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  1. Article ; Online: Unraveling the secret of re-balancing homeostasis in sepsis: give a look at the evidences!

    Bottari, Gabriella

    The International journal of artificial organs

    2022  Volume 45, Issue 7, Page(s) 595–597

    MeSH term(s) Homeostasis ; Humans ; Sepsis/therapy
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 80456-3
    ISSN 1724-6040 ; 0391-3988
    ISSN (online) 1724-6040
    ISSN 0391-3988
    DOI 10.1177/03913988221092461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1439: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Potential correlation between hemodynamic improvement and an immune-modulation effect in pediatric patients with septic shock treated with renal replacement therapy and CytoSorb

    Bottari, Gabriella / Cecchetti, Corrado / Serpe, Carmela / Grimaldi, David / Taccone, Fabio S

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 25

    MeSH term(s) Humans ; Child ; Shock, Septic/therapy ; Continuous Renal Replacement Therapy ; Renal Replacement Therapy ; Hemodynamics
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-024-04802-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Hemadsorption in Critically Ill Children.

    Duchini, Pier Paolo / Bottari, Gabriella / Deep, Akash / Ricci, Zaccaria

    Contributions to nephrology

    2023  Volume 200, Page(s) 242–251

    Abstract: Application of extracorporeal blood purification in children is increasing with the improvement of technology and the broadening of indications in critically ill patients. Furthermore, novel devices are being made available with a miniaturized design to ... ...

    Abstract Application of extracorporeal blood purification in children is increasing with the improvement of technology and the broadening of indications in critically ill patients. Furthermore, novel devices are being made available with a miniaturized design to be applicable to pediatric machines and circuits. Current literature in the pediatric setting is essentially based on case series and observational studies. Novel prospective uncontrolled databases are underway, and the interest is growing in children, since the potential indications for pediatric sepsis and other inflammatory conditions might rely on the enhanced mediator clearance warranted by these techniques. This review will describe the application of hemadsorption in children, the available cartridges, the clinical results available in the pediatric setting, and the potential future uses.
    MeSH term(s) Child ; Humans ; Prospective Studies ; Critical Illness/therapy ; Hemadsorption ; Sepsis/therapy
    Language English
    Publishing date 2023-06-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-2782 ; 0302-5144
    ISSN (online) 1662-2782
    ISSN 0302-5144
    DOI 10.1159/000529904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A simplified protocol of regional citrate anticoagulation with phosphate-containing solutions in infants and children treated with continuous kidney replacement therapy.

    Cappoli, Andrea / Labbadia, Raffaella / Antonucci, Luca / Bottari, Gabriella / Rossetti, Emanuele / Guzzo, Isabella

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 38, Issue 11, Page(s) 3835–3844

    Abstract: Background: Regional citrate anticoagulation (RCA) is the preferred modality of anticoagulation used in continuous kidney replacement therapy (CKRT) in adults and less extensively in children. Potential metabolic complications limit widespread use in ... ...

    Abstract Background: Regional citrate anticoagulation (RCA) is the preferred modality of anticoagulation used in continuous kidney replacement therapy (CKRT) in adults and less extensively in children. Potential metabolic complications limit widespread use in infants, neonates, and in children with liver failure.
    Methods: We report our experience with a simplified protocol in 50 critically ill children, infants, and neonates, some of them with liver failure, with commercially available solutions containing phosphorous and higher concentration of potassium and magnesium.
    Results: RCA allowed attainment of a mean filter lifetime of 54.5 ± 18.2 h, 42.5% of circuits lasted more than 70 h, and scheduled change was the most frequent cause of CKRT interruption. Patient Ca
    Conclusions: In our experience, RCA with commercially available solutions was easily applied and managed in critically ill children, even in patients with low weight or with liver failure. Solutions containing phosphate and higher concentrations of magnesium and potassium allowed reduction of metabolic derangement during CKRT. Prolonged filter life was ensured with no detrimental effects on patients and reduced staff workload. A higher resolution version of the Graphical abstract is available as Supplementary information.
    MeSH term(s) Adult ; Infant, Newborn ; Humans ; Child ; Infant ; Citric Acid/adverse effects ; Anticoagulants/adverse effects ; Phosphates ; Critical Illness/therapy ; Magnesium ; Acute Kidney Injury/etiology ; Citrates ; Hemofiltration/methods ; Liver Failure
    Chemical Substances Citric Acid (2968PHW8QP) ; Anticoagulants ; Phosphates ; Magnesium (I38ZP9992A) ; Citrates
    Language English
    Publishing date 2023-05-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-05994-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Role of Hemoperfusion With CytoSorb Associated With Continuous Kidney Replacement Therapy on Renal Outcome in Critically III Children With Septic Shock.

    Bottari, Gabriella / Lorenzetti, Giulia / Severini, Flavia / Cappoli, Andrea / Cecchetti, Corrado / Guzzo, Isabella

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 718049

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.718049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Impact of CytoSorb and CKRT on hemodynamics in pediatric patients with septic shock: the PedCyto study.

    Bottari, Gabriella / Guzzo, Isabella / Cappoli, Andrea / Labbadia, Raffaella / Perdichizzi, Salvatore / Serpe, Carmela / Creteur, Jacques / Cecchetti, Corrado / Taccone, Fabio Silvio

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1259384

    Abstract: Background: There is a lack of data to support the use of hemoadsorption in pediatric septic shock. The aim of our study was to assess the effectiveness and safety of CytoSorb therapy in this setting.: Methods: Phase II interventional single arm ... ...

    Abstract Background: There is a lack of data to support the use of hemoadsorption in pediatric septic shock. The aim of our study was to assess the effectiveness and safety of CytoSorb therapy in this setting.
    Methods: Phase II interventional single arm pilot study in which 17 consecutive children admitted with septic shock who required continuous kidney replacement therapy (CKRT) and weighed ≥10 kg were included. A CytoSorb (CytoSorbents Inc, New Jersey, USA) hemoadsorption cartridge was added to the CKRT every 24 h for a maximum of 96 h. A control group of 13 children with septic shock treated with CKRT but not hemoadsorption at Children's Hospital Bambino Gesù and enrolled in the EuroAKId register was selected as an historical cohort. The primary outcome of the study was a reduction in vasopressor or inotrope dose of >50% from baseline by the end of CytoSorb therapy. Secondary outcomes included hemodynamic and biological changes, changes in severity scores, and 28-day mortality.
    Results: There were significant decreases in the Vasoactive Inotropic Score (VIS) and the Pediatric Logistic Organ Dysfunction 2 (PELOD-2) score at 72 and 96 h from the start of the CytoSorb therapy compared to baseline; the reductions were larger in the hemoadsorption group than in the control group (historical cohort). 28-day mortality was lower, although not significantly, in the hemoadsorption group when compared to the control group (5/17 [29%] vs. 8/13 [61%] OR 0.26 [95% CI: 0.05-1.2];
    Conclusions: CytoSorb therapy may have some benefits in pediatric patients with septic shock
    Clinical trial registration: https://clinicaltrials.gov/ct2/show/NCT05658588, identifier (Clinicaltrials.gov NCT05658588).
    Language English
    Publishing date 2023-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1259384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Efficacy of CytoSorb in a Pediatric Case of Severe Multisystem Infammatory Syndrome (MIS-C): A Clinical Case Report.

    Bottari, Gabriella / Confalone, Valerio / Cotugno, Nicola / Guzzo, Isabella / Perdichizzi, Salvatore / Manno, Emma C / Stoppa, Francesca / Cecchetti, Corrado

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 676298

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-06-11
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.676298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Use of Cefiderocol as Salvage Therapy in an Infant Receiving ECMO and Continuous Renal Replacement Therapy.

    Mercadante, Stefania / Tripiciano, Costanza / Romani, Lorenza / Di Nardo, Matteo / Bottari, Gabriella / Goffredo, Bianca Maria / Simeoli, Raffaele / Guzzo, Isabella / Lancella, Laura / Antachopoulos, Charalampos / De Luca, Maia

    Antibiotics (Basel, Switzerland)

    2023  Volume 13, Issue 1

    Abstract: Background: Infections caused by antimicrobial-resistant (AMR) pathogens are increasing worldwide, representing a serious global public health issue with high morbidity and mortality rates The treatment of : Case presentation: This report describes ... ...

    Abstract Background: Infections caused by antimicrobial-resistant (AMR) pathogens are increasing worldwide, representing a serious global public health issue with high morbidity and mortality rates The treatment of
    Case presentation: This report describes the case of a critically ill 8-month-old girl affected by ventilator-associated pneumonia (VAP) infection complicated by bloodstream infection (BSI) sustained by VIM-producing PA. She was treated with cefiderocol as a salvage therapy during ECMO and CRRT support.
    Conclusions: In healthcare settings, treating multidrug-resistant, Gram-negative bacteria poses a serious challenge, especially in pediatric patients. Our findings suggest that cefiderocol can be considered as an off-label rescue therapy in selected pediatric cases.
    Language English
    Publishing date 2023-12-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13010037
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  9. Article ; Online: Hybrid blood purification strategy in pediatric septic shock.

    Bottari, Gabriella / Taccone, Fabio Silvio / Moscatelli, Andrea

    Critical care (London, England)

    2016  Volume 20, Issue 1, Page(s) 366

    Language English
    Publishing date 2016-11-10
    Publishing country England
    Document type Letter
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1466-609X
    ISSN (online) 1466-609X
    ISSN 1466-609X
    DOI 10.1186/s13054-016-1535-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Drug self-poisoning in adolescents: A report of 267 cases.

    Roversi, Marco / Martini, Matteo / Musolino, Antonio / Pisani, Mara / Zampini, Giorgio / Genuini, Leonardo / Bottari, Gabriella / Di Nardo, Matteo / Stoppa, Francesca / Marano, Marco

    Toxicology reports

    2023  Volume 10, Page(s) 680–685

    Abstract: Introduction: The current study aims at describing a sample of adolescents admitted to a tertiary referral pediatric hospital for drug self-poisoning and to identify variables that could explain and predict a higher severity of intoxication.: Methods!# ...

    Abstract Introduction: The current study aims at describing a sample of adolescents admitted to a tertiary referral pediatric hospital for drug self-poisoning and to identify variables that could explain and predict a higher severity of intoxication.
    Methods: We retrospectively reviewed the cases of drug self-poisoning in adolescents admitted to the Bambino Gesù Children's Hospital between January 2014 and June 2022 requiring consultation by the local Pediatric Poison Control Center (PPCC). We reported the type and class of drug ingested and correlated the clinical characteristics of the patients with their Poison Severity Score.
    Results: The data of 267 patients were reported. Most patients were female (85.8 %), with a median age of 15.8 years at presentation. Half of the patients were symptomatic at admission (44.2 %), and most had at least one psychiatric comorbidity (71.1 %). Most patients were hospitalized (79.6 %), 16.6 % of cases required antidote administration and a minority required intensive care. Most patients received a PSS score of 0 (59.6 %). The most frequently ingested drug was acetaminophen (28.1 %) followed by ibuprofen (10.1 %) and aripiprazole (10.1 %). Antipsychotics as a class were the most abused drugs (33.1 %). The correlation of clinical variables with the PSS showed that older and male patients were more prone to be severely intoxicated.
    Conclusions: This single-center study identifies the most commonly ingested drugs in a large sample of adolescents with voluntary drug self-poisoning, also showing that older and male patients are more susceptible to severe intoxication.
    Language English
    Publishing date 2023-05-29
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2023.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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