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Article ; Online: A novel variant in the PTPN11 gene c.1277A>G p.(His426Arg) in a patient with Noonan Syndrome with Multiple Lentigines.

Kuo, Olivia / Molloy, Kevin / Sabir, Ataf / Fleming, Andrew / Edwards, Matthew / Morris-Rosendahl, Deborah / Fassihi, Hiva / Preston, Philip

Clinical and experimental dermatology

2024

Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1093/ced/llae121
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Article ; Online: Reply to Letter to the Editor by Lohmann P, et al.

Nes, Emily / Jaksic, Tom / Edwards, Erika M

Journal of pediatric surgery

2024

Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Letter
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2024.03.048
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Article ; Online: Adaptive P-Splines for challenging filtering problems in biomechanics.

Pohl, Andrew J / Schofield, Matthew R / Edwards, W Brent / Ferber, Reed

Journal of biomechanics

2024 Volume 167, Page(s) 112074

Abstract: Suppression of noise from recorded signals is a critically important data processing step for biomechanical analyses. While a wide variety of filtering or smoothing spline methods are available, the majority of these are not well suited for the analysis ... ...

Abstract	Suppression of noise from recorded signals is a critically important data processing step for biomechanical analyses. While a wide variety of filtering or smoothing spline methods are available, the majority of these are not well suited for the analysis of signals with rapidly changing derivatives such as the processing of motion data for impact-like events. This is because commonly used low-pass filtering approaches or smoothing splines typically assume a single fixed cut-off frequency or regularization penalty which fails to describe rapid changes in the underlying function. To overcome these limitations we examine a class of adaptive penalized splines (APS) that extend commonly used penalized spline smoothers by inferring temporal adaptations in regularization penalty from observed data. Three variations of APS are examined in which temporal variation of spline penalization is described via either a series of independent random variables, an autoregressive process or a smooth cubic spline. Comparing the performance of APS on simulated datasets is promising with APS reducing RMSE by 48%-183% compared to a widely used Butterworth filtering approach. When inferring acceleration from noisy measurements describing the position of a pendulum impacting a barrier we observe between a 13% (independent variables) to 28% (spline) reduction in RMSE when compared to a 4th order Butterworth filter with optimally selected cut-off frequency. In addition to considerable improvement in RMSE, APS can provide estimates of uncertainty for fitted curves and generated quantities such as peak accelerations or durations of stationary periods. As a result, we suggest that researchers should consider the use of APS if features such as impact peaks, rates of loading, or periods of negligible acceleration are of interest.
MeSH term(s)	Biomechanical Phenomena ; Acceleration
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	218076-5
ISSN	1873-2380 ; 0021-9290
ISSN (online)	1873-2380
ISSN	0021-9290
DOI	10.1016/j.jbiomech.2024.112074
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Article ; Online: Nickel and Palladium Complexes of a PP(O)P Pincer Ligand Based upon a

Duvinage, Daniel / Puylaert, Pim / Wieduwilt, Erna K / Malaspina, Lorraine A / Edwards, Alison J / Lork, Enno / Mebs, Stefan / Hupf, Emanuel / Grabowsky, Simon / Beckmann, Jens

Inorganic chemistry

2022 Volume 61, Issue 22, Page(s) 8406–8418

Abstract: A PP(O)P pincer ligand based upon a ...

Abstract	A PP(O)P pincer ligand based upon a
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.1c03266
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Article: Evaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance.

Giroux, Parker / Kyle, Patrick B / Tan, Chalet / Edwards, Joseph D / Nowicki, Michael J / Liu, Hua

World journal of gastrointestinal pathophysiology

2022 Volume 13, Issue 3, Page(s) 73–84

Abstract: Background: Cardiac and hepatic functionality are intertwined in a multifaceted relationship. Pathologic processes involving one may affect the other through a variety of mechanisms, including hemodynamic and membrane transport effects.: Aim: To ... ...

Abstract	Background: Cardiac and hepatic functionality are intertwined in a multifaceted relationship. Pathologic processes involving one may affect the other through a variety of mechanisms, including hemodynamic and membrane transport effects. Aim: To better understand the effect of extrahepatic cholestasis on regulations of membrane transporters involving digoxin and its implication for digoxin clearance. Methods: Twelve adult rats were included in this study; baseline hepatic and renal laboratory values and digoxin pharmacokinetic (PK) studies were established before evenly dividing them into two groups to undergo bile duct ligation (BDL) or a sham procedure. After 7 d repeat digoxin PK studies were completed and tissue samples were taken to determine the expressions of cell membrane transport proteins by quantitative western blot and real-time polymerase chain reaction. Data were analyzed using SigmaStat 3.5. Means between pre-surgery and post-surgery in the same experimental group were compared by paired Results: Digoxin clearance was decreased and liver function, but not renal function, was impaired in BDL rats. BDL resulted in significant up-regulation of multidrug resistance 1 expression in the liver and kidney and its down-regulation in the small intestine. Organic anion transporting polypeptides (OATP)1A4 was up-regulated in the liver but down-regulated in intestine after BDL. OATP4C1 expression was markedly increased in the kidney following BDL. Conclusion: The results suggest that cell membrane transporters of digoxin are regulated during extrahepatic cholestasis. These regulations are favorable for increasing digoxin excretion in the kidney and decreasing its absorption from the intestine to compensate for reduced digoxin clearance due to cholestasis.
Language	English
Publishing date	2022-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2583474-5
ISSN	2150-5330
ISSN	2150-5330
DOI	10.4291/wjgp.v13.i3.73
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Article ; Online: Constraining the p-Mode-g-Mode Tidal Instability with GW170817.

Abbott, B P / Abbott, R / Abbott, T D / Acernese, F / Ackley, K / Adams, C / Adams, T / Addesso, P / Adhikari, R X / Adya, V B / Affeldt, C / Agarwal, B / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aiello, L / Ain, A / Ajith, P /

Allen, B / Allen, G / Allocca, A / Aloy, M A / Altin, P A / Amato, A / Ananyeva, A / Anderson, S B / Anderson, W G / Angelova, S V / Antier, S / Appert, S / Arai, K / Araya, M C / Areeda, J S / Arène, M / Arnaud, N / Arun, K G / Ascenzi, S / Ashton, G / Ast, M / Aston, S M / Astone, P / Atallah, D V / Aubin, F / Aufmuth, P / Aulbert, C / AultONeal, K / Austin, C / Avila-Alvarez, A / Babak, S / Bacon, P / Badaracco, F / Bader, M K M / Bae, S / Baker, P T / Baldaccini, F / Ballardin, G / Ballmer, S W / Banagiri, S / Barayoga, J C / Barclay, S E / Barish, B C / Barker, D / Barkett, K / Barnum, S / Barone, F / Barr, B / Barsotti, L / Barsuglia, M / Barta, D / Bartlett, J / Bartos, I / Bassiri, R / Basti, A / Batch, J C / Bawaj, M / Bayley, J C / Bazzan, M / Bécsy, B / Beer, C / Bejger, M / Belahcene, I / Bell, A S / Beniwal, D / Bensch, M / Berger, B K / Bergmann, G / Bernuzzi, S / Bero, J J / Berry, C P L / Bersanetti, D / Bertolini, A / Betzwieser, J / Bhandare, R / Bilenko, I A / Bilgili, S A / Billingsley, G / Billman, C R / Birch, J / Birney, R / Birnholtz, O / Biscans, S / Biscoveanu, S / Bisht, A / Bitossi, M / Bizouard, M A / Blackburn, J K / Blackman, J / Blair, C D / Blair, D G / Blair, R M / Bloemen, S / Bock, O / Bode, N / Boer, M / Boetzel, Y / Bogaert, G / Bohe, A / Bondu, F / Bonilla, E / Bonnand, R / Booker, P / Boom, B A / Booth, C D / Bork, R / Boschi, V / Bose, S / Bossie, K / Bossilkov, V / Bosveld, J / Bouffanais, Y / Bozzi, A / Bradaschia, C / Brady, P R / Bramley, A / Branchesi, M / Brau, J E / Briant, T / Brighenti, F / Brillet, A / Brinkmann, M / Brisson, V / Brockill, P / Brooks, A F / Brown, D D / Brunett, S / Buchanan, C C / Buikema, A / Bulik, T / Bulten, H J / Buonanno, A / Buskulic, D / Buy, C / Byer, R L / Cabero, M / Cadonati, L / Cagnoli, G / Cahillane, C / Calderón Bustillo, J / Callister, T A / Calloni, E / Camp, J B / Canepa, M / Canizares, P / Cannon, K C / Cao, H / Cao, J / Capano, C D / Capocasa, E / Carbognani, F / Caride, S / Carney, M F / Casanueva Diaz, J / Casentini, C / Caudill, S / Cavaglià, M / Cavalier, F / Cavalieri, R / Cella, G / Cepeda, C B / Cerdá-Durán, P / Cerretani, G / Cesarini, E / Chaibi, O / Chamberlin, S J / Chan, M / Chao, S / Charlton, P / Chase, E / Chassande-Mottin, E / Chatterjee, D / Chatziioannou, Katerina / Cheeseboro, B D / Chen, H Y / Chen, X / Chen, Y / Cheng, H-P / Chia, H Y / Chincarini, A / Chiummo, A / Chmiel, T / Cho, H S / Cho, M / Chow, J H / Christensen, N / Chu, Q / Chua, A J K / Chua, S / Chung, K W / Chung, S / Ciani, G / Ciobanu, A A / Ciolfi, R / Cipriano, F / Cirelli, C E / Cirone, A / Clara, F / Clark, J A / Clearwater, P / Cleva, F / Cocchieri, C / Coccia, E / Cohadon, P-F / Cohen, D / Colla, A / Collette, C G / Collins, C / Cominsky, L R / Constancio, M / Conti, L / Cooper, S J / Corban, P / Corbitt, T R / Cordero-Carrión, I / Corley, K R / Cornish, N / Corsi, A / Cortese, S / Costa, C A / Cotesta, R / Coughlin, M W / Coughlin, S B / Coulon, J-P / Countryman, S T / Couvares, P / Covas, P B / Cowan, E E / Coward, D M / Cowart, M J / Coyne, D C / Coyne, R / Creighton, J D E / Creighton, T D / Cripe, J / Crowder, S G / Cullen, T J / Cumming, A / Cunningham, L / Cuoco, E / Canton, T Dal / Dálya, G / Danilishin, S L / D'Antonio, S / Danzmann, K / Dasgupta, A / Costa, C F Da Silva / Dattilo, V / Dave, I / Davier, M / Davis, D / Daw, E J / Day, B / DeBra, D / Deenadayalan, M / Degallaix, J / De Laurentis, M / Deléglise, S / Del Pozzo, W / Demos, N / Denker, T / Dent, T / De Pietri, R / Derby, J / Dergachev, V / De Rosa, R / De Rossi, C / DeSalvo, R / de Varona, O / Dhurandhar, S / Díaz, M C / Di Fiore, L / Di Giovanni, M / Di Girolamo, T / Di Lieto, A / Ding, B / Di Pace, S / Di Palma, I / Di Renzo, F / Dmitriev, A / Doctor, Z / Dolique, V / Donovan, F / Dooley, K L / Doravari, S / Dorrington, I / Dovale Álvarez, M / Downes, T P / Drago, M / Dreissigacker, C / Driggers, J C / Du, Z / Dupej, P / Dwyer, S E / Easter, P J / Edo, T B / Edwards, M C / Effler, A / Eggenstein, H-B / Ehrens, P / Eichholz, J / Eikenberry, S S / Eisenmann, M / Eisenstein, R A / Essick, R C / Estelles, H / Estevez, D / Etienne, Z B / Etzel, T / Evans, M / Evans, T M / Fafone, V / Fair, H / Fairhurst, S / Fan, X / Farinon, S / Farr, B / Farr, W M / Fauchon-Jones, E J / Favata, M / Fays, M / Fee, C / Fehrmann, H / Feicht, J / Fejer, M M / Feng, F / Fernandez-Galiana, A / Ferrante, I / Ferreira, E C / Ferrini, F / Fidecaro, F / Fiori, I / Fiorucci, D / Fishbach, M / Fisher, R P / Fishner, J M / Fitz-Axen, M / Flaminio, R / Fletcher, M / Fong, H / Font, J A / Forsyth, P W F / Forsyth, S S / Fournier, J-D / Frasca, S / Frasconi, F / Frei, Z / Freise, A / Frey, R / Frey, V / Fritschel, P / Frolov, V V / Fulda, P / Fyffe, M / Gabbard, H A / Gadre, B U / Gaebel, S M / Gair, J R / Gammaitoni, L / Ganija, M R / Gaonkar, S G / Garcia, A / García-Quirós, C / Garufi, F / Gateley, B / Gaudio, S / Gaur, G / Gayathri, V / Gemme, G / Genin, E / Gennai, A / George, D / George, J / Gergely, L / Germain, V / Ghonge, S / Ghosh, Abhirup / Ghosh, Archisman / Ghosh, S / Giacomazzo, B / Giaime, J A / Giardina, K D / Giazotto, A / Gill, K / Giordano, G / Glover, L / Goetz, E / Goetz, R / Goncharov, B / González, G / Gonzalez Castro, J M / Gopakumar, A / Gorodetsky, M L / Gossan, S E / Gosselin, M / Gouaty, R / Grado, A / Graef, C / Granata, M / Grant, A / Gras, S / Gray, C / Greco, G / Green, A C / Green, R / Gretarsson, E M / Groot, P / Grote, H / Grunewald, S / Gruning, P / Guidi, G M / Gulati, H K / Guo, X / Gupta, A / Gupta, M K / Gushwa, K E / Gustafson, E K / Gustafson, R / Halim, O / Hall, B R / Hall, E D / Hamilton, E Z / Hamilton, H F / Hammond, G / Haney, M / Hanke, M M / Hanks, J / Hanna, C / Hannam, M D / Hannuksela, O A / Hanson, J / Hardwick, T / Harms, J / Harry, G M / Harry, I W / Hart, M J / Haster, C-J / Haughian, K / Healy, J / Heidmann, A / Heintze, M C / Heitmann, H / Hello, P / Hemming, G / Hendry, M / Heng, I S / Hennig, J / Heptonstall, A W / Hernandez, F J / Heurs, M / Hild, S / Hinderer, T / Hoak, D / Hochheim, S / Hofman, D / Holland, N A / Holt, K / Holz, D E / Hopkins, P / Horst, C / Hough, J / Houston, E A / Howell, E J / Hreibi, A / Huerta, E A / Huet, D / Hughey, B / Hulko, M / Husa, S / Huttner, S H / Huynh-Dinh, T / Iess, A / Indik, N / Ingram, C / Inta, R / Intini, G / Isa, H N / Isac, J-M / Isi, M / Iyer, B R / Izumi, K / Jacqmin, T / Jani, K / Jaranowski, P / Johnson, D S / Johnson, W W / Jones, D I / Jones, R / Jonker, R J G / Ju, L / Junker, J / Kalaghatgi, C V / Kalogera, V / Kamai, B / Kandhasamy, S / Kang, G / Kanner, J B / Kapadia, S J / Karki, S / Karvinen, K S / Kasprzack, M / Katolik, M / Katsanevas, S / Katsavounidis, E / Katzman, W / Kaufer, S / Kawabe, K / Keerthana, N V / Kéfélian, F / Keitel, D / Kemball, A J / Kennedy, R / Key, J S / Khalili, F Y / Khamesra, B / Khan, H / Khan, I / Khan, S / Khan, Z / Khazanov, E A / Kijbunchoo, N / Kim, Chunglee / Kim, J C / Kim, K / Kim, W / Kim, W S / Kim, Y-M / King, E J / King, P J / Kinley-Hanlon, M / Kirchhoff, R / Kissel, J S / Kleybolte, L / Klimenko, S / Knowles, T D / Koch, P / Koehlenbeck, S M / Koley, S / Kondrashov, V / Kontos, A / Korobko, M / Korth, W Z / Kowalska, I / Kozak, D B / Krämer, C / Kringel, V / Krishnan, B / Królak, A / Kuehn, G / Kumar, P / Kumar, R / Kumar, S / Kuo, L / Kutynia, A / Kwang, S / Lackey, B D / Lai, K H / Landry, M / Lang, R N / Lange, J / Lantz, B / Lanza, R K / Lartaux-Vollard, A / Lasky, P D / Laxen, M / Lazzarini, A / Lazzaro, C / Leaci, P / Leavey, S / Lee, C H / Lee, H K / Lee, H M / Lee, H W / Lee, K / Lehmann, J / Lenon, A / Leonardi, M / Leroy, N / Letendre, N / Levin, Y / Li, J / Li, T G F / Li, X / Linker, S D / Littenberg, T B / Liu, J / Liu, X / Lo, R K L / Lockerbie, N A / London, L T / Longo, A / Lorenzini, M / Loriette, V / Lormand, M / Losurdo, G / Lough, J D / Lovelace, G / Lück, H / Lumaca, D / Lundgren, A P / Lynch, R / Ma, Y / Macas, R / Macfoy, S / Machenschalk, B / MacInnis, M / Macleod, D M / Magaña Hernandez, I / Magaña-Sandoval, F / Magaña Zertuche, L / Magee, R M / Majorana, E / Maksimovic, I / Man, N / Mandic, V / Mangano, V / Mansell, G L / Manske, M / Mantovani, M / Marchesoni, F / Marion, F / Márka, S / Márka, Z / Markakis, C / Markosyan, A S / Markowitz, A / Maros, E / Marquina, A / Martelli, F / Martellini, L / Martin, I W / Martin, R M / Martynov, D V / Mason, K / Massera, E / Masserot, A / Massinger, T J / Masso-Reid, M / Mastrogiovanni, S / Matas, A / Matichard, F / Matone, L / Mavalvala, N / Mazumder, N / McCann, J J / McCarthy, R / McClelland, D E / McCormick, S / McCuller, L / McGuire, S C / McIver, J / McManus, D J / McRae, T / McWilliams, S T / Meacher, D / Meadors, G D / Mehmet, M / Meidam, J / Mejuto-Villa, E / Melatos, A / Mendell, G / Mendoza-Gandara, D / Mercer, R A / Mereni, L / Merilh, E L / Merzougui, M / Meshkov, S / Messenger, C / Messick, C / Metzdorff, R / Meyers, P M / Miao, H / Michel, C / Middleton, H / Mikhailov, E E / Milano, L / Miller, A L / Miller, A / Miller, B B / Miller, J / Millhouse, M / Mills, J / Milovich-Goff, M C / Minazzoli, O / Minenkov, Y / Ming, J / Mishra, C / Mitra, S / Mitrofanov, V P / Mitselmakher, G / Mittleman, R / Moffa, D / Mogushi, K / Mohan, M / Mohapatra, S R P / Montani, M / Moore, C J / Moraru, D / Moreno, G / Morisaki, S / Mours, B / Mow-Lowry, C M / Mueller, G / Muir, A W / Mukherjee, Arunava / Mukherjee, D / Mukherjee, S / Mukund, N / Mullavey, A / Munch, J / Muñiz, E A / Muratore, M / Murray, P G / Nagar, A / Napier, K / Nardecchia, I / Naticchioni, L / Nayak, R K / Neilson, J / Nelemans, G / Nelson, T J N / Nery, M / Neunzert, A / Nevin, L / Newport, J M / Ng, K Y / Ng, S / Nguyen, P / Nguyen, T T / Nichols, D / Nielsen, A B / Nissanke, S / Nitz, A / Nocera, F / Nolting, D / North, C / Nuttall, L K / Obergaulinger, M / Oberling, J / O'Brien, B D / O'Dea, G D / Ogin, G H / Oh, J J / Oh, S H / Ohme, F / Ohta, H / Okada, M A / Oliver, M / Oppermann, P / Oram, Richard J / O'Reilly, B / Ormiston, R / Ortega, L F / O'Shaughnessy, R / Ossokine, S / Ottaway, D J / Overmier, H / Owen, B J / Pace, A E / Pagano, G / Page, J / Page, M A / Pai, A / Pai, S A / Palamos, J R / Palashov, O / Palomba, C / Pal-Singh, A / Pan, Howard / Pan, Huang-Wei / Pang, B / Pang, P T H / Pankow, C / Pannarale, F / Pant, B C / Paoletti, F / Paoli, A / Papa, M A / Parida, A / Parker, W / Pascucci, D / Pasqualetti, A / Passaquieti, R / Passuello, D / Patil, M / Patricelli, B / Pearlstone, B L / Pedersen, C / Pedraza, M / Pedurand, R / Pekowsky, L / Pele, A / Penn, S / Perez, C J / Perreca, A / Perri, L M / Pfeiffer, H P / Phelps, M / Phukon, K S / Piccinni, O J / Pichot, M / Piergiovanni, F / Pierro, V / Pillant, G / Pinard, L / Pinto, I M / Pirello, M / Pitkin, M / Poggiani, R / Popolizio, P / Porter, E K / Possenti, L / Post, A / Powell, J / Prasad, J / Pratt, J W W / Pratten, G / Predoi, V / Prestegard, T / Principe, M / Privitera, S / Prodi, G A / Prokhorov, L G / Puncken, O / Punturo, M / Puppo, P / Pürrer, M / Qi, H / Quetschke, V / Quintero, E A / Quitzow-James, R / Rabeling, D S / Radkins, H / Raffai, P / Raja, S / Rajan, C / Rajbhandari, B / Rakhmanov, M / Ramirez, K E / Ramos-Buades, A / Rana, Javed / Rapagnani, P / Raymond, V / Razzano, M / Read, J / Regimbau, T / Rei, L / Reid, S / Reitze, D H / Ren, W / Ricci, F / Ricker, P M / Riles, K / Rizzo, M / Robertson, N A / Robie, R / Robinet, F / Robson, T / Rocchi, A / Rolland, L / Rollins, J G / Roma, V J / Romano, R / Romel, C L / Romie, J H / Rosińska, D / Ross, M P / Rowan, S / Rüdiger, A / Ruggi, P / Rutins, G / Ryan, K / Sachdev, S / Sadecki, T / Sakellariadou, M / Salconi, L / Saleem, M / Salemi, F / Samajdar, A / Sammut, L / Sampson, L M / Sanchez, E J / Sanchez, L E / Sanchis-Gual, N / Sandberg, V / Sanders, J R / Sarin, N / Sassolas, B / Saulson, P R / Sauter, O / Savage, R L / Sawadsky, A / Schale, P / Scheel, M / Scheuer, J / Schmidt, P / Schnabel, R / Schofield, R M S / Schönbeck, A / Schreiber, E / Schuette, D / Schulte, B W / Schutz, B F / Schwalbe, S G / Scott, J / Scott, S M / Seidel, E / Sellers, D / Sengupta, A S / Sentenac, D / Sequino, V / Sergeev, A / Setyawati, Y / Shaddock, D A / Shaffer, T J / Shah, A A / Shahriar, M S / Shaner, M B / Shao, L / Shapiro, B / Shawhan, P / Shen, H / Shoemaker, D H / Shoemaker, D M / Siellez, K / Siemens, X / Sieniawska, M / Sigg, D / Silva, A D / Singer, L P / Singh, A / Singhal, A / Sintes, A M / Slagmolen, B J J / Slaven-Blair, T J / Smith, B / Smith, J R / Smith, R J E / Somala, S / Son, E J / Sorazu, B / Sorrentino, F / Souradeep, T / Spencer, A P / Srivastava, A K / Staats, K / Steinke, M / Steinlechner, J / Steinlechner, S / Steinmeyer, D / Steltner, B / Stevenson, S P / Stocks, D / Stone, R / Stops, D J / Strain, K A / Stratta, G / Strigin, S E / Strunk, A / Sturani, R / Stuver, A L / Summerscales, T Z / Sun, L / Sunil, S / Suresh, J / Sutton, P J / Swinkels, B L / Szczepańczyk, M J / Tacca, M / Tait, S C / Talbot, C / Talukder, D / Tanner, D B / Tápai, M / Taracchini, A / Tasson, J D / Taylor, J A / Taylor, R / Tewari, S V / Theeg, T / Thies, F / Thomas, E G / Thomas, M / Thomas, P / Thorne, K A / Thrane, E / Tiwari, S / Tiwari, V / Tokmakov, K V / Toland, K / Tonelli, M / Tornasi, Z / Torres-Forné, A / Torrie, C I / Töyrä, D / Travasso, F / Traylor, G / Trinastic, J / Tringali, M C / Trozzo, L / Tsang, K W / Tse, M / Tso, R / Tsuna, D / Tsukada, L / Tuyenbayev, D / Ueno, K / Ugolini, D / Urban, A L / Usman, S A / Vahlbruch, H / Vajente, G / Valdes, G / van Bakel, N / van Beuzekom, M / van den Brand, J F J / Van Den Broeck, C / Vander-Hyde, D C / van der Schaaf, L / van Heijningen, J V / van Veggel, A A / Vardaro, M / Varma, V / Vass, S / Vasúth, M / Vecchio, A / Vedovato, G / Veitch, J / Veitch, P J / Venkateswara, K / Venugopalan, G / Verkindt, D / Vetrano, F / Viceré, A / Viets, A D / Vinciguerra, S / Vine, D J / Vinet, J-Y / Vitale, S / Vo, T / Vocca, H / Vorvick, C / Vyatchanin, S P / Wade, A R / Wade, L E / Wade, M / Walet, R / Walker, M / Wallace, L / Walsh, S / Wang, G / Wang, H / Wang, J Z / Wang, W H / Wang, Y F / Ward, R L / Warner, J / Was, M / Watchi, J / Weaver, B / Wei, L-W / Weinert, M / Weinstein, A J / Weiss, R / Wellmann, F / Wen, L / Wessel, E K / Weßels, P / Westerweck, J / Wette, K / Whelan, J T / Whiting, B F / Whittle, C / Wilken, D / Williams, D / Williams, R D / Williamson, A R / Willis, J L / Willke, B / Wimmer, M H / Winkler, W / Wipf, C C / Wittel, H / Woan, G / Woehler, J / Wofford, J K / Wong, W K / Worden, J / Wright, J L / Wu, D S / Wysocki, D M / Xiao, S / Yam, W / Yamamoto, H / Yancey, C C / Yang, L / Yap, M J / Yazback, M / Yu, Hang / Yu, Haocun / Yvert, M / Zadrożny, A / Zanolin, M / Zelenova, T / Zendri, J-P / Zevin, M / Zhang, J / Zhang, L / Zhang, M / Zhang, T / Zhang, Y-H / Zhao, C / Zhou, M / Zhou, Z / Zhu, S J / Zhu, X J / Zimmerman, A B / Zucker, M E / Zweizig, J / Weinberg, N N

Physical review letters

2019 Volume 122, Issue 6, Page(s) 61104

Abstract: We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron ... we compute the Bayes factor (lnB_{!pg}^{pg}) comparing our p-g model to a standard one. We find ... that the observed signal is consistent with waveform models that neglect p-g effects, with lnB_{!pg}^{pg}=0.03_{-0 ...

Abstract	We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron stars on GW170817. This nonresonant instability transfers energy from the orbit of the binary to internal modes of the stars, accelerating the gravitational-wave driven inspiral. We model the impact of this instability on the phasing of the gravitational wave signal using three parameters per star: an overall amplitude, a saturation frequency, and a spectral index. Incorporating these additional parameters, we compute the Bayes factor (lnB_{!pg}^{pg}) comparing our p-g model to a standard one. We find that the observed signal is consistent with waveform models that neglect p-g effects, with lnB_{!pg}^{pg}=0.03_{-0.58}^{+0.70} (maximum a posteriori and 90% credible region). By injecting simulated signals that do not include p-g effects and recovering them with the p-g model, we show that there is a ≃50% probability of obtaining similar lnB_{!pg}^{pg} even when p-g effects are absent. We find that the p-g amplitude for 1.4 M_{⊙} neutron stars is constrained to less than a few tenths of the theoretical maximum, with maxima a posteriori near one-tenth this maximum and p-g saturation frequency ∼70 Hz. This suggests that there are less than a few hundred excited modes, assuming they all saturate by wave breaking. For comparison, theoretical upper bounds suggest ≲10^{3} modes saturate by wave breaking. Thus, the measured constraints only rule out extreme values of the p-g parameters. They also imply that the instability dissipates ≲10^{51} erg over the entire inspiral, i.e., less than a few percent of the energy radiated as gravitational waves.
Language	English
Publishing date	2019-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.122.061104
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Article ; Online: Oronasal vs Nasal Masks: The Impact of Mask Type on CPAP Requirement, Pharyngeal Critical Closing Pressure (P

Landry, Shane A / Mann, Dwayne L / Beare, Richard / McIntyre, Richard / Beatty, Caroline / Thomson, Luke D J / Collet, Jinny / Joosten, Simon A / Hamilton, Garun S / Edwards, Bradley A

Chest

2023 Volume 164, Issue 3, Page(s) 747–756

Abstract: ... collapsibility was assessed using the pharyngeal critical closing pressure (P: Results: The oronasal mask was ... associated with higher therapeutic pressure requirements (ΔM ± SEM; +2.6 ± 0.5; P < .001) and higher P ...

Abstract	Background: CPAP delivered via an oronasal mask is associated with lower adherence, higher residual apnea-hypopnea index (AHI), and increased CPAP therapeutic pressure compared with nasal masks. However, the mechanisms underlying the increased pressure requirements are not well understood. Research question: How do oronasal masks affect upper airway anatomy and collapsibility? Study design and methods: Fourteen patients with OSA underwent a sleep study with both a nasal and oronasal mask, each for one-half of the night (order randomized). CPAP was manually titrated to determine therapeutic pressure. Upper airway collapsibility was assessed using the pharyngeal critical closing pressure (P Results: The oronasal mask was associated with higher therapeutic pressure requirements (ΔM ± SEM; +2.6 ± 0.5; P < .001) and higher P Interpretation: Oronasal masks are associated with a more collapsible airway than nasal masks, which likely contributes to the need for a higher therapeutic pressure.
MeSH term(s)	Humans ; Sleep Apnea, Obstructive/therapy ; Masks ; Continuous Positive Airway Pressure/methods ; Respiration ; Larynx
Language	English
Publishing date	2023-03-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2023.03.025
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Article ; Online: Effects of substance P on human cerebral microvascular endothelial cell line hCMEC/D3 are mediated exclusively through a truncated NK-1 receptor and depend on cell confluence.

Gao, Xin / Frakich, Nanci / Filippini, Perla / Edwards, Laura J / Vinkemeier, Uwe / Gran, Bruno / Tanasescu, Radu / Bayraktutan, Ulvi / Colombo, Sergio / Constantinescu, Cris S

Neuropeptides

2022 Volume 95, Page(s) 102265

Abstract: The neuropeptide substance P (SP) mediates pain transmission, immune modulation, vasodilation and ...

Abstract	The neuropeptide substance P (SP) mediates pain transmission, immune modulation, vasodilation and neurogenic inflammation. Its role in the peripheral nervous system has been well characterised. However, its actions on the blood-brain barrier (BBB) are less clear and warrant further study. The aim of this study was to characterise the effect of SP on the brain microvascular endothelial cells using the immortalized human brain microvascular endothelial cell line hCMEC/D3. As part of our studies, we have evaluated changes in expression, at mRNA and protein levels, of genes involved in the function of the blood-brain barrier such as occludin, induced by exposure to SP. We show that the effect of SP is dependent on cell confluence status. Thus, at low confluence but not at full confluence, SP treatment reduced occludin expression. The expression of the SP receptor, neurokinin-1 receptor (NK-1R) (the truncated form of the receptor expressed exclusively in this cell line) was also modulated in a similar pattern. SP treatment stimulated extracellular signal-regulated kinase (Erk2) phosphorylation which was not associated to changes in Interleukin-6 (IL-6), Interleukin-8 (IL-8), or Intercellular Adhesion Molecule 1 (ICAM-1) protein expression. In addition, SP treatment effectively recovered nitric oxide production on cells exposed to tumour necrosis factor alpha (TNF-α). SP did not trigger intracellular calcium release in hCMEC/D3 cells. We conclude that hCMEC/D3 cells are partially responsive to SP, that the effects are mediated through the truncated form of the receptor and are dependent on the confluence status of these cells.
MeSH term(s)	Blood-Brain Barrier/metabolism ; Cell Line ; Endothelial Cells ; Humans ; Occludin/metabolism ; Occludin/pharmacology ; Receptors, Neurokinin-1/metabolism ; Substance P/metabolism ; Substance P/pharmacology
Chemical Substances	Occludin ; Receptors, Neurokinin-1 ; Substance P (33507-63-0)
Language	English
Publishing date	2022-06-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	9048-7
ISSN	1532-2785 ; 0143-4179
ISSN (online)	1532-2785
ISSN	0143-4179
DOI	10.1016/j.npep.2022.102265
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Article ; Online: A novel HRAS c.466C>T p.(Phe156Leu) variant in two patients with attenuated features of Costello syndrome.

Lindsey-Temple, Suzanna / Edwards, Matt / Rickassel, Verena / Nauth, Theresa / Rosenberger, Georg

European journal of human genetics : EJHG

2022 Volume 30, Issue 9, Page(s) 1088–1093

Abstract: ... the HRAS variant p.Gly12Ser that is associated with a typical, homogeneous phenotype. Rarer pathogenic HRAS ... variants (e.g., p.Thr56Ile) were identified in individuals with attenuated CS phenotypes. The obvious ... on two boys with the novel de novo HRAS variant c.466 C > T p.(Phe156Leu). Both had severe feeding ...

Abstract	Costello syndrome (CS) is caused by heterozygous HRAS germline mutations. Most patients share the HRAS variant p.Gly12Ser that is associated with a typical, homogeneous phenotype. Rarer pathogenic HRAS variants (e.g., p.Thr56Ile) were identified in individuals with attenuated CS phenotypes. The obvious phenotypical variability reflects different dysfunctional consequences of distinct HRAS variants. We report on two boys with the novel de novo HRAS variant c.466 C > T p.(Phe156Leu). Both had severe feeding difficulties, airway obstruction and developmental delay, which are typical findings in CS. They showed subtle facial and dermatologic features consistent with attenuated CS. They significantly differed in their musculoskeletal, cardiovascular and endocrinologic manifestations underscoring the clinical variability of individuals with identical, in particular rarer pathogenic HRAS variants. Functional studies revealed enhanced effector-binding, increased downstream signaling activation and impaired growth factor-induced signaling dynamics in cells expressing HRAS
MeSH term(s)	Child ; Costello Syndrome/genetics ; Costello Syndrome/pathology ; Germ-Line Mutation ; Heterozygote ; Humans ; Male ; Phenotype ; Proto-Oncogene Proteins p21(ras)/genetics ; Signal Transduction/genetics
Chemical Substances	HRAS protein, human (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2022-06-29
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-022-01139-1
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Article ; Online: Mutually inhibitory Ras-PI(3,4)P

Li, Xiaoguang / Edwards, Marc / Swaney, Kristen F / Singh, Nilmani / Bhattacharya, Sayak / Borleis, Jane / Long, Yu / Iglesias, Pablo A / Chen, Jie / Devreotes, Peter N

Proceedings of the National Academy of Sciences of the United States of America

2018 Volume 115, Issue 39, Page(s) E9125–E9134

Abstract: ... phosphatidylinositol (3,4)-bisphosphate [PI(3,4)P ...

Abstract	Signal transduction and cytoskeleton networks in a wide variety of cells display excitability, but the mechanisms are poorly understood. Here, we show that during random migration and in response to chemoattractants, cells maintain complementary spatial and temporal distributions of Ras activity and phosphatidylinositol (3,4)-bisphosphate [PI(3,4)P
MeSH term(s)	Cell Membrane/genetics ; Cell Membrane/metabolism ; Dictyostelium/genetics ; Dictyostelium/metabolism ; Phosphatidylinositol Phosphates/genetics ; Phosphatidylinositol Phosphates/metabolism ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Signal Transduction/physiology ; ras Proteins/genetics ; ras Proteins/metabolism
Chemical Substances	Phosphatidylinositol Phosphates ; Protozoan Proteins ; phosphatidylinositol 3,4-diphosphate ; ras Proteins (EC 3.6.5.2)
Language	English
Publishing date	2018-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1809039115
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