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Article: A New Fern-like Plant

Yang, Jiang-Nan / Wang, De-Ming

2022 Volume 11, Issue 11

Abstract: Palaeozoic fern-like plants show great diversity in their morphology and/or anatomy. Within this group, a novel taxon, ...

Abstract	Palaeozoic fern-like plants show great diversity in their morphology and/or anatomy. Within this group, a novel taxon,
Language	English
Publishing date	2022-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11111568
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Article ; Online: Versatile Cell and Animal Models for Advanced Investigation of Lead Poisoning.

Yang, De-Ming / Chang, Yu-Fen

Biosensors

2021 Volume 11, Issue 10

Abstract: The heavy metal, lead (Pb) can irreversibly damage the human nervous system. To help understand Pb-induced damage, we applied a genetically encoded Förster resonance energy transfer (FRET)-based Pb biosensor Met-lead 1.44 M1 to two living systems to ... ...

Abstract	The heavy metal, lead (Pb) can irreversibly damage the human nervous system. To help understand Pb-induced damage, we applied a genetically encoded Förster resonance energy transfer (FRET)-based Pb biosensor Met-lead 1.44 M1 to two living systems to monitor the concentration of Pb: induced pluripotent stem cell (iPSC)-derived cardiomyocytes as a semi-tissue platform and
MeSH term(s)	Animals ; Biosensing Techniques ; Drosophila melanogaster ; Fluorescence Resonance Energy Transfer ; Lead ; Lead Poisoning ; Models, Animal
Chemical Substances	Lead (2P299V784P)
Language	English
Publishing date	2021-10-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios11100371
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Article ; Online: A New Fern-like Plant Xinhangia spina Gen. et sp. Nov. from the Upper Devonian of China

Jiang-Nan Yang / De-Ming Wang

Biology, Vol 11, Iss 1568, p

2022 Volume 1568

Abstract: Palaeozoic fern-like plants show great diversity in their morphology and/or anatomy. Within this group, a novel taxon, Xinhangia spina gen. et sp. nov., is now reported from the Upper Devonian (Famennian) Wutong Formation of Anhui Province, China. The ... ...

Abstract	Palaeozoic fern-like plants show great diversity in their morphology and/or anatomy. Within this group, a novel taxon, Xinhangia spina gen. et sp. nov., is now reported from the Upper Devonian (Famennian) Wutong Formation of Anhui Province, China. The primary and secondary branches are borne alternately and sometimes in a triseriate pattern. Spines are evident on the main axes or stems and on the primary branches. Vegetative ultimate appendages with recurved tips are alternate, usually dichotomous 1–2 times, and sometimes as an aphlebia located at the base of primary or secondary branches. Fertile ultimate appendages are alternate, usually dichotomous 1–2 times, and terminate in elongated and paired sporangia. The stele has a clepsydroid-like primary xylem with each end bearing a protoxylem strand. The secondary xylem surrounding the primary xylem illustrates uniseriate rays. With rare divisions in both the vegetative and fertile ultimate appendages, Xinhangia represents a morphologically primitive plant. It is of uncertain affinity at the class or order level. The stelar architecture suggests that the clepsydroid stele may not be emphasized in discussing the relationship among fern-like plants such as rhacophytaleans.
Keywords	fern-like plants ; triseriate branching ; Late Devonian ; stele ; Xinhangia ; Wutong Formation ; Biology (General) ; QH301-705.5
Subject code	580
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cross‑talk between lymphangiogenesis and malignant melanoma cells: New opinions on tumour drainage and immunization (Review).

Ju, Wei / Cai, Hong-Hua / Zheng, Wei / Li, De-Ming / Zhang, Wei / Yang, Xi-Hu / Yan, Zhi-Xin

Oncology letters

2024 Volume 27, Issue 2, Page(s) 81

Abstract: Malignant melanoma (MM) is a highly aggressive tumour that can easily metastasize through the lymphatic system at the early stages. Lymph node (LN) involvement and lymphatic vessel (LV) density (LVD) represent a harbinger of an adverse prognosis, ... ...

Abstract	Malignant melanoma (MM) is a highly aggressive tumour that can easily metastasize through the lymphatic system at the early stages. Lymph node (LN) involvement and lymphatic vessel (LV) density (LVD) represent a harbinger of an adverse prognosis, indicating a strong link between the state of the lymphatic system and the advancement of MM. Permeable capillary lymphatic vessels are the optimal conduits for melanoma cell (MMC) invasion, and lymphatic endothelial cells (LECs) can also release a variety of chemokines that actively attract MMCs expressing chemokine ligands through a gradient orientation. Moreover, due to the lower oxidative stress environment in the lymph compared with the blood circulation, MMCs are more likely to survive and colonize. The number of LVs surrounding MM is associated with tumour-infiltrating lymphocytes (TILs), which is crucial for the effectiveness of immunotherapy. On the other hand, MMCs can release various endothelial growth factors such as VEGF-C/D-VEGFR3 to mediate LN education and promote lymphangiogenesis. Tumour-derived extracellular vesicles are also used to promote lymphangiogenesis and create a microenvironment that is more conducive to tumour progression. MM is surrounded by a large number of lymphocytes. However, both LECs and MMCs are highly plastic, playing multiple roles in evading immune surveillance. They achieve this by expressing inhibitory ligands or reducing antigen recognition. In recent years, tertiary lymphoid structures have been shown to be associated with response to anti-immune checkpoint therapy, which is often a positive prognostic feature in MM. The present review discusses the interaction between lymphangiogenesis and MM metastasis, and it was concluded that the relationship between LVD and TILs and patient prognosis is analogous to a dynamically tilted scale.
Language	English
Publishing date	2024-01-05
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2024.14215
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Article ; Online: Portable FRET-Based Biosensor Device for On-Site Lead Detection.

Lai, Wei-Qun / Chang, Yu-Fen / Chou, Fang-Ning / Yang, De-Ming

Biosensors

2022 Volume 12, Issue 3

Abstract: Most methods for measuring environmental lead (Pb) content are time consuming, expensive, hazardous, and restricted to specific analytical systems. To provide a facile, safe tool to detect Pb, we created pMet-lead, a portable fluorescence resonance ... ...

Abstract	Most methods for measuring environmental lead (Pb) content are time consuming, expensive, hazardous, and restricted to specific analytical systems. To provide a facile, safe tool to detect Pb, we created pMet-lead, a portable fluorescence resonance energy transfer (FRET)-based Pb-biosensor. The pMet-lead device comprises a 3D-printed frame housing a 405-nm laser diode-an excitation source for fluorescence emission images (YFP and CFP)-accompanied by optical filters, a customized sample holder with a Met-lead 1.44 M1 (the most recent version)-embedded biochip, and an optical lens aligned for smartphone compatibility. Measuring the emission ratios (Y/C) of the FRET components enabled Pb detection with a dynamic range of nearly 2 (1.96), a pMet-lead/Pb dissociation constant (K
MeSH term(s)	Biosensing Techniques/methods ; Fluorescence Resonance Energy Transfer/methods ; Smartphone ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2022-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios12030157
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Article ; Online: Portable sensing devices for smart healthcare and prevention of lead poisoning.

Lai, Wei-Qun / Huang, Ta-Chou / Liang, Kung-Hao / Chang, Yu-Fen / Yang, De-Ming

Journal of the Chinese Medical Association : JCMA

2023 Volume 86, Issue 5, Page(s) 459–464

Abstract: Lead (Pb) poisoning can damage human bodies silently, without specific symptoms or conspicuous warning signs. To provide safe and user-friendly tools for detecting heavy metals at low concentrations, scientists have developed and optimized versatile ... ...

Abstract	Lead (Pb) poisoning can damage human bodies silently, without specific symptoms or conspicuous warning signs. To provide safe and user-friendly tools for detecting heavy metals at low concentrations, scientists have developed and optimized versatile biosensors. To practically employ the developed biosensors specific for Pb (eg, the optimized Met-lead 1.44 M1), smartphone applications designed for user convenience and are easily operable for the on-site detection of Pb in environmental water, drinking water, food, and blood/urine are urgently needed. To establish a monitoring system for home health maintenance, a portable device and useful apps installed on a smartphone can be integrated, and the data acquired can be sent to and stored in the cloud for further analysis and evidence preservation. With the high transmissions speeds for 4G and 4G wireless Internet, such a system can be applied for health protection; water-quality data can be provided by anyone and publicly shared for display on smartphone interfaces, alerting individuals of heavy metal contamination. In this review, we describe recent developments in heavy metal-sensing devices, including home health maintenance systems, which have been successfully and practically applied to prevent heavy metal Pb poisoning.
MeSH term(s)	Humans ; Lead ; Metals, Heavy ; Lead Poisoning/diagnosis ; Lead Poisoning/prevention & control ; Mobile Applications ; Water
Chemical Substances	Lead (2P299V784P) ; Metals, Heavy ; Water (059QF0KO0R)
Language	English
Publishing date	2023-02-17
Publishing country	Netherlands
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1097/JCMA.0000000000000904
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Article: [Clinical analysis of interventional embolization for 9 cases with frontal arteriovenous malformation].

Li, Xiao / Fan, Xin-Dong / Wang, De-Ming / Yang, Xi-Tao / Su, Li-Xin

Shanghai kou qiang yi xue = Shanghai journal of stomatology

2023 Volume 32, Issue 3, Page(s) 332–336

Abstract: Purpose: To investigate the efficacy and safety of interventional embolization in the treatment of frontal arteriovenous malformation (AVM).: Methods: A retrospective study was used to analyze 9 patients with frontal AVM who were treated in Shanghai ... ...

Abstract	Purpose: To investigate the efficacy and safety of interventional embolization in the treatment of frontal arteriovenous malformation (AVM). Methods: A retrospective study was used to analyze 9 patients with frontal AVM who were treated in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. The patients were treated with interventional embolization under the guidance of DSA. The scope of lesions was observed through DSA, and the injection dose of sclerosing agent was predicted so that the drug could be injected into the lesion cavity. The efficacy, adverse reactions and complications of all patients were observed and analyzed. Results: Among the 9 patients, there were 7 males(77.8%) and 2 females(22.2%), aged from 1.5-20 years old. Local swelling or mass was the main reported symptom(66.7%). The blood supply arteries of the cases involved in this study included superficial temporal artery and ophthalmic artery. All patients received interventional embolization treatment under general anesthesia, a total of 19 times (each patient received 1-6 times, average 2.1 times/person), and the average single dose of absolute ethanol was 9.0 mL. A total of 80 coils (4.2 coils/time on average) were used for 5 times (80 coils/19 times) with absolute ethanol embolization. In addition, bleomycin was used 3 times, pingyangmycin was used 2 times, and 3% polydocanol was used 1 time to assist embolization. Among the 9 cases included in this study, 4 cases were cured, 3 cases were basically cured, 2 cases were improved, and the effective rate of treatment was 100%. No local or systemic complications were reported in all patients. Conclusions: In the treatment of frontal arteriovenous malformation, correct diagnosis according to clinical and imaging manifestations, and interventional embolization with anhydrous ethanol according to DSA angiography results can reduce trauma, improve symptoms, control lesions, and obtain relatively satisfactory treatment results. This scheme is safe and effective.
MeSH term(s)	Male ; Female ; Humans ; Infant ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Retrospective Studies ; China ; Arteriovenous Malformations/diagnostic imaging ; Arteriovenous Malformations/therapy ; Treatment Outcome ; Embolization, Therapeutic/adverse effects ; Embolization, Therapeutic/methods ; Ethanol
Chemical Substances	Ethanol (3K9958V90M)
Language	Chinese
Publishing date	2023-10-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2269714-7
ISSN	1006-7248
ISSN	1006-7248
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Article: Identification and characterization of the cupin_1 domain-containing proteins in ma bamboo (

Zhu, Peng-Kai / Yang, Jing / Yang, De-Ming / Xu, Yan-Ping / He, Tian-You / Rong, Jun-Dong / Zheng, Yu-Shan / Chen, Ling-Yan

Frontiers in plant science

2023 Volume 14, Page(s) 1260856

Abstract: Cupin_1 domain-containing protein (CDP) family, which is a member of the cupin superfamily with the most diverse functions in plants, has been found to be involved in hormone pathways that are closely related to rhizome sprouting (RS), a vital form of ... ...

Abstract	Cupin_1 domain-containing protein (CDP) family, which is a member of the cupin superfamily with the most diverse functions in plants, has been found to be involved in hormone pathways that are closely related to rhizome sprouting (RS), a vital form of asexual reproduction in plants. Ma bamboo is a typical clumping bamboo, which mainly reproduces by RS. In this study, we identified and characterized 53
Language	English
Publishing date	2023-10-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1260856
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Article ; Online: Effects of neutrophil fate on inflammation.

Xiao, Yuan / Cheng, Yang / Liu, Wen-Jie / Liu, Kun / Wang, Yan / Xu, Feng / Wang, De-Ming / Yang, Yi

Inflammation research : official journal of the European Histamine Research Society ... [et al.

2023 Volume 72, Issue 12, Page(s) 2237–2248

Abstract: Introduction: Neutrophils are important participants in the innate immune response. They rapidly and efficiently identify and clear infectious agents by expressing large numbers of membrane receptors. Upon tissue injury or pathogen invasion, neutrophils ...

Abstract	Introduction: Neutrophils are important participants in the innate immune response. They rapidly and efficiently identify and clear infectious agents by expressing large numbers of membrane receptors. Upon tissue injury or pathogen invasion, neutrophils are the first immune cells to reach the site of injury and participate in the inflammatory response. Materials and methods: A thorough search on PubMed related to neutrophil death or clearance pathways was performed. Conclusion: Inflammatory response and tissue damage can be aggravated when neutrophils are not removed rapidly from the site of injury. Recent studies have shown that neutrophils can be cleared through a variety of pathways, including non-inflammatory and inflammatory death, as well as reverse migration. Non-inflammatory death pathways include apoptosis and autophagy. Inflammatory death pathways include necroptosis, pyroptosis and NETosis. This review highlights the basic properties of neutrophils and the impact of their clearance pathways on the inflammatory response.
MeSH term(s)	Humans ; Neutrophils ; Apoptosis/physiology ; Inflammation ; Autophagy ; Immunity, Innate
Language	English
Publishing date	2023-11-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1221794-3
ISSN	1420-908X ; 1023-3830
ISSN (online)	1420-908X
ISSN	1023-3830
DOI	10.1007/s00011-023-01811-2
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Article ; Online: Combinatorial roles of mitochondria and cGMP/PKG pathway in the generation of neuronal free Zn2+ under the presence of nitric oxide.

Yang, De-Ming / Huang, Chien-Chang / Chang, Yu-Fen

Journal of the Chinese Medical Association : JCMA

2020 Volume 83, Issue 4, Page(s) 357–366

Abstract: Background: Nitric oxide (NO), which possesses both protective and toxic properties, has been observed to have a complicated biphasic character within various types of tissues, including neuronal cells. NO was also found to cause the increase of another ...

Abstract	Background: Nitric oxide (NO), which possesses both protective and toxic properties, has been observed to have a complicated biphasic character within various types of tissues, including neuronal cells. NO was also found to cause the increase of another important signaling molecular Zn (termed as NZR). The molecular mechanism of NZR has been extensively investigated, but the source of Zn is present of a major candidate that is yet to be answered. The NO-protein kinase G (PKG) pathway, mitochondria, and metallothioneins (MTs), are all proposed to be the individual source of NZR. However, this hypothesis remains inconclusive. In this study, we examined the function of PKG signaling cascades, the mitochondria storage, and MT-1 during NZR of living PC12 cells. Methods: We applied live-cell imaging in combination with pharmacological inhibitors and activators as well as in vitro Zn assay to dissect the functions of the above candidates in NZR. Results: Two mechanisms, namely, mitochondria as the only Zn source and the opening of NO-PKG-dependent mitochondrial ATP-sensitive potassium channels (mKATP) as the key to releasing NO-induced increase in mitochondrial Zn, were proven to be the two critical paths of NZR in neuronal-related cells. Conclusion: This new finding provides a reasonable explanation to previously existing and contradictory conclusions regarding the function of mitochondria/mKATP and PKG signaling on the molecular mechanism of NZR.
MeSH term(s)	Animals ; Cyclic GMP/physiology ; Cyclic GMP-Dependent Protein Kinases/physiology ; KATP Channels/physiology ; Mitochondria/physiology ; Neurons/metabolism ; Nitric Oxide/physiology ; PC12 Cells ; Rats ; Zinc/metabolism
Chemical Substances	KATP Channels ; Nitric Oxide (31C4KY9ESH) ; Cyclic GMP-Dependent Protein Kinases (EC 2.7.11.12) ; Cyclic GMP (H2D2X058MU) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2020-02-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1097/JCMA.0000000000000280
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