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  1. Article ; Online: Processing, Characterization and Disintegration Properties of Biopolymers Based on Mater-Bi

    Villegas, Carolina / Martínez, Sara / Torres, Alejandra / Rojas, Adrián / Araya, Rocío / Guarda, Abel / Galotto, María José

    Polymers

    2023  Volume 15, Issue 6

    Abstract: Among the most promising synthetic biopolymers to replace conventional plastics in numerous applications is ... ...

    Abstract Among the most promising synthetic biopolymers to replace conventional plastics in numerous applications is MaterBi
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15061548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Processing, Characterization and Disintegration Properties of Biopolymers Based on Mater-Bi ® and Ellagic Acid/Chitosan Coating

    Carolina Villegas / Sara Martínez / Alejandra Torres / Adrián Rojas / Rocío Araya / Abel Guarda / María José Galotto

    Polymers, Vol 15, Iss 1548, p

    2023  Volume 1548

    Abstract: Among the most promising synthetic biopolymers to replace conventional plastics in numerous applications is MaterBi ® (MB), a commercial biodegradable polymer based on modified starch and synthetic polymers. Actually, MB has important commercial ... ...

    Abstract Among the most promising synthetic biopolymers to replace conventional plastics in numerous applications is MaterBi ® (MB), a commercial biodegradable polymer based on modified starch and synthetic polymers. Actually, MB has important commercial applications as it shows interesting mechanical properties, thermal stability, processability and biodegradability. On the other hand, research has also focused on the incorporation of natural, efficient and low-cost active compounds into various materials with the aim of incorporating antimicrobial and/or antioxidant capacities into matrix polymers to extend the shelf life of foods. Among these is ellagic acid (EA), a polyphenolic compound abundant in some fruits, nuts and seeds, but also in agroforestry and industrial residues, which seems to be a promising biomolecule with interesting biological activities, including antioxidant activity, antibacterial activity and UV-barrier properties. The objective of this research is to develop a film based on commercial biopolymer Mater-Bi ® (MB) EF51L, incorporating active coating from chitosan with a natural active compound (EA) at two concentrations (2.5 and 5 wt.%). The formulations obtained complete characterization and were carried out in order to evaluate whether the incorporation of the coating significantly affects thermal, mechanical, structural, water-vapor barrier and disintegration properties. From the results, FTIR analysis yielded identification, through characteristic peaks, that the type of MB used is constituted by three polymers, namely PLA, TPS and PBAT. With respect to the mechanical properties, the values of tensile modulus and tensile strength of the MB-CHI film were between 15 and 23% lower than the values obtained for the MB film. The addition of 2.5 wt.% EA to the CHI layer did not generate changes in the mechanical properties of the system, whereas a 5 wt.% increase in ellagic acid improved the mechanical properties of the CHI film through the addition of natural phenolic compounds at high ...
    Keywords Mater-Bi ® ; ellagic acid ; chitosan ; coating ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Janus-Type Mesoporous Silica Nanoparticles for Sequential Tumoral Cell and Mitochondria Targeting.

    Villegas, Maria Rocio / Lopez, Victoria / Rodríguez-García, Verónica / Baeza, Alejandro / Vallet-Regí, María

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2275, Page(s) 341–361

    Abstract: The development of nanoparticles has provided a powerful weapon in the fight against cancer due to the discovery of their selective accumulation in tumoral tissues, known as enhanced permeation and retention (EPR) effect (Peer et al, Nat Nanotechnol 2: ... ...

    Abstract The development of nanoparticles has provided a powerful weapon in the fight against cancer due to the discovery of their selective accumulation in tumoral tissues, known as enhanced permeation and retention (EPR) effect (Peer et al, Nat Nanotechnol 2:751-760, 2007). Tumoral tissues require afastformation of blood vessels to sustain this rapid growth.
    MeSH term(s) Animals ; Cell Line, Tumor ; Drug Delivery Systems ; Folate Receptors, GPI-Anchored/metabolism ; Folic Acid/chemistry ; Folic Acid/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Mice ; Mitochondria/chemistry ; Nanoparticles ; Organophosphorus Compounds/chemistry ; Porosity ; Prostatic Neoplasms/metabolism ; Silicon Dioxide/chemistry
    Chemical Substances Folate Receptors, GPI-Anchored ; Organophosphorus Compounds ; triphenylphosphine (26D26OA393) ; Silicon Dioxide (7631-86-9) ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2021-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1262-0_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Immunological follow-up of patients with renal transplants: A proposal for clinical practice in Colombia

    Ortiz, Melissa Andrea / Álvarez, Cristiam Mauricio / Arrunátegui, Ana María / Arias, Yazmin Rocío / Villegas, Adriana

    Biomedica : revista del Instituto Nacional de Salud

    2020  Volume 40, Issue 3, Page(s) 479–486

    Title translation Seguimiento inmunológico después de trasplante renal: una propuesta para la práctica clínica en Colombia.
    MeSH term(s) Acute Disease ; Aftercare/methods ; Algorithms ; Antibody Specificity ; Colombia ; Delayed Diagnosis ; Early Diagnosis ; Follow-Up Studies ; Graft Rejection/diagnosis ; Graft Rejection/immunology ; Graft Rejection/pathology ; Histocompatibility/immunology ; Humans ; Kidney Transplantation ; Time Factors
    Language Spanish
    Publishing date 2020-09-01
    Publishing country Colombia
    Document type Journal Article
    ZDB-ID 2059952-3
    ISSN 2590-7379 ; 0120-4157
    ISSN (online) 2590-7379
    ISSN 0120-4157
    DOI 10.7705/biomedica.5092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Seguimiento inmunológico después de trasplante renal

    Melissa Andrea Ortiz / Cristiam Mauricio Álvarez / Ana María Arrunátegui / Yazmin Rocío Arias / Adriana Villegas

    Biomédica: revista del Instituto Nacional de Salud, Vol 40, Iss 3, Pp 479-

    una propuesta para la práctica clínica en Colombia

    2020  Volume 486

    Abstract: El daño del injerto es un proceso multifactorial que se inicia tempranamente después de la mayoría de los trasplantes de donantes sin HLA idéntico. Puede deberse a las comorbilidades del receptor, al estado del donante, al tiempo de isquemia, y al ... ...

    Abstract El daño del injerto es un proceso multifactorial que se inicia tempranamente después de la mayoría de los trasplantes de donantes sin HLA idéntico. Puede deberse a las comorbilidades del receptor, al estado del donante, al tiempo de isquemia, y al fenómeno de isquemia y reperfusión, entre otros, condiciones que inducen factores metabólicos e inmunológicos que finalmente desembocan en la disfunción del injerto. Sin embargo, entre el momento del trasplante y la aparición de los signos y síntomas existe un periodo que puede tardar semanas o años. Por ello, después del trasplante renal, es importante hacer un seguimiento racional que incluya la evaluación clínica y permita anticiparse al daño inmunológico del injerto. En este ensayo se propone un algoritmo de seguimiento del injerto renal después del trasplante.
    Keywords trasplante de riñón ; isoanticuerpos ; rechazo de injerto ; Medicine ; R ; Arctic medicine. Tropical medicine ; RC955-962
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Instituto Nacional de Salud
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A Contextualization of Transgender Women and Condom Use Using the HIV Syndemic Framework: Scoping Review.

    Moncayo-Quevedo, Jorge Eduardo / Pérez-Arizabaleta, María Del Mar / Rodríguez-Ortiz, Alejandra Rocio / Villegas-Trujillo, Lina María

    International journal of sexual health : official journal of the World Association for Sexual Health

    2024  Volume 36, Issue 2, Page(s) 221–235

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ISSN 1931-762X
    ISSN (online) 1931-762X
    DOI 10.1080/19317611.2024.2319323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Telephonic Follow-up and the Risk of Death in Ambulatory Patients with COVID-19.

    Vargas-Sánchez, Héctor Raúl / Tomás-López, Juan Carlos / Álvarez-Medina, Verónica / Gil-Velázquez, Luisa Estela / Vega-Vega, Hortensia / Alarcón-López, Alejandro / Pérez-Villegas, Rafael / Carbajal-García, Claudia María / Rivera-Tello, Eugenia Del Rocío / Cervantes-Ocampo, Manuel / Duque-Molina, Célida / Ascencio-Montiel, Iván de Jesús

    Journal of the American Board of Family Medicine : JABFM

    2022  Volume 36, Issue 1, Page(s) 164–169

    Abstract: Background: Primary care level close monitoring of mild COVID-19 patients has shown to provide a risk reduction in hospitalization and death. We aimed to compare the risk of all-cause death among COVID-19 ambulatory patients who received and did not ... ...

    Abstract Background: Primary care level close monitoring of mild COVID-19 patients has shown to provide a risk reduction in hospitalization and death. We aimed to compare the risk of all-cause death among COVID-19 ambulatory patients who received and did not receive telephonic follow-up in primary health care settings.
    Methods: A secondary database analysis, 2-group comparative study, was conducted with data from the medical information systems of the Mexican Institute of Social Security. A total of 1,498,808 ambulatory patients aged 20 years old and over and with laboratory confirmed SARS-CoV-2 by PCR or rapid antigen test were analyzed. Of them, 535,898 (35.8%) where followed by telephonic calls. The cases were attended from October 14, 2020, to April 10, 2022. Death incidence was evaluated. To assess the association between death and telephonic follow-up we calculated risk ratio using a multivariate logistic model.
    Results: Case fatality rate was 1.29% in the patients who received telephonic follow-up and 2.95% in the cases who did not receive phone calls. Medical history of chronic kidney disease, COPD, cardiovascular disease, tobacco consumption and diabetes were associated with increased risk of death. In the multivariate model, telephonic follow-up was associated with lower risk of all-cause death, with an adjusted risk ratio of 0.61 (95% confidence interval from 0.59, 0.64).
    Conclusion: Our data suggest that telephonic follow-up is associated with a risk of death reduction in adult outpatients with mild COVID-19, in the context of a multimodal strategy in the primary health care settings.
    MeSH term(s) Adult ; Humans ; Young Adult ; COVID-19/epidemiology ; SARS-CoV-2 ; Follow-Up Studies ; Hospitalization ; Time Factors
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2239939-2
    ISSN 1558-7118 ; 1557-2625
    ISSN (online) 1558-7118
    ISSN 1557-2625
    DOI 10.3122/jabfm.2022.220214R1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Infections and risk factors for infection-related mortality after pediatric allogeneic hematopoietic stem cell transplantation in Mexico: A single center retrospective study.

    Jiménez-Hernández, Elva / Núñez-Enriquez, Juan Carlos / Arellano-Galindo, José / de Los Angeles Del Campo-Martínez, María / Reynoso-Arenas, Perla Verónica / Reyes-López, Alfonso / Delgado-Gaytan, Alejandra Viridiana / Del Socorro Méndez-Tovar, María / Marín-Palomares, Teresa / Dueñas-Gonzalez, María Teresa / Ortíz-Fernández, Antonio / Montero-Ponce, Inés / Espinosa-Hernández, Laura Eugenia / Núñez-Villegas, Nora Nancy / Pérez-Casillas, Ruy / Sánchez-Jara, Berenice / García-Soto, Angel / Herver-Olivares, Annecy Nelly / Jaimes-Reyes, Ethel Zulie /
    Tiznado-García, Hector Manuel / Martínez-Villegas, Octavio / Valdez-Garibay, Betzayda / Del Rocío Loza-Santiaguillo, Paloma / García-Jiménez, Xochiketzalli / Ortíz-Torres, Guadalupe / Fernández-Castillo, Gabriela Jazmin / Aguilar-Olivares, Dulce María / Díaz-Padilla, Luis Alejandro / Noya-Rodríguez, Mario Alberto / García-Jiménez, Mariana / Mejía-Aranguré, Juan Manuel

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0284628

    Abstract: Objective: To identify the type of infections and risk factors for infection-related mortality (IRM) after allogeneic hematopoietic stem cell transplantation (HSCT).: Methods: Retrospective cohort study of patients <16 years of age treated in 2010- ... ...

    Abstract Objective: To identify the type of infections and risk factors for infection-related mortality (IRM) after allogeneic hematopoietic stem cell transplantation (HSCT).
    Methods: Retrospective cohort study of patients <16 years of age treated in 2010-2019 was conducted. Unadjusted hazard ratios (HR) and adjusted hazard ratios (aHR) with 95% confidence intervals (95% CIs) were estimated using Cox regression. Cumulative incidence was calculated.
    Results: Data for 99 pediatric patients were analyzed. The myeloablative conditioning was the most used regimen (78.8%) and the hematopoietic stem cell source was predominantly peripheral blood (80.8%). Primary graft failure occurred in 19.2% of patients. Frequency of acute graft-versus-host disease was 46.5%. Total of 136 infectious events was recorded, the most common of which were bacterial (76.4%) followed by viral infection (15.5%) and then fungal infection (8.1%). The best predictors for infection subtypes where the following: a) for bacterial infection (the age groups of 10.1-15 years: aHR = 3.33; 95% CI: 1.62-6.85 and. >15 years: aHR = 3.34; 95% CI: 1.18-9.45); b) for viral infection (graft versus host disease: aHR = 5.36; 95% CI: 1.62-17.68), however, for fungal infection statistically significant predictors were not identified. Related mortality was 30% (n = 12). Increased risk for infection-related mortality was observed in patients with unrelated donor and umbilical cord stem cells recipients (HR = 3.12; 95% CI: 1.00-9.85).
    Conclusions: Frequencies of infections and infection-related mortality appear to be similar to those reported. Unrelated donors and stem cells from umbilical cord recipients were associated with a high risk of mortality.
    MeSH term(s) Humans ; Child ; Adolescent ; Retrospective Studies ; Mexico/epidemiology ; Transplantation, Homologous/adverse effects ; Hematopoietic Stem Cell Transplantation/adverse effects ; Graft vs Host Disease/etiology ; Risk Factors ; Unrelated Donors ; Mycoses/etiology ; Transplantation Conditioning/adverse effects
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: High occurrence of CRLF2 abnormalities in Mexican children with B-cell acute lymphoblastic leukemia.

    Juárez-Velázquez, María Del Rocío / Moreno-Lorenzana, Dafné Linda / Martínez Anaya, Daniel Alejandro / Hernández Monterde, Eduardo Adrián / Aguilar-Hernández, María Montserrat / Reyes-León, Adriana / Chávez-González, María Antonieta / López Santiago, Norma / Zapata Tarrés, Marta / Juárez Villegas, Luis / Rivera Sánchez, Netzi / Soto Lerma, Oscar / Vega-Vega, Lourdes / Rivera Luna, Roberto / Pérez-Vera, Patricia

    Cytokine

    2022  Volume 155, Page(s) 155896

    Abstract: The P2RY8-CRLF2 and IGH-CRLF2 rearrangements induce the overexpression of cytokine receptor-like factor 2 (CRLF2) and have been associated with relapse and poor prognosis in B-cell acute lymphoblastic leukemia (B-ALL). Additionally, they are frequently ... ...

    Abstract The P2RY8-CRLF2 and IGH-CRLF2 rearrangements induce the overexpression of cytokine receptor-like factor 2 (CRLF2) and have been associated with relapse and poor prognosis in B-cell acute lymphoblastic leukemia (B-ALL). Additionally, they are frequently documented in high-risk Hispanic populations. To better understand the potential causes of the adverse prognosis of childhood B-ALL in Mexico, we analyzed these rearrangements and the CRLF2 mRNA and protein levels in 133 Mexican children with B-ALL. We collected bone marrow samples at diagnosis and evaluated the CRLF2 gene expression by qRT-PCR and the total CRLF2 protein by flow cytometry. P2RY8-CRLF2 and IGH-CRLF2 were detected by RT-PCR and FISH, respectively. The median time of follow-up to determine the prognostic significance of the CRLF2 abnormalities was three years. In 82% of the participants, the mRNA levels correlated with the cell-surface and intracellular CRLF2 protein levels. The P2RY8-CRLF2 rearrangement was present in 31.5% (42/133) of the patients, while the IGH-CRLF2 rearrangement was detected in 13.5% (9/67) of patients with high expression of CRLF2 (6.8% of the total sample). CRLF2 copy number variations (gain) were also detected in 7.5% (5/67) of patients with high protein levels. The overall survival (OS) presented significantly lower rates in patients with high white blood cell count (≥50x10
    MeSH term(s) DNA Copy Number Variations ; Humans ; Mexico ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Prognosis ; RNA, Messenger/genetics ; Receptors, Cytokine/genetics
    Chemical Substances CRLF2 protein, human ; RNA, Messenger ; Receptors, Cytokine
    Language English
    Publishing date 2022-05-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2022.155896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Characterization of Philadelphia-like Pre-B Acute Lymphoblastic Leukemia: Experiences in Mexican Pediatric Patients.

    Martínez-Anaya, Daniel / Moreno-Lorenzana, Dafné / Reyes-León, Adriana / Juárez-Figueroa, Ulises / Dean, Michael / Aguilar-Hernández, María Montserrat / Rivera-Sánchez, Netzi / García-Islas, Jessica / Vieyra-Fuentes, Victoria / Zapata-Tarrés, Marta / Juárez-Villegas, Luis / Paredes-Aguilera, Rogelio / Vega-Vega, Lourdes / Rivera-Luna, Roberto / Juárez-Velázquez, María Del Rocío / Pérez-Vera, Patricia

    International journal of molecular sciences

    2022  Volume 23, Issue 17

    Abstract: Ph-like subtypes ... ...

    Abstract Ph-like subtypes with
    MeSH term(s) Gene Rearrangement ; Humans ; Mexico ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Receptors, Cytokine/genetics ; Receptors, Cytokine/metabolism ; STAT5 Transcription Factor/metabolism
    Chemical Substances Receptors, Cytokine ; STAT5 Transcription Factor
    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23179587
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