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  1. Book ; Online ; E-Book: Flow cytometry today

    Ortolani, Claudio

    everything you need to know about flow cytometry

    2022  

    Author's details Claudio Ortolani
    Keywords Flow cytometry
    Subject code 571.6028
    Language English
    Size 1 Online-Ressource (xxix, 544 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030644277
    ISBN 978-3-031-10836-5 ; 9783031108358 ; 3-031-10836-1 ; 3031108353
    DOI 10.1007/978-3-031-10836-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Flow cytometry of hematological malignancies

    Ortolani, Claudio

    2021  

    Author's details Claudio Ortolani
    Keywords Hematologic Neoplasms / diagnosis ; Flow Cytometry / methods
    Language English
    Size xxi, 442 Seiten, Illustrationen
    Edition Second edition
    Publisher Wiley-Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT020969237
    ISBN 978-1-119-61125-7 ; 1-119-61125-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 834 available for loan (reading room) Lesesaal EG

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  3. Book: Flow cytometry of hematological malignancies

    Ortolani, Claudio

    2011  

    Author's details Claudio Ortolani
    Keywords Hematologic Neoplasms / diagnosis ; Flow Cytometry / methods
    Language English
    Size XIV, 311 S. : Ill., graph. Darst., 29 cm
    Publisher Wiley-Blackwell
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Note Formerly CIP Uk. - Includes bibliographical references and index
    HBZ-ID HT016955943
    ISBN 978-1-4443-3588-0 ; 1-4443-3588-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 3537 order for loan Magazin

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  4. Book ; Conference proceedings: 7th International Symposium on Immunological, Chemical and Clinical Problems of Food Allergy

    Ortolani, Claudio

    Italy, 4 - 7 October 1998

    (Allergy : Supplement ; 46)

    1998  

    Event/congress International Symposium on Immunological, Chemical and Clinical Problems of Food Allergy (7, 1998, Giardini)
    Author's details guest ed.: C. Ortolani
    Series title Allergy : Supplement ; 46
    Allergy
    Allergy ; Supplement
    Collection Allergy
    Allergy ; Supplement
    Language English
    Size 145 S. : graph. Darst.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book ; Conference proceedings
    HBZ-ID HT009135788
    ISBN 87-16-16323-0 ; 978-87-16-16323-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 150 -Suppl.46- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Flow Cytometry and Its Applications to Molecular Biology and Diagnosis 2.0.

    Papa, Stefano / Ortolani, Claudio / Fernández, Paula / O'Connor, José-Enrique

    International journal of molecular sciences

    2023  Volume 24, Issue 22

    Abstract: Flow cytometry is a single-cell based technology aimed to quantify the scattering of light and the emission of multiple fluorescence signals by individual cells, biological vesicles, or synthetic microscopical particles when examined one by one at high ... ...

    Abstract Flow cytometry is a single-cell based technology aimed to quantify the scattering of light and the emission of multiple fluorescence signals by individual cells, biological vesicles, or synthetic microscopical particles when examined one by one at high speed using lasers or other suitable illumination sources [...].
    MeSH term(s) Flow Cytometry ; Molecular Biology
    Language English
    Publishing date 2023-11-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Atlas on mechanisms in adverse reactions to food

    Ortolani, Claudio

    (Allergy : Supplement ; 20)

    1995  

    Author's details ed. by Claudio Ortolani
    Series title Allergy : Supplement ; 20
    Allergy
    Allergy ; Supplement
    Collection Allergy
    Allergy ; Supplement
    Keywords Food Hypersensitivity ; Lebensmittelallergie
    Subject Alimentäre Allergie ; Nahrungsmittelallergie
    Language English
    Size 81 S. : Ill., graph. Darst.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT006543532
    ISBN 87-16-15139-9 ; 978-87-16-15139-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 150 -Suppl.20- verfügbar in Königswinter Königswinter

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  7. Article: Hydroxychloroquine and dexamethasone in COVID-19: who won and who lost?

    Ortolani, Claudio / Pastorello, Elide A

    Clinical and molecular allergy : CMA

    2020  Volume 18, Page(s) 17

    Abstract: Background: On June 30, 2020, the WHO reported over 10 millions of COVID-19 cases worldwide with over half a million deaths. In severe cases the disease progresses into an Acute Respiratory Distress Syndrome (ARDS), which in turn depends on an ... ...

    Abstract Background: On June 30, 2020, the WHO reported over 10 millions of COVID-19 cases worldwide with over half a million deaths. In severe cases the disease progresses into an Acute Respiratory Distress Syndrome (ARDS), which in turn depends on an overproduction of cytokines (IL-6, TNFα, IL-12, IL-8, CCL-2 and IL1) that causes alveolar and vascular lung damage. Clearly, it is essential to find an immunological treatment that controls the "cytokine storm". In the meantime, however, it is essential to have effective antiviral and anti-inflammatory drugs available immediately.
    Pharmacologic therapy for covid-19: Hydroxychloroquine or chloroquine have been widely adopted worldwide for the treatment of SARS-CoV-2 pneumonia. However, the choice of this treatment was based on low quality of evidence, i.e. retrospective, non-randomized controlled studies. Recently, four large Randomized Controlled Trials (RCTs) have been performed in record time delivering reliable data: (1) the National Institutes of Health (NIH) RCT included 60 hospitals participating all over the world and showed the efficacy of remdesivir in reducing the recovery time in hospitalized adults with COVID-19 pneumonia; (2) three large RCTs already completed, for hydroxychloroquine, dexamethasone and Lopinavir and Ritonavir respectively. These trials were done under the umbrella of the 'Recovery' project, headed by the University of Oxford. The project includes 176 participating hospitals in the UK and was set up to verify the efficacy of some of the treatments used for COVID-19. These three 'Recovery' RCTs concluded definitely: (a) that treatment with hydroxychloroquine provides no benefits in patients hospitalized with COVID-19; (b) that treatment with dexamethasone reduced deaths by one-third in COVID-19 patients that were mechanically ventilated, and by one-fifth in patients receiving oxygen only; (c) that the combination of Lopinavir and Ritonavir is not effective in reducing mortality in COVID-19 hospitalized patients.
    Conclusions: The results of these four large RCTs have provided sound indications to doctors for the treatment of patients with COVID-19 and prompted the correction of many institutional provisions and guidelines on COVID-19 treatments (i.e. FDA, NIH, UK Health Service, etc.). Even though a definitive treatment for COVID-19 has not yet been found, large RCTs stand as the Gold Standards for COVID-19 therapy and offer a solid scientific base on which to base treatment decisions.
    Keywords covid19
    Language English
    Publishing date 2020-09-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2126317-6
    ISSN 1476-7961
    ISSN 1476-7961
    DOI 10.1186/s12948-020-00132-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hydroxychloroquine and dexamethasone in COVID-19

    Claudio Ortolani / Elide A. Pastorello

    Clinical and Molecular Allergy, Vol 18, Iss 1, Pp 1-

    who won and who lost?

    2020  Volume 7

    Abstract: Abstract Background On June 30, 2020, the WHO reported over 10 millions of COVID-19 cases worldwide with over half a million deaths. In severe cases the disease progresses into an Acute Respiratory Distress Syndrome (ARDS), which in turn depends on an ... ...

    Abstract Abstract Background On June 30, 2020, the WHO reported over 10 millions of COVID-19 cases worldwide with over half a million deaths. In severe cases the disease progresses into an Acute Respiratory Distress Syndrome (ARDS), which in turn depends on an overproduction of cytokines (IL-6, TNFα, IL-12, IL-8, CCL-2 and IL1) that causes alveolar and vascular lung damage. Clearly, it is essential to find an immunological treatment that controls the “cytokine storm”. In the meantime, however, it is essential to have effective antiviral and anti-inflammatory drugs available immediately. Pharmacologic therapy for COVID-19 Hydroxychloroquine or chloroquine have been widely adopted worldwide for the treatment of SARS-CoV-2 pneumonia. However, the choice of this treatment was based on low quality of evidence, i.e. retrospective, non-randomized controlled studies. Recently, four large Randomized Controlled Trials (RCTs) have been performed in record time delivering reliable data: (1) the National Institutes of Health (NIH) RCT included 60 hospitals participating all over the world and showed the efficacy of remdesivir in reducing the recovery time in hospitalized adults with COVID-19 pneumonia; (2) three large RCTs already completed, for hydroxychloroquine, dexamethasone and Lopinavir and Ritonavir respectively. These trials were done under the umbrella of the 'Recovery' project, headed by the University of Oxford. The project includes 176 participating hospitals in the UK and was set up to verify the efficacy of some of the treatments used for COVID-19. These three ‘Recovery’ RCTs concluded definitely: (a) that treatment with hydroxychloroquine provides no benefits in patients hospitalized with COVID-19; (b) that treatment with dexamethasone reduced deaths by one-third in COVID-19 patients that were mechanically ventilated, and by one-fifth in patients receiving oxygen only; (c) that the combination of Lopinavir and Ritonavir is not effective in reducing mortality in COVID-19 hospitalized patients. Conclusions The results of these four large RCTs have provided sound indications to doctors for the treatment of patients with COVID-19 and prompted the correction of many institutional provisions and guidelines on COVID-19 treatments (i.e. FDA, NIH, UK Health Service, etc.). Even though a definitive treatment for COVID-19 has not yet been found, large RCTs stand as the Gold Standards for COVID-19 therapy and offer a solid scientific base on which to base treatment decisions.
    Keywords COVID-19 ; SARS-CoV-2 ; Cytokine storm syndrome ; ARDS ; Hydroxychloroquine ; Remdesivir ; Immunologic diseases. Allergy ; RC581-607 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Author Correction: 3D measurement techniques for the hindfoot alignment angle from weight-bearing CT in a clinical population.

    Pavani, Chiara / Belvedere, Claudio / Ortolani, Maurizio / Girolami, Mauro / Durante, Stefano / Berti, Lisa / Leardini, Alberto

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 19902

    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-24322-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: 3D measurement techniques for the hindfoot alignment angle from weight-bearing CT in a clinical population.

    Pavani, Chiara / Belvedere, Claudio / Ortolani, Maurizio / Girolami, Mauro / Durante, Stefano / Berti, Lisa / Leardini, Alberto

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 16900

    Abstract: Cone-beam CT (CBCT) scans now enable accurate measurements on foot skeletal structures with the advantage of observing these in 3D and in weight-bearing. Among the most common skeletal deformities, the varus/valgus of the hindfoot is the most complex to ... ...

    Abstract Cone-beam CT (CBCT) scans now enable accurate measurements on foot skeletal structures with the advantage of observing these in 3D and in weight-bearing. Among the most common skeletal deformities, the varus/valgus of the hindfoot is the most complex to be represented, and a number of measure proposals have been published. This study aims to analyze and to compare these measurements from CBCT scans in a real clinical population with large such deformity. Ten patients with severe acquired adult flatfoot and indication for surgery underwent CBCT scans (Carestream, USA) while standing on that leg, before and after surgical correction. Corresponding 3D shape of each bone of the distal shank and hindfoot were defined (Materialise, Belgium). Six different techniques from the literature were used to calculate the varus/valgus deformity, i.e. the inclination of the hindfoot in the frontal plane of the shank. Standard clinical measurements by goniometers were taken for comparison. According to these techniques, and starting from a careful 3D reconstruction of the relevant foot skeletal structures, a large spectrum of measurements was found to represent the same hindfoot alignment angle. Most of them were very different from the traditional clinical measures. The assessment of the pre-operative valgus deformity and of the corresponding post-operative correction varied considerably. CBCT finally allows 3D assessment of foot deformities in weight-bearing. Measurements from the different available techniques do not compare well, as they are based on very different approaches. It is recommended to be aware of the anatomical and functional concepts behind these techniques before clinical and surgical conclusions.
    MeSH term(s) Adult ; Cone-Beam Computed Tomography ; Flatfoot/diagnostic imaging ; Flatfoot/surgery ; Foot/diagnostic imaging ; Foot Deformities ; Humans ; Weight-Bearing
    Language English
    Publishing date 2022-10-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-21440-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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