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Article ; Online: Comparing unequal volumes of HIIT and MICT does not introduce bias.

Vollaard, Niels B J / Metcalfe, Richard S / Astorino, Todd A

Trends in endocrinology and metabolism: TEM

2023 Volume 34, Issue 6, Page(s) 315–316

MeSH term(s)	Humans ; Blood Pressure ; Exercise
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Letter
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2023.03.007
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Zs.A 2999: Show issues

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Article ; Online: Vaccinatie van immuungecompromitteerde patiënten.

Goorhuis, Abraham / Garcia-Garrido, Hannah M / Vollaard, Albert M

Nederlands tijdschrift voor geneeskunde

2020 Volume 164

Abstract: Immunocompromised individuals are at increased risk of infectious diseases and their complications. The main examples of these are pneumococcal disease and influenza, infections that are both vaccine-preventable. However, responses to vaccination are ... ...

Title translation	Vaccination of immunocompromised patients: when and when not to vaccinate.
Abstract	Immunocompromised individuals are at increased risk of infectious diseases and their complications. The main examples of these are pneumococcal disease and influenza, infections that are both vaccine-preventable. However, responses to vaccination are often impaired in immunocompromised patients. In addition, live-attenuated vaccines, including the measles-mumps-rubella and yellow fever vaccine, cannot be administered to these patients for safety reasons. In view of the decreasing herd immunity caused by a drop in global vaccination coverage, immunocompromised individuals are at increased risk of infections such as measles, especially during travel abroad. Despite these developments, the improved quality of life resulting from novel treatment options means that immunocompromised patients are travelling more and further than ever. It is the responsibility of the treating physician of the immunocompromised individual to ensure that all the required vaccines are provided in time. To this end, the physician may also refer the patient to the general practitioner or travel clinic for the actual vaccination.
MeSH term(s)	Female ; Humans ; Immunocompromised Host ; Measles-Mumps-Rubella Vaccine/adverse effects ; Middle Aged ; Travel ; Vaccines, Attenuated/adverse effects ; Yellow Fever Vaccine/adverse effects ; Young Adult
Chemical Substances	Measles-Mumps-Rubella Vaccine ; Vaccines, Attenuated ; Yellow Fever Vaccine
Language	Dutch
Publishing date	2020-09-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Ua VI Zs.18: Show issues

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Article ; Online: Acceptance and timeliness of post-exposure vaccination against mpox in high-risk contacts, Amsterdam, the Netherlands, May-July 2022.

van Ewijk, C E / Smit, C / Bavalia, R / Ainslie, K / Vollaard, A / van Rijckevorsel, G / Hahné, S J M

Vaccine

2023 Volume 41, Issue 47, Page(s) 6952–6959

Abstract: Background: May 2022, several countries reported mpox outbreaks among men-who-have-sex-with-men. In the Netherlands, high-risk contacts were offered the third-generation smallpox vaccine as post-exposure-prophylaxis (PEP) within 4 but maximum 14 days ... ...

Abstract	Background: May 2022, several countries reported mpox outbreaks among men-who-have-sex-with-men. In the Netherlands, high-risk contacts were offered the third-generation smallpox vaccine as post-exposure-prophylaxis (PEP) within 4 but maximum 14 days after exposure. We investigated their PEP acceptance, timeliness of uptake and development of mpox for the region of the Public Health Service (PHS) Amsterdam. Methods: High-risk contacts identified during 20 May-22 July 2022 were included. Contacts were followed-up 21 days after exposure and classified as: no patient (no mpox symptoms or orthopoxvirus PCR-negative) or mpox patient (clinically suspected mpox or orthopoxvirus PCR-positive). We calculated time intervals between date of last exposure and first PHS consultation, PEP administration, and symptom onset. Results: Two-hundred-ninety contacts were at high-risk of mpox predominantly due to sexual and/or direct skin-skin contact (212/290, 73 %). First PHS consultation was a median of 5 (IQR 3, 7) days after exposure, at which point 26/290 (9 %) contacts were ineligible for PEP. 84 % (223/264) of contacts eligible for PEP, received PEP within a median of 6 (IQR 3, 8) days after exposure. Of 282 contacts (missing outcome n = 8) 38 (14 %) developed mpox a median of 7 (IQR 5, 12) days after exposure, of whom 50 % (19/38) developed mpox before their first PHS consultation. Among contacts eligible for PEP, 2/38 (5 %) unvaccinated and 16/218 (7 %) vaccinated contact developed mpox. Conclusions: PEP acceptance among contacts of mpox patients was high. However, PEP timeliness was inadequate. Half of contacts received PEP 6 or more days after exposure, and half of contacts who developed mpox had an onset prior to their first PHS consultation. Estimating PEP vaccine effectiveness is problematic due to the timeliness of PEP and the time it takes to generate vaccine-induced immunity. It is important to assess how PEP timeliness may improve and to promote pre-exposure vaccination to control mpox outbreaks.
MeSH term(s)	Male ; Humans ; Homosexuality, Male ; Netherlands/epidemiology ; Mpox (monkeypox) ; Sexual and Gender Minorities ; Vaccination
Language	English
Publishing date	2023-10-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.10.013
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article ; Online: Predicting the consequences of physical activity: An investigation into the relationship between anxiety sensitivity, interoceptive accuracy and action.

Tabor, Abby / Vollaard, Niels / Keogh, Edmund / Eccleston, Christopher

PloS one

2019 Volume 14, Issue 3, Page(s) e0210853

Abstract: The ability to predict the consequences of our actions is imperative for the everyday success of our interactions. From negotiating an uneven surface, to mounting an immune response, we continually infer the limits of our body. The current investigation ... ...

Abstract	The ability to predict the consequences of our actions is imperative for the everyday success of our interactions. From negotiating an uneven surface, to mounting an immune response, we continually infer the limits of our body. The current investigation considered the impact that the inferred consequences of action has on the placement of limits. We hypothesised that the performance of individuals in a novel, sprint task would reflect both their ability to accurately detect changes in bodily arousal (Interoceptive Accuracy) and the inferred consequences associated with heightened arousal signals (Anxiety Sensitivity). We found that individuals who demonstrated accuracy associated with physiological arousal changes, and who showed a heightened fear of the consequences of arousal symptoms, modified their actions by decreasing their power output (mean Watts•kg-1) in a sprint task (ΔR2 = 0.19; F(1,34) = 19.87); p<0.001). These findings provide a basis for understanding the varying actions taken as we encounter bodily perturbation.
MeSH term(s)	Adult ; Anxiety/diagnosis ; Arousal/physiology ; Exercise/physiology ; Exercise/psychology ; Female ; Humans ; Interoception/physiology ; Male ; Young Adult
Language	English
Publishing date	2019-03-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0210853
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Article ; Online: Affecting Effects on Affect: The Impact of Protocol Permutations on Affective Responses to Sprint Interval Exercise; A Systematic Review and Meta-Analysis of Pooled Individual Participant Data.

Metcalfe, Richard S / Williams, Sean / Fernandes, Gwen S / Astorino, Todd A / Stork, Matthew J / Phillips, Shaun M / Niven, Ailsa / Vollaard, Niels B J

Frontiers in sports and active living

2022 Volume 4, Page(s) 815555

Abstract: Responses to sprint interval exercise (SIE) are hypothesized to be perceived as unpleasant, but SIE protocols are diverse, and moderating effects of various SIE protocol parameters on affective responses are unknown. We performed a systematic search to ... ...

Abstract	Responses to sprint interval exercise (SIE) are hypothesized to be perceived as unpleasant, but SIE protocols are diverse, and moderating effects of various SIE protocol parameters on affective responses are unknown. We performed a systematic search to identify studies (up to 01/05/2021) measuring affective valence using the Feeling Scale during acute SIE in healthy adults. Thirteen studies involving 18 unique trials and 316 unique participant (142 women and 174 men) affective responses to SIE were eligible for inclusion. We received individual participant data for all participants from all studies. All available end-of-sprint affect scores from each trial were combined in a linear mixed model with sprint duration, mode, intensity, recovery duration, familiarization and baseline affect included as covariates. Affective valence decreased significantly and proportionally with each additional sprint repetition, but this effect was modified by sprint duration: affect decreased more during 30 s (0.84 units/sprint; 95% CI: 0.74-0.93) and 15-20 s sprints (1.02 units/sprint; 95% CI: 0.93-1.10) compared with 5-6 s sprints (0.20 units/sprint; 95% CI: 0.18-0.22) (both Systematic review registration: Open Science Framework, https://osf.io/sbyn3.
Language	English
Publishing date	2022-02-17
Publishing country	Switzerland
Document type	Systematic Review
ISSN	2624-9367
ISSN (online)	2624-9367
DOI	10.3389/fspor.2022.815555
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Article ; Online: Improvements in Maximal Oxygen Uptake After Sprint-Interval Training Coincide with Increases in Central Hemodynamic Factors.

Mandić, Mirko / Hansson, Björn / Lovrić, Alen / Sundblad, Patrik / Vollaard, Niels B J / Lundberg, Tommy R / Gustafsson, Thomas / Rullman, Eric

Medicine and science in sports and exercise

2022 Volume 54, Issue 6, Page(s) 944–952

Abstract: Introduction: Sprint-interval training has been shown to improve maximal oxygen uptake, in part through peripheral muscle adaptations that increase oxygen utilization. In contrast, the adaptations of central hemodynamic factors in this context remain ... ...

Abstract	Introduction: Sprint-interval training has been shown to improve maximal oxygen uptake, in part through peripheral muscle adaptations that increase oxygen utilization. In contrast, the adaptations of central hemodynamic factors in this context remain unexplored. Purpose: The aim of the current study was to explore the effects of sprint-interval training on maximal oxygen uptake and central hemodynamic factors. Methods: Healthy men and women (n = 29; mean age, 27 ± 5 yr; height, 175 ± 8 cm; body mass, 72.5 ± 12.0 kg) performed 6 wk of sprint-interval training consisting of three weekly sessions of 10-min low-intensity cycling interspersed with 3 × 30-s all-out sprints. Maximal oxygen uptake, total blood volume, and maximal cardiac output were measured before and after the intervention. Results: Maximal oxygen uptake increased by 10.3% (P < 0.001). Simultaneously, plasma volume, blood volume, total hemoglobin mass, and cardiac output increased by 8.1% (276 ± 234 mL; P < 0.001), 6.8% (382 ± 325 mL; P < 0.001), 5.7% (42 ± 41 g; P < 0.001), and 8.5% (1.0 ± 0.9 L·min-1; P < 0.001), respectively. Increased total hemoglobin mass along with measures of body surface area had a significant impact on the improvements in maximal oxygen uptake. Conclusions: Six weeks of sprint-interval training results in significant increases in hemoglobin mass, blood volume, and cardiac output. Because these changes were associated with marked improvements in maximal oxygen uptake, we conclude that central hemodynamic adaptations contribute to the improvement in maximal oxygen uptake during sprint-interval training.
MeSH term(s)	Adult ; Female ; Hemodynamics ; Hemoglobins ; High-Intensity Interval Training/methods ; Humans ; Male ; Oxygen ; Oxygen Consumption/physiology ; Young Adult
Chemical Substances	Hemoglobins ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603994-7
ISSN	1530-0315 ; 0195-9131 ; 0025-7990
ISSN (online)	1530-0315
ISSN	0195-9131 ; 0025-7990
DOI	10.1249/MSS.0000000000002872
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Zs.A 869: Show issues

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Book ; Online: Electricity Requirements for a Digital Society

Baer, Walter S / Hassell, Scott / Vollaard, Ben A

2002

Keywords	Environmental policy & protocols ; Technology: general issues ; Political Science ; Technology
Language	English
Size	1 Online-Ressource
Publisher	RAND Corporation
Document type	Book ; Online
Note	English
HBZ-ID	HT030612364
ISBN	9780833032799 ; 0833032798
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Uitbraak van monkeypox: een nieuwe pandemie?

de Stoppelaar, Sacha F / Hoornenborg, Elske / van Rijckevorsel, Gini / Vollaard, Albert / Brandwagt, Diederik A H / de Vries, Henry J C / Schinkel, Janke / Welkers, Matthijs R A / Goorhuis, A

Nederlands tijdschrift voor geneeskunde

2022 Volume 166

Abstract: Monkeypox (MPX) is a disease caused by the monkeypox virus. It is a viral zoonotic disease, endemic in Central and West Africa. Human-to-human spread also occurs and is a feature of the current global outbreak. As far as we know, exponential transmission ...

Title translation	Monkeypox, a new pandemic?
Abstract	Monkeypox (MPX) is a disease caused by the monkeypox virus. It is a viral zoonotic disease, endemic in Central and West Africa. Human-to-human spread also occurs and is a feature of the current global outbreak. As far as we know, exponential transmission during this outbreak is not related to changed viral characteristics but due to multiple high-risk contacts in a subset of people that have contracted the virus, so far almost exclusively affecting men who have sex with men (MSM). Appropriate public health measures and increased alertness of all health care providers is needed to increase case-finding and decrease transmission. There is a real chance of MPX to become endemic in large parts of the world.
MeSH term(s)	Male ; Humans ; Mpox (monkeypox)/epidemiology ; Homosexuality, Male ; Pandemics ; Sexual and Gender Minorities ; Monkeypox virus
Language	Dutch
Publishing date	2022-09-08
Publishing country	Netherlands
Document type	English Abstract ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Ua VI Zs.18: Show issues

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Article: Immunogenicity of the 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Followed by the 23-Valent Pneumococcal Polysaccharide Vaccine (PPSV23) in Adults with and without Immunosuppressive Therapy.

Garcia Garrido, Hannah M / Vollaard, Albert / D'Haens, Geert R / Spuls, Phyllis I / Bemelman, Frederike J / Tanck, Michael W / de Bree, Godelieve J / Meek, Bob / Grobusch, Martin P / Goorhuis, Abraham

Vaccines

2022 Volume 10, Issue 5

Abstract: Immunosuppressive therapy increases the risk of pneumococcal disease. This risk can be mitigated by pneumococcal vaccination. The objective of this study was to investigate the immunogenicity of the 13-valent pneumococcal conjugate vaccine (PCV13), ... ...

Abstract	Immunosuppressive therapy increases the risk of pneumococcal disease. This risk can be mitigated by pneumococcal vaccination. The objective of this study was to investigate the immunogenicity of the 13-valent pneumococcal conjugate vaccine (PCV13), followed by the 23-valent pneumococcal polysaccharide vaccine (PPSV23), in adults with and without immunosuppressive therapy. We performed a prospective cohort study among adults using conventional immunomodulators (cIM), biological immunomodulators (bIM), combination therapy, and controls during 12 months. The primary outcome was seroprotection, defined as the proportion of patients with a postimmunization IgG concentration of ≥1.3 µg/mL for at least 70% (17/24) of the serotypes of PCV13 + PPSV23. We included 214 participants. For all 24 vaccine serotypes, IgG levels increased significantly in both treatment subgroups and controls, with peak seroprotection rates of 44% (combination therapy), 58% (cIM), 57% (bIM), and 82% (controls). By month 12, seroprotection had decreased to 24%, 48%, 39%, and 63%, respectively. Although pneumococcal vaccination with PCV13 + PPSV23 was immunogenic in all treatment groups, impaired vaccination responses were observed in patients using immunosuppressive medication. Apart from the obvious recommendation to administer vaccines before such medication is started, alternative vaccination strategies, such as additional PCV13 doses or higher-valent pneumococcal vaccines, should be investigated.
Language	English
Publishing date	2022-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10050795
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Article ; Online: The effect of low volume sprint interval training in patients with non-alcoholic fatty liver disease.

MacLean, Catriona / Dillon, John / Babraj, John A / Vollaard, Niels Bj

The Physician and sportsmedicine

2017 Volume 46, Issue 1, Page(s) 87–92

Abstract: Objectives: Exercise is an important part of disease management in patients with non-alcoholic fatty liver disease (NAFLD), but adherence to current exercise recommendations is poor. Novel low-volume sprint interval training (SIT) protocols with total ... ...

Abstract	Objectives: Exercise is an important part of disease management in patients with non-alcoholic fatty liver disease (NAFLD), but adherence to current exercise recommendations is poor. Novel low-volume sprint interval training (SIT) protocols with total training time commitments of ≤30 min per week have been shown to improve cardiometabolic risk and functional capacity in healthy sedentary participants, but the efficacy of such protocols in the management of NAFLD remains unknown. The aim of the present study was to examine whether a low-volume SIT protocol can be used to improve liver function, insulin resistance, body composition, physical fitness, cognitive function and general well-being in patients with NAFLD. Methods: In the present study, 7 men and 2 women with NAFLD (age: 45 ± 8 y, BMI: 28.7 ± 4.1 kg·m Results: Walking speed during the walk test (+12%), estimated V̇O Conclusion: This study does not support the use of 6 weeks of a low volume SIT protocol involving twice-weekly sessions with 5-10 × 6-s 'all-out' cycle sprints as an intervention for NAFLD disease management.
MeSH term(s)	Activities of Daily Living ; Adult ; Blood Pressure ; Body Composition ; Cardiovascular Diseases/prevention & control ; Cognition ; Disease Management ; Exercise ; Female ; High-Intensity Interval Training ; Humans ; Insulin Resistance ; Liver/pathology ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/therapy ; Oxygen Consumption ; Physical Fitness/physiology ; Platelet Count ; Quality of Life ; Running/physiology ; Walking
Language	English
Publishing date	2017-12-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	753046-8
ISSN	2326-3660 ; 0091-3847
ISSN (online)	2326-3660
ISSN	0091-3847
DOI	10.1080/00913847.2018.1411171
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