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  1. Article ; Online: Reply to Cuervo et al and Horinouchi et al.

    Danneels, Pierre / Hamel, Jean-François / Lemaignen, Adrien / Cattoir, Vincent / Dubée, Vincent

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  Volume 76, Issue 8, Page(s) 1525–1528

    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac956
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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  2. Article ; Online: [No title information]

    Dhersin, Robin / Bazeries, Paul / Chenouard, Rachel / Dubée, Vincent

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2022  Volume 194, Issue 23, Page(s) E832–E833

    Title translation Diagnostic retardé de la tuberculose urinaire.
    MeSH term(s) Delayed Diagnosis ; Humans ; Tuberculosis, Urogenital/diagnosis ; Urinary Tract Infections/diagnosis
    Language French
    Publishing date 2022-06-11
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.210889-f
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  3. Article ; Online: Delayed diagnosis of urinary tuberculosis.

    Dhersin, Robin / Bazeries, Paul / Chenouard, Rachel / Dubée, Vincent

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2022  Volume 194, Issue 8, Page(s) E310

    MeSH term(s) Adult ; Delayed Diagnosis ; Humans ; Male ; Renal Insufficiency/etiology ; Tomography, X-Ray Computed ; Tuberculosis, Urogenital/complications ; Tuberculosis, Urogenital/diagnosis ; Tuberculosis, Urogenital/drug therapy ; Tuberculosis, Urogenital/urine ; Urine/microbiology
    Language English
    Publishing date 2022-02-28
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.210889
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  4. Article: Caractéristiques cliniques et épidémiologiques de la Covid-19.

    Mahieu, Rafael / Dubée, Vincent

    Actualites pharmaceutiques

    2020  Volume 59, Issue 599, Page(s) 24–26

    Abstract: Severe acute respiratory syndrome coronavirus 2, the coronavirus with respiratory tropism responsible for COVID-19, was isolated for the first time in China at the end of 2019. Several months after its discovery and despite its pandemic spread, there are ...

    Title translation Clinical and epidemiological characteristics of COVID-19.
    Abstract Severe acute respiratory syndrome coronavirus 2, the coronavirus with respiratory tropism responsible for COVID-19, was isolated for the first time in China at the end of 2019. Several months after its discovery and despite its pandemic spread, there are still many grey areas concerning the pathophysiology and treatment of COVID-19. However, we have strong data on its epidemiological characteristics and the clinical expression of this disease is now well described.
    Keywords covid19
    Language French
    Publishing date 2020-08-21
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 885063-x
    ISSN 0515-3700
    ISSN 0515-3700
    DOI 10.1016/j.actpha.2020.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3126: Show issues Location:
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  5. Article ; Online: COVID-19 and Fungal infections: a double debacle.

    Mina, Sara / Yaakoub, Hajar / Annweiler, Cédric / Dubée, Vincent / Papon, Nicolas

    Microbes and infection

    2022  Volume 24, Issue 8, Page(s) 105039

    Abstract: Fungal infections remain hardly treatable because of unstandardized diagnostic tests, limited antifungal armamentarium, and more specifically, potential toxic interactions between antifungals and immunosuppressants used during anti-inflammatory therapies, ...

    Abstract Fungal infections remain hardly treatable because of unstandardized diagnostic tests, limited antifungal armamentarium, and more specifically, potential toxic interactions between antifungals and immunosuppressants used during anti-inflammatory therapies, such as those set up in critically ill COVID-19 patients. Taking into account pre-existing difficulties in treating vulnerable COVID-19 patients, any co-occurrence of infectious diseases like fungal infections constitutes a double debacle for patients, healthcare experts, and the public economy. Since the first appearance of SARS-CoV-2, a significant rise in threatening fungal co-infections in COVID-19 patients has been testified in the scientific literature. Better management of fungal infections in COVID-19 patients is, therefore, a priority and requires highlighting common risk factors, relationships with immunosuppression, as well as challenges in fungal diagnosis and treatment. The present review attempts to highlight these aspects in the three most identified causative agents of fungal co-infections in COVID-19 patients: Aspergillus, Candida, and Mucorales species.
    MeSH term(s) Humans ; COVID-19/complications ; Coinfection/epidemiology ; SARS-CoV-2 ; Mycoses/drug therapy ; Mycoses/epidemiology ; Candida ; Antifungal Agents/therapeutic use
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2022-08-24
    Publishing country France
    Document type Review ; Journal Article
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2022.105039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5014: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Caractéristiques cliniques et épidémiologiques de la Covid-19

    Mahieu, Rafael / Dubée, Vincent

    Actualités Pharmaceutiques

    2020  Volume 59, Issue 599, Page(s) 24–26

    Keywords Pharmacology (medical) ; Pharmacology ; covid19
    Language French
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 885063-x
    ISSN 0515-3700
    ISSN 0515-3700
    DOI 10.1016/j.actpha.2020.08.006
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Zs.A 3126: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Cerebrospinal fluid concentrations of cefiderocol during the treatment of extensively drug-resistant Pseudomonas aeruginosa ventriculitis.

    Luque-Paz, David / Bennis, Youssef / Jaubert, Paul / Dubée, Vincent / Wolff, Michel / Mortaza, Satar

    The Journal of antimicrobial chemotherapy

    2022  Volume 77, Issue 6, Page(s) 1787–1789

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cephalosporins/therapeutic use ; Cerebral Ventriculitis/drug therapy ; Drug Resistance, Multiple, Bacterial ; Humans ; Microbial Sensitivity Tests ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa ; Cefiderocol
    Chemical Substances Anti-Bacterial Agents ; Cephalosporins
    Language English
    Publishing date 2022-02-22
    Publishing country England
    Document type Letter
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac066
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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  8. Article: Caractéristiques cliniques et épidémiologiques de la Covid-19./ [Clinical and epidemiological characteristics of COVID-19]

    Mahieu, Rafael / Dubée, Vincent

    Actual Pharm

    Abstract: Severe acute respiratory syndrome coronavirus 2, the coronavirus with respiratory tropism responsible for COVID-19, was isolated for the first time in China at the end of 2019. Several months after its discovery and despite its pandemic spread, there are ...

    Abstract Severe acute respiratory syndrome coronavirus 2, the coronavirus with respiratory tropism responsible for COVID-19, was isolated for the first time in China at the end of 2019. Several months after its discovery and despite its pandemic spread, there are still many grey areas concerning the pathophysiology and treatment of COVID-19. However, we have strong data on its epidemiological characteristics and the clinical expression of this disease is now well described.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #866342
    Database COVID19

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  9. Article: Impact of a strategy based on unique blood culture sampling on contamination rate and detection of bloodstream infections in critically ill patients.

    Mahieu, Rafael / Lemarié, Carole / Douillet, Delphine / Mercat, Alain / Cormier, Hélène / Eveillard, Matthieu / Dubée, Vincent / Riou, Jérémie / Kouatchet, Achille

    Annals of intensive care

    2023  Volume 13, Issue 1, Page(s) 13

    Abstract: Background: Unique blood culture (UBC) has been proposed to limit the number of venipuncture and to decrease the risk of BC contaminations (BCC) without affecting their yield. We hypothesized that a multi-faceted program based on UBC in the ICU may ... ...

    Abstract Background: Unique blood culture (UBC) has been proposed to limit the number of venipuncture and to decrease the risk of BC contaminations (BCC) without affecting their yield. We hypothesized that a multi-faceted program based on UBC in the ICU may reduce the rate of contaminants with a similar performance for bloodstream infections (BSI) identification.
    Methods: In a before and after design, we compared the proportion of BSI and BCC. A first 3-year period with multi-sampling (MS) strategy followed by a 4-month washout period, where staff received education and training for using UBC, and a 32-month period, where UBC was routinely used, while education and feedback were maintained. During the UBC period, a large volume of blood (40 mL) was sampled through a unique venipuncture with additional BC collections discouraged for 48 h.
    Results: Of the 4,491 patients included (35% female patients, mean age 62 years) 17,466 BC were collected. The mean volume of blood per bottle collected increased from 2.8 ± 1.8 mL to 8.2 ± 3.9 mL between the MS and UBC periods, P < 0.01. A 59.6% reduction (95% CI 56.7-62.3; P < 0.001) of BC bottles collected per week was observed between the MS and UBC periods. The rate of BCC per patient decreased between the two periods from 11.2% to 3.8% (73.4% reduction; P < 0.001) for the MS and UBC periods, P < 0.001. Meanwhile, the rate of BSI per patient remained stable at 13.2% and 13.2% for the MS and UBC periods, P = 0.98.
    Conclusions: In ICU patients, a strategy based on UBC reduces the contamination rate of cultures without affecting their yield.
    Language English
    Publishing date 2023-03-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-023-01107-y
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  10. Article ; Online: Impact of ceftriaxone and temocillin on fecal abundance of extended-spectrum β-lactamase producing Escherichia coli in a mouse model.

    Chenouard, Rachel / Mahieu, Rafael / Luque Paz, David / Marion, Estelle / Eveillard, Matthieu / Dubée, Vincent

    PloS one

    2021  Volume 16, Issue 3, Page(s) e0248177

    Abstract: Background: Gut colonization by ESBL-producing Enterobacteriaceae (ESBL-PE) is widespread and is promoted by antibiotic exposure. Higher fecal abundance of ESBL-PE promotes the dissemination of the bacteria in the environment and is associated with ... ...

    Abstract Background: Gut colonization by ESBL-producing Enterobacteriaceae (ESBL-PE) is widespread and is promoted by antibiotic exposure. Higher fecal abundance of ESBL-PE promotes the dissemination of the bacteria in the environment and is associated with increased risk of infection. Ceftriaxone and temocillin are commonly used antibiotics with a different activity on gut flora. Their impact on fecal abundance of ESBL-producing Enterobacteriaceae has not been studied. The objective of this study was to compare the propensity of ceftriaxone and temocillin to modify the abundance of ESBL-producing Escherichia coli in feces of colonized mice.
    Methods: Mice received broad-spectrum antibiotics in order to disrupt their normal gut flora. A CTX-M-type ESBL-producing E. coli clinical isolate was then administered orally, leading to durable colonization. Thirty days later, mice received either temocillin or ceftriaxone with drinking water at a concentration simulating human intestinal exposure. Third-generation-cephalosporin resistant (3GCR) E. coli were enumerated in feces on selective medium before, 2 days and 10 days after the end of antibiotic exposure. The experiment was performed with two E. coli isolates with different temocillin minimum inhibitory concentrations.
    Results: Exposure to ceftriaxone induced an increase in the fecal abundance of 3GCR E. coli. In contrast, temocillin had no effect or transiently decreased the number of 3GCR E. coli. Results obtained with the two strains were similar.
    Conclusion: Contrary to ceftriaxone, temocillin does not promote expansion of ESBL-producing E. coli in feces of colonized mice. Thus temocillin may be a therapeutic of choice when a temocillin-susceptible strain infection is suspected or proven to prevent the expansion of ESBL-PE in a previously colonized patient.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Ceftriaxone/metabolism ; Ceftriaxone/pharmacology ; Disease Models, Animal ; Enterobacteriaceae/drug effects ; Escherichia coli/drug effects ; Escherichia coli Infections/drug therapy ; Feces/chemistry ; Feces/microbiology ; Female ; Humans ; Male ; Mice ; Microbial Sensitivity Tests ; Penicillins/metabolism ; Penicillins/pharmacology ; beta-Lactamases/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Penicillins ; temocillin (03QB156W6I) ; Ceftriaxone (75J73V1629) ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0248177
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