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  1. Book ; Online: Resilience and Economic Intelligence Through Digitalization and Big Data Analytics

    Dima, Alina

    (Proceedings of the International Conference on Economics and Social Sciences)

    2021  

    Series title Proceedings of the International Conference on Economics and Social Sciences
    Keywords Research & development management ; Computing & information technology ; Finance & accounting ; Civil service & public sector ; resilience ; business intelligence ; digitalization ; big data
    Language 0|e
    Size 1 electronic resource (495 pages)
    Publisher De Gruyter
    Publishing place Berlin/Boston
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021610925
    ISBN 9788366675704 ; 836667570X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; Conference proceedings: Innovative Models to Revive the Global Economy : Proceedings of the 3rd International Conference on Economics and Social Sciences

    Dima, Alina Mihaela

    2020  

    Keywords Economic systems & structures ; Business and Economics, Business Management, Management Accounting, Financial Controlling, Cost Calculation, Investment, Business Development, Change Management, Cooperation, Industries, Public Sector, Public Private Partnerships, Public Administration
    Size 1 electronic resource (1059 pages)
    Publisher De Gruyter
    Document type Book ; Online ; Conference proceedings
    Note English ; Open Access
    HBZ-ID HT021047686
    ISBN 9788395815072 ; 8395815077
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; Conference proceedings: Collaborative Research for Excellence in Economics and Social Sciences : Proceedings of the 2nd International Conference on Economics and Social Sciences

    Mihaela Dima, Alina

    2019  

    Keywords Economic systems & structures ; Business and Economics, Business Management, Management Accounting, Financial Controlling, Cost Calculation, Investment, Business Development, Change Management, Cooperation, Industries, Public Sector, Public Private Partnerships, Public Administration
    Size 1 electronic resource (330 pages)
    Publisher De Gruyter
    Document type Book ; Online ; Conference proceedings
    Note German ; Open Access
    HBZ-ID HT021047179
    ISBN 9788366675322 ; 8366675327
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Technological Challenges and Sustainable Development

    Alina Mihaela Dima

    Amfiteatru Economic, Vol 25, Iss Special Issue No. 17, Pp 947 -

    2023  Volume 949

    Abstract: In the contemporary context dominated by rapid technological advances, sustainable development has emerged as an essential and globally significant topic of discussion. While the undeniable benefits technology brings to everyday life, we must also ... ...

    Abstract In the contemporary context dominated by rapid technological advances, sustainable development has emerged as an essential and globally significant topic of discussion. While the undeniable benefits technology brings to everyday life, we must also confront the significant challenges it poses to sustainable development goals. One of the major challenges we face in promoting sustainable development is the increasing dependence on the Earth's limited resources. Advanced technologies, including electronic devices and electric vehicles, generate a growing demand for natural resources. This phenomenon can lead to overexploitation of resources and significant negative environmental impacts. Addressing this challenge and finding solutions requires the development of more efficient and sustainable technologies, the promotion of advanced recycling practices, and the identification of innovative alternatives. Paradoxically, technology can also be a significant source of solutions for promoting sustainable development. Through innovations like the Internet of Things (IoT) and Artificial Intelligence (AI), we have the opportunity to monitor and efficiently manage resources such as energy and water, thereby reducing waste and inefficiencies. Furthermore, technology can facilitate sustainable development by providing increased access to information and education in critical areas related to the environment and sustainability.
    Keywords editorial ; Business ; HF5001-6182 ; Economics as a science ; HB71-74
    Subject code 690
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Academy of Economic Studies of Bucharest
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Resilience and Economic Intelligence through Digitalization and Big Data Analytics

    Alina Mihaela Dima

    Amfiteatru Economic, Vol 23, Iss Special Issue No. 15, Pp 896-

    2021  Volume 898

    Abstract: The concept of “resilience” has gained popularity during the COVID-19 pandemic, especially from the perspective of networking of issues that had mostly been treated separately before. It has become clear that the interconnected systems of economy, ... ...

    Abstract The concept of “resilience” has gained popularity during the COVID-19 pandemic, especially from the perspective of networking of issues that had mostly been treated separately before. It has become clear that the interconnected systems of economy, environment and society need consistent and solid approaches for building resilience to similar shocks, thus avoiding cascading and widespread failure. The digital transformation process has been accelerated and it proved to be the lifeline for many businesses and public systems. However, digitalization exacerbated the social divide and put pressure on the companies that did not have the resources to face the challenges of new technology integration. The onlife digitalization is the new phase of society digitalization where big data and smart algorithms based on artificial intelligence changed the decision process mechanism in the public and private sectors. During 2020, leaders found themselves at historic crossroads, taking decisions under remarkable pressures and uncertainties. However, new opportunities are available to shape the economic recovery, restore the health of the environment, develop sustainable business models, strengthen regional development, revitalize global cooperation, harness Industry 4.0, and redesign the social contracts, skills, and jobs.
    Keywords editorial ; resilience ; Business ; HF5001-6182 ; Economics as a science ; HB71-74
    Subject code 300
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Academy of Economic Studies of Bucharest
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: The pivotal role of EMT-related noncoding RNAs regulatory axes in hepatocellular carcinoma.

    Ghionescu, Alina-Veronica / Sorop, Andrei / Dima, Simona Olimpia

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1270425

    Abstract: Hepatocellular carcinoma (HCC) remains a major health problem worldwide, being the leading cause of cancer-related deaths, with limited treatment options, especially in its advanced stages. Tumor resistance is closely associated with the activation of ... ...

    Abstract Hepatocellular carcinoma (HCC) remains a major health problem worldwide, being the leading cause of cancer-related deaths, with limited treatment options, especially in its advanced stages. Tumor resistance is closely associated with the activation of the EMT phenomenon and its reversal, being modulated by different molecules, including noncoding RNAs (ncRNAs). Noncoding RNAs have the potential to function as both tumor suppressors and oncogenic molecules, controlling the malignant potential of HCC cells. Basically, these molecules circulate in the tumor microenvironment, encapsulated in exosomes. Their impact on cell biology is more significant than originally expected, which makes related research rather complex. The temporal and spatial expression patterns, precise roles and mechanisms of specific ncRNAs encapsulated in exosomes remain primarily unknown in different stages of the disease. This review aims to highlight the recent advances in ncRNAs related to EMT and classifies the described mechanism as direct and indirect, for a better summarization. Moreover, we provide an overview of current research on the role of ncRNAs in several drug resistance-related pathways, including the emergence of resistance to sorafenib, doxorubicin, cisplatin and paclitaxel therapy. Nevertheless, we comprehensively discuss the underlying regulatory mechanisms of exosomal ncRNAs in EMT-HCC via intercellular communication pathways.
    Language English
    Publishing date 2023-09-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1270425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: EM-transcriptomic signature predicts drug response in advanced stages of high-grade serous ovarian carcinoma based on ascites-derived primary cultures.

    Constantinescu, Diana-Roxana / Sorop, Andrei / Ghionescu, Alina-Veronica / Lixandru, Daniela / Herlea, Vlad / Bacalbasa, Nicolae / Dima, Simona Olimpia

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1363142

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1363142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Production networks and resilience: How dense production networks shield economies in financial crisis.

    Caraiani, Petre / Dima, Alina Mihaela / Păun, Cristian / Stamule, Tănase / Vargas, Madalina Vanesa

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0302012

    Abstract: The research delves into the underexplored area of how production network structures influence the severity of economic downturns, particularly during the last financial crisis. Utilizing the RSTAN database from the OECD, we meticulously derived critical ...

    Abstract The research delves into the underexplored area of how production network structures influence the severity of economic downturns, particularly during the last financial crisis. Utilizing the RSTAN database from the OECD, we meticulously derived critical measures from the input-output matrices for 61 economies. Our methodology entailed a panel analysis spanning from 2008 to 2010, which is a period marked by significant recessionary pressures. This analysis aimed to correlate economic performance with various production network metrics, taking into account control factors such as interest rates and the prevalence of service sectors. The findings reveal a noteworthy positive correlation between the density of production networks and economic resilience during the crisis, which remained consistent across multiple model specifications. Conversely, as anticipated, higher interest rates were linked to poorer economic performance, highlighting the critical interplay between monetary policy and economic outcomes during periods of financial instability. Given these insights, we propose a policy recommendation emphasizing the strategic enhancement of production network density as a potential buffer against economic downturns. This approach suggests that policymakers should consider the structural aspects of production networks in designing economic stability and growth strategies, thus potentially mitigating the impacts of future financial crises.
    MeSH term(s) Resilience, Psychological
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0302012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Diagnostic Application of Volatile Organic Compounds as Potential Biomarkers for Detecting Digestive Neoplasia: A Systematic Review.

    Dima, Augustin Catalin / Balaban, Daniel Vasile / Dima, Alina

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 12

    Abstract: Volatile organic compounds (VOCs) are part of the exhaled breath that were proposed as non-invasive breath biomarkers via different human discharge products like saliva, breath, urine, blood, or tissues. Particularly, due to the non-invasive approach, ... ...

    Abstract Volatile organic compounds (VOCs) are part of the exhaled breath that were proposed as non-invasive breath biomarkers via different human discharge products like saliva, breath, urine, blood, or tissues. Particularly, due to the non-invasive approach, VOCs were considered as potential biomarkers for non-invasive early cancer detection. We herein aimed to review the data over VOCs utility in digestive neoplasia as early diagnosis or monitoring biomarkers. A systematic literature search was done using MEDLINE via PubMed, Cochrane Library, and Thomson Reuters' Web of Science Core Collection. We identified sixteen articles that were included in the final analysis. Based on the current knowledge, we cannot identify a single VOC as a specific non-invasive biomarker for digestive neoplasia. Several combinations of up to twelve VOCs seem promising for accurately detecting some neoplasia types. A combination of different VOCs breath expression are promising tools for digestive neoplasia screening.
    Language English
    Publishing date 2021-12-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11122317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Rheumatoid vasculitis in 2023: Changes and challenges since the biologics era.

    Mertz, Philippe / Wollenschlaeger, Clara / Chasset, François / Dima, Alina / Arnaud, Laurent

    Autoimmunity reviews

    2023  Volume 22, Issue 9, Page(s) 103391

    Abstract: Background: Significant changes in the epidemiology and natural history of rheumatoid vasculitis (RV) have occurred with the introduction of biological therapies such as TNF inhibitors (TNFi) and rituximab.: Purpose: This scoping review aims to ... ...

    Abstract Background: Significant changes in the epidemiology and natural history of rheumatoid vasculitis (RV) have occurred with the introduction of biological therapies such as TNF inhibitors (TNFi) and rituximab.
    Purpose: This scoping review aims to address the key current challenges and propose updated criteria for RV. This will aid future descriptive observational studies and prospective therapeutic trials.
    Methodology: The MEDLINE database was searched for eligible articles from inception through December 2022. Articles were selected based on language and publication date after 1998, corresponding to the approval of the first TNFi in rheumatic diseases.
    Results: Sixty articles were included in the review. The mean incidence of RV has decreased since the approval of biologic therapies in RA, from 9.1 (95% CI: 6.8-12.0) per million between 1988 and 2000 to 3.9 (95% CI: 2.3-6.2) between 2001 and 2010, probably due to significant improvement in RA severity and a decrease in smoking habits. Factors associated with an increased risk of RV include smoking at RA diagnosis, longer disease duration, severe RA, immunopositivity, and male gender (regardless of age). Homozygosity for the HLA-DRB104 shared epitope is linked to RV, while the presence of HLA-C3 is a significant predictor of vasculitis in patients without HLA-DRB104. Cutaneous (65-88%), neurologic (35-63%), and cardiac (33%) manifestations are common in RV, often associated with constitutional symptoms (70%). Histologic findings range from small vessel vasculitis to medium-sized necrotizing arteritis, but definite evidence of vasculitis is not required in the 1984 Scott and Bacon diagnostic criteria. Existing data on RV treatment are retrospective, and no formal published guidelines are currently available.
    Conclusion: The understanding of RV pathogenesis has improved since its initial diagnostic criteria, with a wider range of clinical manifestations identified. However, a validated and updated criteria that incorporates these advances is currently lacking, impeding the development of descriptive observational studies and prospective therapeutic trials.
    Primary funding source: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
    MeSH term(s) Humans ; Male ; Rheumatoid Vasculitis/drug therapy ; Rheumatoid Vasculitis/epidemiology ; Rheumatoid Vasculitis/etiology ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/complications ; Retrospective Studies ; Biological Products/therapeutic use ; Rituximab/therapeutic use ; Antirheumatic Agents/therapeutic use
    Chemical Substances Biological Products ; Rituximab (4F4X42SYQ6) ; Antirheumatic Agents
    Language English
    Publishing date 2023-07-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2023.103391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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