MED Medicine, Health

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2022 A 657	available for loan (reading room)	Lesesaal EG

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Article ; Online: The sixth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen: ensuring quality and standardization in basic examination of human ejaculates.

Björndahl, Lars / Kirkman Brown, Jackson

Fertility and sterility

2022 Volume 117, Issue 2, Page(s) 246–251

Abstract: A basic semen investigation has established principles that are necessary for ascertaining reliable and internationally comparable results. Although these principles have been present in the WHO manual since its inception, the baseline issue across most ... ...

Abstract	A basic semen investigation has established principles that are necessary for ascertaining reliable and internationally comparable results. Although these principles have been present in the WHO manual since its inception, the baseline issue across most published studies and practice in reproductive medicine (in which the male is considered) is repetitive failure to adhere to these principles, thereby leading to relevant comparable data and accuracy. To address this failure, the sixth edition of the WHO manual includes revised basic methods, and a complementary formal standard of the International Standards Organization (ISO23162:2021) for basic semen examination has been published. Perhaps the most significant change in the sixth edition is the reintroduction of the four-category distinction of sperm motility, which causes additional work for laboratories in changing reporting parameters but is clinically important. Another essential change is the widened focus from mainly a prognostic tool for medically assisted reproduction to additionally raising awareness of semen examination as a measure of male reproductive functions and general male health.
MeSH term(s)	Ejaculation ; Fertility ; Humans ; Infertility, Male/diagnosis ; Infertility, Male/pathology ; Infertility, Male/physiopathology ; Male ; Manuals as Topic/standards ; Predictive Value of Tests ; Quality Assurance, Health Care/standards ; Quality Control ; Quality Indicators, Health Care/standards ; Reproducibility of Results ; Semen Analysis/standards ; Spermatozoa/pathology ; World Health Organization
Language	English
Publishing date	2022-01-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2021.12.012
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Zs.A 73: Show issues

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Article ; Online: Improving standard practices in studies using results from basic human semen examination.

Björndahl, Lars / Esteves, Sandro C / Ferlin, Alberto / Jørgensen, Niels / O'Flaherty, Cristian

Andrology

2023 Volume 11, Issue 7, Page(s) 1225–1231

Abstract: The purpose of this article is to provide an explanation of the background behind a checklist that declares the laboratory methods used in a scientific study. It focuses primarily on implementing laboratory procedures to yield reliable results in basic ... ...

Abstract	The purpose of this article is to provide an explanation of the background behind a checklist that declares the laboratory methods used in a scientific study. It focuses primarily on implementing laboratory procedures to yield reliable results in basic semen examinations. While the World Health Organization (WHO) and international standards provide recommendations for basic semen examination, manuscripts submitted to Andrology frequently lack transparency regarding the specific techniques used. In addition, the terminology used for semen examination results often fails to provide a clear definition of the groups under study. Furthermore, the WHO's reference limits are often misinterpreted as strict boundaries between fertility and infertility. It is important to note that valid clinical andrological diagnoses and treatments cannot rely solely on semen examination results; they require proper laboratory procedures as a foundation for diagnosing and treating male patients. Therefore, scientific journals should promote the adoption of robust laboratory practices and an accurate definition of patient groups. A checklist can facilitate the design of high-quality studies and the creation of informative publications. Further, it can help journals assess submitted manuscripts and improve the overall quality of their publications.
MeSH term(s)	Humans ; Male ; Semen ; Semen Analysis/methods ; Fertility ; Infertility ; Andrology ; Infertility, Male/diagnosis
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13504
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Zs.A 6983: Show issues

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Article ; Online: Sperm motility assessed by deep convolutional neural networks into WHO categories.

Haugen, Trine B / Witczak, Oliwia / Hicks, Steven A / Björndahl, Lars / Andersen, Jorunn M / Riegler, Michael A

Scientific reports

2023 Volume 13, Issue 1, Page(s) 14777

Abstract: Semen analysis is central in infertility investigation. Manual assessment of sperm motility according to the WHO recommendations is the golden standard, and extensive training is a requirement for accurate and reproducible results. Deep convolutional ... ...

Abstract	Semen analysis is central in infertility investigation. Manual assessment of sperm motility according to the WHO recommendations is the golden standard, and extensive training is a requirement for accurate and reproducible results. Deep convolutional neural networks (DCNN) are especially suitable for image classification. In this study, we evaluated the performance of the DCNN ResNet-50 in predicting the proportion of sperm in the WHO motility categories. Two models were evaluated using tenfold cross-validation with 65 video recordings of wet semen preparations from an external quality assessment programme for semen analysis. The corresponding manually assessed data was obtained from several of the reference laboratories, and the mean values were used for training of the DCNN models. One model was trained to predict the three categories progressive motility, non-progressive motility, and immotile spermatozoa. Another model was used in predicting four categories, where progressive motility was differentiated into rapid and slow. The resulting average mean absolute error (MAE) was 0.05 and 0.07, and the average ZeroR baseline was 0.09 and 0.10 for the three-category and the four-category model, respectively. Manual and DCNN-predicted motility was compared by Pearson's correlation coefficient and by difference plots. The strongest correlation between the mean manually assessed values and DCNN-predicted motility was observed for % progressively motile spermatozoa (Pearson's r = 0.88, p < 0.001) and % immotile spermatozoa (r = 0.89, p < 0.001). For rapid progressive motility, the correlation was moderate (Pearson's r = 0.673, p < 0.001). The median difference between manual and predicted progressive motility was 0 and 2 for immotile spermatozoa. The largest bias was observed at high and low percentages of progressive and immotile spermatozoa. The DCNN-predicted value was within the range of the interlaboratory variation of the results for most of the samples. In conclusion, DCNN models were able to predict the proportion of spermatozoa into the WHO motility categories with significantly lower error than the baseline. The best correlation between the manual and the DCNN-predicted motility values was found for the categories progressive and immotile. Of note, there was considerable variation between the mean motility values obtained for each category by the reference laboratories, especially for rapid progressive motility, which impacts the training of the DCNN models.
MeSH term(s)	Male ; Humans ; Sperm Motility ; Semen ; Semen Analysis ; Neural Networks, Computer ; World Health Organization
Language	English
Publishing date	2023-09-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41871-2
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Article ; Online: Presence of key cholinergic enzymes in human spermatozoa and seminal fluid†.

Thakur, Banita / Hasooni, Laila Pamela / Gera, Ruchi / Mitra, Sumonto / Björndahl, Lars / Darreh-Shori, Taher

Biology of reproduction

2023 Volume 110, Issue 1, Page(s) 63–77

Abstract: Little is known about the non-neuronal spermic cholinergic system, which may regulate sperm motility and the acrosome reaction initiation process. We investigated the presence of the key acetylcholine (ACh)-biosynthesizing enzyme, choline ... ...

Abstract	Little is known about the non-neuronal spermic cholinergic system, which may regulate sperm motility and the acrosome reaction initiation process. We investigated the presence of the key acetylcholine (ACh)-biosynthesizing enzyme, choline acetyltransferase (ChAT), and the acetylcholine-degrading enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and two ACh-receptors in human spermatozoa and seminal plasma. Fresh ejaculates were used for intra- and extracellular flow cytometric analysis of ChAT, AChE, BChE, and alpha-7-nicotinic and M1-muscarinic ACh-receptors in sperm. For determining the source of soluble enzymes, frozen seminal samples (n = 74) were selected on two bases: (1) from vasectomized (n = 37) and non-vasectomized (n = 37) subjects and (2) based on levels of alpha-glucosidase, fructose, or zinc to define sample subgroups with high or low fluid contribution from the epididymis and seminal vesicle, and prostate, respectively. Flow cytometric analyses revealed that ChAT was expressed intracellularly in essentially all spermatozoa. ChAT was also present in a readily membrane-detachable form at the extracellular membrane of at least 18% of the spermatozoa. These were also highly positive for intra- and extracellular BChE (>83%) and M1 (>84%) and α7 (>59%) ACh-receptors. Intriguingly, the sperm was negative for AChE. Analyses of seminal plasma revealed that spermatozoa and epididymides were major sources of soluble ChAT and BChE, whereas soluble AChE most likely originated from epididymides and seminal vesicles. Prostate had relatively minor contribution to the pool of the soluble enzymes in the seminal fluid. In conclusion, human spermatozoa exhibited a cholinergic phenotype and were one of the major sources of soluble ChAT and BChE in ejaculate. We also provide the first evidence for ChAT as an extracellularly membrane-anchored protein.
MeSH term(s)	Humans ; Male ; Acetylcholinesterase/genetics ; Acetylcholinesterase/metabolism ; Acetylcholine ; Butyrylcholinesterase/metabolism ; Semen/metabolism ; Sperm Motility ; Spermatozoa/metabolism ; Cholinergic Agents
Chemical Substances	Acetylcholinesterase (EC 3.1.1.7) ; Acetylcholine (N9YNS0M02X) ; Butyrylcholinesterase (EC 3.1.1.8) ; Cholinergic Agents
Language	English
Publishing date	2023-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1093/biolre/ioad127
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