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Article: Vertebral compression fractures: to brace or not to brace?

Mikula, Anthony Loren / Pennington, Zach / Elder, Benjamin D / Fogelson, Jeremy L

2023 Volume 9, Issue 3, Page(s) 236–237

Language	English
Publishing date	2023-07-27
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2874556-5
ISSN	2414-4630 ; 2414-469X
ISSN (online)	2414-4630
ISSN	2414-469X
DOI	10.21037/jss-23-71
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Introduction. Adult hydrocephalus: advancements in diagnosis, treatment, and patient outcomes.

Hamilton, Mark G / Israelsson, Hanna / Palandri, Giorgio / Elder, Benjamin D / Williams, Michael A

Neurosurgical focus

2023 Volume 54, Issue 4, Page(s) E1

MeSH term(s)	Humans ; Adult ; Hydrocephalus/diagnosis ; Hydrocephalus/surgery
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2023.1.FOCUS22641
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Article ; Online: 3D Stem Cell Spheroids with 2D Hetero-Nanostructures for In Vivo Osteogenic and Immunologic Modulated Bone Repair.

Liu, Xifeng / Astudillo Potes, Maria D / Dashtdar, Babak / Schreiber, Areonna C / Tilton, Maryam / Li, Linli / Elder, Benjamin D / Lu, Lichun

Advanced healthcare materials

2024 , Page(s) e2303772

Abstract: 3D stem cell spheroids have immense potential for various tissue engineering applications. However, current spheroid fabrication techniques encounter cell viability issues due to limited oxygen access for cells trapped within the core, as well as ... ...

Abstract	3D stem cell spheroids have immense potential for various tissue engineering applications. However, current spheroid fabrication techniques encounter cell viability issues due to limited oxygen access for cells trapped within the core, as well as nonspecific differentiation issues due to the complicated environment following transplantation. In this study, functional 3D spheroids are developed using mesenchymal stem cells with 2D hetero-nanostructures (HNSs) composed of single-stranded DNA (ssDNA) binding carbon nanotubes (sdCNTs) and gelatin-bind black phosphorus nanosheets (gBPNSs). An osteogenic molecule, dexamethasone (DEX), is further loaded to fabricate an sdCNTgBP-DEX HNS. This approach aims to establish a multifunctional cell-inductive 3D spheroid with improved oxygen transportation through hollow nanotubes, stimulated stem cell growth by phosphate ions supplied from BP oxidation, in situ immunoregulation, and osteogenesis induction by DEX molecules after implantation. Initial transplantation of the 3D spheroids in rat calvarial bone defect shows in vivo macrophage shifts to an M2 phenotype, leading to a pro-healing microenvironment for regeneration. Prolonged implantation demonstrates outstanding in vivo neovascularization, osteointegration, and new bone regeneration. Therefore, these engineered 3D spheroids hold great promise for bone repair as they allow for stem cell delivery and provide immunoregulative and osteogenic signals within an all-in-one construct.
Language	English
Publishing date	2024-01-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202303772
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Zs.A 6966: Show issues

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Article: Spinal fusion of biodegradable poly(propylene fumarate) and poly(propylene fumarate-co-caprolactone) copolymers in rabbits.

Xu, Hao / Liao, Hui / Liu, Xifeng / Miller, A Lee / Elder, Benjamin D / Lu, Lichun

Journal of orthopaedics

2023 Volume 48, Page(s) 52–59

Abstract: Background: Autologous bone grafts are currently the standard in orthopedic surgery despite limited donor sources and the prevalence of donor site morbidity. Other alternatives such as allografts are more readily available than autografts but have lower ...

Abstract	Background: Autologous bone grafts are currently the standard in orthopedic surgery despite limited donor sources and the prevalence of donor site morbidity. Other alternatives such as allografts are more readily available than autografts but have lower rates of graft incorporation. Methods: Here, we propose a novel graft alternative consisting of an injectable poly(propylene fumarate) (PPF) and poly(propylene fumarate-co-caprolactone) P(PF- Results: Of the 4 experimental groups, the injectable P(PF- Conclusion: Injectable P(PF-co-CL) polymers showed promising spine fusion abilities in rabbits after 12 weeks of posterolateral implantation.
Language	English
Publishing date	2023-10-28
Publishing country	India
Document type	Journal Article
ZDB-ID	2240839-3
ISSN	0972-978X
ISSN	0972-978X
DOI	10.1016/j.jor.2023.10.023
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Article ; Online: Patients with normal pressure hydrocephalus have fewer enlarged perivascular spaces in the centrum semiovale compared to cognitively unimpaired individuals.

Switzer, Aaron R / Graff-Radford, Jonathan / Gunter, Jeffery L / Elder, Benjamin D / Jones, David T / Huston, John / Jack, Clifford R / Cogswell, Petrice M

Clinical neurology and neurosurgery

2024 Volume 237, Page(s) 108123

Abstract: Introduction: Enlarged perivascular spaces (ePVS) may be an indicator of glymphatic dysfunction. Limited studies have evaluated the role of ePVS in idiopathic normal pressure hydrocephalus (iNPH). We aimed to characterize the distribution and number of ... ...

Abstract	Introduction: Enlarged perivascular spaces (ePVS) may be an indicator of glymphatic dysfunction. Limited studies have evaluated the role of ePVS in idiopathic normal pressure hydrocephalus (iNPH). We aimed to characterize the distribution and number of ePVS in iNPH compared to controls. Methods: Thirty-eight patients with iNPH and a pre-shunt MRI were identified through clinical practice. Age- and sex-matched controls who had negative MRIs screening for intracranial metastases were identified through a medical record linkage system. The number of ePVS were counted in the basal nuclei (BN) and centrum semiovale (CS) using the Wardlaw method blinded to clinical diagnosis. Imaging features of disproportionately enlarged subarachnoid space hydrocephalus (DESH), callosal angle, Fazekas white matter hyperintensity (WMH) grade, and the presence of microbleeds and lacunes were also evaluated. Results: Both iNPH patients and controls had a mean age of 74 ± 7 years and were 34% female with equal distributions of hypertension, dyslipidemia, diabetes, stroke, and history of smoking. There were fewer ePVS in the CS of patients with iNPH compared to controls (12.66 vs. 20.39, p < 0.001) but the same in the BN (8.95 vs. 11.11, p = 0.08). This remained significant in models accounting for vascular risk factors (p = 0.002) and MRI features of DESH and WMH grade (p = 0.03). Conclusions: Fewer centrum semiovale ePVS may be a biomarker for iNPH. This pattern may be caused by mechanical obstruction due to upward displacement of the brain leading to reduced glymphatic clearance.
MeSH term(s)	Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Hydrocephalus, Normal Pressure/diagnostic imaging ; Magnetic Resonance Imaging ; Brain ; Corpus Callosum ; Basal Ganglia ; Nervous System Malformations
Language	English
Publishing date	2024-01-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2024.108123
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Article: Normal pressure hydrocephalus, or Hakim syndrome: review and update.

Tipton, Philip W / Elder, Benjamin D / Cogswell, Petrice M / Graff-Radford, Neill

Neurologia i neurochirurgia polska

2023 Volume 58, Issue 1, Page(s) 8–20

Abstract: This review makes the case that idiopathic normal pressure hydrocephalus (iNPH) is an outdated term because new information indicates that the syndrome is less idiopathic and that the cerebrospinal fluid (CSF) pressure of normal individuals is affected ... ...

Abstract	This review makes the case that idiopathic normal pressure hydrocephalus (iNPH) is an outdated term because new information indicates that the syndrome is less idiopathic and that the cerebrospinal fluid (CSF) pressure of normal individuals is affected by several factors such as body mass index, age, and sex. Our review updates the epidemiology of iNPH and provides a clinical approach to the management of these patients. All the clinical features of iNPH are common in older individuals, and each has many causes, so the diagnosis is difficult. The first step in reaching an accurate diagnosis is to address the possible contributory factors to the gait abnormality and determine what if any role iNPH may be playing. The two best diagnostic tests are neuroimaging and cerebrospinal fluid (CSF) diversion (large volume lumbar puncture or external lumbar drainage) with pre/post gait evaluation. This review provides an update on the growing evidence that vascular disease, impaired CSF absorption, congenital, and genetic factors all contribute to the pathogenesis of iNPH. We suggest replacing the term iNPH with the term Hakim syndrome (HS) in acknowledgement of the first person to describe this syndrome. Lastly, we discuss the improvements in shunt technology and surgical techniques that have decreased the risks and long-term complications of shunt surgery.
MeSH term(s)	Aged ; Humans ; Cerebrospinal Fluid Shunts/methods ; Gait ; Hydrocephalus, Normal Pressure/diagnostic imaging ; Hydrocephalus, Normal Pressure/epidemiology ; Neuroimaging ; Syndrome ; Male ; Female
Language	English
Publishing date	2023-12-06
Publishing country	Poland
Document type	Review ; Journal Article
ZDB-ID	415519-1
ISSN	1897-4260 ; 0028-3843
ISSN (online)	1897-4260
ISSN	0028-3843
DOI	10.5603/pjnns.97343
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Zs.B 739: Show issues

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Article ; Online: Decompression Alone Versus Interspinous/Interlaminar Device Placement for Degenerative Lumbar Pathologies: Systematic Review and Meta-Analysis.

Pennington, Zach / Lakomkin, Nikita / Mikula, Anthony L / Elsamadicy, Aladine A / Astudillo Potes, Maria / Fogelson, Jeremy L / Grossbach, Andrew J / Elder, Benjamin D

World neurosurgery

2024

Abstract: Introduction: Interspinous devices (ISDs) and interlaminar devices (ILDs) are marketed as alternatives to conventional surgery for degenerative lumbar conditions; comparisons with decompression alone are limited. The present study reviews the extant ... ...

Abstract	Introduction: Interspinous devices (ISDs) and interlaminar devices (ILDs) are marketed as alternatives to conventional surgery for degenerative lumbar conditions; comparisons with decompression alone are limited. The present study reviews the extant literature comparing the cost and effectiveness of ISDs/ILDs with decompression alone. Methods: Articles comparing decompression alone with ISD/ILD were identified; outcomes of interest included general and disease-specific patient-reported outcomes, perioperative complications, and total treatment costs. Outcomes were analyzed at <6 weeks, 3 months, 6 months, 1 year, 2 years, and last follow-up. Analyses were performed using random effects modeling. Results: Twenty-nine studies were included in the final analysis. ILD/ISD showed greater leg pain improvement at 3 months (mean difference, -1.43; 95% confidence interval, [-1.78, -1.07]; P < 0.001), 6 months (-0.89; [-1.55, -0.24]; P = 0.008), and 12 months (-0.97; [-1.25, -0.68]; P < 0.001), but not 2 years (P = 0.22) or last follow-up (P = 0.09). Back pain improvement was better after ISD/ILD only at 1 year (-0.87; [-1.62, -0.13]; P = 0.02). Short-Form 36 physical component scores or Zurich Claudication Questionnaire (ZCQ) symptom severity scores did not differ between the groups. ZCQ physical function scores improved more after decompression alone at 6 months (0.35; [0.07, 0.63]; P = 0.01) and 12 months (0.23; [0.00, 0.46]; P = 0.05). Oswestry Disability Index and EuroQoL 5 dimensions scores favored ILD/ISD at all time points except 6 months (P = 0.07). Reoperations (odds ratio, 1.75; [1.23, 2.48]; P = 0.002) and total care costs (standardized mean difference, 1.19; [0.62, 1.77]; P < 0.001) were higher in the ILD/ISD group; complications did not differ significantly between the groups (P = 0.41). Conclusions: Patient-reported outcomes are similar after decompression alone and ILD/ISD; the observed differences do not reach accepted minimum clinically important difference thresholds. ISD/ILDs have higher associated costs and reoperation rates, suggesting current evidence does not support ILD/ISDs as a cost-effective alternative to decompression alone.
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.03.054
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Article: Significant Reduction in Bone Density as Measured by Hounsfield Units in Patients with Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis.

Swart, Alexander / Hamouda, Abdelrahman / Pennington, Zach / Lakomkin, Nikita / Mikula, Anthony L / Martini, Michael L / Shafi, Mahnoor / Subramaniam, Thirusivapragasam / Sebastian, Arjun S / Freedman, Brett A / Nassr, Ahmad N / Fogelson, Jeremy L / Elder, Benjamin D

Journal of clinical medicine

2024 Volume 13, Issue 5

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13051430
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Article ; Online: 3D-printed scaffolds with 2D hetero-nanostructures and immunomodulatory cytokines provide pro-healing microenvironment for enhanced bone regeneration.

Liu, Xifeng / Gaihre, Bipin / Park, Sungjo / Li, Linli / Dashtdar, Babak / Astudillo Potes, Maria D / Terzic, Andre / Elder, Benjamin D / Lu, Lichun

Bioactive materials

2023 Volume 27, Page(s) 216–230

Abstract: Three-dimensional (3D) printing technology is driving forward the progresses of various engineering fields, including tissue engineering. However, the pristine 3D-printed scaffolds usually lack robust functions in stimulating desired activity for varied ... ...

Abstract	Three-dimensional (3D) printing technology is driving forward the progresses of various engineering fields, including tissue engineering. However, the pristine 3D-printed scaffolds usually lack robust functions in stimulating desired activity for varied regeneration applications. In this study, we combined the two-dimensional (2D) hetero-nanostructures and immuno-regulative interleukin-4 (IL-4) cytokines for the functionalization of 3D-printed scaffolds to achieve a pro-healing immuno-microenvironment for optimized bone injury repair. The 2D hetero-nanostructure consists of graphene oxide (GO) layers, for improved cell adhesion, and black phosphorous (BP) nanosheets, for the continuous release of phosphate ions to stimulate cell growth and osteogenesis. In addition, the 2D hetero-nanolayers facilitated the adsorption of large content of immuno-regulative IL-4 cytokines, which modulated the polarization of macrophages into M2 phenotype. After
Language	English
Publishing date	2023-04-13
Publishing country	China
Document type	Journal Article
ISSN	2452-199X
ISSN (online)	2452-199X
DOI	10.1016/j.bioactmat.2023.03.021
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Article ; Online: Transforaminal Lumbar Interbody Fusion With Double Cages: 2-Dimensional Operative Video.

Mikula, Anthony L / Lakomkin, Nikita / Elder, Benjamin D / Fogelson, Jeremy L

Operative neurosurgery (Hagerstown, Md.)

2021 Volume 22, Issue 1, Page(s) e52

Abstract: We provide a step-by-step technique guide for performing a transforaminal lumbar interbody fusion (TLIF) with double cages. An illustrative case was presented with detailed narration and discussion of technical nuances. Double TLIF cages create an ... ...

Abstract	We provide a step-by-step technique guide for performing a transforaminal lumbar interbody fusion (TLIF) with double cages. An illustrative case was presented with detailed narration and discussion of technical nuances. Double TLIF cages create an anterior lumbar interbody fusion-sized footprint that increases the surface area for arthrodesis and force distribution while avoiding the added morbidity of an anterior approach. An appropriate TLIF technique creates lordosis through an all-posterior approach, and using a large TLIF window avoids the need for retraction of the nerve roots or thecal sac. The patient gave informed consent for the procedure and video recording. There is no identifying information in this video. Institutional review board approval was deemed unnecessary.
Language	English
Publishing date	2021-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1227/ONS.0000000000000025
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