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  1. Article: Concomitant multiple subretinal cysticerci in neurocysticercosis.

    Chhabra, Simran / Narang, Subina / Bhattacharyya, Anusuya / Kaur, Ravinder

    Tropical parasitology

    2023  Volume 13, Issue 1, Page(s) 65–67

    Abstract: We present a unique case of asymptomatic NCC that was accidently diagnosed on radiological investigations after a road traffic accident. An Ophthalmologic consult was sought to rule out intraocular or optic nerve cysticercosis. Fundoscopy showed multiple ...

    Abstract We present a unique case of asymptomatic NCC that was accidently diagnosed on radiological investigations after a road traffic accident. An Ophthalmologic consult was sought to rule out intraocular or optic nerve cysticercosis. Fundoscopy showed multiple white-pale yellow lesions in the right eye which on ultrasonography confirmed cyst lined by a cyst wall consistent with subretinal cysticercosis. The patient was treated with diode laser photocoagulation. A high index of suspicion is required to diagnose NCCin endemic areas. In the right eye which on ultrasonography confirmed cyst lined by a cyst wall consistent with subretinal cysticercosis. The patient was treated with diode laser photocoagulation.
    Language English
    Publishing date 2023-05-19
    Publishing country India
    Document type Case Reports
    ZDB-ID 2628177-6
    ISSN 2229-7758 ; 2229-5070
    ISSN (online) 2229-7758
    ISSN 2229-5070
    DOI 10.4103/tp.tp_17_22
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  2. Article ; Online: Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19.

    Bhattacharyya, Anusuya / Sarma, Phulen / Kaur, Hardeep / Medhi, Bikash

    Annals of internal medicine

    2021  Volume 174, Issue 3, Page(s) 434

    MeSH term(s) Adult ; COVID-19/drug therapy ; Coronavirus Infections ; Humans ; Hydroxychloroquine/therapeutic use ; SARS-CoV-2
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L21-0001
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    Ua VI Zs.178/2: Show issues Location:
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  3. Article ; Online: Acute pancreatitis presenting as Purtscher-like retinopathy.

    Narang, Subina / Aggarwal, Purnima / Bhattacharyya, Anusuya / Singla, Sejal / Negi, Reetika / D Cruz, Sanjay

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2022  Volume 22, Issue 2, Page(s) 333–334

    MeSH term(s) Acute Disease ; Adult ; Humans ; Male ; Pancreatitis/complications ; Pancreatitis/diagnosis ; Retinal Diseases/complications ; Retinal Diseases/diagnosis ; Retinal Diseases/diagnostic imaging ; Retinal Diseases/etiology ; Retinal Hemorrhage/etiology
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2022.01.005
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    Zs.A 5553: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Letter to the editor: Possible role of topical povidone iodine in case of accidental ocular exposure to SARS-CoV-2.

    Sarma, Phulen / Kaur, Hardeep / Medhi, Bikash / Bhattacharyya, Anusuya

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2020  Volume 258, Issue 11, Page(s) 2575–2578

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Povidone ; Povidone-Iodine/adverse effects ; SARS Virus ; SARS-CoV-2
    Chemical Substances Povidone-Iodine (85H0HZU99M) ; Povidone (FZ989GH94E)
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-020-04864-9
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    Ul I Zs.15: Show issues Location:
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  5. Article ; Online: Possible prophylactic or preventive role of topical povidone iodine during accidental ocular exposure to 2019-nCoV.

    Sarma, Phulen / Kaur, Hardeep / Medhi, Bikash / Bhattacharyya, Anusuya

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2020  Volume 258, Issue 11, Page(s) 2563–2565

    MeSH term(s) Administration, Ophthalmic ; Anti-Infective Agents, Local/administration & dosage ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Eye Infections, Viral/prevention & control ; Eye Infections, Viral/transmission ; Humans ; Ophthalmic Solutions ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Povidone-Iodine/administration & dosage ; SARS-CoV-2
    Chemical Substances Anti-Infective Agents, Local ; Ophthalmic Solutions ; Povidone-Iodine (85H0HZU99M)
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country Germany
    Document type Letter
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-020-04752-2
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    Ul I Zs.15: Show issues Location:
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  6. Article ; Online: Role of intravenous aspirin versus oral aspirin in the treatment of acute coronary syndrome: Answering a clinical query by systematic review and meta-analysis of randomized controlled trials.

    Kaur, Hardeep / Sarma, Phulen / Bhattacharyya, Anusuya / Rohit, Manojkumar / Prajapat, Manisha / Kumar, Subodh / Prakash, Ajay / Medhi, Bikash

    Indian journal of pharmacology

    2023  Volume 55, Issue 2, Page(s) 133–137

    Abstract: Background: Aspirin is indicated in the emergency management of acute coronary syndrome. However, oral aspirin has erratic bioavailability compared to i.v. formulation.: Objective: The objective of this study was to evaluate the comparative efficacy ... ...

    Abstract Background: Aspirin is indicated in the emergency management of acute coronary syndrome. However, oral aspirin has erratic bioavailability compared to i.v. formulation.
    Objective: The objective of this study was to evaluate the comparative efficacy and safety of intravenous (IV) and oral aspirin in acute coronary syndrome.
    Study design: This was a systematic review and meta-analysis.
    Results: Two randomized controlled trials were included. Compared to oral aspirin, lower platelet aggregability was seen with IV aspirin at 5 min and 20 min. Lower thromboxane B2 and lower platelet CD-62p levels were noted in the IV group; however, no significant difference was observed in terms of "composite cardiovascular death, stroke, and myocardial infarction (MI) at 4-6 weeks," "any cause mortality," "cardiovascular mortality," "occurrence of stroke," and "occurrence of MI/reinfarction." However, no difference was noted in terms of the occurrence of serious adverse events.
    Conclusion: IV aspirin showed some advantages in terms of platelet aggregability biomarkers at 20 min and 1 week with comparable safety to oral aspirin. No difference was seen in terms of clinical outcomes (at 24 h, 7, and 30 days) and the occurrence of serious adverse events.
    MeSH term(s) Humans ; Acute Coronary Syndrome/drug therapy ; Aspirin/therapeutic use ; Randomized Controlled Trials as Topic ; Administration, Intravenous ; Stroke/drug therapy ; Stroke/prevention & control
    Chemical Substances Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2023-06-13
    Publishing country India
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 605829-2
    ISSN 1998-3751 ; 0253-7613
    ISSN (online) 1998-3751
    ISSN 0253-7613
    DOI 10.4103/ijp.ijp_1147_20
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    Zs.A 1983: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 311: Show issues

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  7. Article ; Online: Efficacy, tolerability and safety of perampanel in population with pharmacoresistant focal seizures: A systematic review and meta-analysis.

    Mahajan, Sonia Shinde / Prakash, Ajay / Sarma, Phulen / Niraj, Niraj / Bhattacharyya, Anusuya / Medhi, Bikash

    Epilepsy research

    2022  Volume 182, Page(s) 106895

    Abstract: Background: Focal seizures are associated with various co-morbidities. Seizure disorders also affect the quality of life of the patients. A huge proportion of patients continue to have uncontrolled seizures despite the availability of numerous ... ...

    Abstract Background: Focal seizures are associated with various co-morbidities. Seizure disorders also affect the quality of life of the patients. A huge proportion of patients continue to have uncontrolled seizures despite the availability of numerous antiepileptic drugs. Novel therapeutic targets too, have failed to overcome this problem. Therefore, drugs acting on conventional targets are being explored. Perampanel is one such drug. The present study aimed to assess its efficacy, safety, and effect on quality of life and cognition in patients aged 12 years and above.
    Methods: Database search was conducted using keywords perampanel, partial seizures and randomized controlled trials (RCTs). Single and double blinded RCTs were included in the analysis. The primary outcomes assessed were 50% responder rate and seizure freedom rates. Secondary outcomes assessed were Improvement in Clinical Global Improvement for Change (CGI-C), number of patients who experienced adverse events, number of patients who withdrew from trials, adverse drug reaction (ADR) profile from Vigibase, long term safety, quality of Life (QoL) assessment and cognitive assessment, especially in adolescents. The Risk ratios (RR) were calculated for these parameters.
    Results: 24 full text articles were obtained out of a total 421 studies. From these seven double blind randomized controlled trials were included in the meta-analysis. Perampanel treated patients showed higher 50% responder rates than those treated with placebo. The Risk Ratios (RRs) were 1.39 [95% confidence interval (CI) 1.08-1.79], 1.83 [95% CI 1.51 - 2.22] and 1.81 [95% CI 1.45-2.27] for the 4 mg per day, 8 mg once daily and 12 mg once daily subgroups of perampanel respectively. The RRs for the seizure freedom rates were 4.52 [95% CI 1.30-15.73], 3.65 [95% CI 1.40-9.52] and 2.14 [95% CI 1.11-4.11] for 4 mg per day, 8 mg once daily and 12 mg once daily subgroups of perampanel respectively. There was a significantly higher risk of TEAEs with the 8 mg and 12 mg doses of perampanel as compared to that with placebo. Number of patients who withdrew from the trials due to adverse events was statistically significant in only the 12 mg subgroup of perampanel in comparison to that with placebo group.
    Conclusion: Perampanel was observed to be an effective add on drug for treating pharmacoresistant focal seizures. The patients achieved higher 50% response rates and freedom from seizures with its use. Tolerability of perampanel was more at lower doses.
    MeSH term(s) Adolescent ; Epilepsies, Partial/chemically induced ; Epilepsies, Partial/drug therapy ; Humans ; Nitriles ; Pyridones/adverse effects ; Randomized Controlled Trials as Topic ; Seizures/chemically induced ; Seizures/drug therapy ; Treatment Outcome
    Chemical Substances Nitriles ; Pyridones ; perampanel (H821664NPK)
    Language English
    Publishing date 2022-03-04
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2022.106895
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    Zs.A 2193: Show issues Location:
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  8. Article: Possible prophylactic or preventive role of topical povidone iodine during accidental ocular exposure to 2019-nCoV

    Sarma, Phulen / Kaur, Hardeep / Medhi, Bikash / Bhattacharyya, Anusuya

    Graefes Arch Clin Exp Ophthalmol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #324248
    Database COVID19

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  9. Article: Letter to the editor: Possible role of topical povidone iodine in case of accidental ocular exposure to SARS-CoV-2

    Sarma, Phulen / Kaur, Hardeep / Medhi, Bikash / Bhattacharyya, Anusuya

    Graefes Arch Clin Exp Ophthalmol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #680060
    Database COVID19

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  10. Article: A comprehensive insight on the challenges for COVID-19 vaccine: A lesson learnt from other viral vaccines.

    Singh, Rahul Soloman / Singh, Ashutosh / Masih, Gladson David / Batra, Gitika / Sharma, Amit Raj / Joshi, Rupa / Prakash, Ajay / Suroy, Benjamin / Sarma, Phulen / Prajapat, Manisha / Kaur, Hardeep / Bhattacharyya, Anusuya / Upadhyay, Sujata / Medhi, Bikash

    Heliyon

    2023  Volume 9, Issue 6, Page(s) e16813

    Abstract: The aim of this study is to comprehensively analyze previous viral vaccine programs and identify potential challenges and effective measures for the COVID-19 vaccine program. Previous viral vaccine programs, such as those for HIV, Zika, Influenza, Ebola, ...

    Abstract The aim of this study is to comprehensively analyze previous viral vaccine programs and identify potential challenges and effective measures for the COVID-19 vaccine program. Previous viral vaccine programs, such as those for HIV, Zika, Influenza, Ebola, Dengue, SARS, and MERS, were evaluated. Paramount challenges were identified, including quasi-species, cross-reactivity, duration of immunity, revaccination, mutation, immunosenescence, and adverse events related to viral vaccines. Although a large population has been vaccinated, mutations in SARS-CoV-2 and adverse events related to vaccines pose significant challenges. Previous vaccine programs have taught us that predicting the final outcome of the current vaccine program for COVID-19 cannot be determined at a given state. Long-term follow-up studies are essential. Validated preclinical studies, long-term follow-up studies, alternative therapeutic approaches, and alternative vaccines are necessary.
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16813
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