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Article: Intracerebral Transplantation of BDNF-overexpressing Human Neural Stem Cells (HB1.F3.BDNF) Promotes Migration, Differentiation and Functional Recovery in a Rodent Model of Huntington's Disease.

Kim, Hyun Sook / Jeon, Iksoo / Noh, Jeong-Eun / Lee, Hyunseung / Hong, Kwan Soo / Lee, Nayeon / Pei, Zhong / Song, Jihwan

Experimental neurobiology

2020 Volume 29, Issue 2, Page(s) 130–137

Abstract: Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by abnormally expanded CAG repeats in ... ...

Abstract	Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by abnormally expanded CAG repeats in the
Language	English
Publishing date	2020-05-14
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2639017-6
ISSN	2093-8144 ; 1226-2560
ISSN (online)	2093-8144
ISSN	1226-2560
DOI	10.5607/en20011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical Features of

Jeon, Hyeshin / Jeong, Young Hwan / Choi, Hee-Young / Lee, Ji Eun / Byon, Iksoo / Park, Sung Who

Ocular immunology and inflammation

2018 Volume 27, Issue 5, Page(s) 829–835

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Adult ; Aged ; Animals ; Eye Infections, Parasitic/parasitology ; Eye Infections, Parasitic/pathology ; Eye Infections, Parasitic/physiopathology ; Eye Pain/etiology ; Female ; Humans ; Male ; Middle Aged ; Optic Neuritis/parasitology ; Optic Neuritis/pathology ; Optic Neuritis/physiopathology ; Papilledema/pathology ; Republic of Korea ; Retrospective Studies ; Toxocara ; Toxocariasis/pathology ; Toxocariasis/physiopathology ; Visual Acuity/physiology ; Young Adult
Language	English
Publishing date	2018-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2018.1449866
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Article: Neural Transplants From Human Induced Pluripotent Stem Cells Rescue the Pathology and Behavioral Defects in a Rodent Model of Huntington's Disease.

Yoon, Yongwoo / Kim, Hyun Sook / Hong, Chang Pyo / Li, Endan / Jeon, Iksoo / Park, Hyun Jung / Lee, Nayeon / Pei, Zhong / Song, Jihwan

Frontiers in neuroscience

2020 Volume 14, Page(s) 558204

Abstract: Huntington's disease (HD) is a devastating, autosomal-dominant inheritance disorder with the progressive loss of medium spiny neurons (MSNs) and corticostriatal connections in the brain. Cell replacement therapy has been proposed as a potential ... ...

Abstract	Huntington's disease (HD) is a devastating, autosomal-dominant inheritance disorder with the progressive loss of medium spiny neurons (MSNs) and corticostriatal connections in the brain. Cell replacement therapy has been proposed as a potential therapeutic strategy to treat HD. Among various types of stem cells, human-induced pluripotent stem cells (iPSCs) have received special attention to develop disease modeling and cell therapy for HD. In the present study, the therapeutic effects of neural precursor cells (NPCs) derived from a human iPSC line (1231A3-NPCs) were investigated in the quinolinic acid (QA)-lesioned rat model of HD. 1231A3-NPCs were transplanted into the ipsilateral striatum 1 week after QA lesioning, and the transplanted animals showed significant behavioral improvements for up to 12 weeks based on the staircase, rotarod, stepping, apomorphine-induced rotation, and cylinder tests. Transplanted 1231A3-NPCs also partially replaced the lost neurons, enhanced endogenous neurogenesis, reduced inflammatory responses, and reconstituted the damaged neuronal connections. Taken together, these results strongly indicate that NPCs derived from iPSCs can potentially be useful to treat HD in the future.
Language	English
Publishing date	2020-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2020.558204
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Article ; Online: Implantation of the clinical-grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington's disease.

Yoon, Yongwoo / Kim, Hyun Sook / Jeon, Iksoo / Noh, Jeong-Eun / Park, Hyun Jung / Lee, Suji / Park, In-Hyun / Stevanato, Lara / Hicks, Caroline / Corteling, Randolph / Barker, Roger A / Sinden, John D / Song, Jihwan

Stem cells (Dayton, Ohio)

2020 Volume 38, Issue 8, Page(s) 936–947

Abstract: Huntington's disease (HD) is a devastating, autosomal-dominant neurodegenerative disease, for which there are currently no disease-modifying therapies. Clinical trials to replace the damaged striatal medium spiny neurons (MSNs) have been attempted in the ...

Abstract	Huntington's disease (HD) is a devastating, autosomal-dominant neurodegenerative disease, for which there are currently no disease-modifying therapies. Clinical trials to replace the damaged striatal medium spiny neurons (MSNs) have been attempted in the past two decades but have met with only limited success. In this study, we investigated whether a clonal, conditionally immortalized neural stem cell line (CTX0E03), which has already shown safety and signals of efficacy in chronic ischemic stroke patients, could rescue deficits seen in an animal model of HD. After CTX0E03 transplantation into the quinolinic acid-lesioned rat model of HD, behavioral changes were measured using the rotarod, stepping, and staircase tests. In vivo differentiation and neuronal connections of the transplanted CTX0E03 cells were evaluated with immunohistochemical staining and retrograde tracing with Fluoro-Gold. We found that transplantation of CTX0E03 gave rise to a significant behavioral improvement compared with the sham- or fibroblast-transplanted group. Transplanted CTX0E03 formed MSNs (DARPP-32) and GABAergic neurons (GABA, GAD65/67) with BDNF expression in the striatum, while cortically transplanted cells formed Tbr1-positive neurons. Using a retrograde label, we also found stable engraftment and connection of the transplanted cells with host brain tissues. CTX0E03 transplantation also reduced glial scar formation and inflammation, as well as increasing endogenous neurogenesis and angiogenesis. Overall, our results demonstrate that CTX0E03, a clinical-grade neural stem cell line, is effective for preclinical test in HD, and, therefore, will be useful for clinical development in the treatment of HD patients.
Language	English
Publishing date	2020-05-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1143556-2
ISSN	1549-4918 ; 1066-5099
ISSN (online)	1549-4918
ISSN	1066-5099
DOI	10.1002/stem.3191
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Article ; Online: Interleukin-1 receptor antagonist-mediated neuroprotection by umbilical cord-derived mesenchymal stromal cells following transplantation into a rodent stroke model.

Oh, Seung-Hun / Choi, Chunggab / Noh, Jeong-Eun / Lee, Nayeon / Jeong, Yong-Woo / Jeon, Iksoo / Shin, Jeong-Min / Kim, Ji-Hye / Kim, Ho-Jin / Lee, Ji-Min / Kim, Hyun-Sook / Kim, Ok-Joon / Song, Jihwan

Experimental & molecular medicine

2018 Volume 50, Issue 4, Page(s) 1–12

Abstract: The human umbilical cord is a promising source of mesenchymal stromal cells (MSCs). Intravenous administration of human umbilical cord-derived MSCs (IV-hUMSCs) showed a favorable effect in a rodent stroke model by a paracrine mechanism. However, its ... ...

Abstract	The human umbilical cord is a promising source of mesenchymal stromal cells (MSCs). Intravenous administration of human umbilical cord-derived MSCs (IV-hUMSCs) showed a favorable effect in a rodent stroke model by a paracrine mechanism. However, its underlying therapeutic mechanisms must be determined for clinical application. We investigated the therapeutic effects and mechanisms of our good manufacturing practice (GMP)-manufactured hUMSCs using various cell doses and delivery time points in a rodent model of stroke. IV-hUMSCs at a dose of 1 × 10
MeSH term(s)	Animals ; Brain/metabolism ; Brain Ischemia/etiology ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Brain Ischemia/therapy ; Cell Line ; Cyclic AMP Response Element-Binding Protein/metabolism ; Disease Models, Animal ; Gene Expression Profiling ; Humans ; Interleukin 1 Receptor Antagonist Protein/genetics ; Interleukin 1 Receptor Antagonist Protein/metabolism ; Macrophages/metabolism ; Male ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Mice ; Neurons/metabolism ; Neuroprotection ; Rats ; Stroke/etiology ; Stroke/metabolism ; Stroke/pathology ; Stroke/therapy ; Umbilical Cord/cytology
Chemical Substances	Cyclic AMP Response Element-Binding Protein ; Interleukin 1 Receptor Antagonist Protein
Language	English
Publishing date	2018-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-018-0041-1
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Zs.A 4775: Show issues

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Article ; Online: PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line.

Moon, Seok-Ho / Kim, Dae-Kwan / Cha, Young / Jeon, Iksoo / Song, Jihwan / Park, Kyung-Soon

International journal of oncology

2013 Volume 42, Issue 3, Page(s) 921–928

Abstract: Malignant gliomas are the most common primary brain tumor in adults. A number of genes have been implicated in glioblastoma including mutation and deletion of PTEN. PTEN is a regulator of PI3K-mediated Akt signaling pathways and has been recognized as a ... ...

Abstract	Malignant gliomas are the most common primary brain tumor in adults. A number of genes have been implicated in glioblastoma including mutation and deletion of PTEN. PTEN is a regulator of PI3K-mediated Akt signaling pathways and has been recognized as a therapeutic target in glioblastoma. To achieve potent therapeutic inhibition of the PI3K-Akt pathway in glioblastoma, it is essential to understand the interplay between the regulators of its activation. Here, ectopic expression of PTEN in the U-87MG human glioblastoma-astrocytoma cell line is shown to result in the depletion of glioblastoma stem cells (GSCs) and to cause growth retardation and senescence. These effects are likely to be associated with PTEN-mediated cooperative perturbation of Akt and Stat3 signals. Using an in vivo rat model of glioblastoma, we showed that PTEN-overexpressing U-87MG cells failed to induce tumor formation, while untreated U-87MG cells did so. Furthermore, cells expressing the phosphorylated form of Stat3 were completely absent from the brain of rats implanted with PTEN-overexpressing U-87MG cells. Based on these results, PTEN appears to function as a crucial inhibitor of GSCs and as an inducer of senescence, suggesting that functional enhancement of the PTEN pathway will be useful to provide a therapeutic strategy for targeting glioblastoma.
MeSH term(s)	Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cellular Senescence ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Male ; Neoplasm Transplantation ; Neoplastic Stem Cells/physiology ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol Phosphates/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Xenograft Model Antitumor Assays
Chemical Substances	Phosphatidylinositol Phosphates ; STAT3 Transcription Factor ; STAT3 protein, human ; phosphatidylinositol 3,4,5-triphosphate ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
Language	English
Publishing date	2013-03
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2013.1765
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Zs.A 3690: Show issues

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Article ; Online: Interleukin-1 receptor antagonist-mediated neuroprotection by umbilical cord-derived mesenchymal stromal cells following transplantation into a rodent stroke model

Seung-Hun Oh / Chunggab Choi / Jeong-Eun Noh / Nayeon Lee / Yong-Woo Jeong / Iksoo Jeon / Jeong-Min Shin / Ji-Hye Kim / Ho-Jin Kim / Ji-Min Lee / Hyun-Sook Kim / Ok-Joon Kim / Jihwan Song

Experimental and Molecular Medicine, Vol 50, Iss 4, Pp 1-

2018 Volume 12

Abstract: Stroke: Cells from umbilical cords offer potential treatment Cells harvested from umbilical cords might improve the prospects for stroke patients by reducing the inflammation that causes brain damage. Researchers at CHA University in South Korea led by ... ...

Abstract	Stroke: Cells from umbilical cords offer potential treatment Cells harvested from umbilical cords might improve the prospects for stroke patients by reducing the inflammation that causes brain damage. Researchers at CHA University in South Korea led by Jihwan Song, Ok-Joon Kim and Seung-Hun Oh used a rodent model of stroke to investigate the mechanism behind the protective effect of connective tissue cells called mesenchymal stromal cells (MSCs). The benefits of these cells were already known, but the mechanism responsible for their effect was unclear. The researchers found that intravenous administration of MSCs initiated biochemical changes that reduced the inflammatory effects of a natural signaling protein called interleukin-1. This limited the damage caused by strokes that block blood flow, resulting in reduced blood supply (ischemia) to parts of the brain. The insights should help efforts to treat ischemic forms of stroke.
Keywords	Medicine ; R ; Biochemistry ; QD415-436
Subject code	610
Language	English
Publishing date	2018-04-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
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Article: In Vivo Roles of a Patient-Derived Induced Pluripotent Stem Cell Line (HD72-iPSC) in the YAC128 Model of Huntington's Disease.

Jeon, Iksoo / Choi, Chunggab / Lee, Nayeon / Im, Wooseok / Kim, Manho / Oh, Seung-Hun / Park, In-Hyun / Kim, Hyun Sook / Song, Jihwan

International journal of stem cells

2014 Volume 7, Issue 1, Page(s) 43–47

Abstract: Induced pluripotent stem cells (iPSCs) generated from somatic cells of patients can provide immense opportunities to model human diseases, which may lead to develop novel therapeutics. Huntington's disease (HD) is a devastating neurodegenerative genetic ... ...

Abstract	Induced pluripotent stem cells (iPSCs) generated from somatic cells of patients can provide immense opportunities to model human diseases, which may lead to develop novel therapeutics. Huntington's disease (HD) is a devastating neurodegenerative genetic disease, with no available therapeutic options at the moment. We recently reported the characteristics of a HD patient-derived iPSC carrying 72 CAG repeats (HD72-iPSC). In this study, we investigated the in vivo roles of HD72-iPSC in the YAC128 transgenic mice, a commonly used HD mouse model carrying 128 CAG repeats. To do this, we transplanted HD72-iPSC-derived neural precursors into the striatum of YAC128 mice bilaterally and observed a significant behavioral improvement in the grafted mice. Interestingly, the transplanted HD72-iPSC-derived neural precursors formed GABAeric neurons efficiently, but no EM48-positive protein aggregates were detected at 12 weeks after transplantation. Taken together, these results indicate no HD pathology was developed from the grafted cells, or no transmission of HD pathology from the host to the graft occurred at 12 weeks post-transplantation.
Language	English
Publishing date	2014-05-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2914134-5
ISSN	2005-5447 ; 2005-3606
ISSN (online)	2005-5447
ISSN	2005-3606
DOI	10.15283/ijsc.2014.7.1.43
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Article: Microbiome Changes in Layer Pullets Reared in Floor Pens along the Growth Period.

Kim, Hee-Jin / Kim, Hyun-Soo / Yun, Yeon-Seo / Shin, Hyekyoung / Lee, Woo-Do / Son, Jiseon / Hong, Eui-Chul / Jeon, Ik-Soo / Kang, Hwan-Ku

Life (Basel, Switzerland)

2023 Volume 13, Issue 12

Abstract: The gastrointestinal tract microbiome is essential for regulating nutrient absorption, gut immune function, and host growth and development. In the present study, we characterized the development of ileum and cecum microbiota in pullets throughout the ... ...

Abstract	The gastrointestinal tract microbiome is essential for regulating nutrient absorption, gut immune function, and host growth and development. In the present study, we characterized the development of ileum and cecum microbiota in pullets throughout the rearing period, encompassing a period from the day of hatching to 18 weeks of age. The growth performance and intestinal microbiome (ileum and cecum) of pullets were analyzed at 1, 5, 11, and 18 weeks of age. The richness of the ileum and cecum bacterial communities (alpha diversity) was higher in pullets at 18 weeks of age than in those at 1 and 5 weeks of age. Microbiota from weeks 1, 5, 11, and 18 were distinctly grouped in a NMDS plot, representing beta diversity within the ileum. However, the results for cecum microbiota did not reveal evident separation among the different age groups in the weighted UniFrac. In conclusion, our findings demonstrate variations and diversification in ileum and cecum microbiota across different rearing stages in pullets. These insights have the potential to inform the development of nutritional strategies that promote gut health and contribute to the improved development of pullets.
Language	English
Publishing date	2023-12-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13122302
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Article ; Online: Microbiome Changes in Layer Pullets Reared in Floor Pens along the Growth Period

Hee-Jin Kim / Hyun-Soo Kim / Yeon-Seo Yun / Hyekyoung Shin / Woo-Do Lee / Jiseon Son / Eui-Chul Hong / Ik-Soo Jeon / Hwan-Ku Kang

Life, Vol 13, Iss 12, p

2023 Volume 2302

Abstract	The gastrointestinal tract microbiome is essential for regulating nutrient absorption, gut immune function, and host growth and development. In the present study, we characterized the development of ileum and cecum microbiota in pullets throughout the rearing period, encompassing a period from the day of hatching to 18 weeks of age. The growth performance and intestinal microbiome (ileum and cecum) of pullets were analyzed at 1, 5, 11, and 18 weeks of age. The richness of the ileum and cecum bacterial communities (alpha diversity) was higher in pullets at 18 weeks of age than in those at 1 and 5 weeks of age. Microbiota from weeks 1, 5, 11, and 18 were distinctly grouped in a NMDS plot, representing beta diversity within the ileum. However, the results for cecum microbiota did not reveal evident separation among the different age groups in the weighted UniFrac. In conclusion, our findings demonstrate variations and diversification in ileum and cecum microbiota across different rearing stages in pullets. These insights have the potential to inform the development of nutritional strategies that promote gut health and contribute to the improved development of pullets.
Keywords	gut microbiome ; pullet ; floor ; layer hen ; rearing period ; Science ; Q
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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