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  1. Article ; Online: Additional resources.

    Saravanamuttu, R

    British dental journal

    2022  Volume 233, Issue 12, Page(s) 981

    Language English
    Publishing date 2022-12-16
    Publishing country England
    Document type Letter
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-022-5362-8
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  2. Article ; Online: Hydrogen peroxide mouthwash.

    Saravanamuttu, R

    British dental journal

    2020  Volume 228, Issue 10, Page(s) 734

    MeSH term(s) Hydrogen Peroxide/adverse effects ; Mouthwashes/adverse effects
    Chemical Substances Mouthwashes ; Hydrogen Peroxide (BBX060AN9V)
    Keywords covid19
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Letter
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-020-1643-2
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  3. Article ; Online: Periodontology: A little caution.

    Saravanamuttu, R

    British dental journal

    2015  Volume 218, Issue 8, Page(s) 438

    MeSH term(s) Humans ; Periodontics
    Language English
    Publishing date 2015-04-24
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/sj.bdj.2015.299
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  4. Article ; Online: Self-Organized Lattices of Nonlinear Optochemical Waves in Photopolymerizable Fluids: The Spontaneous Emergence of 3-D Order in a Weakly Correlated System.

    Ponte, Matthew R / Hudson, Alexander D / Saravanamuttu, Kalaichelvi

    The journal of physical chemistry letters

    2018  Volume 9, Issue 5, Page(s) 1146–1155

    Abstract: Many of the extraordinary three-dimensional architectures that pattern our physical world emerge from complex nonlinear systems or dynamic populations whose individual constituents are only weakly correlated to each other. Shoals of fish, murmuration ... ...

    Abstract Many of the extraordinary three-dimensional architectures that pattern our physical world emerge from complex nonlinear systems or dynamic populations whose individual constituents are only weakly correlated to each other. Shoals of fish, murmuration behaviors in birds, congestion patterns in traffic, and even networks of social conventions are examples of spontaneous pattern formation, which cannot be predicted from the properties of individual elements alone. Pattern formation at a different scale has been observed or predicted in weakly correlated systems including superconductors, atomic gases near Bose Einstein condensation, and incoherent optical fields. Understanding pattern formation in nonlinear weakly correlated systems, which are often unified through mathematical expression, could pave intelligent self-organizing pathways to functional materials, architectures, and computing technologies. However, it is experimentally difficult to directly visualize the nonlinear dynamics of pattern formation in most populations-especially in three dimensions. Here, we describe the collective behavior of large populations of nonlinear optochemical waves, which are poorly correlated in both space and time. The optochemical waves-microscopic filaments of white light entrapped within polymer channels-originate from the modulation instability of incandescent light traveling in photopolymerizable fluids. By tracing the three-dimensional distribution of optical intensity in the nascent polymerizing system, we find that populations of randomly distributed, optochemical waves synergistically and collectively shift in space to form highly ordered lattices of specific symmetries. These, to our knowledge, are the first three-dimensionally periodic structures to emerge from a system of weakly correlated waves. Their spontaneous formation in an incoherent and effectively chaotic field is counterintuitive, but the apparent contradiction of known behaviors of light including the laws of optical interference can be explained through the soliton-like interactions of optochemical waves with nearest neighbors. Critically, this work casts fundamentally new insight into the collective behaviors of poorly correlated nonlinear waves in higher dimensions and provides a rare, accessible platform for further experimental studies of these previously unexplored behaviors. Furthermore, it defines a self-organization paradigm that, unlike conventional counterparts, could generate polymer microstructures with symmetries spanning all the Bravais lattices.
    Language English
    Publishing date 2018-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.7b03177
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  5. Article ; Online: Impaired motor cortical facilitatory-inhibitory circuit interaction in Parkinson's disease.

    Saravanamuttu, James / Radhu, Natasha / Udupa, Kaviraja / Baarbé, Julianne / Gunraj, Carolyn / Chen, Robert

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2021  Volume 132, Issue 10, Page(s) 2685–2692

    Abstract: Objective: Motor cortical (M1) inhibition and facilitation can be studied with short-interval intracortical inhibition (SICI) and short-interval intracortical facilitation (SICF). These circuits are altered in Parkinson's disease (PD). The sensorimotor ... ...

    Abstract Objective: Motor cortical (M1) inhibition and facilitation can be studied with short-interval intracortical inhibition (SICI) and short-interval intracortical facilitation (SICF). These circuits are altered in Parkinson's disease (PD). The sensorimotor measure short latency afferent inhibition (SAI) is possibly altered in PD. The aim was to determine if the manner in which these circuits interact with each other is abnormal in PD.
    Methods: Fifteen PD patients were studied at rest in ON and OFF medication states, and were compared to 16 age-matched controls. A triple-stimulus transcranial magnetic stimulation paradigm was used to elicit a circuit of interest in the presence of another circuit.
    Results: SICF was increased in PD OFF and PD ON conditions compared to controls. SICI facilitated SICF in controls and PD ON, but not in PD OFF. SICF in the presence of SICI negatively correlated with UPDRS-III scores in OFF and ON medication conditions. SAI showed similar inhibition of SICI in controls, PD OFF and PD ON conditions.
    Conclusions: The facilitatory effect of SICI on SICF is absent in PD OFF, but is restored with dopaminergic medication.
    Significance: Impaired interaction between M1 circuits is a pathophysiological feature of PD.
    MeSH term(s) Aged ; Electromyography/methods ; Evoked Potentials, Motor/physiology ; Female ; Humans ; Male ; Middle Aged ; Motor Cortex/physiopathology ; Nerve Net/physiopathology ; Neural Inhibition/physiology ; Parkinson Disease/diagnosis ; Parkinson Disease/physiopathology ; Transcranial Magnetic Stimulation/methods
    Language English
    Publishing date 2021-07-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2021.05.032
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  6. Article ; Online: 3-D Spiraling Self-Trapped Light Beams in Photochemical Systems.

    Morim, Derek R / Bevern, Damian / Vargas-Baca, Ignacio / Saravanamuttu, Kalaichelvi

    The journal of physical chemistry letters

    2019  Volume 10, Issue 19, Page(s) 5957–5962

    Abstract: A pair of visible laser beams self-trap and spiral about each other as they propagate through polymer gels undergoing two different photochemical reactions. When launched into gels that undergo photopolymerization of methacrylate substituents or photo- ... ...

    Abstract A pair of visible laser beams self-trap and spiral about each other as they propagate through polymer gels undergoing two different photochemical reactions. When launched into gels that undergo photopolymerization of methacrylate substituents or photo-oxidation of iodide anion, two non-coplanar (skewed) Gaussian beams collide and spiral about each other as they advance through the evolving medium. In the absence of chemical reactions, the linearly polarized beams broaden naturally and propagate along their original, straight-pathed trajectories. By contrast, refractive index gradients generated by the photochemical reactions elicit self-trapping and introduce an attractive interaction between the self-trapped beams. The self-trapped beams spiral about each other when this mutual attraction perfectly counterbalances their original tendency to diverge away from each other. These findings show that the photochemically mediated interactions of incident optical fields within the gel medium impart a helical trajectory and angular velocity to the self-trapped beam pair.
    Language English
    Publishing date 2019-09-23
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.9b02302
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  7. Article ; Online: ANTIDIABETIC PLANTS AND THEIR ACTIVE INGREDIENTS

    Sivani Saravanamuttu

    International Journal of Pharmaceutical Sciences and Research, Vol 3, Iss 10, Pp 3639-

    A REVIEW

    2012  Volume 3650

    Abstract: Diabetes mellitus is a lifestyle disorder that is rapidly becoming a major threat to populations all over the globe. Over the past 30 years, the status of diabetes has changed from being considered as a mild lifestyle disorder of the elderly to one of ... ...

    Abstract Diabetes mellitus is a lifestyle disorder that is rapidly becoming a major threat to populations all over the globe. Over the past 30 years, the status of diabetes has changed from being considered as a mild lifestyle disorder of the elderly to one of the major causes of morbidity and mortality, affecting people of all ages. India is slated to be the diabetic capital of the world, with 50.8 million diabetics. There seems to be a renewed interest in herbal medicines across the world today and plants are a powerhouse of sources for antidiabetic principles. Hence, a review on the antidiabetic plants has been done and the plants with antidiabetic principles isolated have been tabulated. Electronic searches were conducted in numerous databases and relevant journals. Sources also included various books and newspaper articles. Hand searches were also carried out in additional journals and secondary references. Researchers in the field of Ayurveda, Siddha, Unani and Homeopathy were consulted for access to ongoing research and various references. Molecular docking studies were performed on three selected plants to authenticate their affinity and therapeutic efficacy.
    Keywords School of Genomics and Bioinformatics ; Department of Advanced Zoology and Biotechnology ; Loyola College ; Chennai 600 034 ; Tamil Nadu ; India ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 580
    Language English
    Publishing date 2012-10-01T00:00:00Z
    Publisher Society of Pharmaceutical Sciences and Research
    Document type Article ; Online
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  8. Article ; Online: Reversibly Trapping Visible Laser Light through the Catalytic Photo-oxidation of I(-) by Ru(bpy)3(2+).

    Morim, Derek R / Vargas-Baca, Ignacio / Saravanamuttu, Kalaichelvi

    The journal of physical chemistry letters

    2016  Volume 7, Issue 8, Page(s) 1585–1589

    Abstract: A Gaussian, visible laser beam traveling in a hydrogel doped with NaI and Ru(bpy)3Cl2 spontaneously transforms into a localized, self-trapped beam, which propagates without diverging through the medium. The catalytic, laser-light-induced oxidation of I(-) ...

    Abstract A Gaussian, visible laser beam traveling in a hydrogel doped with NaI and Ru(bpy)3Cl2 spontaneously transforms into a localized, self-trapped beam, which propagates without diverging through the medium. The catalytic, laser-light-induced oxidation of I(-) by [Ru(bpy)3](2+) generates I3(-) species, which create a refractive index increase along the beam path. The result is a cylindrical waveguide, which traps the optical field as bound modes and suppresses natural diffraction. When the beam is switched off, diffusion of I3(-) erases the waveguide within minutes and the system reverts to its original composition, enabling regeneration of the self-trapped beam. Our findings demonstrate reversible self-trapping for the first time in a precisely controllable, molecular-level photoreaction and could open routes to circuitry-free photonics devices powered by the interactions of switchable self-trapped beams.
    Language English
    Publishing date 2016-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.6b00126
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  9. Article ; Online: A soft photopolymer cuboid that computes with binary strings of white light.

    Hudson, Alexander D / Ponte, Matthew R / Mahmood, Fariha / Pena Ventura, Thomas / Saravanamuttu, Kalaichelvi

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 2310

    Abstract: Next-generation stimuli-responsive materials must be configured with local computational ability so that instead of a discrete on-off responsiveness, they sense, process and interact reciprocally with environmental stimuli. Because of their varied ... ...

    Abstract Next-generation stimuli-responsive materials must be configured with local computational ability so that instead of a discrete on-off responsiveness, they sense, process and interact reciprocally with environmental stimuli. Because of their varied architectures and tunable responsiveness to a range of physical and chemical stimuli, polymers hold particular promise in the generation of such "materials that compute". Here, we present a photopolymer cuboid that autonomously performs pattern recognition and transfer, volumetric encoding and binary arithmetic with incandescent beams. The material's nonlinear response to incident beams generates one, two or three mutually orthogonal ensembles of white-light filaments, which respectively self-organize into disordered, 1-D and 2-D periodic geometries. Data input as binary (dark-bright) strings generate a unique distribution of filament geometries, which corresponds to the result of a specific operation. The working principles of this material that computes with light is transferrable to other nonlinear systems and incoherent sources including light emitting diodes.
    Language English
    Publishing date 2019-05-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-10166-4
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  10. Article ; Online: Interhemispheric pathways in agenesis of the corpus callosum and Parkinson's disease.

    Lizarraga, Karlo J / Saravanamuttu, James / Baarbé, Julianne K / Lang, Anthony E / Chen, Robert

    Brain stimulation

    2019  Volume 13, Issue 2, Page(s) 360–362

    Language English
    Publishing date 2019-11-04
    Publishing country United States
    Document type Letter
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2019.11.003
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