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  1. Article ; Online: Hydroxychloroquine-azithromycin for COVID-19 - Warranted or dangerous?

    Popescu, Corneliu P / Fischer, Philip R

    Travel medicine and infectious disease

    2020  Volume 35, Page(s) 101764

    MeSH term(s) Azithromycin ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; France ; Humans ; Hydroxychloroquine ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
    Keywords covid19
    Language English
    Publishing date 2020-05-30
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101764
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  3. Article ; Online: Hydroxychloroquine-azithromycin for COVID-19 – Warranted or dangerous?

    Popescu, Corneliu P. / Fischer, Philip R.

    Travel Medicine and Infectious Disease

    2020  Volume 35, Page(s) 101764

    Keywords Public Health, Environmental and Occupational Health ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101764
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  4. Article ; Online: Results of Response-Guided Therapy with Pegylated Interferon Alpha 2a in Chronic Hepatitis B and D.

    Gherlan, George S / Lazar, Stefan D / Culinescu, Augustina / Smadu, Dana / Vatafu, Andreea R / Popescu, Corneliu P / Florescu, Simin A / Ceausu, Emanoil / Calistru, Petre I

    Tropical medicine and infectious disease

    2024  Volume 9, Issue 4

    Abstract: Pegylated interferon alpha 2a continues to be used for the treatment of chronic hepatitis D. The reported on-treatment virologic response varies between 17 and 47%, with relapses in more than 50% of these patients. No stopping rules have been defined, ... ...

    Abstract Pegylated interferon alpha 2a continues to be used for the treatment of chronic hepatitis D. The reported on-treatment virologic response varies between 17 and 47%, with relapses in more than 50% of these patients. No stopping rules have been defined, and the duration of the treatment is not clearly established, but it should be between 48 and 96 weeks. In total, 76 patients with compensated liver disease treated with peg-interferon according to the Romanian National protocol for the treatment of hepatitis D were retrospectively included. The duration of treatment was up to 96 weeks, with the following stopping rules: less than a 2 log HDV RNA decrease by week 24 and less than a 1 log decrease every 6 months afterwards. Six months after stopping the treatment, it can be restarted for unlimited cycles. The inclusion criteria were aged above 18, HBs Ag-positive, HDV RNA detectable, ALT above ULN and/or liver fibrosis at least F1 at liver biopsy, or Fibrotest and/or Fibroscan higher than 7 KPa and/or inflammation at least A1 at liver biopsy or Fibrotest. We monitored our patients for a total period of 4 years (including those that repeated the cycle). After the first 6 months of treatment, 27 patients (35.5%) had a greater than 2 log HDV RNA decrease, 19 of them achieving undetectable HDV RNA. Seventeen patients (22.3%) had undetectable HDV RNA 24 weeks after stopping 96 weeks of treatment, and none relapsed in the following 2 years. Of these 17 patients, 6 were cirrhotic, and 4 had F3. Undetectable HDV RNA at 24 weeks was the only parameter that predicted a long-term suppression of HDV RNA. In 49 patients, the treatment was stopped after 6 months according to protocol, but it was restarted 6 months later. Five of these patients finished a 48-week course of treatment; none achieved undetectable HDV RNA. During the first course of therapy, 45 patients had at least one moderate adverse reaction to treatment. In one patient, the treatment was stopped due to a serious adverse event (osteomyelitis). Treatment doses had to be reduced in 29 patients. The virologic response at week 24 can select the patients who will benefit from continuing the treatment from those who should be changed to another type of medication when available.
    Language English
    Publishing date 2024-03-30
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed9040073
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  5. Article ; Online: COVID-19 impact on EuroTravNet infectious diseases sentinel surveillance in Europe.

    Grobusch, Martin P / Weld, Leisa / Schnyder, Jenny L / Larsen, Carsten Schade / Lindner, Andreas K / Popescu, Corneliu Petru / Huits, Ralph / Goorhuis, A / Gautret, Philippe / Schlagenhauf, Patricia

    Travel medicine and infectious disease

    2023  Volume 53, Page(s) 102583

    Abstract: Background: The COVID-19 pandemic resulted in a sharp decline of post-travel patient encounters at the European sentinel surveillance network (EuroTravNet) of travellers' health. We report on the impact of COVID-19 on travel-related infectious diseases ... ...

    Abstract Background: The COVID-19 pandemic resulted in a sharp decline of post-travel patient encounters at the European sentinel surveillance network (EuroTravNet) of travellers' health. We report on the impact of COVID-19 on travel-related infectious diseases as recorded by EuroTravNet clinics.
    Methods: Travelers who presented between January 1, 2019 and September 30, 2021 were included. Comparisons were made between the pre-pandemic period (14 months from January 1, 2019 to February 29, 2020); and the pandemic period (19 months from March 1, 2020 to September 30, 2021).
    Results: Of the 15,124 visits to the network during the 33-month observation period, 10,941 (72%) were during the pre-pandemic period, and 4183 (28%) during the pandemic period. Average monthly visits declined from 782/month (pre-COVID-19 era) to 220/month (COVID-19 pandemic era). Among non-migrants, the top-10 countries of exposure changed after onset of the COVID-19 pandemic; destinations such as Italy and Austria, where COVID-19 exposure peaked in the first months, replaced typical travel destinations in Asia (Thailand, Indonesia, India). There was a small decline in migrant patients reported, with little change in the top countries of exposure (Bolivia, Mali). The three top diagnoses with the largest overall decreases in relative frequency were acute gastroenteritis (-5.3%), rabies post-exposure prophylaxis (-2.8%), and dengue (-2.6%). Apart from COVID-19 (which rose from 0.1% to 12.7%), the three top diagnoses with the largest overall relative frequency increase were schistosomiasis (+4.9%), strongyloidiasis (+2.7%), and latent tuberculosis (+2.4%).
    Conclusions: A marked COVID-19 pandemic-induced decline in global travel activities is reflected in reduced travel-related infectious diseases sentinel surveillance reporting.
    MeSH term(s) Humans ; Sentinel Surveillance ; Travel ; Pandemics ; Travel-Related Illness ; COVID-19/epidemiology ; Communicable Diseases/epidemiology ; Communicable Diseases/diagnosis ; Europe/epidemiology ; Thailand
    Language English
    Publishing date 2023-05-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2023.102583
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  6. Article: Upsurge in cases of travellers' malaria ex Zanzibar indicates that malaria is on the rebound in the archipelago.

    Florescu, Simin Aysel / Larsen, Carsten Schade / Helleberg, Marie / Marin, Alexandru / Popescu, Corneliu Petru / Schlagenhauf, Patricia

    New microbes and new infections

    2024  Volume 57, Page(s) 101226

    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2024.101226
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  7. Article ; Online: Emergence of Toscana Virus, Romania, 2017-2018.

    Popescu, Corneliu P / Cotar, Ani I / Dinu, Sorin / Zaharia, Mihaela / Tardei, Gratiela / Ceausu, Emanoil / Badescu, Daniela / Ruta, Simona / Ceianu, Cornelia S / Florescu, Simin A

    Emerging infectious diseases

    2021  Volume 27, Issue 5, Page(s) 1482–1485

    Abstract: We describe a series of severe neuroinvasive infections caused by Toscana virus, identified by real-time reverse transcription PCR testing, in 8 hospitalized patients in Bucharest, Romania, during the summer seasons of 2017 and 2018. Of 8 patients, 5 ... ...

    Abstract We describe a series of severe neuroinvasive infections caused by Toscana virus, identified by real-time reverse transcription PCR testing, in 8 hospitalized patients in Bucharest, Romania, during the summer seasons of 2017 and 2018. Of 8 patients, 5 died. Sequencing showed that the circulating virus belonged to lineage A.
    MeSH term(s) Bunyaviridae Infections ; Humans ; Romania ; Sandfly fever Naples virus
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2705.204598
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  8. Article ; Online: 6G-Enabling the New Smart City: A Survey.

    Murroni, Maurizio / Anedda, Matteo / Fadda, Mauro / Ruiu, Pietro / Popescu, Vlad / Zaharia, Corneliu / Giusto, Daniele

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 17

    Abstract: Smart cities and 6G are technological areas that have the potential to transform the way we live and work in the years to come. Until this transformation comes into place, there is the need, underlined by research and market studies, for a critical ... ...

    Abstract Smart cities and 6G are technological areas that have the potential to transform the way we live and work in the years to come. Until this transformation comes into place, there is the need, underlined by research and market studies, for a critical reassessment of the entire wireless communication sector for smart cities, which should include the IoT infrastructure, economic factors that could improve their adoption rate, and strategies that enable smart city operations. Therefore, from a technical point of view, a series of stringent issues, such as interoperability, data privacy, security, the digital divide, and implementation issues have to be addressed. Notably, to concentrate the scrutiny on smart cities and the forthcoming influence of 6G, the groundwork laid by the current 5G, with its multifaceted role and inherent limitations within the domain of smart cities, is embraced as a foundational standpoint. This examination culminates in a panoramic exposition, extending beyond the mere delineation of the 6G standard toward the unveiling of the extensive gamut of potential applications that this emergent standard promises to introduce to the smart cities arena. This paper provides an update on the SC ecosystem around the novel paradigm of 6G, aggregating a series of enabling technologies accompanied by the descriptions of their roles and specific employment schemes.
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23177528
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  9. Article ; Online: Emergence of Toscana Virus, Romania, 2017–2018

    Corneliu P. Popescu / Ani I. Cotar / Sorin Dinu / Mihaela Zaharia / Gratiela Tardei / Emanoil Ceausu / Daniela Badescu / Simona Ruta / Cornelia S. Ceianu / Simin A. Florescu

    Emerging Infectious Diseases, Vol 27, Iss 5, Pp 1482-

    2021  Volume 1485

    Abstract: We describe a series of severe neuroinvasive infections caused by Toscana virus, identified by real-time reverse transcription PCR testing, in 8 hospitalized patients in Bucharest, Romania, during the summer seasons of 2017 and 2018. Of 8 patients, 5 ... ...

    Abstract We describe a series of severe neuroinvasive infections caused by Toscana virus, identified by real-time reverse transcription PCR testing, in 8 hospitalized patients in Bucharest, Romania, during the summer seasons of 2017 and 2018. Of 8 patients, 5 died. Sequencing showed that the circulating virus belonged to lineage A.
    Keywords Toscana virus ; Toscana phlebovirus ; TOSV ; Phlebovirus ; Phenuiviridae ; encephalitis ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
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  10. Article ; Online: Predicting long-term mortality after acute pulmonary embolism: One issue, multiple faces.

    Aurelian-Corneliu, Moraru / Mariana, Floria / Maria, Tanase Daniela / Anca, Ouatu / Dragoş-Marian, Popescu

    Anatolian journal of cardiology

    2022  Volume 26, Issue 1, Page(s) 75–76

    MeSH term(s) Acute Disease ; Humans ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/mortality
    Language English
    Publishing date 2022-02-22
    Publishing country Turkey
    Document type Letter ; Comment
    ZDB-ID 2278670-3
    ISSN 2149-2271 ; 2149-2271
    ISSN (online) 2149-2271
    ISSN 2149-2271
    DOI 10.5152/AnatolJCardiol.2021.862
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