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Article ; Online: Distrust of the State and observance of the law among peasants in the San Nicolas Valley

Nicolasa María Durán-Palacio / Sonia Natalia Cogollo-Ospina / Norman Darío Moreno-Carmona

Revista de Economia e Sociologia Rural, Vol 59, Iss

2020 Volume 1

Abstract: ... In this scenario the Territorial Arrangement Planning of the San Nicolas Valley, in the East of the department ... sampling was carried out, including 380 peasants, members of civic-rural associations of the San Nicolas ...

Abstract	Abstract In Colombia, political decisions related to the countryside preserve an unjust social order, maintaining inequities and obstacles to the well-being and life quality of farmers. In this scenario the Territorial Arrangement Planning of the San Nicolas Valley, in the East of the department of Antioquia, has generated a series of rural conflicts that accentuate the vulnerabilities of rural residents, threatening the agricultural tradition in this subregion. Thus, this study inquired about the perceptions of legality in the peasant population of the area. A descriptive-correlational study with non-probabilistic sampling was carried out, including 380 peasants, members of civic-rural associations of the San Nicolas Valley, evaluating in four scales: beliefs, values, knowledge of the law and perceived legality in the context. Statistical analyses were performed in SPSS v.22 software. The findings indicated significant relationships between the study variables. Despite the state abandonment of the proletariat to market forces in an area with socioeconomic imbalances, no determining link was found between low income and violation of the law.
Keywords	perception ; social justice ; peasants ; beliefs ; social values ; Agriculture (General) ; S1-972
Subject code	910
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Sociedade Brasileira de Economia e Sociologia Rural
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transcription-Coupled Nucleotide Excision Repair and the Transcriptional Response to UV-Induced DNA Damage.

Nieto Moreno, Nicolás / Olthof, Anouk M / Svejstrup, Jesper Q

Annual review of biochemistry

2023 Volume 92, Page(s) 81–113

Abstract: Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which threaten genome stability and cell viability. Cells have evolved two main repair pathways to remove such lesions: global genome nucleotide excision repair (GG-NER) ... ...

Abstract	Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which threaten genome stability and cell viability. Cells have evolved two main repair pathways to remove such lesions: global genome nucleotide excision repair (GG-NER) and transcription-coupled nucleotide excision repair (TC-NER). The modes by which these subpathways recognize DNA lesions are distinct, but they converge onto the same downstream steps for DNA repair. Here, we first summarize the current understanding of these repair mechanisms, specifically focusing on the roles of stalled RNA polymerase II, Cockayne syndrome protein B (CSB), CSA and UV-stimulated scaffold protein A (UVSSA) in TC-NER. We also discuss the intriguing role of protein ubiquitylation in this process. Additionally, we highlight key aspects of the effect of UV irradiation on transcription and describe the role of signaling cascades in orchestrating this response. Finally, we describe the pathogenic mechanisms underlying xeroderma pigmentosum and Cockayne syndrome, the two main diseases linked to mutations in NER factors.
MeSH term(s)	Humans ; Cockayne Syndrome/genetics ; Cockayne Syndrome/metabolism ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/metabolism ; Transcription, Genetic ; DNA Repair ; DNA Damage ; DNA/genetics ; DNA/metabolism ; Carrier Proteins/metabolism
Chemical Substances	DNA Repair Enzymes (EC 6.5.1.-) ; DNA (9007-49-2) ; UVSSA protein, human ; Carrier Proteins
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	207924-0
ISSN	1545-4509 ; 0066-4154
ISSN (online)	1545-4509
ISSN	0066-4154
DOI	10.1146/annurev-biochem-052621-091205
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Article ; Online: What's an early triadic interaction made of? A methodological proposal to study the musical dynamics of interaction.

Moreno-Núñez, Ana / Alessandroni, Nicolás

Infant behavior & development

2021 Volume 63, Page(s) 101572

Abstract: Classical theories of intersubjectivity hold that the first interactions in which children participate are dyadic (adult-baby). However, thanks to the material shift that is taking place in the cognitive sciences, an increasing number of authors began to ...

Abstract	Classical theories of intersubjectivity hold that the first interactions in which children participate are dyadic (adult-baby). However, thanks to the material shift that is taking place in the cognitive sciences, an increasing number of authors began to recognise the constitutive role that materiality has for cognition, from the very beginning of life. Interactions do not occur in a vacuum, but within a meaning-loaded material world that adults actively seek to bring to children. While in the field of dyadic interactions studies on communicative musicality have shown how interactive exchanges are structured and how that structure unfolds over time, little is known yet about the internal structure of early triadic interactions. In this paper, we propose a longitudinal, mixed and multilevel methodological framework aimed at describing the dynamics of the musical organisation of early triadic interactions between adults, babies and things, and its development over different timescales. We conclude that if researchers want to fully understand early triadic interactions and their musical structuring, further studies that take into account the cognitive relevance of things and the dynamics of our interactions with and through materiality are needed.
MeSH term(s)	Adult ; Child ; Communication ; Humans ; Infant ; Interpersonal Relations ; Music
Language	English
Publishing date	2021-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	224510-3
ISSN	1934-8800 ; 1879-0453 ; 0163-6383
ISSN (online)	1934-8800 ; 1879-0453
ISSN	0163-6383
DOI	10.1016/j.infbeh.2021.101572
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Article ; Online: Assessment of injuries patterns produced by a 9mm P.A.K "rubber ball" blank firing weapon: porcine model.

Moreno, Nicolas Castillo / Zambrano, Juan Pablo / Dorado, Luis Felipe / Ricaurte, Ana Inés

International journal of legal medicine

2024

Abstract: The use of less lethal weapons aims to mitigate civilian casualties caused by firearm use. However, due to numerous cases in which these weapons caused serious injuries, even lethal injuries, both legislation and the forensic field are interested in ... ...

Abstract	The use of less lethal weapons aims to mitigate civilian casualties caused by firearm use. However, due to numerous cases in which these weapons caused serious injuries, even lethal injuries, both legislation and the forensic field are interested in characterizing and regulating them better. In the forensic field, there is a lack of strong research about injury patterns of these weapons which makes it difficult to identify the type of weapon employed. In this study, the main objective was to characterize the injury pattern produced by the impact of the 9 mm P.A.K. projectile. A porcine model was used. Four different distances were studied: firm contact, 10 cm, 60 cm and 110 cm, using 3 of the more representative anatomical sites: the head, the hind leg and the ribs. The average measurement of the entrance orifice varied according to the anatomical site, being 6.67 mm wide and 6.25 mm long in the thorax, 7.3 mm wide and 8.8 mm long in the hind legs, and 7.62 mm wide and 7.54 mm long in the head. The variation in width and length measurements was not found to be directly related to the shot distance. The gunshot residues had similar characteristics to those of conventional lead projectiles, however there was more unburned powder deposit near the wounds, with a less dense soot and more dense powder tattoo. Depth varied widely regardless of tissue and firing distance, although loss of penetrating power and injury is observed as one moves away from the target.
Language	English
Publishing date	2024-04-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1055109-8
ISSN	1437-1596 ; 0937-9827
ISSN (online)	1437-1596
ISSN	0937-9827
DOI	10.1007/s00414-024-03238-8
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Article ; Online: Do galectins serve as soluble ligands for immune checkpoint receptors?

Torres, Nicolas I / Baudou, Federico G / Scheidegger, Marco A / Dalotto-Moreno, Tomás / Rabinovich, Gabriel A

Journal for immunotherapy of cancer

2024 Volume 12, Issue 4

MeSH term(s)	Humans ; Galectins ; Immunotherapy ; Neoplasms/drug therapy ; Receptors, Immunologic ; Ligands
Chemical Substances	Galectins ; Receptors, Immunologic ; Ligands
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2024-008984
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Article ; Online: Effects of Hand Motor Interventions on Cognitive Outcomes Post-stroke: A Systematic Review and Bayesian Network Meta-analysis.

Valenzuela-López, Laura / Moreno-Verdú, Marcos / Cuenca-Zaldívar, Juan Nicolás / Romero, Juan Pablo

Archives of physical medicine and rehabilitation

2024

Abstract: Objective: To synthetize the evidence on the effects of hand rehabilitation (RHB) interventions on cognition post-stroke and compare their efficacy.: Data sources: PubMed, Embase, Cochrane, Scopus, Web of Science, and CINAHL were searched from ... ...

Abstract	Objective: To synthetize the evidence on the effects of hand rehabilitation (RHB) interventions on cognition post-stroke and compare their efficacy. Data sources: PubMed, Embase, Cochrane, Scopus, Web of Science, and CINAHL were searched from inception to November 2022. Data selection: Randomized controlled trials conducted in adults with stroke where the effects of hand motor interventions on any cognitive domains were assessed. Data extraction: Data were extracted by 2 independent reviewers. A Bayesian Network Meta-analysis (NMA) was applied for measures with enough studies and comparisons. Risk of bias was assessed with the Cochrane Risk of Bias tool. Data synthesis: Fifteen studies were included in qualitative synthesis, and 11 in NMA. Virtual reality (VR) (n=7), robot-assisted (n=5), or handgrip strength (n=3) training were the experimental interventions and conventional RHB (n=14) control intervention. Two separate NMA were performed with MoCA (n=480 participants) and MMSE (n=350 participants) as outcome measures. Both coincided that the most probable best interventions were robot-assisted and strength training, according to SUCRA and rankogram, followed by conventional RHB and VR training. No significant differences between any of the treatments were found in the MoCA network, but in the MMSE, robot-assisted and strength training were significantly better than conventional RHB and VR. No significant differences between robot-assisted and strength training were found nor between conventional RHB and VR. Conclusions: Motor interventions can improve MoCA/MMSE scores post-stroke. Most probable best interventions were robot-assisted and strength training. Limited literature assessing domain-specific cognitive effects was found.
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80057-0
ISSN	1532-821X ; 0003-9993
ISSN (online)	1532-821X
ISSN	0003-9993
DOI	10.1016/j.apmr.2023.12.013
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Article ; Online: Exposure of multidrug-resistant

Vazquez, Nicolas M / Moreno, Silvia / Galván, Estela M

Biofilm

2022 Volume 4, Page(s) 100085

Abstract: Klebsiella ... ...

Abstract	Klebsiella pneumoniae
Language	English
Publishing date	2022-10-04
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-2075
ISSN (online)	2590-2075
DOI	10.1016/j.bioflm.2022.100085
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Article ; Online: Computational modeling of passive transport of functionalized nanoparticles.

Moreno-Chaparro, Daniela / Moreno, Nicolas / Usabiaga, Florencio Balboa / Ellero, Marco

The Journal of chemical physics

2023 Volume 158, Issue 10, Page(s) 104108

Abstract: Functionalized nanoparticles (NPs) are complex objects present in a variety of systems ranging from synthetic grafted nanoparticles to viruses. The morphology and number of the decorating groups can vary widely between systems. Thus, the modeling of ... ...

Abstract	Functionalized nanoparticles (NPs) are complex objects present in a variety of systems ranging from synthetic grafted nanoparticles to viruses. The morphology and number of the decorating groups can vary widely between systems. Thus, the modeling of functionalized NPs typically considers simplified spherical objects as a first-order approximation. At the nanoscale label, complex hydrodynamic interactions are expected to emerge as the morphological features of the particles change, and they can be further amplified when the NPs are confined or near walls. Direct estimation of these variations can be inferred via diffusion coefficients of the NPs. However, the evaluation of the coefficients requires an improved representation of the NPs morphology to reproduce important features hidden by simplified spherical models. Here, we characterize the passive transport of free and confined functionalized nanoparticles using the Rigid Multi-Blob (RMB) method. The main advantage of RMB is its versatility to approximate the mobility of complex structures at the nanoscale with significant accuracy and reduced computational cost. In particular, we investigate the effect of functional groups' distribution, size, and morphology over nanoparticle translational and rotational diffusion. We identify that the presence of functional groups significantly affects the rotational diffusion of the nanoparticles; moreover, the morphology of the groups and number induce characteristic mobility reduction compared to non-functionalized nanoparticles. Confined NPs also evidenced important alterations in their diffusivity, with distinctive signatures in the off-diagonal contributions of the rotational diffusion. These results can be exploited in various applications, including biomedical, polymer nanocomposite fabrication, drug delivery, and imaging.
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0136833
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Article ; Online: Ionic effects on supramolecular hosts: solvation and counter-ion binding in polar media.

Moreno-Gómez, Nicolás / Vargas, Edgar F / Buchner, Richard

Physical chemistry chemical physics : PCCP

2022 Volume 24, Issue 4, Page(s) 2040–2050

Abstract: For the progress of synthetic supramolecular chemistry in aqueous solution the design of host molecules soluble in this medium is essential. A possible route is the introduction of ionic residues, with the additional advantage that also electrostatic ... ...

Abstract	For the progress of synthetic supramolecular chemistry in aqueous solution the design of host molecules soluble in this medium is essential. A possible route is the introduction of ionic residues, with the additional advantage that also electrostatic interactions can be used to form supramolecular architectures. In this work we study the effect of different ionic substituents on a resorcin[4]arene host on solvation and counterion binding in water and dimethyl sulfoxide (DMSO). To do so, we combine dielectric relaxation spectroscopy (DRS) at 298.15 K and dilute-solution conductivity measurements covering 278.15-308.15 K. The results indicate that studied substituents lead to a comparable increase in solubility in both water and the dipolar-aprotic DMSO. However, solvation and counterion binding not only depend on the nature of the ionic substituent but also on the solvent. Although intrinsically hydrophobic in nature, resorcin[4]arenes with ionic substituents also show strong hydrophilic hydration in water, with the extent depending on the nature of the ionic group. In contrast to that, solvophobicity apparently dominates the interactions of DMSO with the solute. Counterion binding was found for both solvents and is essentially determined by solvent polarity. It appears that, compared to neat DMSO, the solubility of the cationic resorcin[4]arene with dimethylamine substituents is strongly increased in water-DMSO mixtures due to the formation of hydrogen bonds between two DMSO molecules and one water molecule.
Language	English
Publishing date	2022-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d1cp05444a
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Article: The carbon footprint cost of travel to Canadian Urological Association conferences.

Vanin Moreno, Nicolas M / Paco, Charles / Touma, Naji

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

2023 Volume 17, Issue 6, Page(s) E172–E175

Abstract: Introduction: Canadian Urological Association (CUA) conferences are held annually across Canada. Guests from across the world attended, contributing to the overall carbon footprint of the conference with their travel and accommodations. This study ... ...

Abstract	Introduction: Canadian Urological Association (CUA) conferences are held annually across Canada. Guests from across the world attended, contributing to the overall carbon footprint of the conference with their travel and accommodations. This study identified the carbon footprint of each of the 2016 (Vancouver), 2018 (Halifax), and 2019 (Quebec City) CUA conferences to investigate their carbon footprint and help determine the most eco-friendly location to hold future conferences. Methods: Registrant home institution was used to estimate the distance and method of transportation of attendee travel. Carbon footprint was calculated using an online calculator in tons of CO Results: Vancouver had the largest number of attendees (n=473; 407 flying, 66 driving), followed by Halifax (n=382; 331 flying, 51 driving), and Quebec City (n=362; 265 flying, 97 driving). The mean distance attendees travelled was greatest for the Vancouver CUA (6041 km/roundtrip) compared to Quebec City (3096 km/roundtrip, p<0.0001) and Halifax (2985 km/roundtrip, p<0.0001). There was no difference in mean distance travelled between Halifax and Quebec City (p=0.95). The highest total carbon footprint was seen in Vancouver (tCO Conclusions: The estimated emissions associated with the Vancouver CUA conference is greater than both the Halifax and Quebec City locations combined. In-person conferences provide several benefits to the urological community. Incorporating environmental considerations into conference planning, such as conference location, could reduce the CUA conference's overall carbon footprint, mitigating the contribution to rising temperatures and negative health outcomes.
Language	English
Publishing date	2023-03-23
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2431403-1
ISSN	1911-6470
ISSN	1911-6470
DOI	10.5489/cuaj.8132
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