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  1. Article ; Online: Skin, Autoimmunity and Inflammation: A Comprehensive Exploration through Scientific Research.

    Diotallevi, Federico / Offidani, Annamaria

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: Human skin, as the body's largest organ, orchestrates a multifaceted interplay of cellular interactions that regulate essential physiological processes, including inflammation, immune responses, wound healing, and angiogenesis [ ... ]. ...

    Abstract Human skin, as the body's largest organ, orchestrates a multifaceted interplay of cellular interactions that regulate essential physiological processes, including inflammation, immune responses, wound healing, and angiogenesis [...].
    MeSH term(s) Humans ; Autoimmunity ; Skin ; Wound Healing/physiology ; Immunity ; Inflammation
    Language English
    Publishing date 2023-11-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115857
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  2. Article ; Online: Skin, Autoimmunity and Inflammation

    Federico Diotallevi / Annamaria Offidani

    International Journal of Molecular Sciences, Vol 24, Iss 21, p

    A Comprehensive Exploration through Scientific Research

    2023  Volume 15857

    Abstract: Human skin, as the body’s largest organ, orchestrates a multifaceted interplay of cellular interactions that regulate essential physiological processes, including inflammation, immune responses, wound healing, and angiogenesis [.] ...

    Abstract Human skin, as the body’s largest organ, orchestrates a multifaceted interplay of cellular interactions that regulate essential physiological processes, including inflammation, immune responses, wound healing, and angiogenesis [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Modified upside-down technique with Gore tapered iliac limbs for isolated iliac artery aneurysms.

    Pennetta, Federico Francisco / De Santis, Francesco / Millarelli, Massimiliano / Diotallevi, Nicolò / Chiappa, Roberto

    Vascular

    2024  , Page(s) 17085381241242859

    Abstract: Purpose: To describe the off-label use of tapered iliac limbs for the treatment of isolated iliac aneurysms with proximal landing zone significantly larger than distal landing zone.: Technique: Inversion of a Gore Excluder tapered leg (W. L. Gore & ... ...

    Abstract Purpose: To describe the off-label use of tapered iliac limbs for the treatment of isolated iliac aneurysms with proximal landing zone significantly larger than distal landing zone.
    Technique: Inversion of a Gore Excluder tapered leg (W. L. Gore & Associates Inc, Flagstaff, Arizona) with a modified upside-down technique is described. The endoprosthesis, with the olive at the tip of the releasing system previously cut, is inserted in a tip-to-tip fashion into a 15 Fr introducer sheath. The graft is released inside the introducer. An 18 Fr introducer sheath is advanced up to the proximal sealing zone. Following the removal of the 18 Fr dilator, the 15 Fr introducer with the pre-released graft is inserted co-axially into the 18 Fr introducer. A pre-cut 15 Fr dilator is brought up to the endograft and used as a pusher. A pull-back maneuver of the co-axial system, countertractioning with the dilator maintained in position, allows the delivery of the endograft.
    Conclusion: This technique might offer a feasible option in case of endovascular exclusion of isolated iliac artery aneurysms with significant landing zone diameter mismatch. Extracorporeal inversion is time-saving and could be safer in terms of graft damage and infection.
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2137151-9
    ISSN 1708-539X ; 1708-5381
    ISSN (online) 1708-539X
    ISSN 1708-5381
    DOI 10.1177/17085381241242859
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    Zs.A 4277: Show issues Location:
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  4. Article ; Online: Latest combination therapies in psoriasis: Narrative review of the literature.

    Diotallevi, Federico / Paolinelli, Matteo / Radi, Giulia / Offidani, Annamaria

    Dermatologic therapy

    2022  Volume 35, Issue 10, Page(s) e15759

    Abstract: Biological therapies revolutionized the treatment of many chronic inflammatory skin diseases, first of all psoriasis, thanks to their high efficacy and the reduced number of side effects. However, the use of a single biologic drug does not always provide ...

    Abstract Biological therapies revolutionized the treatment of many chronic inflammatory skin diseases, first of all psoriasis, thanks to their high efficacy and the reduced number of side effects. However, the use of a single biologic drug does not always provide complete control of the disease or associated comorbidities over time. The first biological drugs used for the treatment of psoriasis, tumor necrosis factor alpha inhibitors, have long been used in combination with traditional topical and systemic therapies to induce a complete remission of the disease that could not be achieved with innovative drug alone. Even with the advent of new biological therapies with more precise molecular targets, the challenge of using combination therapies remained. Psoriatic patients often have major comorbidities, such as arthritis, inflammatory bowel disease, uveitis or have other concomitant conditions such as chronic spontaneous urticaria and atopic dermatitis, which may require different biologic treatments than those indicated in psoriasis. The objective of this article is, through a comprehensive revision of the literature, to analyze in which cases the use of the combination of the latest therapies for psoriasis may be useful.
    MeSH term(s) Arthritis, Psoriatic/drug therapy ; Biological Products/adverse effects ; Humans ; Psoriasis/pathology ; Remission Induction ; Tumor Necrosis Factor-alpha
    Chemical Substances Biological Products ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.15759
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    Zs.A 5181: Show issues Location:
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  5. Article ; Online: Efficacy and Safety of Botulinum Toxin B in Focal Hyperhidrosis: A Narrative Review.

    Campanati, Anna / Diotallevi, Federico / Radi, Giulia / Martina, Emanuela / Marconi, Barbara / Bobyr, Ivan / Offidani, Annamaria

    Toxins

    2023  Volume 15, Issue 2

    Abstract: Botulinum toxin type B (BoNT-B), known as ... ...

    Abstract Botulinum toxin type B (BoNT-B), known as Myobloc
    MeSH term(s) Humans ; Botulinum Toxins, Type A/therapeutic use ; Europe ; Hyperhidrosis/drug therapy ; Serogroup
    Chemical Substances Botulinum Toxins, Type A (EC 3.4.24.69) ; rimabotulinumtoxinB (0Y70779M1F)
    Language English
    Publishing date 2023-02-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins15020147
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  6. Article ; Online: Trichorhinophalangeal syndrome: a case report and brief literature review.

    Simonetti, Oriana / Radi, Giulia / Molinelli, Elisa / Diotallevi, Federico / Offidani, Annamaria

    Acta dermatovenerologica Alpina, Pannonica, et Adriatica

    2022  Volume 31, Issue 1, Page(s) 43–46

    Abstract: Trichorhinophalangeal syndrome is an autosomal dominant disease caused by mutations in TRPS gene, characterized by skeletal, skin appendage, and endocrinological manifestations. Clinical presentation may vary widely, and the syndrome frequently remains ... ...

    Abstract Trichorhinophalangeal syndrome is an autosomal dominant disease caused by mutations in TRPS gene, characterized by skeletal, skin appendage, and endocrinological manifestations. Clinical presentation may vary widely, and the syndrome frequently remains undiagnosed. The diagnosis is mainly clinical, supported by radiographic images, and is confirmed by genetic investigation. Familiarity with this genetic disorder is crucial for providing correct and early identification, and for determining adequate supportive management, especially to prevent orthopedic complications.
    MeSH term(s) Humans ; Langer-Giedion Syndrome/diagnosis ; Langer-Giedion Syndrome/genetics ; Langer-Giedion Syndrome/therapy
    Language English
    Publishing date 2022-03-23
    Publishing country Slovenia
    Document type Case Reports ; Journal Article
    ZDB-ID 1235900-2
    ISSN 1581-2979 ; 1318-4458 ; 0302-4466
    ISSN (online) 1581-2979
    ISSN 1318-4458 ; 0302-4466
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4287: Show issues Location:
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  7. Article: Treatment of Moderate to Severe Psoriasis during the COVID-19 Pandemic: Lessons Learned and Opportunities.

    Campanati, Anna / Diotallevi, Federico / Martina, Emanuela / Radi, Giulia / Offidani, Annamaria

    Journal of clinical medicine

    2022  Volume 11, Issue 9

    Abstract: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, clinicians have been overwhelmed by questions beyond the SARS-CoV-2 infection itself. In dermatology practice, clinicians have been facing difficulties concerning therapeutic ... ...

    Abstract Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, clinicians have been overwhelmed by questions beyond the SARS-CoV-2 infection itself. In dermatology practice, clinicians have been facing difficulties concerning therapeutic management of chronic immune-mediated skin disease, above all psoriasis. Major challenges arisen were to understand the role of immunosuppression or immunomodulation on COVID-19 evolution, the benefit/risk ratio related to discontinuation or modification of ongoing treatment, and the appropriateness of initiating new treatments, the optimization of timing in vaccination administration to patients under immunomodulatory treatments, and finally how to find new strategy of patients' management through remote assistance. In this comprehensive review, we present the current evidence about the course and management of psoriasis during the COVID-19 pandemic. The general message from dermatologists was that data did not suggest that having PSO or its treatment significantly increased risk of SARS-CoV-2 infection or more severe COVID-19 course, the vaccination is highly recommended in all psoriatic patients, beyond ongoing treatment, and that the telehealth experience was a success overall.
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11092422
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  8. Article ; Online: Should we be concerned about gastrointestinal-related adverse events in patients with plaque psoriasis receiving secukinumab therapy? A retrospective, real-life study.

    Diotallevi, Federico / Gambini, Daisy / Radi, Giulia / Simonetti, Oriana / Offidani, Annamaria

    Dermatologic therapy

    2022  Volume 35, Issue 11, Page(s) e15794

    Abstract: Real-world secukinumab gastrointestinal-related adverse events (GIRAE) data in psoriatic patients treated with secukinumab are lacking. A descriptive, retrospective study was performed by reviewing the medical records of patients who received secukinumab ...

    Abstract Real-world secukinumab gastrointestinal-related adverse events (GIRAE) data in psoriatic patients treated with secukinumab are lacking. A descriptive, retrospective study was performed by reviewing the medical records of patients who received secukinumab for plaque psoriasis for at least 1 year and who made a follow-up visit to the dermatology clinic of "Ospedali Riuniti Umberto I" in Ancona between December 1, 2021, and March 31, 2022. The patients' medical history and clinical data were collected at T0, before treatment, and at T1, corresponding to the last follow-up visit. Special attention was given to gastrointestinal adverse events (GIRAE). A total of 108 patients were included in the study. At baseline median PASI was 14.8 (range 2.2-27, SD 6.1), and median DLQI was 9.3 (5-16, SD 2.6). The median PASI for treated patients was 0.7 (0-3, SD 0.8; p < 0.00) 1and median DLQI was 0.3 (0-1, SD 0.5; p < 0.001). At T1 54/114 patients (50%) reached PASI100, of the other 54, 48 (88.9%) reached PASI 90 while the other six discontinued for secondary ineffectiveness. Only three patients reported a GIRAE (diarrhea), however, when screened, no IBD was found. Consistent with data in the literature, secukinumab is an effective and safe drug for the treatment of plaque psoriasis also in a real-life experience context. There should be no concern in choosing the drug for fear of possible IBDs-related GIRAE if there is no personal history or familiarity for IBDs.
    MeSH term(s) Humans ; Retrospective Studies ; Treatment Outcome ; Psoriasis/drug therapy ; Antibodies, Monoclonal, Humanized/adverse effects ; Severity of Illness Index
    Chemical Substances secukinumab (DLG4EML025) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2022-09-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.15794
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  9. Article ; Online: Acral Leukoderma: Is It Always Vitiligo?

    Martina, Emanuela / Diotallevi, Federico / Campanati, Anna / Radi, Giulia / Offidani, Annamaria

    Dermatitis : contact, atopic, occupational, drug

    2021  Volume 32, Issue 6, Page(s) e159–e161

    MeSH term(s) Acrylates/adverse effects ; Adult ; Allergens/adverse effects ; Dermatitis, Allergic Contact/etiology ; Humans ; Male ; Occupational Exposure/adverse effects ; Patch Tests/statistics & numerical data ; Vitiligo/chemically induced
    Chemical Substances Acrylates ; Allergens
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1097/DER.0000000000000769
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    Zs.A 3680: Show issues Location:
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  10. Article: A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside.

    Radi, Giulia / Campanti, Anna / Diotallevi, Federico / Martina, Emanuela / Marani, Andrea / Offidani, Annamaria

    Biomedicines

    2022  Volume 10, Issue 11

    Abstract: Atopic dermatitis (AD) is a common chronic inflammatory and immune-mediated skin disease with a complex pathophysiology and still represents a therapeutic challenge, owing to limited responses to available treatments. However, recent advances in the ... ...

    Abstract Atopic dermatitis (AD) is a common chronic inflammatory and immune-mediated skin disease with a complex pathophysiology and still represents a therapeutic challenge, owing to limited responses to available treatments. However, recent advances in the understanding of AD pathophysiology have led to the discovery of several new potential therapeutic targets, and research in the field of new molecules with therapeutic perspectives is boiling, with more than 70 new promising drugs in development. The aim of this systematic review is to provide the state of the art on the current knowledge concerning the pathophysiology of the disease and on novel agents currently being investigated for AD, and to highlight which type of evolution is going to take place in therapeutic approaches of atopic dermatitis in the coming years.
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10112700
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