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  1. Article ; Online: Does virtual reality enhance the effects of inhibitory control training for loss-of-control eating? A pilot factorial experiment.

    Manasse, Stephanie M / Trainor, Claire / Payne-Reichert, Adam / Abber, Sophie R / Lampe, Elizabeth W / Gillikin, Lindsay M / Juarascio, Adrienne S / Forman, Evan M

    Eating behaviors

    2023  Volume 50, Page(s) 101749

    Abstract: Inhibitory control, one's ability to inhibit automatic responses to desirable stimuli, may be inadequately targeted in interventions for loss-of-control eating (LOC). Promising evidence has identified inhibitory control trainings (ICTs) as an avenue to ... ...

    Abstract Inhibitory control, one's ability to inhibit automatic responses to desirable stimuli, may be inadequately targeted in interventions for loss-of-control eating (LOC). Promising evidence has identified inhibitory control trainings (ICTs) as an avenue to target inhibitory control directly; however, effects of ICTs on real-world behavior are limited. Compared to typical computerized trainings, virtual reality (VR) presents several potential advantages that may address key shortcomings of traditional ICTs, i.e. poor approximation to everyday life. The present study utilized a 2 × 2 factorial design of treatment type (ICT vs sham) by treatment modality (VR vs standard computer), which allows for increased statistical power by collapsing across conditions. Our primary aim was to examine the feasibility and acceptability of six weeks of daily training among groups. A secondary aim was to preliminarily assess main and interactive effects of treatment type and modality on target engagement and efficacy (i.e., training compliance, change in LOC episodes, inhibitory control, and implicit liking of foods). Participants (N = 35) with ≥1×/weekly LOC were assigned to one of four conditions and completed ICTs daily for six weeks. The trainings were feasible and acceptable, evinced by high retention and compliance across time and condition. Although completing daily trainings across treatment types and modalities was associated with large decreases in LOC, there were no meaningful effects of either treatment type or modality, nor a significant interaction effect, on LOC or mechanistic variables. Future research should aim to increase the efficacy of ICT (both standard and VR-based) and test in fully-powered clinical trials.
    MeSH term(s) Humans ; Virtual Reality ; Feeding and Eating Disorders/therapy ; Pilot Projects
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2073366-5
    ISSN 1873-7358 ; 1471-0153
    ISSN (online) 1873-7358
    ISSN 1471-0153
    DOI 10.1016/j.eatbeh.2023.101749
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  2. Article ; Online: Factors Associated With Prolonged Respiratory Virus Detection From Polymerase Chain Reaction of Nasal Specimens Collected Longitudinally in Healthy Children in a US Birth Cohort.

    Teoh, Zheyi / Conrey, Shannon / McNeal, Monica / Burrell, Allison / Burke, Rachel M / Mattison, Claire P / McMorrow, Meredith / Thornburg, Natalie / Payne, Daniel C / Morrow, Ardythe L / Staat, Mary Allen

    Journal of the Pediatric Infectious Diseases Society

    2024  Volume 13, Issue 3, Page(s) 189–195

    Abstract: Background: Respiratory viral shedding is incompletely characterized by existing studies due to the lack of longitudinal nasal sampling and limited inclusion of healthy/asymptomatic children. We describe characteristics associated with prolonged virus ... ...

    Abstract Background: Respiratory viral shedding is incompletely characterized by existing studies due to the lack of longitudinal nasal sampling and limited inclusion of healthy/asymptomatic children. We describe characteristics associated with prolonged virus detection by polymerase chain reaction (PCR) in a community-based birth cohort.
    Methods: Children were followed from birth to 2 years of age in the PREVAIL cohort. Weekly nasal swabs were collected and tested using the Luminex Respiratory Pathogen Panel. Weekly text surveys were administered to ascertain the presence of acute respiratory illnesses defined as fever and/or cough. Maternal reports and medical chart abstractions identified healthcare utilization. Prolonged virus detection was defined as a persistently positive test lasting ≥4 weeks. Factors associated with prolonged virus detection were assessed using mixed effects multivariable logistic regression.
    Results: From a sub-cohort of 101 children with ≥70% weekly swabs collected, a total of 1489 viral infections were detected. Prolonged virus detection was found in 23.4% of viral infections overall, 39% of bocavirus infections, 33% of rhinovirus/enterovirus infections, 14% of respiratory syncytial virus (RSV) A infections, and 7% of RSV B infections. No prolonged detection was found for influenza virus A or B, coronavirus 229E or HKU1, and parainfluenza virus 2 or 4 infections. First-lifetime infection with each virus, and co-detection of another respiratory virus were significantly associated with prolonged detection, while symptom status, child sex, and child age were not.
    Conclusions: Prolonged virus detection was observed in 1 in 4 viral infections in this cohort of healthy children and varied by pathogen, occurring most often for bocavirus and rhinovirus/enterovirus. Evaluating the immunological basis of how viral co-detections and recurrent viral infections impact duration of virus detection by PCR is needed to better understand the dynamics of prolonged viral shedding.
    MeSH term(s) Child ; Humans ; Infant ; Birth Cohort ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Viruses/genetics ; Virus Diseases ; Respiratory Syncytial Virus Infections ; Rhinovirus/genetics ; Respiratory Syncytial Virus, Human/genetics ; Polymerase Chain Reaction
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piae009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A consensus statement on perinatal mental health during the COVID-19 pandemic and recommendations for post-pandemic recovery and re-build.

    Jackson, Leanne / Greenfield, Mari / Payne, Elana / Burgess, Karen / Oza, Munira / Storey, Claire / Davies, Siân M / De Backer, Kaat / Kent-Nye, Flora E / Pilav, Sabrina / Worrall, Semra / Bridle, Laura / Khazaezadeh, Nina / Rajasingam, Daghni / Carson, Lauren E / De Pascalis, Leonardo / Fallon, Victoria / Hartley, Julie M / Montgomery, Elsa /
    Newburn, Mary / Wilson, Claire A / Harrold, Joanne A / Howard, Louise M / Sandall, Jane / Magee, Laura A / Sheen, Kayleigh S / Silverio, Sergio A

    Frontiers in global women's health

    2024  Volume 5, Page(s) 1347388

    Abstract: Introduction: The COVID-19 pandemic posed a significant lifecourse rupture, not least to those who had specific physical vulnerabilities to the virus, but also to those who were suffering with mental ill health. Women and birthing people who were ... ...

    Abstract Introduction: The COVID-19 pandemic posed a significant lifecourse rupture, not least to those who had specific physical vulnerabilities to the virus, but also to those who were suffering with mental ill health. Women and birthing people who were pregnant, experienced a perinatal bereavement, or were in the first post-partum year (i.e., perinatal) were exposed to a number of risk factors for mental ill health, including alterations to the way in which their perinatal care was delivered.
    Methods: A consensus statement was derived from a cross-disciplinary collaboration of experts, whereby evidence from collaborative work on perinatal mental health during the COVID-19 pandemic was synthesised, and priorities were established as recommendations for research, healthcare practice, and policy.
    Results: The synthesis of research focused on the effect of the COVID-19 pandemic on perinatal health outcomes and care practices led to three immediate recommendations: what to retain, what to reinstate, and what to remove from perinatal mental healthcare provision. Longer-term recommendations for action were also made, categorised as follows: Equity and Relational Healthcare; Parity of Esteem in Mental and Physical Healthcare with an Emphasis on Specialist Perinatal Services; and Horizon Scanning for Perinatal Mental Health Research, Policy, & Practice.
    Discussion: The evidence base on the effect of the pandemic on perinatal mental health is growing. This consensus statement synthesises said evidence and makes recommendations for a post-pandemic recovery and re-build of perinatal mental health services and care provision.
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-5059
    ISSN (online) 2673-5059
    DOI 10.3389/fgwh.2024.1347388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Endemic coronavirus infections are associated with strong homotypic immunity in a US cohort of children from birth to 4 years.

    Morrow, Ardythe L / Payne, Daniel C / Conrey, Shannon C / McMorrow, Meredith / McNeal, Monica M / Niu, Liang / Burrell, Allison R / Schlaudecker, Elizabeth P / Mattison, Claire / Burke, Rachel M / DeFranco, Emily / Teoh, Zheyi / Wrammert, Jens / Atherton, Lydia J / Thornburg, Natalie J / Staat, Mary A

    Journal of the Pediatric Infectious Diseases Society

    2024  

    Abstract: Background: The endemic coronaviruses OC43, HKU1, NL63 and 229E cause cold-like symptoms and are related to SARS-CoV-2, but their natural histories are poorly understood. In a cohort of children followed from birth to 4 years, we documented all ... ...

    Abstract Background: The endemic coronaviruses OC43, HKU1, NL63 and 229E cause cold-like symptoms and are related to SARS-CoV-2, but their natural histories are poorly understood. In a cohort of children followed from birth to 4 years, we documented all coronavirus infections, including SARS-CoV-2, to understand protection against subsequent infections with the same virus (homotypic immunity) or a different coronavirus (heterotypic immunity).
    Methods: Mother-child pairs were enrolled in metropolitan Cincinnati during the third trimester of pregnancy in 2017-18. Mothers reported their child's socio-demographics, risk factors, and weekly symptoms. Mid-turbinate nasal swabs were collected weekly. Blood was collected at 6 weeks, 6, 12, 18, 24 months and annually thereafter. Infections were detected by testing nasal swabs by an RT-PCR multi-pathogen panel and by serum IgG responses. Health care visits were documented from pediatric records. Analysis was limited to 116 children with high sample adherence. Re-consent for monitoring SARS-CoV-2 infections from June 2020 through November 2021 was obtained for 74 (64%) children.
    Results: We detected 345 endemic coronavirus infections (1.1 infections/child-year) and 21 SARS-CoV-2 infections (0.3 infections/child-year). Endemic coronavirus and SARS-CoV-2 infections were asymptomatic or mild. Significant protective homotypic immunity occurred after a single infection with OC43 (77%) and HKU1 (84%), and after two infections with NL63 (73%). No heterotypic protection against endemic coronaviruses or SARS-CoV-2 was identified.
    Conclusions: Natural coronavirus infections were common and resulted in strong homotypic immunity but not heterotypic immunity against other coronaviruses, including SARS-CoV-2. Endemic coronavirus and SARS-CoV-2 infections in this US cohort were typically asymptomatic or mild.
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piae016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correlates of Rotavirus Vaccine Shedding and Seroconversion in a U.S. Cohort of Healthy Infants.

    Burke, Rachel M / Payne, Daniel C / McNeal, Monica / Conrey, Shannon C / Burrell, Allison R / Mattison, Claire P / Casey-Moore, Mary C / Mijatovic-Rustempasic, Slavica / Gautam, Rashi / Esona, Mathew D / Thorman, Alexander W / Bowen, Michael D / Parashar, Umesh D / Tate, Jacqueline E / Morrow, Ardythe L / Staat, Mary A

    The Journal of infectious diseases

    2024  

    Abstract: Background: Rotavirus is a leading cause of severe pediatric gastroenteritis; two highly effective vaccines are used in the US. We aimed to identify correlates of immune response to rotavirus vaccination in a US cohort.: Methods: PREVAIL is a birth ... ...

    Abstract Background: Rotavirus is a leading cause of severe pediatric gastroenteritis; two highly effective vaccines are used in the US. We aimed to identify correlates of immune response to rotavirus vaccination in a US cohort.
    Methods: PREVAIL is a birth cohort of 245 mother-child pairs enrolled 2017-2018 and followed for 2 years. Infant stool samples and symptom information were collected weekly. Shedding was defined as RT-PCR detection of rotavirus vaccine virus in stools collected 4-28 days after dose one. Seroconversion was defined as a threefold rise in IgA between the six-week and six-month blood draws. Correlates were analyzed using generalized estimating equations and logistic regression.
    Results: Pre-vaccination IgG (OR=0.84, 95% CI [0.75-0.94] per 100-unit increase) was negatively associated with shedding. Shedding was also less likely among infants with a single-nucleotide polymorphism inactivating FUT2 antigen secretion ("non-secretors") with non-secretor mothers, versus all other combinations (OR 0.37 [0.16-0.83]). Of 141 infants with data, 105 (74%) seroconverted; 78 (77%) had shed vaccine virus following dose one. Pre-vaccination IgG and secretor status were significantly associated with seroconversion. Neither shedding nor seroconversion significantly differed by vaccine product.
    Discussion: In this US cohort, pre-vaccination IgG and maternal and infant secretor status were associated with rotavirus vaccine response.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae055
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  6. Article ; Online: Temporal, geochemical and isotopic constraints on plume-driven felsic and mafic components in a Mesoproterozoic flood rhyolite province

    Claire E. Wade / Justin L. Payne / Karin M. Barovich / Anthony J. Reid / Elizabeth A. Jagodzinski / Stacey Curtis / Jesse Hill

    Results in Geochemistry, Vol 9, Iss , Pp 100019- (2022)

    2022  

    Keywords Chemistry ; QD1-999 ; Geology ; QE1-996.5
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Does virtual reality enhance the effects of inhibitory control training for loss-of-control eating? A pilot factorial experiment

    Manasse, Stephanie M. / Trainor, Claire / Payne-Reichert, Adam / Abber, Sophie R. / Lampe, Elizabeth W. / Gillikin, Lindsay M. / Juarascio, Adrienne S. / Forman, Evan M.

    Eating Behaviors. 2023 May 24, p.101749-

    2023  , Page(s) 101749–

    Abstract: Inhibitory control, one's ability to inhibit automatic responses to desirable stimuli, may be inadequately targeted in interventions for loss-of-control eating (LOC). Promising evidence has identified inhibitory control trainings (ICTs) as an avenue to ... ...

    Abstract Inhibitory control, one's ability to inhibit automatic responses to desirable stimuli, may be inadequately targeted in interventions for loss-of-control eating (LOC). Promising evidence has identified inhibitory control trainings (ICTs) as an avenue to target inhibitory control directly; however, effects of ICTs on real-world behavior are limited. Compared to typical computerized trainings, virtual reality (VR) presents several potential advantages that may address key shortcomings of traditional ICTs, i.e. poor approximation to everyday life. The present study utilized a 2 × 2 factorial design of treatment type (ICT vs sham) by treatment modality (VR vs standard computer), which allows for increased statistical power by collapsing across conditions. Our primary aim was to examine the feasibility and acceptability of six weeks of daily training among groups. A secondary aim was to preliminarily assess main and interactive effects of treatment type and modality on target engagement and efficacy (i.e., training compliance, change in LOC episodes, inhibitory control, and implicit liking of foods). Participants (N = 35) with ≥1×/weekly LOC were assigned to one of four conditions and completed ICTs daily for six weeks. The trainings were feasible and acceptable, evinced by high retention and compliance across time and condition. Although completing daily trainings across treatment types and modalities was associated with large decreases in LOC, there were no meaningful effects of either treatment type or modality, nor a significant interaction effect, on LOC or mechanistic variables. Future research should aim to increase the efficacy of ICT (both standard and VR-based) and test in fully-powered clinical trials.
    Keywords compliance ; computer simulation ; computers ; Loss-of-control eating ; Inhibitory control ; Virtual reality ; Computerized training
    Language English
    Dates of publication 2023-0524
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 2073366-5
    ISSN 1471-0153
    ISSN 1471-0153
    DOI 10.1016/j.eatbeh.2023.101749
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Burden of Respiratory Viruses in Children Less Than 2 Years Old in a Community-based Longitudinal US Birth Cohort.

    Teoh, Zheyi / Conrey, Shannon / McNeal, Monica / Burrell, Allison / Burke, Rachel M / Mattison, Claire / McMorrow, Meredith / Payne, Daniel C / Morrow, Ardythe L / Staat, Mary Allen

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 6, Page(s) 901–909

    Abstract: Background: Respiratory viral infections are a major cause of morbidity and hospitalization in young children. Nevertheless, the population burden of respiratory viral infections, especially asymptomatic cases, is not known due to the lack of ... ...

    Abstract Background: Respiratory viral infections are a major cause of morbidity and hospitalization in young children. Nevertheless, the population burden of respiratory viral infections, especially asymptomatic cases, is not known due to the lack of prospective community-based cohort studies with intensive monitoring.
    Methods: To address this gap, we enacted the PREVAIL cohort, a Centers for Disease Control and Prevention-sponsored birth cohort in Cincinnati, Ohio, where children were followed from 0 to 2 years of age. Weekly text surveys were administered to record acute respiratory illnesses (ARIs), which were defined as the presence of cough or fever (≥38°C). Weekly midturbinate nasal swabs were collected and tested using the Luminex Respiratory Pathogen Panel, which detected 16 viral pathogens. Viral infection was defined as ≥1 positive tests from the same virus or viral subtype ≤30 days of a previous positive test. Maternal report and medical chart abstractions identified healthcare utilization.
    Results: From 4/2017 to 7/2020, 245 mother-infant pairs were recruited and followed. From the 13 781 nasal swabs tested, a total of 2211 viral infections were detected, of which 821 (37%) were symptomatic. Children experienced 9.4 respiratory viral infections/child-year; half were rhinovirus/enterovirus. Viral ARI incidence was 3.3 episodes/child-year. Emergency department visits or hospitalization occurred with only 15% of respiratory syncytial virus infections, 10% of influenza infections, and only 4% of all viral infections. Regardless of pathogen, most infections were asymptomatic or mild.
    Conclusions: Respiratory viral infections are common in children 0-2 years. Most viral infections are asymptomatic or non-medically attended, underscoring the importance of community-based cohort studies.
    MeSH term(s) Infant ; Humans ; Child, Preschool ; Respiratory Tract Infections/epidemiology ; Birth Cohort ; Viruses ; Virus Diseases/epidemiology ; Respiratory Syncytial Virus Infections/epidemiology
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad289
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  9. Article ; Online: In silico trials for treatment of acute ischemic stroke: Design and implementation.

    Miller, Claire / Padmos, Raymond M / van der Kolk, Max / Józsa, Tamás I / Samuels, Noor / Xue, Yidan / Payne, Stephen J / Hoekstra, Alfons G

    Computers in biology and medicine

    2021  Volume 137, Page(s) 104802

    Abstract: An in silico trial simulates a disease and its corresponding therapies on a cohort of virtual patients to support the development and evaluation of medical devices, drugs, and treatment. In silico trials have the potential to refine, reduce cost, and ... ...

    Abstract An in silico trial simulates a disease and its corresponding therapies on a cohort of virtual patients to support the development and evaluation of medical devices, drugs, and treatment. In silico trials have the potential to refine, reduce cost, and partially replace current in vivo studies, namely clinical trials and animal testing. We present the design and implementation of an in silico trial for treatment of acute ischemic stroke. We propose an event-based modelling approach for the simulation of a disease and injury, where changes to the state of the system (the events) are assumed to be instantaneous. Using this approach we are able to combine a diverse set of models, spanning multiple time scales, to model acute ischemic stroke, treatment, and resulting brain tissue injury. The in silico trial is designed to be modular to aid development and reproducibility. It provides a comprehensive framework for application to any potential in silico trial. A statistical population model is used to generate cohorts of virtual patients. Patient functional outcomes are also predicted with a statistical model, using treatment and injury results and the patient's clinical parameters. We demonstrate the functionality of the event-based modelling approach and trial framework by running proof of concept in silico trials. The proof of concept trials simulate the same cohort of patients twice: once with successful treatment (successful recanalisation) and once with unsuccessful treatment (unsuccessful treatment). Ways to overcome some of the challenges and difficulties in setting up such an in silico trial are discussed, such as validation and computational limitations.
    MeSH term(s) Brain Ischemia/drug therapy ; Computer Simulation ; Humans ; Ischemic Stroke ; Reproducibility of Results ; Stroke/drug therapy
    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2021.104802
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  10. Article ; Online: Antidepressants in pregnancy: applying causal epidemiological methods to understand service-use outcomes in women and long-term neurodevelopmental outcomes in exposed children.

    Heuvelman, Hein / Davies, Neil M / Ben-Shlomo, Yoav / Emond, Alan / Evans, Jonathan / Gunnell, David / Liebling, Rachel / Morris, Richard / Payne, Rupert / Storey, Claire / Viner, Maria / Rai, Dheeraj

    Health technology assessment (Winchester, England)

    2023  Volume 27, Issue 15, Page(s) 1–83

    Abstract: Background: Antidepressants are commonly prescribed during pregnancy, despite a lack of evidence from randomised trials on the benefits or risks. Some studies have reported associations of antidepressants during pregnancy with adverse offspring ... ...

    Abstract Background: Antidepressants are commonly prescribed during pregnancy, despite a lack of evidence from randomised trials on the benefits or risks. Some studies have reported associations of antidepressants during pregnancy with adverse offspring neurodevelopment, but whether or not such associations are causal is unclear.
    Objectives: To study the associations of antidepressants for depression in pregnancy with outcomes using multiple methods to strengthen causal inference.
    Design: This was an observational cohort design using multiple methods to strengthen causal inference, including multivariable regression, propensity score matching, instrumental variable analysis, negative control exposures, comparison across indications and exposure discordant pregnancies analysis.
    Setting: This took place in UK general practice.
    Participants: Participants were pregnant women with depression.
    Interventions: The interventions were initiation of antidepressants in pregnancy compared with no initiation, and continuation of antidepressants in pregnancy compared with discontinuation.
    Main outcome measures: The maternal outcome measures were the use of primary care and secondary mental health services during pregnancy, and during four 6-month follow-up periods up to 24 months after pregnancy, and antidepressant prescription status 24 months following pregnancy. The child outcome measures were diagnosis of autism, diagnosis of attention deficit hyperactivity disorder and intellectual disability.
    Data sources: UK Clinical Practice Research Datalink.
    Results: Data on 80,103 pregnancies were used to study maternal primary care outcomes and were linked to 34,274 children with at least 4-year follow-up for neurodevelopmental outcomes. Women who initiated or continued antidepressants during pregnancy were more likely to have contact with primary and secondary health-care services during and after pregnancy and more likely to be prescribed an antidepressant 2 years following the end of pregnancy than women who did not initiate or continue antidepressants during pregnancy (odds ratio
    Limitations: Several causal-inference analyses lacked precision owing to limited numbers. In addition, adherence to the prescribed treatment was not measured.
    Conclusions: Women prescribed antidepressants during pregnancy had greater service use during and after pregnancy than those not prescribed antidepressants. The evidence against any substantial association with autism, attention deficit hyperactivity disorder or intellectual disability in the children of women who continued compared with those who discontinued antidepressants in pregnancy is reassuring. Potential association of initiation of antidepressants during pregnancy with offspring autism needs further investigation.
    Future work: Further research on larger samples could increase the robustness and precision of these findings. These methods applied could be a template for future pharmaco-epidemiological investigation of other pregnancy-related prescribing safety concerns.
    Funding: This project was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (15/80/19) and will be published in full in
    MeSH term(s) Humans ; Child ; Female ; Pregnancy ; Intellectual Disability/drug therapy ; Antidepressive Agents/adverse effects ; Autistic Disorder ; Family ; Technology Assessment, Biomedical
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2006765-3
    ISSN 2046-4924 ; 1366-5278
    ISSN (online) 2046-4924
    ISSN 1366-5278
    DOI 10.3310/AQTF4490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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