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  1. Article ; Online: Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19.

    Paiva, Claudia N / Tausk, Daniel V

    Annals of internal medicine

    2021  Volume 174, Issue 3, Page(s) 432–433

    MeSH term(s) Adult ; COVID-19/drug therapy ; Coronavirus Infections ; Humans ; Hydroxychloroquine/therapeutic use ; SARS-CoV-2
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L20-1424
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  2. Article ; Online: Chitin: A versatile biopolymer-based functional therapy for cartilage regeneration.

    Hameed, Huma / Khan, Mahtab Ahmad / Paiva-Santos, Ana Cláudia / Ereej, Nelofer / Faheem, Saleha

    International journal of biological macromolecules

    2024  Volume 265, Issue Pt 2, Page(s) 131120

    Abstract: Chitin is the second most abundant biopolymer and its inherent biological characteristics make it ideal to use for tissue engineering. For many decades, its properties like non-toxicity, abundant availability, ease of modification, biodegradability, ... ...

    Abstract Chitin is the second most abundant biopolymer and its inherent biological characteristics make it ideal to use for tissue engineering. For many decades, its properties like non-toxicity, abundant availability, ease of modification, biodegradability, biocompatibility, and anti-microbial activity have made chitin an ideal biopolymer for drug delivery. Research studies have also shown many potential benefits of chitin in the formulation of functional therapy for cartilage regeneration. Chitin and its derivatives can be processed into 2D/3D scaffolds, hydrogels, films, exosomes, and nano-fibers, which make it a versatile and functional biopolymer in tissue engineering. Chitin is a biomimetic polymer that provides targeted delivery of mesenchymal stem cells, especially of chondrocytes at the injected donor sites to accelerate regeneration by enhancing cell proliferation and differentiation. Due to this property, chitin is considered an interesting polymer that has a high potential to provide targeted therapy in the regeneration of cartilage. Our paper presents an overview of the method of extraction, structure, properties, and functional role of this versatile biopolymer in tissue engineering, especially cartilage regeneration.
    MeSH term(s) Tissue Scaffolds/chemistry ; Chitin/pharmacology ; Chitin/therapeutic use ; Cartilage ; Tissue Engineering/methods ; Hydrogels/chemistry ; Polymers ; Cartilage, Articular
    Chemical Substances Chitin (1398-61-4) ; Hydrogels ; Polymers
    Language English
    Publishing date 2024-03-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131120
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  3. Article ; Online: ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart.

    Paiva, Claudia N / Medei, Emiliano / Bozza, Marcelo T

    PLoS pathogens

    2018  Volume 14, Issue 4, Page(s) e1006928

    Abstract: The activation of macrophage respiratory burst in response to infection with Trypanosoma cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen species (ROS) in the elimination of T. cruzi was taken for granted, ... ...

    Abstract The activation of macrophage respiratory burst in response to infection with Trypanosoma cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen species (ROS) in the elimination of T. cruzi was taken for granted, but recent evidence suggests parasite growth is stimulated in oxidative environments. It is still a matter of debate whether indeed oxidative environments provide ideal conditions (e.g., iron availability in macrophages) for T. cruzi growth and whether indeed ROS signals directly to stimulate growth. Nitric oxide (NO) and ROS combine to form peroxynitrite, participating in the killing of phagocytosed parasites by activated macrophages. In response to infection, mitochondrial ROS are produced by cardiomyocytes. They contribute to oxidative damage that persists at the chronic stage of infection and is involved in functional impairment of the heart. In this review, we discuss how oxidative stress helps parasite growth during the acute stage and how it participates in the development of cardiomyopathy at the chronic stage.
    MeSH term(s) Animals ; Chagas Disease/complications ; Chagas Disease/microbiology ; Heart Diseases/etiology ; Humans ; Macrophages/microbiology ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Trypanosoma cruzi/pathogenicity
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1006928
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  4. Article ; Online: Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance.

    Silva, Rafael C M C / Travassos, Leonardo H / Paiva, Claudia N / Bozza, Marcelo T

    PLoS pathogens

    2020  Volume 16, Issue 7, Page(s) e1008599

    Abstract: Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to tolerate infection through reduction of tissue damage or affecting resistance, the ... ...

    Abstract Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to tolerate infection through reduction of tissue damage or affecting resistance, the ability of the host to control pathogen loads. In this Review, we will discuss the contribution of HO-1 in different and complex protozoan infections, such as malaria, leishmaniasis, Chagas disease, and toxoplasmosis. The complexity of these infections and the pleiotropic effects of HO-1 constitute an interesting area of study and an opportunity for drug development.
    MeSH term(s) Animals ; Heme Oxygenase-1/metabolism ; Humans ; Immune Tolerance/physiology ; Protozoan Infections/enzymology
    Chemical Substances Heme Oxygenase-1 (EC 1.14.14.18)
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1008599
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  5. Article ; Online: ROS and Trypanosoma cruzi

    Claudia N Paiva / Emiliano Medei / Marcelo T Bozza

    PLoS Pathogens, Vol 14, Iss 4, p e

    Fuel to infection, poison to the heart.

    2018  Volume 1006928

    Abstract: The activation of macrophage respiratory burst in response to infection with Trypanosoma cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen species (ROS) in the elimination of T. cruzi was taken for granted, ... ...

    Abstract The activation of macrophage respiratory burst in response to infection with Trypanosoma cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen species (ROS) in the elimination of T. cruzi was taken for granted, but recent evidence suggests parasite growth is stimulated in oxidative environments. It is still a matter of debate whether indeed oxidative environments provide ideal conditions (e.g., iron availability in macrophages) for T. cruzi growth and whether indeed ROS signals directly to stimulate growth. Nitric oxide (NO) and ROS combine to form peroxynitrite, participating in the killing of phagocytosed parasites by activated macrophages. In response to infection, mitochondrial ROS are produced by cardiomyocytes. They contribute to oxidative damage that persists at the chronic stage of infection and is involved in functional impairment of the heart. In this review, we discuss how oxidative stress helps parasite growth during the acute stage and how it participates in the development of cardiomyopathy at the chronic stage.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2018-04-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Ti

    Ghanbari, Roham / Nazarzadeh Zare, Ehsan / Paiva-Santos, Ana Cláudia / Rabiee, Navid

    Chemosphere

    2022  Volume 311, Issue Pt 2, Page(s) 137191

    Abstract: Nowadays, the evolution of two-dimensional materials like transition metal carbides (MXene) prepares a novel path to surpass the "trade-off" between the membrane permeation and rejection rates. Based on water swelling and oxidation vulnerability, MXene ... ...

    Abstract Nowadays, the evolution of two-dimensional materials like transition metal carbides (MXene) prepares a novel path to surpass the "trade-off" between the membrane permeation and rejection rates. Based on water swelling and oxidation vulnerability, MXene membranes showed vivid defects such as inadequate stability, detrimental adsorption, and haphazardly stacked nanosheets. Here, we prepared Ti
    Language English
    Publishing date 2022-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2022.137191
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    Zs.A 2540: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Heme oxygenase-1 in protozoan infections

    Rafael C M C Silva / Leonardo H Travassos / Claudia N Paiva / Marcelo T Bozza

    PLoS Pathogens, Vol 16, Iss 7, p e

    A tale of resistance and disease tolerance.

    2020  Volume 1008599

    Abstract: Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to tolerate infection through reduction of tissue damage or affecting resistance, the ... ...

    Abstract Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to tolerate infection through reduction of tissue damage or affecting resistance, the ability of the host to control pathogen loads. In this Review, we will discuss the contribution of HO-1 in different and complex protozoan infections, such as malaria, leishmaniasis, Chagas disease, and toxoplasmosis. The complexity of these infections and the pleiotropic effects of HO-1 constitute an interesting area of study and an opportunity for drug development.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The Paradoxical Leishmanicidal Effects of Superoxide Dismutase (SOD)-Mimetic Tempol in

    Oliveira, Laíse B / Celes, Fabiana S / Paiva, Claudia N / de Oliveira, Camila I

    Frontiers in cellular and infection microbiology

    2019  Volume 9, Page(s) 237

    Abstract: Leishmaniasis is an infectious disease caused by protozoans of the ... ...

    Abstract Leishmaniasis is an infectious disease caused by protozoans of the genus
    MeSH term(s) Acetophenones/pharmacology ; Animals ; Antioxidants ; Cyclic N-Oxides/pharmacology ; Disease Models, Animal ; Ditiocarb ; Drug Therapy/methods ; Female ; Hydrogen Peroxide ; Inhibitory Concentration 50 ; Leishmania braziliensis/drug effects ; Leishmaniasis, Cutaneous/drug therapy ; Macrophages/drug effects ; Macrophages/parasitology ; Mice ; Mice, Inbred BALB C ; Parasite Load ; Spin Labels ; Superoxide Dismutase/pharmacology ; Vitamin K 3/pharmacology
    Chemical Substances Acetophenones ; Antioxidants ; Cyclic N-Oxides ; Spin Labels ; Vitamin K 3 (723JX6CXY5) ; Ditiocarb (99Z2744345) ; acetovanillone (B6J7B9UDTR) ; Hydrogen Peroxide (BBX060AN9V) ; Superoxide Dismutase (EC 1.15.1.1) ; tempol (U78ZX2F65X)
    Language English
    Publishing date 2019-06-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2019.00237
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  9. Article: Systemic sclerosis and rheumatoid arthritis overlap syndrome - management of severe cardiac, pulmonary and articular involvement.

    Pinto, Ana Sofia / Santos, Filipe Cunha / Dinis, Sara Paiva / Madeira, Nathalie / Ferreira, Joana Fonseca / Vaz, Claúdia

    Reumatologia

    2023  Volume 61, Issue 1, Page(s) 55–62

    Abstract: Introduction: The presence of another rheumatological condition in patients with systemic sclerosis (SSc) is not uncommon. To report a case of a patient with SSc-RA overlap and perform a review of the cases reported in the literature.: Material and ... ...

    Abstract Introduction: The presence of another rheumatological condition in patients with systemic sclerosis (SSc) is not uncommon. To report a case of a patient with SSc-RA overlap and perform a review of the cases reported in the literature.
    Material and methods: A chart review of the present case report was performed. After, we performed a literature search in MEDLINE, EMBASE and Cochrane databases.
    Results: We included 26 articles. Sixty-three patients were reviewed, 51 were female with a mean age of 45.03 years at the time of the first diagnosis. Sixty-three patients were diagnosed with limited cutaneous SSc. Regarding organ involvement, the most frequently reported were cutaneous, vascular, pulmonary and gastrointestinal involvement. Erosions were presenting 65.08% of patients. A panoply of treatments was used.
    Conclusions: The authors concluded that screening for an associated disease should be encouraged since the overlap with SSc may affect prognosis and treatment.
    Language English
    Publishing date 2023-03-08
    Publishing country Poland
    Document type Case Reports
    ZDB-ID 604151-6
    ISSN 0034-6233
    ISSN 0034-6233
    DOI 10.5114/reum/161299
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  10. Article ; Online: Delayed diagnosis of vertebral fracture in long-standing ankylosing spondylitis.

    Dinis, Sara Paiva / Pinto, Ana Sofia / Santos, Filipe Cunha / Augusto, Duarte / Fonseca Ferreira, Joana / Vaz, Cláudia / Madeira, Nathalie

    Rheumatology advances in practice

    2024  Volume 8, Issue 2, Page(s) rkae025

    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article
    ISSN 2514-1775
    ISSN (online) 2514-1775
    DOI 10.1093/rap/rkae025
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