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  1. Article: Restoration of Calmodulin-Like Skin Protein as Treatment for Alzheimer's Disease.

    Matsuoka, Masaaki

    Frontiers in neurology

    2021  Volume 12, Page(s) 771856

    Language English
    Publishing date 2021-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.771856
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  2. Article: CLSPCOL rescues Alzheimer's disease mouse models.

    Kusakari, Shinya / Nawa, Mikiro / Hashimoto, Yuichi / Matsuoka, Masaaki

    Translational neuroscience

    2022  Volume 13, Issue 1, Page(s) 11–19

    Abstract: Calmodulin-like skin protein (CLSP) inhibits Alzheimer's disease (AD)-related neurotoxicity. The activity of CLSP is reduced in AD. To restore the CLSP activity, we developed a hybrid peptide named CLSPCOL, consisting of CLSP(1-61) and the collagen- ... ...

    Abstract Calmodulin-like skin protein (CLSP) inhibits Alzheimer's disease (AD)-related neurotoxicity. The activity of CLSP is reduced in AD. To restore the CLSP activity, we developed a hybrid peptide named CLSPCOL, consisting of CLSP(1-61) and the collagen-homologous region (COL) of adiponectin. It was previously shown that the CLSPCOL-mediated restoration of the reduced CLSP activity alleviated memory impairment and neuronal synaptic loss in
    Language English
    Publishing date 2022-02-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2581219-1
    ISSN 2081-6936 ; 2081-3856
    ISSN (online) 2081-6936
    ISSN 2081-3856
    DOI 10.1515/tnsci-2022-0209
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  3. Article ; Online: Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA.

    Suzuki, Hiroaki / Matsuoka, Masaaki

    Journal of neurochemistry

    2021  Volume 158, Issue 3, Page(s) 753–765

    Abstract: A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Unconventional translation of the hexanucleotide repeat expansion generates ... ...

    Abstract A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Unconventional translation of the hexanucleotide repeat expansion generates five dipeptide repeat proteins (DPRs). The molecular mechanism underlying the DPR-linked neurotoxicity is under investigation. In this study, using cell-based models, we show that poly-proline-arginine DPR (poly-PR), the most neurotoxic DPR in vitro, binds to adenosine deaminase acting on RNA (ADAR)1p110 and ADAR2 and inhibits their RNA editing activity. We further show that poly-PR impairs cellular stress response that is mediated by ADAR1p110. These results together suggest that the poly-PR-mediated inhibition of the ADAR activity contributes to C9-ALS/FTD-linked neurotoxicity.
    MeSH term(s) Adenosine Deaminase/genetics ; Adenosine Deaminase/metabolism ; Animals ; Arginine/genetics ; Arginine/metabolism ; C9orf72 Protein/genetics ; C9orf72 Protein/metabolism ; Dipeptides/genetics ; Dipeptides/metabolism ; HeLa Cells ; Humans ; Mice ; Neurons/metabolism ; Proline/genetics ; Proline/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
    Chemical Substances C9orf72 Protein ; C9orf72 protein, mouse ; Dipeptides ; RNA-Binding Proteins ; Arginine (94ZLA3W45F) ; Proline (9DLQ4CIU6V) ; ADAR1 protein, mouse (EC 3.5.4.4) ; ADAR2 protein, mouse (EC 3.5.4.4) ; Adenosine Deaminase (EC 3.5.4.4)
    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.15445
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  4. Article ; Online: FGF14 GAA repeat expansion and ZFHX3 GGC repeat expansion in clinically diagnosed multiple system atrophy patients.

    Matsushima, Masaaki / Yaguchi, Hiroaki / Koshimizu, Eriko / Kudo, Akihiko / Shirai, Shinichi / Matsuoka, Takeshi / Ura, Shigehisa / Kawashima, Atsushi / Fukazawa, Toshiyuki / Miyatake, Satoko / Matsumoto, Naomichi / Yabe, Ichiro

    Journal of neurology

    2024  

    Language English
    Publishing date 2024-03-12
    Publishing country Germany
    Document type Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-024-12308-1
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  5. Article ; Online: Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.

    Matsuoka, Masaaki

    Molecular neurobiology

    2014  Volume 51, Issue 3, Page(s) 1232–1239

    Abstract: Humanin is a 24-amino acid, secreted bioactive peptide that prevents various types of cell death and improves some types of cell dysfunction. Humanin inhibits neuronal cell death that is caused by a familial Alzheimer's disease (AD)-linked gene via ... ...

    Abstract Humanin is a 24-amino acid, secreted bioactive peptide that prevents various types of cell death and improves some types of cell dysfunction. Humanin inhibits neuronal cell death that is caused by a familial Alzheimer's disease (AD)-linked gene via binding to the heterotrimeric Humanin receptor (htHNR). This suggests that Humanin may play a protective role in AD-related pathogenesis. Calmodulin-like skin protein (CLSP) has recently been identified as a physiological agonist of htHNR with 10(5)-fold more potent anti-cell death activity than Humanin. Humanin has also shown to have protective effects against some metabolic disorders. In this review, the broad range of functions of Humanin and the functions of CLSP that have been characterized thus far are summarized.
    MeSH term(s) Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Animals ; Calcium-Binding Proteins/metabolism ; Cell Death/physiology ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Neurons/metabolism
    Chemical Substances Amyloid beta-Peptides ; CALML5 protein, human ; Calcium-Binding Proteins ; Intracellular Signaling Peptides and Proteins ; humanin
    Language English
    Publishing date 2014-06-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-014-8799-1
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  6. Article ; Online: A New CD10 Antibody Inhibits the Growth of Malignant Mesothelioma.

    Mizutani, Natsuko / Abe, Masaaki / Kajino, Kazunori / Matsuoka, Shuji

    Monoclonal antibodies in immunodiagnosis and immunotherapy

    2021  Volume 40, Issue 1, Page(s) 21–27

    Abstract: Malignant mesotheliomas (MMs) are aggressive therapy-resistant tumors that generally have a poor prognosis. We previously reported the establishment of four new monoclonal antibodies (mAbs) for the diagnosis and treatment of MM. In this report, we ... ...

    Abstract Malignant mesotheliomas (MMs) are aggressive therapy-resistant tumors that generally have a poor prognosis. We previously reported the establishment of four new monoclonal antibodies (mAbs) for the diagnosis and treatment of MM. In this report, we characterized one of these antibodies, JMAM-1. The molecules whose antibodies were calibrated were picked up, transfected assuming CD10, and elucidated by fluorescence activated cell sorter. Survival experiments were performed using tumor-bearing mice model. JMAM-1 mAb was found to bind with CD10 antigen. The Kaplan-Meier survival curve showed a small but prolonged survival effect. JMAM-1 mAb-treated MSTO-211H cells showed increased cell cycle arrest involved by cyclin-dependent-kinase. JMAM-1 antibody has cytostatic effect and may be a candidate for the treatment of MM. Among mesothelioma, CD10-positive cases have been reported to have a poorer prognosis than negative cases, which can be used as a tool for diagnosis.
    MeSH term(s) Animals ; Antibodies, Monoclonal ; Lung Neoplasms/drug therapy ; Mesothelioma/diagnosis ; Mesothelioma/drug therapy ; Mesothelioma, Malignant ; Mice
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article
    ISSN 2167-9436
    ISSN (online) 2167-9436
    DOI 10.1089/mab.2020.0033
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  7. Article: [Practical training of pharmacokinetics with an web-based simulation application].

    Hara, Ichie / Suzuki, Hiroaki / Kusakari, Shinya / Matsuoka, Masaaki

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2020  Volume 155, Issue 1, Page(s) 51–55

    Abstract: A computer simulation application on pharmacokinetics, which we developed using a software, named " ... ...

    Abstract A computer simulation application on pharmacokinetics, which we developed using a software, named "Stella
    MeSH term(s) Animals ; Computer Simulation ; Humans ; Internet ; Microcomputers ; Software ; Students, Medical
    Language Japanese
    Publishing date 2020-01-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.19057
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    Zs.A 439: Show issues Location:
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  8. Article ; Online: Exploratory study of oxatomide derivatives with high P2X<sub>7</sub> receptor inhibitory activity.

    Yamagiwa, Noriyuki / Komine, Mika / Hanaoka, Fumi / Nobuta, Tomoya / Yoshida, Kazuki / Ito, Masaaki / Matsuoka, Isao

    Bioorganic & medicinal chemistry letters

    2022  Volume 77, Page(s) 129035

    Abstract: Various oxatomide derivatives were designed and synthesized to develop novel P2X ... 7 ... receptor (P2X ... 7 ... R) antagonists. Evaluation for in-vitro P2X ... 7 ... R antagonist assay showed that DPM-piperazine moiety of oxatomide was required to ...

    Abstract Various oxatomide derivatives were designed and synthesized to develop novel P2X<sub>7</sub> receptor (P2X<sub>7</sub>R) antagonists. Evaluation for in-vitro P2X<sub>7</sub>R antagonist assay showed that DPM-piperazine moiety of oxatomide was required to maintain an inhibitory activity. The structure of both alkyl chains and aromatic head groups strongly affected P2X<sub>7</sub>R inhibitory activity, and the analogue, with C4-type saturated alkyl chain and a non-substituted or fluorine-substituted indole, was 7.3 to 6.4 times more potent as a P2X<sub>7</sub>R antagonist than oxatomide.
    MeSH term(s) Piperazines/pharmacology ; Receptors, Purinergic P2X7 ; Purinergic P2X Receptor Antagonists/pharmacology ; Purinergic P2X Receptor Antagonists/chemistry
    Chemical Substances oxatomide (J31IL9Z2EE) ; Piperazines ; Receptors, Purinergic P2X7 ; Purinergic P2X Receptor Antagonists
    Language English
    Publishing date 2022-10-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2022.129035
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  9. Article: [Neuronal death-inhibiting therapy for Alzheimer's disease].

    Matsuoka, Masaaki

    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics

    2011  Volume 49, Issue 3, Page(s) 303–306

    MeSH term(s) Alzheimer Disease/drug therapy ; Animals ; Cell Death/drug effects ; Humans ; Intracellular Signaling Peptides and Proteins/physiology ; Neurons/drug effects ; Neurons/pathology ; Receptors, Interleukin-6/isolation & purification
    Chemical Substances Intracellular Signaling Peptides and Proteins ; Receptors, Interleukin-6 ; humanin
    Language Japanese
    Publishing date 2011-03-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604107-3
    ISSN 0300-9173
    ISSN 0300-9173
    DOI 10.3143/geriatrics.49.303
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  10. Article ; Online: Impact of Stent Expansion Index on Stent Failure After Left Main Stenting.

    Watanabe, Yusuke / Mitomo, Satoru / Naganuma, Toru / Nakajima, Akihiro / Matsuoka, Satoshi / Tahara, Satoko / Okutsu, Masaaki / Nakamura, Shotaro / Nakamura, Sunao

    The American journal of cardiology

    2023  Volume 205, Page(s) 164–172

    Abstract: Impact of the stent expansion index (EXPI) in percutaneous coronary intervention (PCI) for unprotected left main distal bifurcation lesions (ULMD) has been not completely understood especially in current-generation drug-eluting stent (cDES) era. We ... ...

    Abstract Impact of the stent expansion index (EXPI) in percutaneous coronary intervention (PCI) for unprotected left main distal bifurcation lesions (ULMD) has been not completely understood especially in current-generation drug-eluting stent (cDES) era. We evaluated the impact of EXPI on clinical outcomes after PCI with cDES for ULMD. We identified 342 patients treated with cDES for ULMD and postintervention intravascular ultrasound between January 2010 and December 2019. In this study, the ratio of minimum stent area (MSA) to reference vessel area at the MSA site was adopted to assess the stent expansion. We defined the patients with the first and second tertile as low-intermediate EXPI group and those with the third tertile as high EXPI group and compared the clinical outcomes between both groups. The primary end point was target lesion failure (TLF). TLF was defined as a composite of cardiac death, target lesion revascularization (TLR) ,and myocardial infarction. The MSA was located in the ostium of left anterior descending coronary artery in most cases (318 of 342 patients; 93.0%). There were no significant differences between both groups in the baseline clinical, lesion, and procedural characteristics. The high EXPI group had lower TLF rate than the low-intermediate EXPI group (10.2% vs 19.9%, log-rank p = 0.033). In conclusion, this is the first report that the higher ratio of MSA to reference vessel area at the MSA site, which was defined as stent EXPI, was associated with more favorable clinical outcomes after PCI for ULMD.
    MeSH term(s) Humans ; Drug-Eluting Stents ; Percutaneous Coronary Intervention ; Stents ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Myocardial Infarction/epidemiology ; Myocardial Infarction/surgery
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.07.157
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