Article ; Online: HyPE study: hydroxychloroquine prophylaxis-related adverse events' analysis among healthcare workers during COVID-19 pandemic: a rising public health concern.
Journal of public health (Oxford, England)
2020 Volume 42, Issue 3, Page(s) 493–503
Abstract: Background: The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature.: Methods: A ... ...
| Abstract | Background: The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature. Methods: A retrospective, cross-sectional study was conducted across the country using semi-structured web-based questionnaire among COVID-19 negative and asymptomatic healthcare workers, taking hydroxychloroquine prophylaxis. Descriptive and multivariate logistic-regression models were applied for analysis. Results: Of the 166 participants, at least one adverse event was experienced by 37.9% participants, gastrointestinal being the most common (30.7%). Risk was higher in participants <40 years age (odd's ratio (OR): 2.44, 95% confidence interval (CI): 1.18-5.05) and after first dose of hydroxychloroquine (51.2%, OR: 2.38, 95%CI: 1.17-4.84). Hydroxychloroquine prophylaxis was initiated without electrocardiography by 80.1% of HCWs. Only 21.6% of those with cardiovascular disease could get prior ECG. Conclusions: A higher incidence of adverse events was observed when results were compared with studies involving patients on long-term hydroxychloroquine therapy. Younger age and first dose were associated with greater incidence of adverse events though all were self-limiting. Monitoring prior and during prophylaxis was inadequate even among those with cardiovascular disease and risk-factors. However, no serious cardiovascular events were reported. |
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| MeSH term(s) | Adult ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Cross-Sectional Studies ; Female ; Health Personnel/statistics & numerical data ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/therapeutic use ; Incidence ; India/epidemiology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Public Health/statistics & numerical data ; Retrospective Studies ; Risk Assessment ; Risk Factors |
| Chemical Substances | Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-06-01 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2142082-8 |
| ISSN | 1741-3850 ; 1741-3842 |
| ISSN (online) | 1741-3850 |
| ISSN | 1741-3842 |
| DOI | 10.1093/pubmed/fdaa074 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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