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  1. Article ; Online: Comment on: Serum Strem-1 in adult-onset Still's disease: a novel biomarker of disease activity and a potential predictor of the chronic course.

    Ugurlu, Serdal / Egeli, Bugra Han

    Rheumatology (Oxford, England)

    2020  Volume 59, Issue 11, Page(s) e115

    MeSH term(s) Adult ; Biomarkers ; Humans ; Still's Disease, Adult-Onset/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-08-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keaa465
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  2. Article ; Online: In Familial Mediterranean Fever, soluble TREM-1 plasma level is higher in case of amyloidosis.

    Ugurlu, Serdal / Egeli, Bugra Han

    Innate immunity

    2020  Volume 26, Issue 3, Page(s) 231

    MeSH term(s) Amyloidosis ; Familial Mediterranean Fever ; Humans ; Triggering Receptor Expressed on Myeloid Cells-1
    Chemical Substances Triggering Receptor Expressed on Myeloid Cells-1
    Language English
    Publishing date 2020-03-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2381250-3
    ISSN 1753-4267 ; 1753-4259
    ISSN (online) 1753-4267
    ISSN 1753-4259
    DOI 10.1177/1753425920908645
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  3. Article ; Online: The clinical role of anakinra in the armamentarium against familial Mediterranean fever.

    Parlar, Kerem / Ates, Muhammed Bahaddin / Egeli, Bugra Han / Ugurlu, Serdal

    Expert review of clinical immunology

    2023  Volume 20, Issue 5, Page(s) 441–453

    Abstract: Introduction: Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease that has mainly been treated with colchicine since 1972. A significant portion of patients do not respond to colchicine and require further treatment, mainly IL- ...

    Abstract Introduction: Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease that has mainly been treated with colchicine since 1972. A significant portion of patients do not respond to colchicine and require further treatment, mainly IL-1β antagonists such as anakinra, canakinumab and rilonacept as IL-1β has a crucial role in pathogenesis of FMF. This review summarizes the current approach to treating FMF and discovers the pharmacological and clinical utility of IL-1 blocking agents based on accumulated evidence with a focus on anakinra.
    Areas covered: This review focuses on anakinra treatment in FMF. The data obtained from case reports, case series, retrospective studies and a Phase III trial are analyzed. Safety and efficacy profiles of anakinra are discussed.
    Expert opinion: Anakinra is the cheapest anti-IL-1 agent used in the treatment of colchicine-resistant FMF. It is shown to be effective and safe when used in adjunct to colchicine however its short half-life and potential to cause injection site reactions limit its use.
    MeSH term(s) Humans ; Familial Mediterranean Fever/drug therapy ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Retrospective Studies ; Colchicine/therapeutic use ; Interleukin-1beta
    Chemical Substances Interleukin 1 Receptor Antagonist Protein ; Colchicine (SML2Y3J35T) ; Interleukin-1beta
    Language English
    Publishing date 2023-12-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2023.2299230
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  4. Article ; Online: Correction to: Late-onset familial mediterranean fever: single-center experience and literature review.

    Aydin, Okan / Egeli, Bugra Han / Ozdogan, Huri / Ugurlu, Serdal

    Internal and emergency medicine

    2022  Volume 17, Issue 5, Page(s) 1307

    Language English
    Publishing date 2022-03-04
    Publishing country Italy
    Document type Published Erratum
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-022-02953-7
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    Zs.A 6673: Show issues Location:
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  5. Article ; Online: Familial Mediterranean Fever: Clinical State Of The Art.

    Egeli, Bugra Han / Ugurlu, Serdal

    QJM : monthly journal of the Association of Physicians

    2020  

    Abstract: As the inflammation research improves year by year, so does our understanding of the autoinflammatory conditions. Over the past years, the number of monogenic autoinflammatory conditions snowballed thanks to our understanding of basic immunology and ... ...

    Abstract As the inflammation research improves year by year, so does our understanding of the autoinflammatory conditions. Over the past years, the number of monogenic autoinflammatory conditions snowballed thanks to our understanding of basic immunology and genetics. Familial Mediterranean Fever (FMF), being the entrance to this fascinating world, still has clinical relevance as it enables us to understand our approach to these patients, treatment modalities, and pathological mechanisms. This review can be used as a tool for clinicians already working with FMF patients to update themselves on recent scientific literature.
    Language English
    Publishing date 2020-10-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcaa291
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  6. Article ; Online: A Novel Homozygous

    Ozler, Oguz / Egeli, Bugra Han / Zeybek, Selcan / Eris, Erdem / Teke Kisa, Pelin

    Clinical pediatrics

    2022  Volume 62, Issue 6, Page(s) 537–540

    MeSH term(s) Humans ; Cataract/complications ; Cataract/diagnosis ; Cataract/genetics ; Mutation ; Jaundice/etiology
    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/00099228221136120
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    Zs.A 454: Show issues Location:
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  7. Article ; Online: Late-onset familial mediterranean fever: single-center experience and literature review.

    Aydin, Okan / Egeli, Bugra Han / Ozdogan, Huri / Ugurlu, Serdal

    Internal and emergency medicine

    2022  Volume 17, Issue 5, Page(s) 1301–1306

    Abstract: Familial Mediterranean fever (FMF) is a hereditary, autoinflammatory disease characterized by recurrent fever and serositis attacks. The disease onset occurs before 20 years of age in 90% of patients and rarely after the 4th decade. The aim of this study ...

    Abstract Familial Mediterranean fever (FMF) is a hereditary, autoinflammatory disease characterized by recurrent fever and serositis attacks. The disease onset occurs before 20 years of age in 90% of patients and rarely after the 4th decade. The aim of this study is to screen our FMF patient pool for patients with disease onset after age of 40 and to compare them to patients with early onset with regard to clinical and genetic features. The charts of 2020 patients registered in our FMF center in the years 2008-2017 were screened with regard to age of disease onset. Patients with disease onset after the age of 40 were considered as late-onset group (Group 1). The control group (Group 2) consisted of patients with a disease onset before the age of 20 who were randomly selected from the patient pool with twice the number of probands. Demographic, clinical and genetic data were recorded. Out of 2020 patients, the attacks of FMF had started after the fourth decade in 41 patients (2.02%), (Group 1). The male to female ratio was 1:1.7 in both groups. The delay of diagnosis was 5.6 ± 5.75 years in group 1, 10.7 ± 12.3 years in group 2. The only significant difference with regard to clinical features between two groups was the frequency of fever, which was present in 26 (63.4%) patients in group 1 and 67 (81.7%) in group 2 (p = 0.026). M694V mutation was more prevalent among early-onset group whereas exon 2 variants were more frequent in patients with late onset. The mean colchicine dose in the last 6 months was 1.38 ± 0.64 mg in group 1, and 1.61 ± 0.47 mg in group 2. FMF may start after 40 years of age in approximately 2% of the patients. Lower frequency of fever, lower daily colchicine dose and lower prevalence of exon 10 mutations point out that FMF patients with a disease onset after 40 years of age experience a milder disease compared to those with an onset before the second decade of life.
    MeSH term(s) Colchicine/therapeutic use ; Familial Mediterranean Fever/diagnosis ; Familial Mediterranean Fever/drug therapy ; Familial Mediterranean Fever/epidemiology ; Female ; Fever ; Humans ; Male ; Mutation
    Chemical Substances Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2022-01-21
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02912-8
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  8. Article ; Online: Hereditary Bisalbuminemia in Sjögren’s Syndrome and Rheumatoid Arthritis

    Serdal Ugurlu / Bugra Han Egeli / Ibrahim Murat Bolayirli

    Journal of Clinical and Diagnostic Research, Vol 15, Iss 5, Pp OD01-OD

    2021  Volume 02

    Abstract: Bisalbuminemia is rare finding of bifid albumin bands in serum electrophoresis. The protein abnormality can be sporadic and inherited. So far, this albumin variant was not found to cause or coexist with a specific pathology. This is a case of ... ...

    Abstract Bisalbuminemia is rare finding of bifid albumin bands in serum electrophoresis. The protein abnormality can be sporadic and inherited. So far, this albumin variant was not found to cause or coexist with a specific pathology. This is a case of bisalbuminemia in 43-year-old female patient with a past medical history of Rheumatoid Arthritis (RA) and Sjogren’s Syndrome (SS). Similar electrophoresis findings were seen in two siblings of the patient. Rheumatology focused work-up of the family was negative. We could not find an association between this blood protein variant and the patient’s rheumatologic condition. Bisalbuminemia should not be a concern to the rheumatologist as it does not hint towards pathology.
    Keywords albumin variant ; autoimmunity ; protein electrophoresis ; Medicine ; R
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Effects of vitamin supplements on clinical cardiovascular outcomes: Time to move on! - A comprehensive review.

    Simsek, Bahadir / Selte, Atakan / Egeli, Bugra Han / Çakatay, Ufuk

    Clinical nutrition ESPEN

    2021  Volume 42, Page(s) 1–14

    Abstract: Background & aims: Vitamin supplementations have increasingly been advertised on media and reported to be widely used by the general public to improve cardiovascular health. Due to the COVID-19 pandemic, people have become more interested in ways to ... ...

    Abstract Background & aims: Vitamin supplementations have increasingly been advertised on media and reported to be widely used by the general public to improve cardiovascular health. Due to the COVID-19 pandemic, people have become more interested in ways to improve and maintain their health. Increased awareness of people on healthy lifestyle is translating into inquisition regarding dietary supplements.
    Aim: First, focus on the most commonly used vitamin supplements and comprehensively review the evidence for and against recommending them to patients to improve and/or maintain cardiovascular health. Second, illustrate how the interest in studies shifted over time from Vitamin A, E, C, and B to Vitamin D and observational studies led to randomized controlled trials.
    Methods: A thorough PubMed search with the phrase: "Vitamin supplements and cardiovascular health" was performed. In the present review, focus was maintained on the evidence for the use of vitamin supplements in the prevention of major cardiovascular events and/or the maintenance of cardiovascular health by comprehensively reviewing all previous studies indexed in PubMed. Studies with clinical 'hard' end-points were included only.
    Results: A total of 87 studies met the inclusion criteria and were reviewed in the present article. High-quality evidence suggesting benefits for the use of vitamin supplements to maintain or improve cardiovascular health in people is minimal to non-existent.
    Conclusions: Vitamin supplementation does not improve clinical cardiovascular outcomes in general population. Counseling on the importance of maintaining a healthy lifestyle with adequate and nutritious food intake seems more appropriate to improve and maintain cardiovascular health.
    MeSH term(s) COVID-19 ; Cardiovascular System ; Databases, Factual ; Dietary Supplements ; Humans ; SARS-CoV-2 ; Vitamin D ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-02-25
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2021.02.014
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  10. Article ; Online: A Rare Cause of AA Amyloidosis: Idiopathic Retroperitoneal Fibrosis.

    Ugurlu, Serdal / Egeli, Bugra Han / Aslan, Samil / Oztas, Mert / Melikoglu, Melike

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2021  Volume 27, Issue 8S, Page(s) S685

    MeSH term(s) Amyloidosis/diagnosis ; Amyloidosis/etiology ; Humans ; Retroperitoneal Fibrosis/diagnosis ; Retroperitoneal Fibrosis/etiology ; Serum Amyloid A Protein
    Chemical Substances Serum Amyloid A Protein
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001613
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    Zs.A 4815: Show issues Location:
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