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  1. Article ; Online: Qi Dan Li Xin pill improves chronic heart failure by regulating mTOR/p70S6k-mediated autophagy and inhibiting apoptosis.

    Shi, Binhao / Huang, Yuting / Ni, Jingyu / Chen, Jingrui / Wei, Jing / Gao, Hui / Li, Lan / Zhou, Zhengcan / Wang, Yili / Xu, Yunsheng / Xu, Zongpei / Mao, Jingyuan / Fan, Guanwei

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 6105

    Abstract: ... apoptosis and autophagy. This study assessed the effects of Qi Dan Li Xin Pill (QD) on heart function ... of the mTOR/P70S6K signaling pathway, suggesting that the traditional Chinese medicine Qi Dan Li Xin pill is ...

    Abstract Myocardial remodeling represents a key factor in chronic heart failure (CHF) development, and is characterized by chronic death of cardiomyocytes. Cardiac function changes may be attributed to inflammation, apoptosis and autophagy. This study assessed the effects of Qi Dan Li Xin Pill (QD) on heart function, inflammatory factors, autophagy and apoptosis in cardiac remodeling in CHF rats upon myocardial infarction (MI) induction. Male SD rats underwent a sham procedure or left anterior descending coronary artery (LADCA) ligation, causing MI. Twenty-eight days after modeling, the animals were treated daily with QD, valsartan and saline for 4 weeks. Echocardiography after 4 weeks of drug intervention revealed substantially improved left ventricular remodeling and cardiac function following QD treatment. As demonstrated by decreased IL-1β, IL-6 and TNF-α amounts, this treatment also inhibited the apoptotic process and protected the viability of the myocardium. These outcomes may be attributed to enhanced autophagy in cardiomyocytes, which further reduced pro-inflammatory and pro apoptotic effects. This process may be achieved by QD regulation of the mTOR/P70S6K signaling pathway, suggesting that the traditional Chinese medicine Qi Dan Li Xin pill is effective in heart protective treatment, and is worth further investigation.
    MeSH term(s) Animals ; Apoptosis ; Autophagy ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Heart Failure/drug therapy ; Interleukins/genetics ; Interleukins/metabolism ; Male ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Rats ; Rats, Sprague-Dawley ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Cardiotonic Agents ; Drugs, Chinese Herbal ; Interleukins ; Tumor Necrosis Factor-alpha ; qidan ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1)
    Language English
    Publishing date 2020-04-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-63090-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tongxinluo (Tong xin luo or Tong-xin-luo) capsule for unstable angina pectoris.

    Wu, Taixiang / Harrison, R A / Chen, Xiaoyan / Ni, Juan / Zhou, Likun / Qiao, Jieqi / Wang, Qin / Wei, Jiafu / Xin, Duan / Zheng, Jie

    The Cochrane database of systematic reviews

    2006  , Issue 4, Page(s) CD004474

    Abstract: Background: Tongxinluo capsule is a medicine consisting of traditional Chinese herbs and insects used for cardiovascular diseases in China and some other Asian countries. To date the evidence of its effect has not previously been subject to systematic ... ...

    Abstract Background: Tongxinluo capsule is a medicine consisting of traditional Chinese herbs and insects used for cardiovascular diseases in China and some other Asian countries. To date the evidence of its effect has not previously been subject to systematic review, making it difficult to derive robust conclusions about its actual benefits, and indeed, possible harms.
    Objectives: To assess systematically the effects of tongxinluo capsule in people with unstable angina pectoris.
    Search strategy: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) on The Cochrane Library, Issue 4 2004, MEDLINE, EMBASE, Chinese Biomedical Database, China National Knowledge Infrastructure, Japana Centra Revuo Medicina (all 1995 to 2005). We also handsearched the relevant Chinese journals, checked with manufacturers and registers of ongoing studies.
    Selection criteria: Randomised trials comparing either tongxinluo capsule only or standard treatment plus tongxinluo capsule with standard treatment or other anti-angina pectoris drugs, placebo or no intervention.
    Data collection and analysis: Two authors identified relevant studies for the review independently and went on to abstract data, and assess trial quality. Authors of included studies were contacted to obtain further information as required.
    Main results: 18 short term follow-up trials involving 1413 people were included. The studies did not provide strong support of a benefit of tongxinluo for reducing the combined outcome of acute myocardial infarction, angioplasty (PTCA) coronary artery bypass graft (CABG) and sudden death or all-cause mortality (RR 0.42, 95% CI 0.07 to 2.59, P=0.35; RR 0.33, 95% CI 0.01to 7.78, P=0.49, respectively). Tongxinluo reduced the frequency of acute angina attacks (WMD -1.20, 95%CI -1.38 to -1.02, P<0.00001 and RR -2.36, 95%CI -2.53 to -2.18, P<0.00001, respectively), improved ECG (RR 1.31, 95% CI 1.08 to 1.57, P=0.005) and angina symptoms (RR 1.21, 95% CI 1.06 to 1.40; P=0.007).
    Authors' conclusions: Tongxinluo in combination with routine angina therapy appears to reduce the risk of subsequent AMI, PTCA or CABG, angina attacks and severity, as well as improving symptoms and ischaemic changes on the electrocardiogram (ECG). Due to the methodological limitations of the studies, the evidence is insufficient to make any conclusive recommendations about the use of this treatment for patients presenting with unstable angina. Large high quality randomised controlled trials are warranted.
    MeSH term(s) Angina, Unstable/drug therapy ; Capsules ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Phytotherapy ; Randomized Controlled Trials as Topic
    Chemical Substances Capsules ; Drugs, Chinese Herbal ; tongxinluo
    Language English
    Publishing date 2006-10-18
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD004474.pub2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Qi Dan Li Xin pill improves chronic heart failure by regulating mTOR/p70S6k-mediated autophagy and inhibiting apoptosis

    Binhao Shi / Yuting Huang / Jingyu Ni / Jingrui Chen / Jing Wei / Hui Gao / Lan Li / Zhengcan Zhou / Yili Wang / Yunsheng Xu / Zongpei Xu / Jingyuan Mao / Guanwei Fan

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 10

    Abstract: ... to inflammation, apoptosis and autophagy. This study assessed the effects of Qi Dan Li Xin Pill (QD) on heart ... of the mTOR/P70S6K signaling pathway, suggesting that the traditional Chinese medicine Qi Dan Li Xin pill is ...

    Abstract Abstract Myocardial remodeling represents a key factor in chronic heart failure (CHF) development, and is characterized by chronic death of cardiomyocytes. Cardiac function changes may be attributed to inflammation, apoptosis and autophagy. This study assessed the effects of Qi Dan Li Xin Pill (QD) on heart function, inflammatory factors, autophagy and apoptosis in cardiac remodeling in CHF rats upon myocardial infarction (MI) induction. Male SD rats underwent a sham procedure or left anterior descending coronary artery (LADCA) ligation, causing MI. Twenty-eight days after modeling, the animals were treated daily with QD, valsartan and saline for 4 weeks. Echocardiography after 4 weeks of drug intervention revealed substantially improved left ventricular remodeling and cardiac function following QD treatment. As demonstrated by decreased IL-1β, IL-6 and TNF-α amounts, this treatment also inhibited the apoptotic process and protected the viability of the myocardium. These outcomes may be attributed to enhanced autophagy in cardiomyocytes, which further reduced pro-inflammatory and pro apoptotic effects. This process may be achieved by QD regulation of the mTOR/P70S6K signaling pathway, suggesting that the traditional Chinese medicine Qi Dan Li Xin pill is effective in heart protective treatment, and is worth further investigation.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Book: Xin bian fang ji xue

    Ni, Cheng

    2006  

    Title variant Fang ji xue
    Author's details Ni Cheng bian zhu ; Peng Huairen, Zhang Dechao zhu shen
    MeSH term(s) Formularies as Topic ; Medicine, Chinese Traditional
    Keywords China
    Language Chinese
    Size 4, 3, 7, 605 p. ;, 27 cm.
    Edition Di 1 ban.
    Publisher Ren min wei sheng chu ban she
    Publishing place Beijing Shi
    Document type Book
    ISBN 9787117073417 ; 7117073411
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Book: Xin yi ba shi gui ju song

    Xuanzang / Ni, Liangkang

    (Gu ji jin zhu xin yi cong shu ; 古籍今注新譯叢書)

    2005  

    Title variant Ba shi gui ju song ; 八識規矩頌
    Author's details Ni Liangkang zhu yi
    Series title Gu ji jin zhu xin yi cong shu
    古籍今注新譯叢書
    Keywords Vijñaptimātratā ; Yogācāra (Buddhism)
    Language Chinese
    Size 2, 1, 80 p, 21 cm
    Edition Chu ban
    Publisher San min shu ju
    Publishing place Taibei
    Document type Book
    Note Includes bibliographical references (p. 75-80)
    ISBN 9571442534 ; 9571442542 ; 9789571442532 ; 9789571442549
    Database Former special subject collection: coastal and deep sea fishing

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  6. Book: You zhi tao xin pin zhong feng chan zai pei

    Wang, Guoping / Hong, Ni

    2000  

    Title variant Youzhili xinpinzhong fengchan zaipei
    Author's details Wang Guoping, Hong Ni bian zhu
    Keywords Peach/Varieties
    Language Chinese
    Size 5, 180 p., 20 p. of plates :, ill. ;, 19 cm.
    Edition Di 1 ban.
    Publisher Jin dun chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 7508211014 ; 9787508211015
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: [Effect of ma-xin-shi-gan tang on the immune function in children with acute lower respiratory tract infection].

    Yue, Q / Ni, Z Y

    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine

    1990  Volume 10, Issue 10, Page(s) 600–2, 581

    Abstract: This paper reported the effect of Ma-Xin-Shi-Gan tang (Decoction of Herba Ephedrae, Semen ...

    Abstract This paper reported the effect of Ma-Xin-Shi-Gan tang (Decoction of Herba Ephedrae, Semen Armeniacae Amarum, Radix Glycyrrhizae and Gypsum Fibrosum) on the immune function of the children with acute lower respiratory tract infection (ALRTI). 64 cases of ALRTI children were chosen for clinical observation. Laboratory researches including 7 immune indexes: blood OKT3+ cell, OKT4+ cell, OKT8+ cell and OKT4+/OKT8+ cell ratio, serum IgG, IgA, IgM. Some tests in experimental mice were also made. The results showed: (1) Before treatment, the blood OKT3+ cell, OKT4+ cell and OKT4+/OKT8+ cell ratio of the ALRTI children were lower, OKT8+ cell was higher than that of the normal group, which indicated lowered function of cell mediated immunity (CMI) in ALRTI children. Furthermore, IgM content in serum of the ALRTI children was significantly higher than that of the normal group, which indicated a hyperhumoral immunity (HI). (2) Blood OKT4+ cell and OKT4+/OKT8+ cell ratio in children after treatment with the Decoction were higher than those before treatment, which suggested the Decoction can regulate the cell ratio of OKT4+ and OKT8+, and relieve the functional inhibition of CMI in ALRTI children, while comparing with the western medicine (WM) group, the blood OKT3+ cell, OKT4+ cell and serum IgG content in the Decoction group after treatment were higher. In the WM group, the serum IgG and IgA contents were lower than those of the normal group, which indicated inhibited function of HI after treatment. (3) In experimental mice, the Decoction can increase the phagocytic index of the macrophage, the spleen index and the level of serum hemolysin. It can also enhance the skin delayed allergic reaction of the mice.(ABSTRACT TRUNCATED AT 250 WORDS)
    MeSH term(s) Antibody Formation ; Bronchitis/drug therapy ; Bronchitis/immunology ; Child ; Child, Preschool ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Infant ; Male ; Pneumonia/drug therapy ; Pneumonia/immunology ; T-Lymphocyte Subsets/immunology
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 1990-10
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0254-9034
    ISSN 0254-9034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: O-linked β-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells.

    Zhou, Xu-Chang / Ni, Guo-Xin

    World journal of stem cells

    2024  Volume 16, Issue 3, Page(s) 228–231

    Abstract: Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been gradually elucidated, ... ...

    Abstract Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been gradually elucidated, the potential mechanisms of O-GlcNAcylation in bone metabolism, particularly, in the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) remains unexplored. In this study, the literature related to O-GlcNAcylation and BMSC osteogenic differentiation was reviewed, assuming that it could trigger more scholars to focus on research related to O-GlcNAcylation and bone metabolism and provide insights into the development of novel therapeutic targets for bone metabolism disorders such as osteoporosis.
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2583482-4
    ISSN 1948-0210
    ISSN 1948-0210
    DOI 10.4252/wjsc.v16.i3.228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fatigue, Pain, and Medication: Mining Online Posts Regarding Rheumatoid Arthritis From Reddit.

    Xin, Yi / Ni, Congning / Song, Qingyuan / Yin, Zhijun

    AMIA ... Annual Symposium proceedings. AMIA Symposium

    2024  Volume 2023, Page(s) 754–763

    Abstract: Rheumatoid arthritis (RA), a chronic and systemic autoimmune disease that primarily attacks the joints around the body, is affecting a large number of people worldwide through severe symptoms and complications. Therefore, it is crucial to understand ... ...

    Abstract Rheumatoid arthritis (RA), a chronic and systemic autoimmune disease that primarily attacks the joints around the body, is affecting a large number of people worldwide through severe symptoms and complications. Therefore, it is crucial to understand these patients' problems and support needs such that effective strategies or solutions can be made to improve their long-term treatment experience. In this paper, we present an in-depth study that is based on the structural topic model to uncover the themes and concerns in online RA posts from Reddit, an American social news aggregation, content rating, and discussion website. In addition, we compared the topic prevalence differences before and after the COVID-19 pandemic to understand the impact of the pandemic on these online users. This study demonstrates the potential of using text-mining techniques on social media data to learn the treatment experiments of RA patients.
    MeSH term(s) Humans ; Pandemics ; COVID-19/epidemiology ; Arthritis, Rheumatoid/drug therapy ; Social Media ; Fatigue/epidemiology ; Pain
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 1942-597X
    ISSN (online) 1942-597X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Safety of Continuing Aspirin Use in Patients With Coronary Heart Disease Who Undergo Thyroid Surgery During the Perioperative Period.

    Rao, Yuansheng / Wang, Jianhong / Yang, Fan / Ni, Xin

    Ear, nose, & throat journal

    2024  , Page(s) 1455613241230844

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613241230844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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